Variant ID: 12-25398285-C-G

NM_033360.2(KRAS):c.34G>C;(p.Gly12Arg)

This variant was identified in 628 publications




Publications:


Multitarget stool DNA test compared with fecal occult blood test for colorectal cancer screening.

Oncology Letters
C Yang, W Wu, Y Yang, X Yang, J Sun, W Zhang, K Liu, H Ying, S Jiang, X Yu, Y Shi, Y Zhou, S Zhu, Y Xu, Y Ding, L Xie, B Cai, X Xin, P Chen, R Zhao, Y Wu
Publication Date: 2020-08

Variant appearance in text: KRAS: Gly12Arg
PMID: 32724359
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Defining relative mutational difficulty to understand cancer formation.

Cell Discovery
L Shan, J Yu, Z He, S Chen, M Liu, H Ding, L Xu, J Zhao, A Yang, H Jiang
Publication Date: 2020

Variant appearance in text: KRAS: G12R
PMID: 32704382
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Time-saving method for directly amplifying and capturing a minimal amount of pancreatic tumor-derived mutations from fine-needle aspirates using digital PCR.

Scientific Reports
Y Ono, A Hayashi, C Maeda, M Suzuki, R Wada, H Sato, H Kawabata, T Okada, T Goto, H Karasaki, Y Mizukami, T Okumura
Publication Date: 2020-07-23

Variant appearance in text: KRAS: G12R
PMID: 32704002
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Applied precision medicine in metastatic pancreatic ductal adenocarcinoma.

Therapeutic Advances In Medical Oncology
H Taghizadeh, L Müllauer, RM Mader, M Schindl, GW Prager
Publication Date: 2020

Variant appearance in text: KRAS: Gly12Arg
PMID: 32699558
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miRNAs-Based Molecular Signature for KRAS Mutated and Wild Type Colorectal Cancer: An Explorative Study.

Journal Of Immunology Research
E Milanesi, M Dobre, AI Bucuroiu, V Herlea, TE Manuc, A Salvi, G De Petro, M Manuc, G Becheanu
Publication Date: 2020

Variant appearance in text: KRAS: G12R
PMID: 32676506
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Implementing cell-free DNA of pancreatic cancer patient-derived organoids for personalized oncology.

Jci Insight
Z Dantes, HY Yen, N Pfarr, C Winter, K Steiger, A Muckenhuber, A Hennig, S Lange, T Engleitner, R Öllinger, R Maresch, F Orben, I Heid, GA Kaissis, K Shi, GJ Topping, F Stögbauer, M Wirth, K Peschke, A Papargyriou, M Rezaee-Oghazi, K Feldmann, APG Schäfer, R Ranjan, C Lubeseder-Martellato, DE Stange, T Welsch, ME Martignoni, GO Ceyhan, H Friess, A Herner, L Liotta, M Treiber, G von Figura, M Abdelhafez, P Klare, C Schlag, H Algül, JT Siveke, RF Braren, G Weirich, W Weichert, D Saur, R Rad, R Schmid, G Schneider, M Reichert
Publication Date: 2020-07-02

Variant appearance in text: KRAS: G12R
PMID: 32614802
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Molecular matching and treatment strategies for advanced stage lung cancer at Dartmouth-Hitchcock Medical Center: A three-year review of a Molecular Tumor Board.

Practical Laboratory Medicine
EB Bernhardt, MD Chamberlin, IP Gorlov, FB de Abreu, KJ Bloch, JD Peterson, GJ Tsongalis, K Shirai, KH Dragnev, TW Miller, LJ Tafe
Publication Date: 2020-08

Variant appearance in text: KRAS: G12R
PMID: 32613070
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Undifferentiated carcinoma with osteoclast-like giant cells of the pancreas harboring KRAS and BRCA mutations: case report and whole exome sequencing analysis.

Bmc Gastroenterology
G Yang, J Yin, K Ou, Q Du, W Ren, Y Jin, L Peng, L Yang
Publication Date: 2020-06-26

Variant appearance in text: KRAS: G12R
PMID: 32590950
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Genetic Tracing of Clonal Expansion and Progression of Pancreatic Ductal Adenocarcinoma: A Case Report and Multi-Region Sequencing Analysis.

Frontiers In Oncology
S Tachibana, Y Mizukami, Y Ono, Y Sugiyama, T Okada, A Kitazaki, J Sasajima, M Tominaga, J Sakamoto, K Kimura, Y Omori, T Furukawa, T Kimura, S Tanaka, K Nagashima, H Karasaki, T Ohta, T Okumura
Publication Date: 2020

Variant appearance in text: KRAS: G12R
PMID: 32582528
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FAM83G Is a Novel Inducer of Apoptosis.

Molecules (Basel, Switzerland)
J Okada, N Sunaga, E Yamada, T Saito, A Ozawa, Y Nakajima, K Okada, JE Pessin, S Okada, M Yamada
Publication Date: 2020-06-18

Variant appearance in text: KRAS: G12R
PMID: 32570757
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Histology and its prognostic effect on KRAS-mutated colorectal carcinomas in Korea.

Oncology Letters
HS Lee, DY Hwang, HS Han
Publication Date: 2020-07

Variant appearance in text: KRAS: G12R
PMID: 32565990
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Low-Dose Vertical Inhibition of the RAF-MEK-ERK Cascade Causes Apoptotic Death of KRAS Mutant Cancers.

Cell Reports
I Ozkan-Dagliyan, JN Diehl, SD George, A Schaefer, B Papke, K Klotz-Noack, AM Waters, CM Goodwin, P Gautam, M Pierobon, S Peng, TSK Gilbert, KH Lin, O Dagliyan, K Wennerberg, EF Petricoin, NL Tran, SV Bhagwat, RV Tiu, SB Peng, LE Herring, LM Graves, C Sers, KC Wood, AD Cox, CJ Der
Publication Date: 2020-06-16

Variant appearance in text: KRAS: G12R
PMID: 32553168
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A novel hotspot and rare somatic mutation p.A138V, at TP53 is associated with poor survival of pancreatic ductal and periampullary adenocarcinoma patients.

Molecular Medicine (Cambridge, Mass.)
G Saha, R Singh, A Mandal, S Das, E Chattopadhyay, P Panja, P Roy, N DeSarkar, S Gulati, S Ghatak, S Ghosh, S Banerjee, B Roy, S Ghosh, D Chaudhuri, N Arora, NK Biswas, N Sikdar
Publication Date: 2020-06-17

Variant appearance in text: KRAS: G12R
PMID: 32552660
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Mir34a constrains pancreatic carcinogenesis.

Scientific Reports
A Hidalgo-Sastre, C Lubeseder-Martellato, T Engleitner, K Steiger, S Zhong, J Desztics, R Öllinger, R Rad, RM Schmid, H Hermeking, JT Siveke, G von Figura
Publication Date: 2020-06-15

Variant appearance in text: KRAS: G12R
PMID: 32541781
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A novel sensitive detection method for DNA methylation in circulating free DNA of pancreatic cancer.

Plos One
K Shinjo, K Hara, G Nagae, T Umeda, K Katsushima, M Suzuki, Y Murofushi, Y Umezu, I Takeuchi, S Takahashi, Y Okuno, K Matsuo, H Ito, S Tajima, H Aburatani, K Yamao, Y Kondo
Publication Date: 2020

Variant appearance in text: KRAS: G12R
PMID: 32520974
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Detection of Colorectal Cancer and Advanced Adenoma by Liquid Biopsy (Decalib Study): The ddPCR Challenge.

Cancers
A Junca, G Tachon, C Evrard, C Villalva, E Frouin, L Karayan-Tapon, D Tougeron
Publication Date: 2020-06-06

Variant appearance in text: KRAS: G12R
PMID: 32517177
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Metabolic Profiling of Early and Late Recurrent Pancreatic Ductal Adenocarcinoma Using Patient-Derived Organoid Cultures.

Cancers
LM Braun, S Lagies, RFU Klar, S Hussung, RM Fritsch, B Kammerer, UA Wittel
Publication Date: 2020-06-01

Variant appearance in text: KRAS: G12R
PMID: 32492856
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Blood-based Genomic Profiling of Circulating Tumor DNA from Patients with Advanced Pancreatic Cancer and its Value to Guide Clinical Treatment.

Journal Of Cancer
H Li, Y Di, J Li, Y Jiang, H He, L Yao, J Gu, J Lu, J Song, S Chen, S Cai, C Jin, Z Yuan, D Fu
Publication Date: 2020

Variant appearance in text: KRAS: G12R
PMID: 32489450
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Synergy of GSK-J4 With Doxorubicin in KRAS-Mutant Anaplastic Thyroid Cancer.

Frontiers In Pharmacology
B Lin, B Lu, IY Hsieh, Z Liang, Z Sun, Y Yi, W Lv, W Zhao, J Li
Publication Date: 2020

Variant appearance in text: KRAS: G12R
PMID: 32477122
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Patient-derived pancreatic tumour organoids identify therapeutic responses to oncolytic adenoviruses.

Ebiomedicine
G Raimondi, A Mato-Berciano, S Pascual-Sabater, M Rovira-Rigau, M Cuatrecasas, C Fondevila, S Sánchez-Cabús, H Begthel, SF Boj, H Clevers, C Fillat
Publication Date: 2020-05-24

Variant appearance in text: KRAS: G12R
PMID: 32460166
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Spectrum of driver mutations and clinical impact of circulating tumor DNA analysis in non-small cell lung cancer: Analysis of over 8000 cases.

Cancer
PC Mack, KC Banks, CR Espenschied, RA Burich, OA Zill, CE Lee, JW Riess, SA Mortimer, A Talasaz, RB Lanman, DR Gandara
Publication Date: 2020-05-04

Variant appearance in text: KRAS: G12R
PMID: 32365229
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RAS Mutational Status Detection in Tissue, Plasma, and Stool Samples for Colorectal Cancer.

Biomed Research International
L Zhu, Y Wang, Y Zhou, Q Dong, Y Liu, J Zhang
Publication Date: 2020

Variant appearance in text: KRAS: G12R
PMID: 32351996
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Molecular Diagnostic of Solid Tumor Using a Next Generation Sequencing Custom-Designed Multi-Gene Panel.

Diagnostics (Basel, Switzerland)
D de Biase, G Acquaviva, M Visani, V Sanza, CM Argento, A De Leo, T Maloberti, A Pession, G Tallini
Publication Date: 2020-04-23

Variant appearance in text: KRAS: G12R
PMID: 32340363
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BRAF and KRAS mutations in papillary thyroid carcinoma in the United Arab Emirates.

Plos One
S Al-Salam, C Sharma, B Afandi, K Al Dahmani, AS Al-Zahrani, A Al Shamsi, J Al Kaabi
Publication Date: 2020

Variant appearance in text: KRAS: G12R
PMID: 32315324
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Combination of KRAS and SMAD4 mutations in formalin-fixed paraffin-embedded tissues as a biomarker for pancreatic cancer.

Cancer Science
T Yokose, M Kitago, S Matsuda, Y Sasaki, Y Masugi, Y Nakamura, M Shinoda, H Yagi, Y Abe, G Oshima, S Hori, Y Fujita, Y Nakano, Y Endo, K Abe, T Tokino, Y Kitagawa
Publication Date: 2020-04-21

Variant appearance in text: KRAS: G12R
PMID: 32314446
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Metabolic characterization of colorectal cancer cells harbouring different KRAS mutations in codon 12, 13, 61 and 146 using human SW48 isogenic cell lines.

Metabolomics : Official Journal Of The Metabolomic Society
D Varshavi, D Varshavi, N McCarthy, K Veselkov, HC Keun, JR Everett
Publication Date: 2020-04-16

Variant appearance in text: KRAS: G12R
PMID: 32300895
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Comprehensive genomic profile of cholangiocarcinomas in China.

Oncology Letters
W Tian, W Hu, X Shi, P Liu, X Ma, W Zhao, L Qu, S Zhang, W Shi, A Liu, J Cao
Publication Date: 2020-04

Variant appearance in text: KRAS: G12R
PMID: 32256810
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Circulating tumour-derived KRAS mutations in pancreatic cancer cases are predominantly carried by very short fragments of cell-free DNA.

Ebiomedicine
M Zvereva, G Roberti, G Durand, C Voegele, MD Nguyen, TM Delhomme, P Chopard, E Fabianova, Z Adamcakova, I Holcatova, L Foretova, V Janout, P Brennan, M Foll, GB Byrnes, JD McKay, G Scelo, F Le Calvez-Kelm
Publication Date: 2020-04-02

Variant appearance in text: KRAS: 34G>C; G12R
PMID: 32249202
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Combinatorial Therapies in Thyroid Cancer: An Overview of Preclinical and Clinical Progresses.

Cells
G Laetitia, S Sven, J Fabrice
Publication Date: 2020-03-30

Variant appearance in text: KRAS: 34G>C; Gly12Arg
PMID: 32235612
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The A818-6 system as an in-vitro model for studying the role of the transportome in pancreatic cancer.

Bmc Cancer
D Tawfik, A Zaccagnino, A Bernt, M Szczepanowski, W Klapper, A Schwab, H Kalthoff, A Trauzold
Publication Date: 2020-03-30

Variant appearance in text: KRAS: G12R
PMID: 32228510
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An enzymatic on/off switch-mediated assay for KRAS hotspot point mutation detection of circulating tumor DNA.

Journal Of Clinical Laboratory Analysis
QL Wang, CL Zhou, YF Yin, L Xiao, Y Wang, K Li
Publication Date: 2020-03-24

Variant appearance in text: KRAS: G12R
PMID: 32207862
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Targeted sequencing analysis of cell-free DNA from metastatic non-small-cell lung cancer patients: clinical and biological implications.

Translational Lung Cancer Research
R Pasquale, L Forgione, C Roma, F Fenizia, F Bergantino, AM Rachiglio, A De Luca, M Gallo, MR Maiello, G Palumbo, A Morabito, R Azzaro, N Normanno
Publication Date: 2020-02

Variant appearance in text: KRAS: Gly12Arg
PMID: 32206554
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Coexisting EGFR and TP53 Mutations in Lung Adenocarcinoma Patients Are Associated With COMP and ITGB8 Upregulation and Poor Prognosis.

Frontiers In Molecular Biosciences
C Zheng, X Li, Y Ren, Z Yin, B Zhou
Publication Date: 2020

Variant appearance in text: N/A
PMID: 32175330
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Prognostic implications of EGFR protein expression in sporadic colorectal tumors: Correlation with copy number status, mRNA levels and miRNA regulation.

Scientific Reports
S Del Carmen, LA Corchete, R Gervas, A Rodriguez, M Garcia, JA Álcazar, J García, O Bengoechea, L Muñoz-Bellvis, JM Sayagués, M Abad
Publication Date: 2020-03-13

Variant appearance in text: KRAS: G12R
PMID: 32170146
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Analysis of tumor microenvironmental features to refine prognosis by T, N risk group in patients with stage III colon cancer (NCCTG N0147) (Alliance).

Annals Of Oncology : Official Journal Of The European Society For Medical Oncology
H Lee, D Sha, NR Foster, Q Shi, SR Alberts, TC Smyrk, FA Sinicrope
Publication Date: 2020-01-25

Variant appearance in text: KRAS: 34G>C; G12R
PMID: 32165096
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Effect of Tumor Location on Clinicopathological and Molecular Markers in Colorectal Cancer in Eastern China Patients: An Analysis of 2,356 Cases.

Frontiers In Genetics
Y Song, L Wang, W Ran, G Li, Y Xiao, X Wang, L Zhang, X Xing
Publication Date: 2020

Variant appearance in text: KRAS: G12R
PMID: 32161617
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An organoid biobank for childhood kidney cancers that captures disease and tissue heterogeneity.

Nature Communications
C Calandrini, F Schutgens, R Oka, T Margaritis, T Candelli, L Mathijsen, C Ammerlaan, RL van Ineveld, S Derakhshan, S de Haan, E Dolman, P Lijnzaad, L Custers, H Begthel, HHD Kerstens, LL Visser, M Rookmaaker, M Verhaar, GAM Tytgat, P Kemmeren, RR de Krijger, R Al-Saadi, K Pritchard-Jones, M Kool, AC Rios, MM van den Heuvel-Eibrink, JJ Molenaar, R van Boxtel, FCP Holstege, H Clevers, J Drost
Publication Date: 2020-03-11

Variant appearance in text: KRAS: G12R
PMID: 32161258
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Association of promoter methylation of RASSF1A and KRAS mutations in non-small cell lung carcinoma in Kashmiri population (India).

Heliyon
NU Din Shah, MN Ali, BA Ganai, S Mudassar, MS Khan, J Kour, AA Waza, MT Rasool, AM Lone
Publication Date: 2020-02

Variant appearance in text: KRAS: 34G>C; G12R
PMID: 32140600
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The Functional Effects of Key Driver KRAS Mutations on Gene Expression in Lung Cancer.

Frontiers In Genetics
J Zhang, H Hu, S Xu, H Jiang, J Zhu, E Qin, Z He, E Chen
Publication Date: 2020

Variant appearance in text: KRAS: G12R
PMID: 32117436
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Dual-molecular barcode sequencing detects rare variants in tumor and cell free DNA in plasma.

Scientific Reports
Y Hirotsu, S Otake, H Ohyama, K Amemiya, R Higuchi, T Oyama, H Mochizuki, T Goto, M Omata
Publication Date: 2020-02-25

Variant appearance in text: KRAS: G12R
PMID: 32099048
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Characterizations of Gene Alterations in Melanoma Patients from Chinese Population.

Biomed Research International
Y Luo, Z Zhang, J Liu, L Li, X Xu, X Yao, Z Dai, X Wang, S Yang, H Wu, J Bu, Y Wu, T Xiang, X Li
Publication Date: 2020

Variant appearance in text: KRAS: G12R
PMID: 32083130
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The paradox of cancer genes in non-malignant conditions: implications for precision medicine.

Genome Medicine
JJ Adashek, S Kato, SM Lippman, R Kurzrock
Publication Date: 2020-02-17

Variant appearance in text: KRAS: G12R
PMID: 32066498
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Comparative Study of NGS Platform Ion Torrent Personal Genome Machine and Therascreen Rotor-Gene Q for the Detection of Somatic Variants in Cancer.

High-Throughput
A Lombardi, M Russo, A Luce, F Morgillo, V Tirino, G Misso, E Martinelli, T Troiani, V Desiderio, G Papaccio, F Iovino, G Argenziano, E Moscarella, P Sperlongano, G Galizia, R Addeo, A Necas, A Necasova, F Ciardiello, A Ronchi, M Caraglia, A Grimaldi
Publication Date: 2020-02-11

Variant appearance in text: KRAS: Gly12Arg
PMID: 32054005
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Pattern of nucleotide variants of TP53 and their correlation with the expression of p53 and its downstream proteins in a Sri Lankan cohort of breast and colorectal cancer patients.

Bmc Cancer
V Manoharan, EH Karunanayake, KH Tennekoon, S De Silva, AIA Imthikab, K De Silva, P Angunawela, S Vishwakula, J Lunec
Publication Date: 2020-01-30

Variant appearance in text: N/A
PMID: 32000721
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Usefulness of rapid on-site evaluation specimens from endoscopic ultrasound-guided fine-needle aspiration for cancer gene panel testing: A retrospective study.

Plos One
T Ishizawa, N Makino, A Matsuda, Y Kakizaki, T Kobayashi, C Ikeda, S Sugahara, M Tsunoda, Y Ueno
Publication Date: 2020

Variant appearance in text: KRAS: G12R
PMID: 31999789
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The current understanding of KRAS protein structure and dynamics.

Computational And Structural Biotechnology Journal
T Pantsar
Publication Date: 2020

Variant appearance in text: KRAS: G12R
PMID: 31988705
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Preoperative detection of KRAS G12D mutation in ctDNA is a powerful predictor for early recurrence of resectable PDAC patients.

British Journal Of Cancer
S Guo, X Shi, J Shen, S Gao, H Wang, S Shen, Y Pan, B Li, X Xu, Z Shao, G Jin
Publication Date: 2020-01-23

Variant appearance in text: KRAS: G12R
PMID: 31969677
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Correlation between clinicopathological features and KRAS, NRAS, and BRAF mutation status in Chinese colorectal cancer patients.

International Journal Of Clinical And Experimental Pathology
X Zhu, X Meng, W Xiang, W Dai, Q Bai, W Sheng, Y Lu, P Qi, L Wu, G Cai, X Zhou
Publication Date: 2018

Variant appearance in text: KRAS: G12R
PMID: 31938404
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Not all mutations of KRAS predict poor prognosis in patients with colorectal cancer.

International Journal Of Clinical And Experimental Pathology
W Li, Y Liu, S Cai, C Yang, Z Lin, L Zhou, L Liu, X Cheng, W Zeng
Publication Date: 2019

Variant appearance in text: KRAS: G12R
PMID: 31933906
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Diversity spectrum analysis identifies mutation-specific effects of cancer driver genes.

Communications Biology
X Dong, D Huang, X Yi, S Zhang, Z Wang, B Yan, P Chung Sham, K Chen, M Jun Li
Publication Date: 2020-01-07

Variant appearance in text: KRAS: G12R
PMID: 31925297
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Single-cell analysis based dissection of clonality in myelofibrosis.

Nature Communications
E Mylonas, K Yoshida, M Frick, K Hoyer, F Christen, J Kaeda, M Obenaus, D Noerenberg, C Hennch, W Chan, Y Ochi, Y Shiraishi, Y Shiozawa, T Zenz, CC Oakes, B Sawitzki, M Schwarz, L Bullinger, P le Coutre, MJJ Rose-Zerilli, S Ogawa, F Damm
Publication Date: 2020-01-07

Variant appearance in text: KRAS: G12R
PMID: 31911629
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Longitudinal monitoring of KRAS-mutated circulating tumor DNA enables the prediction of prognosis and therapeutic responses in patients with pancreatic cancer.

Plos One
F Watanabe, K Suzuki, S Tamaki, I Abe, Y Endo, Y Takayama, H Ishikawa, N Kakizawa, M Saito, K Futsuhara, H Noda, F Konishi, T Rikiyama
Publication Date: 2019

Variant appearance in text: KRAS: G12R
PMID: 31891652
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ATM-Mutated Pancreatic Cancer: Clinical and Molecular Response to Gemcitabine/Nab-Paclitaxel After Genome-Based Therapy Resistance.

Pancreas
C Martino, D Pandya, R Lee, G Levy, T Lo, S Lobo, RC Frank
Publication Date: 2020-01

Variant appearance in text: KRAS: G12R
PMID: 31856090
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Highly specific enrichment of rare nucleic acid fractions using Thermus thermophilus argonaute with applications in cancer diagnostics.

Nucleic Acids Research
J Song, JW Hegge, MG Mauk, J Chen, JE Till, N Bhagwat, LT Azink, J Peng, M Sen, J Mays, EL Carpenter, J van der Oost, HH Bau
Publication Date: 2019-12-12

Variant appearance in text: KRAS: G12R
PMID: 31828328
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Pancreatic cancer organoids recapitulate disease and allow personalized drug screening.

Proceedings Of The National Academy Of Sciences Of The United States Of America
E Driehuis, A van Hoeck, K Moore, S Kolders, HE Francies, MC Gulersonmez, ECA Stigter, B Burgering, V Geurts, A Gracanin, G Bounova, FH Morsink, R Vries, S Boj, J van Es, GJA Offerhaus, O Kranenburg, MJ Garnett, L Wessels, E Cuppen, LAA Brosens, H Clevers
Publication Date: 2019-12-09

Variant appearance in text: KRAS: G12R
PMID: 31818951
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Clinical correlates of blood-derived circulating tumor DNA in pancreatic cancer.

Journal Of Hematology & Oncology
H Patel, R Okamura, P Fanta, C Patel, RB Lanman, VM Raymond, S Kato, R Kurzrock
Publication Date: 2019-12-04

Variant appearance in text: KRAS: G12R
PMID: 31801585
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Using somatic variant richness to mine signals from rare variants in the cancer genome.

Nature Communications
S Chakraborty, A Arora, CB Begg, R Shen
Publication Date: 2019-12-03

Variant appearance in text: KRAS: G12R
PMID: 31796730
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Durable response to olaparib in pancreatic duct adenocarcinoma with deleterious ARID1A mutation.

Chinese Medical Journal
XS Zhao, J Zhou, L Dong, H Zhang, YJ Ye
Publication Date: 2019-11-22

Variant appearance in text: KRAS: G12R
PMID: 31764178
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Circulating tumor DNA as a prognostic indicator in resectable pancreatic ductal adenocarcinoma: A systematic review and meta-analysis.

Scientific Reports
JS Lee, TM Rhee, D Pietrasz, JB Bachet, P Laurent-Puig, SY Kong, E Takai, S Yachida, T Shibata, JW Lee, HC Park, DY Zang, K Jeon, J Lee, M Kim, HS Kim, HJ Kang, YK Lee
Publication Date: 2019-11-18

Variant appearance in text: KRAS: G12R
PMID: 31740696
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The prevalence and prognostic value of KRAS co-mutation subtypes in Chinese advanced non-small cell lung cancer patients.

Cancer Medicine
D Cai, C Hu, L Li, S Deng, J Yang, H Han-Zhang, M Li
Publication Date: 2019-11-10

Variant appearance in text: KRAS: G12R
PMID: 31709742
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A Comparative Analysis of Individual RAS Mutations in Cancer Biology.

Frontiers In Oncology
C Muñoz-Maldonado, Y Zimmer, M Medová
Publication Date: 2019

Variant appearance in text: KRAS: G12R
PMID: 31681616
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DNAJB1-PRKACA fusions occur in oncocytic pancreatic and biliary neoplasms and are not specific for fibrolamellar hepatocellular carcinoma.

Modern Pathology : An Official Journal Of The United States And Canadian Academy Of Pathology, Inc
M Vyas, JF Hechtman, Y Zhang, R Benayed, A Yavas, G Askan, J Shia, DS Klimstra, O Basturk
Publication Date: 2019-11-01

Variant appearance in text: KRAS: G12R
PMID: 31676785
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An integrative pharmacogenomics analysis identifies therapeutic targets in KRAS-mutant lung cancer.

Ebiomedicine
H Wang, Q Lv, Y Xu, Z Cai, J Zheng, X Cheng, Y Dai, PA Jänne, C Ambrogio, J Köhler
Publication Date: 2019-11

Variant appearance in text: KRAS: G12R
PMID: 31668570
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Atypical KRASG12R Mutant Is Impaired in PI3K Signaling and Macropinocytosis in Pancreatic Cancer.

Cancer Discovery
GA Hobbs, NM Baker, AM Miermont, RD Thurman, M Pierobon, TH Tran, AO Anderson, AM Waters, JN Diehl, B Papke, RG Hodge, JE Klomp, CM Goodwin, JM DeLiberty, J Wang, RWS Ng, P Gautam, KL Bryant, D Esposito, SL Campbell, EF Petricoin, DK Simanshu, AJ Aguirre, BM Wolpin, K Wennerberg, U Rudloff, AD Cox, CJ Der
Publication Date: 2019-10-24

Variant appearance in text: KRAS: G12R
PMID: 31649109
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GEFT protein expression in digestive tract malignant tumors and its clinical significance.

Oncology Letters
Y Wang, B Zhang, G Gao, Y Zhang, Q Xia
Publication Date: 2019-11

Variant appearance in text: KRAS: G12R
PMID: 31620201
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KRAS Mutations Predict Response and Outcome in Advanced Lung Adenocarcinoma Patients Receiving First-Line Bevacizumab and Platinum-Based Chemotherapy.

Cancers
AK Ghimessy, A Gellert, E Schlegl, B Hegedus, E Raso, T Barbai, J Timar, G Ostoros, Z Megyesfalvi, B Gieszer, J Moldvay, F Renyi-Vamos, Z Lohinai, MA Hoda, T Klikovits, W Klepetko, V Laszlo, B Dome
Publication Date: 2019-10-09

Variant appearance in text: KRAS: G12R
PMID: 31600989
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Development of Patient-Derived Preclinical Platform for Metastatic Pancreatic Cancer: PDOX and a Subsequent Organoid Model System Using Percutaneous Biopsy Samples.

Frontiers In Oncology
SI Choi, AR Jeon, MK Kim, YS Lee, JE Im, JW Koh, SS Han, SY Kong, KA Yoon, YH Koh, JH Lee, WJ Lee, SJ Park, EK Hong, SM Woo, YH Kim
Publication Date: 2019

Variant appearance in text: KRAS: G12R
PMID: 31572675
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DNA sequencing of cytopathologically inconclusive EUS-FNA from solid pancreatic lesions suspicious for malignancy confirms EUS diagnosis.

Endoscopic Ultrasound
JI Plougmann, P Klausen, A Toxvaerd, AA Abedi, B Kovacevic, JG Karstensen, TS Poulsen, E Kalaitzakis, E Høgdall, P Vilmann
Publication Date: 2019-09-25

Variant appearance in text: KRAS: G12R
PMID: 31552911
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Optimisation of robust singleplex and multiplex droplet digital PCR assays for high confidence mutation detection in circulating tumour DNA.

Scientific Reports
V Rowlands, AJ Rutkowski, E Meuser, TH Carr, EA Harrington, JC Barrett
Publication Date: 2019-09-02

Variant appearance in text: KRAS: G12R
PMID: 31477768
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Targeting plasma membrane phosphatidylserine content to inhibit oncogenic KRAS function.

Life Science Alliance
WE Kattan, W Chen, X Ma, TH Lan, D van der Hoeven, R van der Hoeven, JF Hancock
Publication Date: 2019-10

Variant appearance in text: KRAS: G12R
PMID: 31451509
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Abstracts : 31 st European Congress of Pathology.

Virchows Archiv : An International Journal Of Pathology
.
Publication Date: 2019-09

Variant appearance in text: KRAS: G12R
PMID: 31440833
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Mutation-Derived Neoantigens for Cancer Immunotherapy.

Frontiers In Immunology
JC Castle, M Uduman, S Pabla, RB Stein, JS Buell
Publication Date: 2019

Variant appearance in text: KRAS: G12R
PMID: 31440245
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Impact of smoking on frequency and spectrum of K-RAS and EGFR mutations in treatment naive Indonesian lung cancer patients.

Lung Cancer (Auckland, N.Z.)
N Masykura, J Zaini, E Syahruddin, SL Andarini, A Hudoyo, R Yasril, A Ridwanuloh, H Hidajat, F Nurwidya, A Utomo
Publication Date: 2019

Variant appearance in text: KRAS: G12R
PMID: 31354372
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Omics Approaches in Pancreatic Adenocarcinoma.

Cancers
I González-Borja, A Viúdez, S Goñi, E Santamaria, E Carrasco-García, J Pérez-Sanz, I Hernández-García, P Sala-Elarre, V Arrazubi, E Oyaga-Iriarte, R Zárate, S Arévalo, O Sayar, R Vera, J Fernández-Irigoyen
Publication Date: 2019-07-25

Variant appearance in text: KRAS: G12R
PMID: 31349663
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Microarray Approach Combined with ddPCR: An Useful Pipeline for the Detection and Quantification of Circulating Tumour dna Mutations.

Cells
S Galbiati, F Damin, L Ferraro, N Soriani, V Burgio, M Ronzoni, L Gianni, M Ferrari, M Chiari
Publication Date: 2019-07-24

Variant appearance in text: KRAS: G12R
PMID: 31344983
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Circulating tumor DNA quantity is related to tumor volume and both predict survival in metastatic pancreatic ductal adenocarcinoma.

International Journal Of Cancer
M Strijker, EC Soer, M de Pastena, A Creemers, A Balduzzi, JJ Beagan, OR Busch, OM van Delden, H Halfwerk, JE van Hooft, KP van Lienden, G Marchegiani, SL Meijer, CJ van Noesel, RJ Reinten, E Roos, S Schokker, J Verheij, MJ van de Vijver, C Waasdorp, JW Wilmink, B Ylstra, MG Besselink, MF Bijlsma, F Dijk, HW van Laarhoven
Publication Date: 2019-07-24

Variant appearance in text: KRAS: 34G>C; G12R
PMID: 31340061
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Two Cases of Rare Pancreatic Malignancies.

Journal Of Pancreatic Cancer
W Hanayneh, H Parekh, G Fitzpatrick, M Feely, TJ George, JS Starr
Publication Date: 2019

Variant appearance in text: KRAS: G12R
PMID: 31338486
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Expression and Role of MicroRNAs from the miR-200 Family in the Tumor Formation and Metastatic Propensity of Pancreatic Cancer.

Molecular Therapy. Nucleic Acids
ZV Diaz-Riascos, MM Ginesta, J Fabregat, T Serrano, J Busquets, L Buscail, P Cordelier, G Capellá
Publication Date: 2019-09-06

Variant appearance in text: KRAS: G12R
PMID: 31336236
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Utility of liquid biopsy using urine in patients with pancreatic ductal adenocarcinoma.

Cancer Biology & Therapy
H Terasawa, H Kinugasa, S Ako, M Hirai, H Matsushita, D Uchida, T Tomoda, K Matsumoto, S Horiguchi, H Kato, K Nouso, H Okada
Publication Date: 2019

Variant appearance in text: KRAS: G12R
PMID: 31328611
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Resistance of t(17;19)-acute lymphoblastic leukemia cell lines to multiagents in induction therapy.

Cancer Medicine
A Watanabe, T Inukai, K Kagami, M Abe, M Takagi, T Fukushima, H Fukushima, T Nanmoku, K Terui, T Ito, T Toki, E Ito, J Fujimura, H Goto, M Endo, T Look, M Kamps, M Minegishi, J Takita, T Inaba, H Takahashi, A Ohara, D Harama, T Shinohara, S Somazu, H Oshiro, K Akahane, K Goi, K Sugita
Publication Date: 2019-09

Variant appearance in text: KRAS: G12R
PMID: 31305009
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Evaluation of KRAS, NRAS and BRAF hotspot mutations detection for patients with metastatic colorectal cancer using direct DNA pipetting in a fully-automated platform and Next-Generation Sequencing for laboratory workflow optimisation.

Plos One
P Gilson, C Franczak, L Dubouis, M Husson, M Rouyer, J Demange, M Perceau, A Leroux, JL Merlin, A Harlé
Publication Date: 2019

Variant appearance in text: KRAS: 34G>C; G12R
PMID: 31265477
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Somatic molecular analysis augments cytologic evaluation of pancreatic cyst fluids as a diagnostic tool.

Oncotarget
A Sakhdari, PA Moghaddam, CY Ok, O Walter, K Tomaszewicz, ML Caporelli, X Meng, J LaFemina, G Whalen, E Belkin, J Zivny, W Wassef, BA Woda, LM Hutchinson, EF Cosar
Publication Date: 2019-06-18

Variant appearance in text: KRAS: G12R
PMID: 31258847
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Liquid biopsy in pancreatic ductal adenocarcinoma: current status of circulating tumor cells and circulating tumor DNA.

Molecular Oncology
JS Lee, SS Park, YK Lee, JA Norton, SS Jeffrey
Publication Date: 2019-08

Variant appearance in text: KRAS: G12R
PMID: 31243883
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Integrative analysis of genomic and transcriptomic characteristics associated with progression of aggressive thyroid cancer.

Nature Communications
SK Yoo, YS Song, EK Lee, J Hwang, HH Kim, G Jung, YA Kim, SJ Kim, SW Cho, JK Won, EJ Chung, JY Shin, KE Lee, JI Kim, YJ Park, JS Seo
Publication Date: 2019-06-24

Variant appearance in text: KRAS: G12R
PMID: 31235699
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Validation of Immunohistochemistry for the Detection of BRAF V600E-Mutated Lung Adenocarcinomas.

Cancers
CH Gow, MS Hsieh, YT Lin, YN Liu, JY Shih
Publication Date: 2019-06-21

Variant appearance in text: KRAS: G12R
PMID: 31234388
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Detection of Circulating Tumor DNA with a Single-Molecule Sequencing Analysis Validated for Targeted and Immunotherapy Selection.

Molecular Diagnosis & Therapy
A Atkins, P Gupta, BM Zhang, WS Tsai, J Lucas, M Javey, A Vora, R Mei
Publication Date: 2019-08

Variant appearance in text: KRAS: G12R
PMID: 31209714
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Temporal and spatial effects and survival outcomes associated with concordance between tissue and blood KRAS alterations in the pan-cancer setting.

International Journal Of Cancer
K Mardinian, R Okamura, S Kato, R Kurzrock
Publication Date: 2020-01-15

Variant appearance in text: KRAS: G12R
PMID: 31199507
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Unique Neoantigens Arise from Somatic Mutations in Patients with Gastrointestinal Cancers.

Cancer Discovery
MR Parkhurst, PF Robbins, E Tran, TD Prickett, JJ Gartner, L Jia, G Ivey, YF Li, M El-Gamil, A Lalani, JS Crystal, A Sachs, E Groh, S Ray, LT Ngo, S Kivitz, A Pasetto, R Yossef, FJ Lowery, SL Goff, W Lo, G Cafri, DC Deniger, P Malekzadeh, M Ahmadzadeh, JR Wunderlich, RPT Somerville, SA Rosenberg
Publication Date: 2019-08

Variant appearance in text: KRAS: G12R
PMID: 31164343
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Circulating Tumor DNA as a Clinical Test in Resected Pancreatic Cancer.

Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research
VP Groot, S Mosier, AA Javed, JA Teinor, G Gemenetzis, D Ding, LM Haley, J Yu, RA Burkhart, A Hasanain, M Debeljak, H Kamiyama, A Narang, DA Laheru, L Zheng, MT Lin, CD Gocke, EK Fishman, RH Hruban, MG Goggins, IQ Molenaar, JL Cameron, MJ Weiss, VE Velculescu, J He, CL Wolfgang, JR Eshleman
Publication Date: 2019-08-15

Variant appearance in text: KRAS: G12R
PMID: 31142500
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Transcriptional and metabolic rewiring of colorectal cancer cells expressing the oncogenic KRASG13D mutation.

British Journal Of Cancer
T Charitou, S Srihari, MA Lynn, MA Jarboui, E Fasterius, M Moldovan, S Shirasawa, T Tsunoda, M Ueffing, J Xie, J Xin, X Wang, CG Proud, K Boldt, C Al-Khalili Szigyarto, W Kolch, DJ Lynn
Publication Date: 2019-07

Variant appearance in text: KRAS: G12R
PMID: 31133691
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CMAB009 plus irinotecan versus irinotecan-only as second-line treatment after fluoropyrimidine and oxaliplatin failure in KRAS wild-type metastatic colorectal cancer patients: promising findings from a prospective, open-label, randomized, phase III trial.

Cancer Communications (London, England)
Y Shi, J Li, J Xu, Y Sun, L Wang, Y Cheng, W Liu, G Sun, Y Chen, L Bai, Y Zhang, X He, Y Luo, Z Wang, Y Liu, Q Yao, Y Li, S Qin, X Hu, F Bi, R Zheng, X Ouyang
Publication Date: 2019-05-24

Variant appearance in text: KRAS: Gly12Arg
PMID: 31126331
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Computational Screening and Analysis of Lung Cancer Related Non-Synonymous Single Nucleotide Polymorphisms on the Human Kirsten Rat Sarcoma Gene.

Molecules (Basel, Switzerland)
Q Wang, A Mehmood, H Wang, Q Xu, Y Xiong, DQ Wei
Publication Date: 2019-05-21

Variant appearance in text: N/A
PMID: 31117243
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Magnetic Resonance-Based Texture Analysis Differentiating KRAS Mutation Status in Rectal Cancer.

Cancer Research And Treatment : Official Journal Of Korean Cancer Association
JE Oh, MJ Kim, J Lee, BY Hur, B Kim, DY Kim, JY Baek, HJ Chang, SC Park, JH Oh, SA Cho, DK Sohn
Publication Date: 2019-05-07

Variant appearance in text: KRAS: G12R
PMID: 31096736
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Detection of ERBB2 (HER2) Gene Amplification Events in Cell-Free DNA and Response to Anti-HER2 Agents in a Large Asian Cancer Patient Cohort.

Frontiers In Oncology
J Lee, A Franovic, Y Shiotsu, ST Kim, KM Kim, KC Banks, VM Raymond, RB Lanman
Publication Date: 2019

Variant appearance in text: KRAS: G12R
PMID: 31019892
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Alternative transcript annotations:

Transcript cDNA Protein Consequence Exon Intron
ENST00000256078.4 c.34G>C p.Gly12Arg missense_variant 2/6 -
ENST00000311936.3 c.34G>C p.Gly12Arg missense_variant 2/5 -
ENST00000556131.1 c.34G>C p.Gly12Arg missense_variant 2/3 -
ENST00000557334.1 c.34G>C p.Gly12Arg missense_variant 2/3 -
NM_001369786.1 c.34G>C p.Gly12Arg missense_variant 2/6 -
NM_001369787.1 c.34G>C p.Gly12Arg missense_variant 2/5 -
NM_004985.5 c.34G>C p.Gly12Arg missense_variant 2/5 -
NM_033360.4 c.34G>C p.Gly12Arg missense_variant 2/6 -