KRAS c.34_35delinsAA ;(p.G12N)

Variant ID: 12-25398284-CC-TT

NM_004985.3(KRAS):c.34_35delinsAA;(p.G12N)

This variant was identified in 23 publications

View GRCh38 version.




Publications:


Phase Ib/II Trial of BRAF and EGFR inhibition in BRAFV600E metastatic colorectal cancer and other cancers: EVICT (Erlotinib and Vemurafenib In Combination Trial).

Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research
Tan, Lavinia L; Tran, Ben B; Tie, Jeanne J; Markman, Ben B; Ananda, Sumi S; Tebbutt, Niall C NC; Michael, Michael M; Link, Emma E; Wong, Stephen Q SQ; Chandrashekar, Sushma S; Guinto, Jerick J; Ritchie, David D; Koldej, Rachel R; Solomon, Benjamin J BJ; McArthur, Grant A GA; Hicks, Rodney J RJ; Gibbs, Peter P; Dawson, Sarah-Jane SJ; Desai, Jayesh J
Publication Date: 2023-01-13

Variant appearance in text: KRAS: G12N
PubMed Link: 36638198
Variant Present in the following documents:
  • Main text
View BVdb publication page



Whole-Exome Sequencing Could Distinguish Primary Pulmonary Squamous Cell Carcinoma From Lung Metastases in Individuals With Cervical Squamous Cell Carcinoma.

Pathology Oncology Research : Por
Li, Lihong L; Song, Qianqian Q; Cao, Dandan D; Jiao, Yuchen Y; Yuan, Guangwen G; Song, Yan Y
Publication Date: 2022

Variant appearance in text: KRAS: G12N
PubMed Link: 35645619
Variant Present in the following documents:
  • DataSheet1.xlsx, sheet 3
  • DataSheet1.xlsx, sheet 2
View BVdb publication page



Adjuvant therapy for periampullary carcinoma and the significance of histopathological typing: A systematic review.

Translational Oncology
Duan, Zhiqing Z; Zhang, Yinuo Y; Tang, Yajie Y; Gao, Ruqing R; Bao, Jing J; Liang, Bo B
Publication Date: 2022-06

Variant appearance in text: KRAS: G12N
PubMed Link: 35397420
Variant Present in the following documents:
  • Main text
  • main.pdf
View BVdb publication page



Response prediction and risk stratification of patients with rectal cancer after neoadjuvant therapy through an analysis of circulating tumour DNA.

Ebiomedicine
Liu, Wenyang W; Li, Yifei Y; Tang, Yuan Y; Song, Qianqian Q; Wang, Jingjing J; Li, Ning N; Chen, Silin S; Shi, Jinming J; Wang, Shulian S; Li, Yexiong Y; Jiao, Yuchen Y; Zeng, Yixin Y; Jin, Jing J
Publication Date: 2022-04

Variant appearance in text: KRAS: G12N
PubMed Link: 35306340
Variant Present in the following documents:
  • mmc3.xlsx, sheet 2
View BVdb publication page



Bead-Based Isolation of Circulating Tumor DNA from Pancreatic Cancer Patients Enables High Fidelity Next Generation Sequencing.

Cancer Management And Research
Balendran-Braun, Sukirthini S; Kieler, Markus M; Liebmann-Reindl, Sandra S; Unseld, Matthias M; Bianconi, Daniela D; W Prager, Gerald G; Streubel, Berthold B
Publication Date: 2021

Variant appearance in text: KRAS: G12N
PubMed Link: 34393517
Variant Present in the following documents:
  • Main text
  • cmar-13-6249.pdf
View BVdb publication page



The landscape of driver mutations in cutaneous squamous cell carcinoma.

Npj Genomic Medicine
Chang, Darwin D; Shain, A Hunter AH
Publication Date: 2021-07-16

Variant appearance in text: KRAS: G12N
PubMed Link: 34272401
Variant Present in the following documents:
  • 41525_2021_226_MOESM5_ESM.xlsx, sheet 1
View BVdb publication page



The origins and genetic interactions of KRAS mutations are allele- and tissue-specific.

Nature Communications
Cook, Joshua H JH; Melloni, Giorgio E M GEM; Gulhan, Doga C DC; Park, Peter J PJ; Haigis, Kevin M KM
Publication Date: 2021-03-22

Variant appearance in text: KRAS: G12N
PubMed Link: 33753749
Variant Present in the following documents:
  • 41467_2021_22125_MOESM4_ESM.xlsx, sheet 4
View BVdb publication page



RNF43 Mutations in IPMN Cases: A Potential Prognostic Factor.

Gastroenterology Research And Practice
Chang, Xiao Yan XY; Wu, Yan Y; Jiang, Ying Y; Wang, Peng Yan PY; Chen, Jie J
Publication Date: 2020

Variant appearance in text: KRAS: G12N
PubMed Link: 32934653
Variant Present in the following documents:
  • Main text
  • GRP2020-1457452.pdf
View BVdb publication page



Ribonuclease MCPiP1 contributes to the loss of micro-RNA-200 family members in pancreatic cancer cells.

Oncotarget
Boudouresque, Françoise F; Siret, Carole C; Dobric, Aurélie A; Silvy, Françoise F; Soubeyran, Philippe P; Iovanna, Juan J; Lombardo, Dominique D; Berthois, Yolande Y
Publication Date: 2018-11-13

Variant appearance in text: KRAS: G12N
PubMed Link: 30542509
Variant Present in the following documents:
  • oncotarget-09-35941-s001.pdf
View BVdb publication page



RTK-RAS pathway mutation is enriched in myeloid sarcoma.

Blood Cancer Journal
Choi, Mihong M; Jeon, Yoon Kyung YK; Sun, Choong-Hyun CH; Yun, Hong-Seok HS; Hong, Junshik J; Shin, Dong-Yeop DY; Kim, Inho I; Yoon, Sung-Soo SS; Koh, Youngil Y
Publication Date: 2018-05-23

Variant appearance in text: KRAS: G12N
PubMed Link: 29789584
Variant Present in the following documents:
  • Main text
  • 41408_2018_Article_83.pdf
View BVdb publication page



Circulating tumour DNA sequence analysis as an alternative to multiple myeloma bone marrow aspirates.

Nature Communications
Kis, Olena O; Kaedbey, Rayan R; Chow, Signy S; Danesh, Arnavaz A; Dowar, Mark M; Li, Tiantian T; Li, Zhihua Z; Liu, Jessica J; Mansour, Mark M; Masih-Khan, Esther E; Zhang, Tong T; Bratman, Scott V SV; Oza, Amit M AM; Kamel-Reid, Suzanne S; Trudel, Suzanne S; Pugh, Trevor J TJ
Publication Date: 2017-05-11

Variant appearance in text: KRAS: G12N
PubMed Link: 28492226
Variant Present in the following documents:
  • ncomms15086-s3.xlsx, sheet 1
View BVdb publication page



Genome-wide chemical mutagenesis screens allow unbiased saturation of the cancer genome and identification of drug resistance mutations.

Genome Research
Brammeld, Jonathan S JS; Petljak, Mia M; Martincorena, Inigo I; Williams, Steven P SP; Alonso, Luz Garcia LG; Dalmases, Alba A; Bellosillo, Beatriz B; Robles-Espinoza, Carla Daniela CD; Price, Stacey S; Barthorpe, Syd S; Tarpey, Patrick P; Alifrangis, Constantine C; Bignell, Graham G; Vidal, Joana J; Young, Jamie J; Stebbings, Lucy L; Beal, Kathryn K; Stratton, Michael R MR; Saez-Rodriguez, Julio J; Garnett, Mathew M; Montagut, Clara C; Iorio, Francesco F; McDermott, Ultan U
Publication Date: 2017-04

Variant appearance in text: KRAS: G12N
PubMed Link: 28179366
Variant Present in the following documents:
  • supp_gr.213546.116_Supplemental_Table_S7.xlsx, sheet 1
View BVdb publication page



Multipoint Kras oncogene mutations potentially indicate mucinous carcinoma on the entire spectrum of mucinous ovarian neoplasms.

Oncotarget
Lee, Yi-Ju YJ; Lee, Ming-Yung MY; Ruan, Alexandra A; Chen, Chi-Kuan CK; Liu, Hao-Ping HP; Wang, Chau-Jong CJ; Chao, Wan-Ru WR; Han, Chih-Ping CP
Publication Date: 2016-12-13

Variant appearance in text: KRAS: G12N
PubMed Link: 27888800
Variant Present in the following documents:
  • Main text
  • oncotarget-07-82097.pdf
View BVdb publication page



VarDict: a novel and versatile variant caller for next-generation sequencing in cancer research.

Nucleic Acids Research
Lai, Zhongwu Z; Markovets, Aleksandra A; Ahdesmaki, Miika M; Chapman, Brad B; Hofmann, Oliver O; McEwen, Robert R; Johnson, Justin J; Dougherty, Brian B; Barrett, J Carl JC; Dry, Jonathan R JR
Publication Date: 2016-06-20

Variant appearance in text: KRAS: G12F
PubMed Link: 27060149
Variant Present in the following documents:
  • supp_gkw227_nar-03544-met-k-2015-File003.xls, sheet 2
View BVdb publication page



Genetic alterations of triple negative breast cancer by targeted next-generation sequencing and correlation with tumor morphology.

Modern Pathology : An Official Journal Of The United States And Canadian Academy Of Pathology, Inc
Weisman, Paul S PS; Ng, Charlotte K Y CK; Brogi, Edi E; Eisenberg, Rachel E RE; Won, Helen H HH; Piscuoglio, Salvatore S; De Filippo, Maria R MR; Ioris, Rafael R; Akram, Muzaffar M; Norton, Larry L; Weigelt, Britta B; Berger, Michael F MF; Reis-Filho, Jorge S JS; Wen, Hannah Y HY
Publication Date: 2016-05

Variant appearance in text: KRAS: G12N
PubMed Link: 26939876
Variant Present in the following documents:
  • NIHMS752475-supplement-3.xlsx, sheet 1
View BVdb publication page



Activation of MEK1/2-ERK1/2 signaling during NNK-induced lung carcinogenesis in female A/J mice.

Cancer Medicine
Yamakawa, Keiko K; Yokohira, Masanao M; Nakano, Yuko Y; Kishi, Sosuke S; Kanie, Shohei S; Imaida, Katsumi K
Publication Date: 2016-05

Variant appearance in text: KRAS: G12N
PubMed Link: 26864819
Variant Present in the following documents:
  • Main text
  • CAM4-5-903.pdf
View BVdb publication page



Different prognostic impact of STK11 mutations in non-squamous non-small-cell lung cancer.

Oncotarget
Pécuchet, Nicolas N; Laurent-Puig, Pierre P; Mansuet-Lupo, Audrey A; Legras, Antoine A; Alifano, Marco M; Pallier, Karine K; Didelot, Audrey A; Gibault, Laure L; Danel, Claire C; Just, Pierre-Alexandre PA; Riquet, Marc M; Le Pimpec-Barthes, Françoise F; Damotte, Diane D; Fabre, Elisabeth E; Blons, Hélène H
Publication Date: 2017-04-04

Variant appearance in text: KRAS: G12N
PubMed Link: 26625312
Variant Present in the following documents:
  • oncotarget-08-23831-s002.xls, sheet 1
View BVdb publication page



BRAF and RAS mutations as prognostic factors in metastatic colorectal cancer patients undergoing liver resection.

British Journal Of Cancer
Schirripa, M M; Bergamo, F F; Cremolini, C C; Casagrande, M M; Lonardi, S S; Aprile, G G; Yang, D D; Marmorino, F F; Pasquini, G G; Sensi, E E; Lupi, C C; De Maglio, G G; Borrelli, N N; Pizzolitto, S S; Fasola, G G; Bertorelle, R R; Rugge, M M; Fontanini, G G; Zagonel, V V; Loupakis, F F; Falcone, A A
Publication Date: 2015-06-09

Variant appearance in text: KRAS: G12N
PubMed Link: 25942399
Variant Present in the following documents:
View BVdb publication page



A novel approach to detect KRAS/BRAF mutation for colon cancer: Highly sensitive simultaneous detection of mutations and simple pre-treatment without DNA extraction.

International Journal Of Oncology
Suzuki, Shun-Ichi S; Matsusaka, Satoshi S; Hirai, Mitsuharu M; Shibata, Harumi H; Takagi, Koichi K; Mizunuma, Nobuyuki N; Hatake, Kiyohiko K
Publication Date: 2015-07

Variant appearance in text: KRAS: G12N
PubMed Link: 25936694
Variant Present in the following documents:
  • Main text
View BVdb publication page



Whole-exome sequencing of pancreatic cancer defines genetic diversity and therapeutic targets.

Nature Communications
Witkiewicz, Agnieszka K AK; McMillan, Elizabeth A EA; Balaji, Uthra U; Baek, GuemHee G; Lin, Wan-Chi WC; Mansour, John J; Mollaee, Mehri M; Wagner, Kay-Uwe KU; Koduru, Prasad P; Yopp, Adam A; Choti, Michael A MA; Yeo, Charles J CJ; McCue, Peter P; White, Michael A MA; Knudsen, Erik S ES
Publication Date: 2015-04-09

Variant appearance in text: KRAS: G12N
PubMed Link: 25855536
Variant Present in the following documents:
  • ncomms7744-s2.xlsx, sheet 1
View BVdb publication page



Cutaneous epithelial tumors induced by vemurafenib involve the MAPK and Pi3KCA pathways but not HPV nor HPyV viral infection.

Plos One
Frouin, Eric E; Guillot, Bernard B; Larrieux, Marion M; Tempier, Ariane A; Boulle, Nathalie N; Foulongne, Vincent V; Girard, Céline C; Costes, Valérie V; Solassol, Jérome J
Publication Date: 2014

Variant appearance in text: KRAS: G12N
PubMed Link: 25360634
Variant Present in the following documents:
  • Main text
View BVdb publication page



Clinicopathological features and prognostic roles of KRAS, BRAF, PIK3CA and NRAS mutations in advanced gastric cancer.

Bmc Research Notes
Takahashi, Naoki N; Yamada, Yasuhide Y; Taniguchi, Hirokazu H; Fukahori, Masaru M; Sasaki, Yusuke Y; Shoji, Hirokazu H; Honma, Yoshitaka Y; Iwasa, Satoru S; Takashima, Atsuo A; Kato, Ken K; Hamaguchi, Tetsuya T; Shimada, Yasuhiro Y
Publication Date: 2014-04-29

Variant appearance in text: KRAS: G12N
PubMed Link: 24774510
Variant Present in the following documents:
  • Main text
  • 1756-0500-7-271.pdf
View BVdb publication page



Targeted sequencing of cancer-related genes in colorectal cancer using next-generation sequencing.

Plos One
Han, Sae-Won SW; Kim, Hwang-Phill HP; Shin, Jong-Yeon JY; Jeong, Eun-Goo EG; Lee, Won-Chul WC; Lee, Kyung-Hun KH; Won, Jae-Kyung JK; Kim, Tae-Yong TY; Oh, Do-Youn DY; Im, Seock-Ah SA; Bang, Yung-Jue YJ; Jeong, Seung-Yong SY; Park, Kyu Joo KJ; Park, Jae-Gahb JG; Kang, Gyeong Hoon GH; Seo, Jeong-Sun JS; Kim, Jong-Il JI; Kim, Tae-You TY
Publication Date: 2013

Variant appearance in text: KRAS: G12N
PubMed Link: 23700467
Variant Present in the following documents:
  • pone.0064271.s004.xlsx, sheet 1
View BVdb publication page