KRAS c.34_35delinsTA ;(p.G12Y)

Variant ID: 12-25398284-CC-TA

NM_004985.3(KRAS):c.34_35delinsTA;(p.G12Y)

This variant was identified in 24 publications

View GRCh38 version.




Publications:


The mutational landscape of cancer's vulnerability to ionizing radiation.

Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research
Gopal, Priyanka P; Yard, Brian D BD; Petty, Aaron A; Lal, Jessica C JC; Bera, Titas K TK; Hoang, Trung Q TQ; Buhimschi, Alexandru B AB; Abazeed, Mohamed E ME
Publication Date: 2022-10-12

Variant appearance in text: KRAS: G12Y
PubMed Link: 36222846
Variant Present in the following documents:
  • ccr-22-1914_supplementary_data_3_suppds3.xlsx, sheet 1
  • ccr-22-1914_supplementary_data_2_suppds2.xlsx, sheet 1
View BVdb publication page



Genomic Landscape of RTK/RAS Pathway and Tumor Immune Infiltration as Prognostic Indicator of Lung Adenocarcinoma.

Frontiers In Oncology
Yin, Xiang-Qian XQ; Yin, Xue-Hui XH; Yu, Ya-Qin YQ; Xu, Lang L; Zhang, Mao M
Publication Date: 2022

Variant appearance in text: KRAS: G12Y
PubMed Link: 35936718
Variant Present in the following documents:
  • Table_4.xlsx, sheet 2
View BVdb publication page



Characteristics and Treatment Outcomes in Advanced-Stage Non-Small Cell Lung Cancer Patients with a KRAS G12C Mutation: A Real-World Study.

Journal Of Clinical Medicine
Illini, Oliver O; Fabikan, Hannah H; Hochmair, Maximilian Johannes MJ; Weinlinger, Christoph C; Krenbek, Dagmar D; Brcic, Luka L; Setinek, Ulrike U; Terbuch, Angelika A; Absenger, Gudrun G; Konjić, Selma S; Valipour, Arschang A
Publication Date: 2022-07-15

Variant appearance in text: KRAS: G12Y
PubMed Link: 35887862
Variant Present in the following documents:
  • jcm-11-04098.pdf
View BVdb publication page



Whole-Exome Sequencing Could Distinguish Primary Pulmonary Squamous Cell Carcinoma From Lung Metastases in Individuals With Cervical Squamous Cell Carcinoma.

Pathology Oncology Research : Por
Li, Lihong L; Song, Qianqian Q; Cao, Dandan D; Jiao, Yuchen Y; Yuan, Guangwen G; Song, Yan Y
Publication Date: 2022

Variant appearance in text: KRAS: G12Y
PubMed Link: 35645619
Variant Present in the following documents:
  • DataSheet1.xlsx, sheet 3
  • DataSheet1.xlsx, sheet 2
View BVdb publication page



Response prediction and risk stratification of patients with rectal cancer after neoadjuvant therapy through an analysis of circulating tumour DNA.

Ebiomedicine
Liu, Wenyang W; Li, Yifei Y; Tang, Yuan Y; Song, Qianqian Q; Wang, Jingjing J; Li, Ning N; Chen, Silin S; Shi, Jinming J; Wang, Shulian S; Li, Yexiong Y; Jiao, Yuchen Y; Zeng, Yixin Y; Jin, Jing J
Publication Date: 2022-04

Variant appearance in text: KRAS: G12Y
PubMed Link: 35306340
Variant Present in the following documents:
  • mmc3.xlsx, sheet 2
View BVdb publication page



Identification of RAS mutant biomarkers for EGFR inhibitor sensitivity using a systems biochemical approach.

Cell Reports
McFall, Thomas T; Stites, Edward C EC
Publication Date: 2021-12-14

Variant appearance in text: KRAS: G12Y
PubMed Link: 34910921
Variant Present in the following documents:
  • Main text
  • NIHMS1764636-supplement-2.pdf
  • nihms-1764636.pdf
View BVdb publication page



The landscape of driver mutations in cutaneous squamous cell carcinoma.

Npj Genomic Medicine
Chang, Darwin D; Shain, A Hunter AH
Publication Date: 2021-07-16

Variant appearance in text: KRAS: G12Y
PubMed Link: 34272401
Variant Present in the following documents:
  • 41525_2021_226_MOESM5_ESM.xlsx, sheet 1
View BVdb publication page



Mutation profile and immunoscore signature in thymic carcinomas: An exploratory study and review of the literature.

Thoracic Cancer
Asselta, Rosanna R; Di Tommaso, Luca L; Perrino, Matteo M; Destro, Annarita A; Giordano, Laura L; Cardamone, Giulia G; Rubino, Luca L; Santoro, Armando A; Duga, Stefano S; Zucali, Paolo Andrea PA
Publication Date: 2021-05

Variant appearance in text: KRAS: G12Y
PubMed Link: 33704917
Variant Present in the following documents:
  • TCA-12-1271-s003.xls, sheet 1
View BVdb publication page



Pan-cancer circulating tumor DNA detection in over 10,000 Chinese patients.

Nature Communications
Zhang, Yongliang Y; Yao, Yu Y; Xu, Yaping Y; Li, Lifeng L; Gong, Yan Y; Zhang, Kai K; Zhang, Meng M; Guan, Yanfang Y; Chang, Lianpeng L; Xia, Xuefeng X; Li, Lin L; Jia, Shuqin S; Zeng, Qiang Q
Publication Date: 2021-01-04

Variant appearance in text: KRAS: 34_35delGGinsTA; G12Y
PubMed Link: 33397889
Variant Present in the following documents:
  • 41467_2020_20162_MOESM6_ESM.xlsx, sheet 1
View BVdb publication page



PKCε Is Required for KRAS-Driven Lung Tumorigenesis.

Cancer Research
Garg, Rachana R; Cooke, Mariana M; Benavides, Fernando F; Abba, Martín C MC; Cicchini, Michelle M; Feldser, David M DM; Kazanietz, Marcelo G MG
Publication Date: 2020-12-01

Variant appearance in text: KRAS: G12Y
PubMed Link: 32994205
Variant Present in the following documents:
  • Main text
View BVdb publication page



Functional significance of U2AF1 S34F mutations in lung adenocarcinomas.

Nature Communications
Esfahani, Mohammad S MS; Lee, Luke J LJ; Jeon, Young-Jun YJ; Flynn, Ryan A RA; Stehr, Henning H; Hui, Angela B AB; Ishisoko, Noriko N; Kildebeck, Eric E; Newman, Aaron M AM; Bratman, Scott V SV; Porteus, Matthew H MH; Chang, Howard Y HY; Alizadeh, Ash A AA; Diehn, Maximilian M
Publication Date: 2019-12-13

Variant appearance in text: KRAS: G12Y
PubMed Link: 31836708
Variant Present in the following documents:
  • 41467_2019_13392_MOESM4_ESM.xlsx, sheet 1
View BVdb publication page



An integrative pharmacogenomics analysis identifies therapeutic targets in KRAS-mutant lung cancer.

Ebiomedicine
Wang, Haiyun H; Lv, Qi Q; Xu, Yue Y; Cai, Zhaoqing Z; Zheng, Jie J; Cheng, Xiaojie X; Dai, Yao Y; Jänne, Pasi A PA; Ambrogio, Chiara C; Köhler, Jens J
Publication Date: 2019-11

Variant appearance in text: KRAS: G12Y
PubMed Link: 31668570
Variant Present in the following documents:
  • Main text
  • main.pdf
View BVdb publication page



miR-147b-mediated TCA cycle dysfunction and pseudohypoxia initiate drug tolerance to EGFR inhibitors in lung adenocarcinoma.

Nature Metabolism
Zhang, Wen Cai WC; Wells, Julie M JM; Chow, Kin-Hoe KH; Huang, He H; Yuan, Min M; Saxena, Tanvi T; Melnick, Mary Ann MA; Politi, Katerina K; Asara, John M JM; Costa, Daniel B DB; Bult, Carol J CJ; Slack, Frank J FJ
Publication Date: 2019-04

Variant appearance in text: KRAS: G12Y
PubMed Link: 31535082
Variant Present in the following documents:
  • NIHMS1523414-supplement-Sup_Tables.xlsx, sheet 7
View BVdb publication page



MHC class II restricted neoantigen peptides predicted by clonal mutation analysis in lung adenocarcinoma patients: implications on prognostic immunological biomarker and vaccine design.

Bmc Genomics
Cai, Weijing W; Zhou, Dapeng D; Wu, Weibo W; Tan, Wen Ling WL; Wang, Jiaqian J; Zhou, Caicun C; Lou, Yanyan Y
Publication Date: 2018-08-03

Variant appearance in text: KRAS: G12Y
PubMed Link: 30075702
Variant Present in the following documents:
  • 12864_2018_4958_MOESM4_ESM.xlsx, sheet 1
  • 12864_2018_4958_MOESM3_ESM.xlsx, sheet 1
  • 12864_2018_4958_MOESM5_ESM.xlsx, sheet 1
View BVdb publication page



Single-cell RNA-seq reveals a distinct transcriptome signature of aneuploid hematopoietic cells.

Blood
Zhao, Xin X; Gao, Shouguo S; Wu, Zhijie Z; Kajigaya, Sachiko S; Feng, Xingmin X; Liu, Qingguo Q; Townsley, Danielle M DM; Cooper, James J; Chen, Jinguo J; Keyvanfar, Keyvan K; Fernandez Ibanez, Maria Del Pilar MDP; Wang, Xujing X; Young, Neal S NS
Publication Date: 2017-12-21

Variant appearance in text: KRAS: G12Y
PubMed Link: 29030335
Variant Present in the following documents:
  • Main text
View BVdb publication page



Pan-urologic cancer genomic subtypes that transcend tissue of origin.

Nature Communications
Chen, Fengju F; Zhang, Yiqun Y; Bossé, Dominick D; Lalani, Aly-Khan A AA; Hakimi, A Ari AA; Hsieh, James J JJ; Choueiri, Toni K TK; Gibbons, Don L DL; Ittmann, Michael M; Creighton, Chad J CJ
Publication Date: 2017-08-04

Variant appearance in text: KRAS: G12Y
PubMed Link: 28775315
Variant Present in the following documents:
  • 41467_2017_289_MOESM7_ESM.xlsx, sheet 1
View BVdb publication page



Circulating tumour DNA sequence analysis as an alternative to multiple myeloma bone marrow aspirates.

Nature Communications
Kis, Olena O; Kaedbey, Rayan R; Chow, Signy S; Danesh, Arnavaz A; Dowar, Mark M; Li, Tiantian T; Li, Zhihua Z; Liu, Jessica J; Mansour, Mark M; Masih-Khan, Esther E; Zhang, Tong T; Bratman, Scott V SV; Oza, Amit M AM; Kamel-Reid, Suzanne S; Trudel, Suzanne S; Pugh, Trevor J TJ
Publication Date: 2017-05-11

Variant appearance in text: KRAS: G12Y
PubMed Link: 28492226
Variant Present in the following documents:
  • ncomms15086-s3.xlsx, sheet 1
View BVdb publication page



Genome-wide chemical mutagenesis screens allow unbiased saturation of the cancer genome and identification of drug resistance mutations.

Genome Research
Brammeld, Jonathan S JS; Petljak, Mia M; Martincorena, Inigo I; Williams, Steven P SP; Alonso, Luz Garcia LG; Dalmases, Alba A; Bellosillo, Beatriz B; Robles-Espinoza, Carla Daniela CD; Price, Stacey S; Barthorpe, Syd S; Tarpey, Patrick P; Alifrangis, Constantine C; Bignell, Graham G; Vidal, Joana J; Young, Jamie J; Stebbings, Lucy L; Beal, Kathryn K; Stratton, Michael R MR; Saez-Rodriguez, Julio J; Garnett, Mathew M; Montagut, Clara C; Iorio, Francesco F; McDermott, Ultan U
Publication Date: 2017-04

Variant appearance in text: KRAS: G12Y
PubMed Link: 28179366
Variant Present in the following documents:
  • supp_gr.213546.116_Supplemental_Table_S7.xlsx, sheet 1
View BVdb publication page



VarDict: a novel and versatile variant caller for next-generation sequencing in cancer research.

Nucleic Acids Research
Lai, Zhongwu Z; Markovets, Aleksandra A; Ahdesmaki, Miika M; Chapman, Brad B; Hofmann, Oliver O; McEwen, Robert R; Johnson, Justin J; Dougherty, Brian B; Barrett, J Carl JC; Dry, Jonathan R JR
Publication Date: 2016-06-20

Variant appearance in text: KRAS: 34_35delGGinsTA; G12Y
PubMed Link: 27060149
Variant Present in the following documents:
  • supp_gkw227_nar-03544-met-k-2015-File003.xls, sheet 2
View BVdb publication page



Genetic alterations of triple negative breast cancer by targeted next-generation sequencing and correlation with tumor morphology.

Modern Pathology : An Official Journal Of The United States And Canadian Academy Of Pathology, Inc
Weisman, Paul S PS; Ng, Charlotte K Y CK; Brogi, Edi E; Eisenberg, Rachel E RE; Won, Helen H HH; Piscuoglio, Salvatore S; De Filippo, Maria R MR; Ioris, Rafael R; Akram, Muzaffar M; Norton, Larry L; Weigelt, Britta B; Berger, Michael F MF; Reis-Filho, Jorge S JS; Wen, Hannah Y HY
Publication Date: 2016-05

Variant appearance in text: KRAS: G12Y
PubMed Link: 26939876
Variant Present in the following documents:
  • NIHMS752475-supplement-3.xlsx, sheet 1
View BVdb publication page



Mutant Kras copy number defines metabolic reprogramming and therapeutic susceptibilities.

Nature
Kerr, Emma M EM; Gaude, Edoardo E; Turrell, Frances K FK; Frezza, Christian C; Martins, Carla P CP
Publication Date: 2016-03-03

Variant appearance in text: KRAS: G12Y
PubMed Link: 26909577
Variant Present in the following documents:
  • Main text
  • emss-66648.pdf
View BVdb publication page



LowMACA: exploiting protein family analysis for the identification of rare driver mutations in cancer.

Bmc Bioinformatics
Melloni, Giorgio E M GE; de Pretis, Stefano S; Riva, Laura L; Pelizzola, Mattia M; Céol, Arnaud A; Costanza, Jole J; Müller, Heiko H; Zammataro, Luca L
Publication Date: 2016-02-09

Variant appearance in text: KRAS: G12Y
PubMed Link: 26860319
Variant Present in the following documents:
  • 12859_2016_935_MOESM2_ESM.xlsx, sheet 1
View BVdb publication page



BRAF and RAS mutations as prognostic factors in metastatic colorectal cancer patients undergoing liver resection.

British Journal Of Cancer
Schirripa, M M; Bergamo, F F; Cremolini, C C; Casagrande, M M; Lonardi, S S; Aprile, G G; Yang, D D; Marmorino, F F; Pasquini, G G; Sensi, E E; Lupi, C C; De Maglio, G G; Borrelli, N N; Pizzolitto, S S; Fasola, G G; Bertorelle, R R; Rugge, M M; Fontanini, G G; Zagonel, V V; Loupakis, F F; Falcone, A A
Publication Date: 2015-06-09

Variant appearance in text: KRAS: G12Y
PubMed Link: 25942399
Variant Present in the following documents:
View BVdb publication page



Whole-exome sequencing of pancreatic cancer defines genetic diversity and therapeutic targets.

Nature Communications
Witkiewicz, Agnieszka K AK; McMillan, Elizabeth A EA; Balaji, Uthra U; Baek, GuemHee G; Lin, Wan-Chi WC; Mansour, John J; Mollaee, Mehri M; Wagner, Kay-Uwe KU; Koduru, Prasad P; Yopp, Adam A; Choti, Michael A MA; Yeo, Charles J CJ; McCue, Peter P; White, Michael A MA; Knudsen, Erik S ES
Publication Date: 2015-04-09

Variant appearance in text: KRAS: G12Y
PubMed Link: 25855536
Variant Present in the following documents:
  • ncomms7744-s2.xlsx, sheet 1
View BVdb publication page