Publications:

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Multitarget stool DNA test compared with fecal occult blood test for colorectal cancer screening.

Oncology Letters

C Yang, W Wu, Y Yang, X Yang, J Sun, W Zhang, K Liu, H Ying, S Jiang, X Yu, Y Shi, Y Zhou, S Zhu, Y Xu, Y Ding, L Xie, B Cai, X Xin, P Chen, R Zhao, Y Wu

Publication Date: 2020-08

Variant appearance in text: KRAS: Gly12Arg

PMID: 32724359

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Defining relative mutational difficulty to understand cancer formation.

Cell Discovery

L Shan, J Yu, Z He, S Chen, M Liu, H Ding, L Xu, J Zhao, A Yang, H Jiang

Publication Date: 2020

Variant appearance in text: KRAS: G12R

PMID: 32704382

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Time-saving method for directly amplifying and capturing a minimal amount of pancreatic tumor-derived mutations from fine-needle aspirates using digital PCR.

Scientific Reports

Y Ono, A Hayashi, C Maeda, M Suzuki, R Wada, H Sato, H Kawabata, T Okada, T Goto, H Karasaki, Y Mizukami, T Okumura

Publication Date: 2020-07-23

Variant appearance in text: KRAS: G12R

PMID: 32704002

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Applied precision medicine in metastatic pancreatic ductal adenocarcinoma.

Therapeutic Advances In Medical Oncology

H Taghizadeh, L Müllauer, RM Mader, M Schindl, GW Prager

Publication Date: 2020

Variant appearance in text: KRAS: Gly12Arg

PMID: 32699558

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miRNAs-Based Molecular Signature for KRAS Mutated and Wild Type Colorectal Cancer: An Explorative Study.

Journal Of Immunology Research

E Milanesi, M Dobre, AI Bucuroiu, V Herlea, TE Manuc, A Salvi, G De Petro, M Manuc, G Becheanu

Publication Date: 2020

Variant appearance in text: KRAS: G12R

PMID: 32676506

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Implementing cell-free DNA of pancreatic cancer patient-derived organoids for personalized oncology.

Jci Insight

Z Dantes, HY Yen, N Pfarr, C Winter, K Steiger, A Muckenhuber, A Hennig, S Lange, T Engleitner, R Öllinger, R Maresch, F Orben, I Heid, GA Kaissis, K Shi, GJ Topping, F Stögbauer, M Wirth, K Peschke, A Papargyriou, M Rezaee-Oghazi, K Feldmann, APG Schäfer, R Ranjan, C Lubeseder-Martellato, DE Stange, T Welsch, ME Martignoni, GO Ceyhan, H Friess, A Herner, L Liotta, M Treiber, G von Figura, M Abdelhafez, P Klare, C Schlag, H Algül, JT Siveke, RF Braren, G Weirich, W Weichert, D Saur, R Rad, R Schmid, G Schneider, M Reichert

Publication Date: 2020-07-02

Variant appearance in text: KRAS: G12R

PMID: 32614802

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Molecular matching and treatment strategies for advanced stage lung cancer at Dartmouth-Hitchcock Medical Center: A three-year review of a Molecular Tumor Board.

Practical Laboratory Medicine

EB Bernhardt, MD Chamberlin, IP Gorlov, FB de Abreu, KJ Bloch, JD Peterson, GJ Tsongalis, K Shirai, KH Dragnev, TW Miller, LJ Tafe

Publication Date: 2020-08

Variant appearance in text: KRAS: G12R

PMID: 32613070

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Undifferentiated carcinoma with osteoclast-like giant cells of the pancreas harboring KRAS and BRCA mutations: case report and whole exome sequencing analysis.

Bmc Gastroenterology

G Yang, J Yin, K Ou, Q Du, W Ren, Y Jin, L Peng, L Yang

Publication Date: 2020-06-26

Variant appearance in text: KRAS: G12R

PMID: 32590950

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Genetic Tracing of Clonal Expansion and Progression of Pancreatic Ductal Adenocarcinoma: A Case Report and Multi-Region Sequencing Analysis.

Frontiers In Oncology

S Tachibana, Y Mizukami, Y Ono, Y Sugiyama, T Okada, A Kitazaki, J Sasajima, M Tominaga, J Sakamoto, K Kimura, Y Omori, T Furukawa, T Kimura, S Tanaka, K Nagashima, H Karasaki, T Ohta, T Okumura

Publication Date: 2020

Variant appearance in text: KRAS: G12R

PMID: 32582528

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FAM83G Is a Novel Inducer of Apoptosis.

Molecules (Basel, Switzerland)

J Okada, N Sunaga, E Yamada, T Saito, A Ozawa, Y Nakajima, K Okada, JE Pessin, S Okada, M Yamada

Publication Date: 2020-06-18

Variant appearance in text: KRAS: G12R

PMID: 32570757

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Histology and its prognostic effect on KRAS-mutated colorectal carcinomas in Korea.

Oncology Letters

HS Lee, DY Hwang, HS Han

Publication Date: 2020-07

Variant appearance in text: KRAS: G12R

PMID: 32565990

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Low-Dose Vertical Inhibition of the RAF-MEK-ERK Cascade Causes Apoptotic Death of KRAS Mutant Cancers.

Cell Reports

I Ozkan-Dagliyan, JN Diehl, SD George, A Schaefer, B Papke, K Klotz-Noack, AM Waters, CM Goodwin, P Gautam, M Pierobon, S Peng, TSK Gilbert, KH Lin, O Dagliyan, K Wennerberg, EF Petricoin, NL Tran, SV Bhagwat, RV Tiu, SB Peng, LE Herring, LM Graves, C Sers, KC Wood, AD Cox, CJ Der

Publication Date: 2020-06-16

Variant appearance in text: KRAS: G12R

PMID: 32553168

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A novel hotspot and rare somatic mutation p.A138V, at TP53 is associated with poor survival of pancreatic ductal and periampullary adenocarcinoma patients.

Molecular Medicine (Cambridge, Mass.)

G Saha, R Singh, A Mandal, S Das, E Chattopadhyay, P Panja, P Roy, N DeSarkar, S Gulati, S Ghatak, S Ghosh, S Banerjee, B Roy, S Ghosh, D Chaudhuri, N Arora, NK Biswas, N Sikdar

Publication Date: 2020-06-17

Variant appearance in text: KRAS: G12R

PMID: 32552660

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Mir34a constrains pancreatic carcinogenesis.

Scientific Reports

A Hidalgo-Sastre, C Lubeseder-Martellato, T Engleitner, K Steiger, S Zhong, J Desztics, R Öllinger, R Rad, RM Schmid, H Hermeking, JT Siveke, G von Figura

Publication Date: 2020-06-15

Variant appearance in text: KRAS: G12R

PMID: 32541781

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A novel sensitive detection method for DNA methylation in circulating free DNA of pancreatic cancer.

Plos One

K Shinjo, K Hara, G Nagae, T Umeda, K Katsushima, M Suzuki, Y Murofushi, Y Umezu, I Takeuchi, S Takahashi, Y Okuno, K Matsuo, H Ito, S Tajima, H Aburatani, K Yamao, Y Kondo

Publication Date: 2020

Variant appearance in text: KRAS: G12R

PMID: 32520974

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Detection of Colorectal Cancer and Advanced Adenoma by Liquid Biopsy (Decalib Study): The ddPCR Challenge.

Cancers

A Junca, G Tachon, C Evrard, C Villalva, E Frouin, L Karayan-Tapon, D Tougeron

Publication Date: 2020-06-06

Variant appearance in text: KRAS: G12R

PMID: 32517177

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Metabolic Profiling of Early and Late Recurrent Pancreatic Ductal Adenocarcinoma Using Patient-Derived Organoid Cultures.

Cancers

LM Braun, S Lagies, RFU Klar, S Hussung, RM Fritsch, B Kammerer, UA Wittel

Publication Date: 2020-06-01

Variant appearance in text: KRAS: G12R

PMID: 32492856

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Blood-based Genomic Profiling of Circulating Tumor DNA from Patients with Advanced Pancreatic Cancer and its Value to Guide Clinical Treatment.

Journal Of Cancer

H Li, Y Di, J Li, Y Jiang, H He, L Yao, J Gu, J Lu, J Song, S Chen, S Cai, C Jin, Z Yuan, D Fu

Publication Date: 2020

Variant appearance in text: KRAS: G12R

PMID: 32489450

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Synergy of GSK-J4 With Doxorubicin in KRAS-Mutant Anaplastic Thyroid Cancer.

Frontiers In Pharmacology

B Lin, B Lu, IY Hsieh, Z Liang, Z Sun, Y Yi, W Lv, W Zhao, J Li

Publication Date: 2020

Variant appearance in text: KRAS: G12R

PMID: 32477122

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Patient-derived pancreatic tumour organoids identify therapeutic responses to oncolytic adenoviruses.

Ebiomedicine

G Raimondi, A Mato-Berciano, S Pascual-Sabater, M Rovira-Rigau, M Cuatrecasas, C Fondevila, S Sánchez-Cabús, H Begthel, SF Boj, H Clevers, C Fillat

Publication Date: 2020-05-24

Variant appearance in text: KRAS: G12R

PMID: 32460166

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Spectrum of driver mutations and clinical impact of circulating tumor DNA analysis in non-small cell lung cancer: Analysis of over 8000 cases.

Cancer

PC Mack, KC Banks, CR Espenschied, RA Burich, OA Zill, CE Lee, JW Riess, SA Mortimer, A Talasaz, RB Lanman, DR Gandara

Publication Date: 2020-05-04

Variant appearance in text: KRAS: G12R

PMID: 32365229

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RAS Mutational Status Detection in Tissue, Plasma, and Stool Samples for Colorectal Cancer.

Biomed Research International

L Zhu, Y Wang, Y Zhou, Q Dong, Y Liu, J Zhang

Publication Date: 2020

Variant appearance in text: KRAS: G12R

PMID: 32351996

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Molecular Diagnostic of Solid Tumor Using a Next Generation Sequencing Custom-Designed Multi-Gene Panel.

Diagnostics (Basel, Switzerland)

D de Biase, G Acquaviva, M Visani, V Sanza, CM Argento, A De Leo, T Maloberti, A Pession, G Tallini

Publication Date: 2020-04-23

Variant appearance in text: KRAS: G12R

PMID: 32340363

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BRAF and KRAS mutations in papillary thyroid carcinoma in the United Arab Emirates.

Plos One

S Al-Salam, C Sharma, B Afandi, K Al Dahmani, AS Al-Zahrani, A Al Shamsi, J Al Kaabi

Publication Date: 2020

Variant appearance in text: KRAS: G12R

PMID: 32315324

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Combination of KRAS and SMAD4 mutations in formalin-fixed paraffin-embedded tissues as a biomarker for pancreatic cancer.

Cancer Science

T Yokose, M Kitago, S Matsuda, Y Sasaki, Y Masugi, Y Nakamura, M Shinoda, H Yagi, Y Abe, G Oshima, S Hori, Y Fujita, Y Nakano, Y Endo, K Abe, T Tokino, Y Kitagawa

Publication Date: 2020-04-21

Variant appearance in text: KRAS: G12R

PMID: 32314446

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Metabolic characterization of colorectal cancer cells harbouring different KRAS mutations in codon 12, 13, 61 and 146 using human SW48 isogenic cell lines.

Metabolomics : Official Journal Of The Metabolomic Society

D Varshavi, D Varshavi, N McCarthy, K Veselkov, HC Keun, JR Everett

Publication Date: 2020-04-16

Variant appearance in text: KRAS: G12R

PMID: 32300895

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Comprehensive genomic profile of cholangiocarcinomas in China.

Oncology Letters

W Tian, W Hu, X Shi, P Liu, X Ma, W Zhao, L Qu, S Zhang, W Shi, A Liu, J Cao

Publication Date: 2020-04

Variant appearance in text: KRAS: G12R

PMID: 32256810

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Circulating tumour-derived KRAS mutations in pancreatic cancer cases are predominantly carried by very short fragments of cell-free DNA.

Ebiomedicine

M Zvereva, G Roberti, G Durand, C Voegele, MD Nguyen, TM Delhomme, P Chopard, E Fabianova, Z Adamcakova, I Holcatova, L Foretova, V Janout, P Brennan, M Foll, GB Byrnes, JD McKay, G Scelo, F Le Calvez-Kelm

Publication Date: 2020-04-02

Variant appearance in text: KRAS: 34G>C; G12R

PMID: 32249202

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Combinatorial Therapies in Thyroid Cancer: An Overview of Preclinical and Clinical Progresses.

Cells

G Laetitia, S Sven, J Fabrice

Publication Date: 2020-03-30

Variant appearance in text: KRAS: 34G>C; Gly12Arg

PMID: 32235612

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The A818-6 system as an in-vitro model for studying the role of the transportome in pancreatic cancer.

Bmc Cancer

D Tawfik, A Zaccagnino, A Bernt, M Szczepanowski, W Klapper, A Schwab, H Kalthoff, A Trauzold

Publication Date: 2020-03-30

Variant appearance in text: KRAS: G12R

PMID: 32228510

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An enzymatic on/off switch-mediated assay for KRAS hotspot point mutation detection of circulating tumor DNA.

Journal Of Clinical Laboratory Analysis

QL Wang, CL Zhou, YF Yin, L Xiao, Y Wang, K Li

Publication Date: 2020-03-24

Variant appearance in text: KRAS: G12R

PMID: 32207862

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Targeted sequencing analysis of cell-free DNA from metastatic non-small-cell lung cancer patients: clinical and biological implications.

Translational Lung Cancer Research

R Pasquale, L Forgione, C Roma, F Fenizia, F Bergantino, AM Rachiglio, A De Luca, M Gallo, MR Maiello, G Palumbo, A Morabito, R Azzaro, N Normanno

Publication Date: 2020-02

Variant appearance in text: KRAS: Gly12Arg

PMID: 32206554

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Coexisting EGFR and TP53 Mutations in Lung Adenocarcinoma Patients Are Associated With COMP and ITGB8 Upregulation and Poor Prognosis.

Frontiers In Molecular Biosciences

C Zheng, X Li, Y Ren, Z Yin, B Zhou

Publication Date: 2020

Variant appearance in text: N/A

PMID: 32175330

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Prognostic implications of EGFR protein expression in sporadic colorectal tumors: Correlation with copy number status, mRNA levels and miRNA regulation.

Scientific Reports

S Del Carmen, LA Corchete, R Gervas, A Rodriguez, M Garcia, JA Álcazar, J García, O Bengoechea, L Muñoz-Bellvis, JM Sayagués, M Abad

Publication Date: 2020-03-13

Variant appearance in text: KRAS: G12R

PMID: 32170146

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Analysis of tumor microenvironmental features to refine prognosis by T, N risk group in patients with stage III colon cancer (NCCTG N0147) (Alliance).

Annals Of Oncology : Official Journal Of The European Society For Medical Oncology

H Lee, D Sha, NR Foster, Q Shi, SR Alberts, TC Smyrk, FA Sinicrope

Publication Date: 2020-01-25

Variant appearance in text: KRAS: 34G>C; G12R

PMID: 32165096

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Effect of Tumor Location on Clinicopathological and Molecular Markers in Colorectal Cancer in Eastern China Patients: An Analysis of 2,356 Cases.

Frontiers In Genetics

Y Song, L Wang, W Ran, G Li, Y Xiao, X Wang, L Zhang, X Xing

Publication Date: 2020

Variant appearance in text: KRAS: G12R

PMID: 32161617

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An organoid biobank for childhood kidney cancers that captures disease and tissue heterogeneity.

Nature Communications

C Calandrini, F Schutgens, R Oka, T Margaritis, T Candelli, L Mathijsen, C Ammerlaan, RL van Ineveld, S Derakhshan, S de Haan, E Dolman, P Lijnzaad, L Custers, H Begthel, HHD Kerstens, LL Visser, M Rookmaaker, M Verhaar, GAM Tytgat, P Kemmeren, RR de Krijger, R Al-Saadi, K Pritchard-Jones, M Kool, AC Rios, MM van den Heuvel-Eibrink, JJ Molenaar, R van Boxtel, FCP Holstege, H Clevers, J Drost

Publication Date: 2020-03-11

Variant appearance in text: KRAS: G12R

PMID: 32161258

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Association of promoter methylation of RASSF1A and KRAS mutations in non-small cell lung carcinoma in Kashmiri population (India).

Heliyon

NU Din Shah, MN Ali, BA Ganai, S Mudassar, MS Khan, J Kour, AA Waza, MT Rasool, AM Lone

Publication Date: 2020-02

Variant appearance in text: KRAS: 34G>C; G12R

PMID: 32140600

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The Functional Effects of Key Driver KRAS Mutations on Gene Expression in Lung Cancer.

Frontiers In Genetics

J Zhang, H Hu, S Xu, H Jiang, J Zhu, E Qin, Z He, E Chen

Publication Date: 2020

Variant appearance in text: KRAS: G12R

PMID: 32117436

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Dual-molecular barcode sequencing detects rare variants in tumor and cell free DNA in plasma.

Scientific Reports

Y Hirotsu, S Otake, H Ohyama, K Amemiya, R Higuchi, T Oyama, H Mochizuki, T Goto, M Omata

Publication Date: 2020-02-25

Variant appearance in text: KRAS: G12R

PMID: 32099048

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Characterizations of Gene Alterations in Melanoma Patients from Chinese Population.

Biomed Research International

Y Luo, Z Zhang, J Liu, L Li, X Xu, X Yao, Z Dai, X Wang, S Yang, H Wu, J Bu, Y Wu, T Xiang, X Li

Publication Date: 2020

Variant appearance in text: KRAS: G12R

PMID: 32083130

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The paradox of cancer genes in non-malignant conditions: implications for precision medicine.

Genome Medicine

JJ Adashek, S Kato, SM Lippman, R Kurzrock

Publication Date: 2020-02-17

Variant appearance in text: KRAS: G12R

PMID: 32066498

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Comparative Study of NGS Platform Ion Torrent Personal Genome Machine and Therascreen Rotor-Gene Q for the Detection of Somatic Variants in Cancer.

High-Throughput

A Lombardi, M Russo, A Luce, F Morgillo, V Tirino, G Misso, E Martinelli, T Troiani, V Desiderio, G Papaccio, F Iovino, G Argenziano, E Moscarella, P Sperlongano, G Galizia, R Addeo, A Necas, A Necasova, F Ciardiello, A Ronchi, M Caraglia, A Grimaldi

Publication Date: 2020-02-11

Variant appearance in text: KRAS: Gly12Arg

PMID: 32054005

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Pattern of nucleotide variants of TP53 and their correlation with the expression of p53 and its downstream proteins in a Sri Lankan cohort of breast and colorectal cancer patients.

Bmc Cancer

V Manoharan, EH Karunanayake, KH Tennekoon, S De Silva, AIA Imthikab, K De Silva, P Angunawela, S Vishwakula, J Lunec

Publication Date: 2020-01-30

Variant appearance in text: N/A

PMID: 32000721

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Usefulness of rapid on-site evaluation specimens from endoscopic ultrasound-guided fine-needle aspiration for cancer gene panel testing: A retrospective study.

Plos One

T Ishizawa, N Makino, A Matsuda, Y Kakizaki, T Kobayashi, C Ikeda, S Sugahara, M Tsunoda, Y Ueno

Publication Date: 2020

Variant appearance in text: KRAS: G12R

PMID: 31999789

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The current understanding of KRAS protein structure and dynamics.

Computational And Structural Biotechnology Journal

T Pantsar

Publication Date: 2020

Variant appearance in text: KRAS: G12R

PMID: 31988705

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Preoperative detection of KRAS G12D mutation in ctDNA is a powerful predictor for early recurrence of resectable PDAC patients.

British Journal Of Cancer

S Guo, X Shi, J Shen, S Gao, H Wang, S Shen, Y Pan, B Li, X Xu, Z Shao, G Jin

Publication Date: 2020-01-23

Variant appearance in text: KRAS: G12R

PMID: 31969677

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Correlation between clinicopathological features and KRAS, NRAS, and BRAF mutation status in Chinese colorectal cancer patients.

International Journal Of Clinical And Experimental Pathology

X Zhu, X Meng, W Xiang, W Dai, Q Bai, W Sheng, Y Lu, P Qi, L Wu, G Cai, X Zhou

Publication Date: 2018

Variant appearance in text: KRAS: G12R

PMID: 31938404

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Not all mutations of KRAS predict poor prognosis in patients with colorectal cancer.

International Journal Of Clinical And Experimental Pathology

W Li, Y Liu, S Cai, C Yang, Z Lin, L Zhou, L Liu, X Cheng, W Zeng

Publication Date: 2019

Variant appearance in text: KRAS: G12R

PMID: 31933906

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Diversity spectrum analysis identifies mutation-specific effects of cancer driver genes.

Communications Biology

X Dong, D Huang, X Yi, S Zhang, Z Wang, B Yan, P Chung Sham, K Chen, M Jun Li

Publication Date: 2020-01-07

Variant appearance in text: KRAS: G12R

PMID: 31925297

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Single-cell analysis based dissection of clonality in myelofibrosis.

Nature Communications

E Mylonas, K Yoshida, M Frick, K Hoyer, F Christen, J Kaeda, M Obenaus, D Noerenberg, C Hennch, W Chan, Y Ochi, Y Shiraishi, Y Shiozawa, T Zenz, CC Oakes, B Sawitzki, M Schwarz, L Bullinger, P le Coutre, MJJ Rose-Zerilli, S Ogawa, F Damm

Publication Date: 2020-01-07

Variant appearance in text: KRAS: G12R

PMID: 31911629

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Longitudinal monitoring of KRAS-mutated circulating tumor DNA enables the prediction of prognosis and therapeutic responses in patients with pancreatic cancer.

Plos One

F Watanabe, K Suzuki, S Tamaki, I Abe, Y Endo, Y Takayama, H Ishikawa, N Kakizawa, M Saito, K Futsuhara, H Noda, F Konishi, T Rikiyama

Publication Date: 2019

Variant appearance in text: KRAS: G12R

PMID: 31891652

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ATM-Mutated Pancreatic Cancer: Clinical and Molecular Response to Gemcitabine/Nab-Paclitaxel After Genome-Based Therapy Resistance.

Pancreas

C Martino, D Pandya, R Lee, G Levy, T Lo, S Lobo, RC Frank

Publication Date: 2020-01

Variant appearance in text: KRAS: G12R

PMID: 31856090

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Highly specific enrichment of rare nucleic acid fractions using Thermus thermophilus argonaute with applications in cancer diagnostics.

Nucleic Acids Research

J Song, JW Hegge, MG Mauk, J Chen, JE Till, N Bhagwat, LT Azink, J Peng, M Sen, J Mays, EL Carpenter, J van der Oost, HH Bau

Publication Date: 2019-12-12

Variant appearance in text: KRAS: G12R

PMID: 31828328

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Pancreatic cancer organoids recapitulate disease and allow personalized drug screening.

Proceedings Of The National Academy Of Sciences Of The United States Of America

E Driehuis, A van Hoeck, K Moore, S Kolders, HE Francies, MC Gulersonmez, ECA Stigter, B Burgering, V Geurts, A Gracanin, G Bounova, FH Morsink, R Vries, S Boj, J van Es, GJA Offerhaus, O Kranenburg, MJ Garnett, L Wessels, E Cuppen, LAA Brosens, H Clevers

Publication Date: 2019-12-09

Variant appearance in text: KRAS: G12R

PMID: 31818951

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Clinical correlates of blood-derived circulating tumor DNA in pancreatic cancer.

Journal Of Hematology & Oncology

H Patel, R Okamura, P Fanta, C Patel, RB Lanman, VM Raymond, S Kato, R Kurzrock

Publication Date: 2019-12-04

Variant appearance in text: KRAS: G12R

PMID: 31801585

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Using somatic variant richness to mine signals from rare variants in the cancer genome.

Nature Communications

S Chakraborty, A Arora, CB Begg, R Shen

Publication Date: 2019-12-03

Variant appearance in text: KRAS: G12R

PMID: 31796730

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Durable response to olaparib in pancreatic duct adenocarcinoma with deleterious ARID1A mutation.

Chinese Medical Journal

XS Zhao, J Zhou, L Dong, H Zhang, YJ Ye

Publication Date: 2019-11-22

Variant appearance in text: KRAS: G12R

PMID: 31764178

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Circulating tumor DNA as a prognostic indicator in resectable pancreatic ductal adenocarcinoma: A systematic review and meta-analysis.

Scientific Reports

JS Lee, TM Rhee, D Pietrasz, JB Bachet, P Laurent-Puig, SY Kong, E Takai, S Yachida, T Shibata, JW Lee, HC Park, DY Zang, K Jeon, J Lee, M Kim, HS Kim, HJ Kang, YK Lee

Publication Date: 2019-11-18

Variant appearance in text: KRAS: G12R

PMID: 31740696

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The prevalence and prognostic value of KRAS co-mutation subtypes in Chinese advanced non-small cell lung cancer patients.

Cancer Medicine

D Cai, C Hu, L Li, S Deng, J Yang, H Han-Zhang, M Li

Publication Date: 2019-11-10

Variant appearance in text: KRAS: G12R

PMID: 31709742

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A Comparative Analysis of Individual RAS Mutations in Cancer Biology.

Frontiers In Oncology

C Muñoz-Maldonado, Y Zimmer, M Medová

Publication Date: 2019

Variant appearance in text: KRAS: G12R

PMID: 31681616

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DNAJB1-PRKACA fusions occur in oncocytic pancreatic and biliary neoplasms and are not specific for fibrolamellar hepatocellular carcinoma.

Modern Pathology : An Official Journal Of The United States And Canadian Academy Of Pathology, Inc

M Vyas, JF Hechtman, Y Zhang, R Benayed, A Yavas, G Askan, J Shia, DS Klimstra, O Basturk

Publication Date: 2019-11-01

Variant appearance in text: KRAS: G12R

PMID: 31676785

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An integrative pharmacogenomics analysis identifies therapeutic targets in KRAS-mutant lung cancer.

Ebiomedicine

H Wang, Q Lv, Y Xu, Z Cai, J Zheng, X Cheng, Y Dai, PA Jänne, C Ambrogio, J Köhler

Publication Date: 2019-11

Variant appearance in text: KRAS: G12R

PMID: 31668570

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Atypical KRASG12R Mutant Is Impaired in PI3K Signaling and Macropinocytosis in Pancreatic Cancer.

Cancer Discovery

GA Hobbs, NM Baker, AM Miermont, RD Thurman, M Pierobon, TH Tran, AO Anderson, AM Waters, JN Diehl, B Papke, RG Hodge, JE Klomp, CM Goodwin, JM DeLiberty, J Wang, RWS Ng, P Gautam, KL Bryant, D Esposito, SL Campbell, EF Petricoin, DK Simanshu, AJ Aguirre, BM Wolpin, K Wennerberg, U Rudloff, AD Cox, CJ Der

Publication Date: 2019-10-24

Variant appearance in text: KRAS: G12R

PMID: 31649109

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GEFT protein expression in digestive tract malignant tumors and its clinical significance.

Oncology Letters

Y Wang, B Zhang, G Gao, Y Zhang, Q Xia

Publication Date: 2019-11

Variant appearance in text: KRAS: G12R

PMID: 31620201

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KRAS Mutations Predict Response and Outcome in Advanced Lung Adenocarcinoma Patients Receiving First-Line Bevacizumab and Platinum-Based Chemotherapy.

Cancers

AK Ghimessy, A Gellert, E Schlegl, B Hegedus, E Raso, T Barbai, J Timar, G Ostoros, Z Megyesfalvi, B Gieszer, J Moldvay, F Renyi-Vamos, Z Lohinai, MA Hoda, T Klikovits, W Klepetko, V Laszlo, B Dome

Publication Date: 2019-10-09

Variant appearance in text: KRAS: G12R

PMID: 31600989

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Development of Patient-Derived Preclinical Platform for Metastatic Pancreatic Cancer: PDOX and a Subsequent Organoid Model System Using Percutaneous Biopsy Samples.

Frontiers In Oncology

SI Choi, AR Jeon, MK Kim, YS Lee, JE Im, JW Koh, SS Han, SY Kong, KA Yoon, YH Koh, JH Lee, WJ Lee, SJ Park, EK Hong, SM Woo, YH Kim

Publication Date: 2019

Variant appearance in text: KRAS: G12R

PMID: 31572675

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DNA sequencing of cytopathologically inconclusive EUS-FNA from solid pancreatic lesions suspicious for malignancy confirms EUS diagnosis.

Endoscopic Ultrasound

JI Plougmann, P Klausen, A Toxvaerd, AA Abedi, B Kovacevic, JG Karstensen, TS Poulsen, E Kalaitzakis, E Høgdall, P Vilmann

Publication Date: 2019-09-25

Variant appearance in text: KRAS: G12R

PMID: 31552911

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Optimisation of robust singleplex and multiplex droplet digital PCR assays for high confidence mutation detection in circulating tumour DNA.

Scientific Reports

V Rowlands, AJ Rutkowski, E Meuser, TH Carr, EA Harrington, JC Barrett

Publication Date: 2019-09-02

Variant appearance in text: KRAS: G12R

PMID: 31477768

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Targeting plasma membrane phosphatidylserine content to inhibit oncogenic KRAS function.

Life Science Alliance

WE Kattan, W Chen, X Ma, TH Lan, D van der Hoeven, R van der Hoeven, JF Hancock

Publication Date: 2019-10

Variant appearance in text: KRAS: G12R

PMID: 31451509

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Abstracts : 31 st European Congress of Pathology.

Virchows Archiv : An International Journal Of Pathology

.

Publication Date: 2019-09

Variant appearance in text: KRAS: G12R

PMID: 31440833

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Mutation-Derived Neoantigens for Cancer Immunotherapy.

Frontiers In Immunology

JC Castle, M Uduman, S Pabla, RB Stein, JS Buell

Publication Date: 2019

Variant appearance in text: KRAS: G12R

PMID: 31440245

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Impact of smoking on frequency and spectrum of K-RAS and EGFR mutations in treatment naive Indonesian lung cancer patients.

Lung Cancer (Auckland, N.Z.)

N Masykura, J Zaini, E Syahruddin, SL Andarini, A Hudoyo, R Yasril, A Ridwanuloh, H Hidajat, F Nurwidya, A Utomo

Publication Date: 2019

Variant appearance in text: KRAS: G12R

PMID: 31354372

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Omics Approaches in Pancreatic Adenocarcinoma.

Cancers

I González-Borja, A Viúdez, S Goñi, E Santamaria, E Carrasco-García, J Pérez-Sanz, I Hernández-García, P Sala-Elarre, V Arrazubi, E Oyaga-Iriarte, R Zárate, S Arévalo, O Sayar, R Vera, J Fernández-Irigoyen

Publication Date: 2019-07-25

Variant appearance in text: KRAS: G12R

PMID: 31349663

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Microarray Approach Combined with ddPCR: An Useful Pipeline for the Detection and Quantification of Circulating Tumour dna Mutations.

Cells

S Galbiati, F Damin, L Ferraro, N Soriani, V Burgio, M Ronzoni, L Gianni, M Ferrari, M Chiari

Publication Date: 2019-07-24

Variant appearance in text: KRAS: G12R

PMID: 31344983

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Circulating tumor DNA quantity is related to tumor volume and both predict survival in metastatic pancreatic ductal adenocarcinoma.

International Journal Of Cancer

M Strijker, EC Soer, M de Pastena, A Creemers, A Balduzzi, JJ Beagan, OR Busch, OM van Delden, H Halfwerk, JE van Hooft, KP van Lienden, G Marchegiani, SL Meijer, CJ van Noesel, RJ Reinten, E Roos, S Schokker, J Verheij, MJ van de Vijver, C Waasdorp, JW Wilmink, B Ylstra, MG Besselink, MF Bijlsma, F Dijk, HW van Laarhoven

Publication Date: 2019-07-24

Variant appearance in text: KRAS: 34G>C; G12R

PMID: 31340061

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Two Cases of Rare Pancreatic Malignancies.

Journal Of Pancreatic Cancer

W Hanayneh, H Parekh, G Fitzpatrick, M Feely, TJ George, JS Starr

Publication Date: 2019

Variant appearance in text: KRAS: G12R

PMID: 31338486

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Expression and Role of MicroRNAs from the miR-200 Family in the Tumor Formation and Metastatic Propensity of Pancreatic Cancer.

Molecular Therapy. Nucleic Acids

ZV Diaz-Riascos, MM Ginesta, J Fabregat, T Serrano, J Busquets, L Buscail, P Cordelier, G Capellá

Publication Date: 2019-09-06

Variant appearance in text: KRAS: G12R

PMID: 31336236

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Utility of liquid biopsy using urine in patients with pancreatic ductal adenocarcinoma.

Cancer Biology & Therapy

H Terasawa, H Kinugasa, S Ako, M Hirai, H Matsushita, D Uchida, T Tomoda, K Matsumoto, S Horiguchi, H Kato, K Nouso, H Okada

Publication Date: 2019

Variant appearance in text: KRAS: G12R

PMID: 31328611

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Resistance of t(17;19)-acute lymphoblastic leukemia cell lines to multiagents in induction therapy.

Cancer Medicine

A Watanabe, T Inukai, K Kagami, M Abe, M Takagi, T Fukushima, H Fukushima, T Nanmoku, K Terui, T Ito, T Toki, E Ito, J Fujimura, H Goto, M Endo, T Look, M Kamps, M Minegishi, J Takita, T Inaba, H Takahashi, A Ohara, D Harama, T Shinohara, S Somazu, H Oshiro, K Akahane, K Goi, K Sugita

Publication Date: 2019-09

Variant appearance in text: KRAS: G12R

PMID: 31305009

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Evaluation of KRAS, NRAS and BRAF hotspot mutations detection for patients with metastatic colorectal cancer using direct DNA pipetting in a fully-automated platform and Next-Generation Sequencing for laboratory workflow optimisation.

Plos One

P Gilson, C Franczak, L Dubouis, M Husson, M Rouyer, J Demange, M Perceau, A Leroux, JL Merlin, A Harlé

Publication Date: 2019

Variant appearance in text: KRAS: 34G>C; G12R

PMID: 31265477

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Somatic molecular analysis augments cytologic evaluation of pancreatic cyst fluids as a diagnostic tool.

Oncotarget

A Sakhdari, PA Moghaddam, CY Ok, O Walter, K Tomaszewicz, ML Caporelli, X Meng, J LaFemina, G Whalen, E Belkin, J Zivny, W Wassef, BA Woda, LM Hutchinson, EF Cosar

Publication Date: 2019-06-18

Variant appearance in text: KRAS: G12R

PMID: 31258847

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Liquid biopsy in pancreatic ductal adenocarcinoma: current status of circulating tumor cells and circulating tumor DNA.

Molecular Oncology

JS Lee, SS Park, YK Lee, JA Norton, SS Jeffrey

Publication Date: 2019-08

Variant appearance in text: KRAS: G12R

PMID: 31243883

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Integrative analysis of genomic and transcriptomic characteristics associated with progression of aggressive thyroid cancer.

Nature Communications

SK Yoo, YS Song, EK Lee, J Hwang, HH Kim, G Jung, YA Kim, SJ Kim, SW Cho, JK Won, EJ Chung, JY Shin, KE Lee, JI Kim, YJ Park, JS Seo

Publication Date: 2019-06-24

Variant appearance in text: KRAS: G12R

PMID: 31235699

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Validation of Immunohistochemistry for the Detection of BRAF V600E-Mutated Lung Adenocarcinomas.

Cancers

CH Gow, MS Hsieh, YT Lin, YN Liu, JY Shih

Publication Date: 2019-06-21

Variant appearance in text: KRAS: G12R

PMID: 31234388

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Detection of Circulating Tumor DNA with a Single-Molecule Sequencing Analysis Validated for Targeted and Immunotherapy Selection.

Molecular Diagnosis & Therapy

A Atkins, P Gupta, BM Zhang, WS Tsai, J Lucas, M Javey, A Vora, R Mei

Publication Date: 2019-08

Variant appearance in text: KRAS: G12R

PMID: 31209714

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Temporal and spatial effects and survival outcomes associated with concordance between tissue and blood KRAS alterations in the pan-cancer setting.

International Journal Of Cancer

K Mardinian, R Okamura, S Kato, R Kurzrock

Publication Date: 2020-01-15

Variant appearance in text: KRAS: G12R

PMID: 31199507

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Unique Neoantigens Arise from Somatic Mutations in Patients with Gastrointestinal Cancers.

Cancer Discovery

MR Parkhurst, PF Robbins, E Tran, TD Prickett, JJ Gartner, L Jia, G Ivey, YF Li, M El-Gamil, A Lalani, JS Crystal, A Sachs, E Groh, S Ray, LT Ngo, S Kivitz, A Pasetto, R Yossef, FJ Lowery, SL Goff, W Lo, G Cafri, DC Deniger, P Malekzadeh, M Ahmadzadeh, JR Wunderlich, RPT Somerville, SA Rosenberg

Publication Date: 2019-08

Variant appearance in text: KRAS: G12R

PMID: 31164343

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Circulating Tumor DNA as a Clinical Test in Resected Pancreatic Cancer.

Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research

VP Groot, S Mosier, AA Javed, JA Teinor, G Gemenetzis, D Ding, LM Haley, J Yu, RA Burkhart, A Hasanain, M Debeljak, H Kamiyama, A Narang, DA Laheru, L Zheng, MT Lin, CD Gocke, EK Fishman, RH Hruban, MG Goggins, IQ Molenaar, JL Cameron, MJ Weiss, VE Velculescu, J He, CL Wolfgang, JR Eshleman

Publication Date: 2019-08-15

Variant appearance in text: KRAS: G12R

PMID: 31142500

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Transcriptional and metabolic rewiring of colorectal cancer cells expressing the oncogenic KRASG13D mutation.

British Journal Of Cancer

T Charitou, S Srihari, MA Lynn, MA Jarboui, E Fasterius, M Moldovan, S Shirasawa, T Tsunoda, M Ueffing, J Xie, J Xin, X Wang, CG Proud, K Boldt, C Al-Khalili Szigyarto, W Kolch, DJ Lynn

Publication Date: 2019-07

Variant appearance in text: KRAS: G12R

PMID: 31133691

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CMAB009 plus irinotecan versus irinotecan-only as second-line treatment after fluoropyrimidine and oxaliplatin failure in KRAS wild-type metastatic colorectal cancer patients: promising findings from a prospective, open-label, randomized, phase III trial.

Cancer Communications (London, England)

Y Shi, J Li, J Xu, Y Sun, L Wang, Y Cheng, W Liu, G Sun, Y Chen, L Bai, Y Zhang, X He, Y Luo, Z Wang, Y Liu, Q Yao, Y Li, S Qin, X Hu, F Bi, R Zheng, X Ouyang

Publication Date: 2019-05-24

Variant appearance in text: KRAS: Gly12Arg

PMID: 31126331

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Computational Screening and Analysis of Lung Cancer Related Non-Synonymous Single Nucleotide Polymorphisms on the Human Kirsten Rat Sarcoma Gene.

Molecules (Basel, Switzerland)

Q Wang, A Mehmood, H Wang, Q Xu, Y Xiong, DQ Wei

Publication Date: 2019-05-21

Variant appearance in text: N/A

PMID: 31117243

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Magnetic Resonance-Based Texture Analysis Differentiating KRAS Mutation Status in Rectal Cancer.

Cancer Research And Treatment : Official Journal Of Korean Cancer Association

JE Oh, MJ Kim, J Lee, BY Hur, B Kim, DY Kim, JY Baek, HJ Chang, SC Park, JH Oh, SA Cho, DK Sohn

Publication Date: 2019-05-07

Variant appearance in text: KRAS: G12R

PMID: 31096736

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Detection of ERBB2 (HER2) Gene Amplification Events in Cell-Free DNA and Response to Anti-HER2 Agents in a Large Asian Cancer Patient Cohort.

Frontiers In Oncology

J Lee, A Franovic, Y Shiotsu, ST Kim, KM Kim, KC Banks, VM Raymond, RB Lanman

Publication Date: 2019

Variant appearance in text: KRAS: G12R

PMID: 31019892

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Alternative transcript annotations:

Transcript	cDNA	Protein	Consequence	Exon	Intron
ENST00000256078.4	c.34G>C	p.Gly12Arg	missense_variant	2/6	-
ENST00000311936.3	c.34G>C	p.Gly12Arg	missense_variant	2/5	-
ENST00000556131.1	c.34G>C	p.Gly12Arg	missense_variant	2/3	-
ENST00000557334.1	c.34G>C	p.Gly12Arg	missense_variant	2/3	-
NM_001369786.1	c.34G>C	p.Gly12Arg	missense_variant	2/6	-
NM_001369787.1	c.34G>C	p.Gly12Arg	missense_variant	2/5	-
NM_004985.5	c.34G>C	p.Gly12Arg	missense_variant	2/5	-
NM_033360.4	c.34G>C	p.Gly12Arg	missense_variant	2/6	-