Variant ID: 12-25398285-C-T

NM_033360.2(KRAS):c.34G>A;(p.Gly12Ser)

This variant was identified in 816 publications




Publications:


Multitarget stool DNA test compared with fecal occult blood test for colorectal cancer screening.

Oncology Letters
C Yang, W Wu, Y Yang, X Yang, J Sun, W Zhang, K Liu, H Ying, S Jiang, X Yu, Y Shi, Y Zhou, S Zhu, Y Xu, Y Ding, L Xie, B Cai, X Xin, P Chen, R Zhao, Y Wu
Publication Date: 2020-08

Variant appearance in text: KRAS: Gly12Ser
PMID: 32724359
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Glutaminase Inhibition on NSCLC Depends on Extracellular Alanine Exploitation.

Cells
E Caiola, M Colombo, G Sestito, M Lupi, M Marabese, R Pastorelli, M Broggini, L Brunelli
Publication Date: 2020-07-23

Variant appearance in text: KRAS: G12S
PMID: 32718002
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Study of Ras Mutations' Prognostic Value in Metastatic Colorectal Cancer: STORIA Analysis.

Cancers
A Ottaiano, N Normanno, S Facchini, A Cassata, A Nappi, C Romano, L Silvestro, A De Stefano, AM Rachiglio, C Roma, MR Maiello, S Scala, P Delrio, F Tatangelo, A Di Mauro, G Botti, A Avallone, G Nasti
Publication Date: 2020-07-16

Variant appearance in text: KRAS: G12S
PMID: 32708575
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Time-saving method for directly amplifying and capturing a minimal amount of pancreatic tumor-derived mutations from fine-needle aspirates using digital PCR.

Scientific Reports
Y Ono, A Hayashi, C Maeda, M Suzuki, R Wada, H Sato, H Kawabata, T Okada, T Goto, H Karasaki, Y Mizukami, T Okumura
Publication Date: 2020-07-23

Variant appearance in text: KRAS: G12S
PMID: 32704002
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miRNAs-Based Molecular Signature for KRAS Mutated and Wild Type Colorectal Cancer: An Explorative Study.

Journal Of Immunology Research
E Milanesi, M Dobre, AI Bucuroiu, V Herlea, TE Manuc, A Salvi, G De Petro, M Manuc, G Becheanu
Publication Date: 2020

Variant appearance in text: KRAS: G12S
PMID: 32676506
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Impact of concurrent genomic alterations in epidermal growth factor receptor (EGFR)-mutated lung cancer.

Journal Of Thoracic Disease
B Gini, N Thomas, CM Blakely
Publication Date: 2020-05

Variant appearance in text: KRAS: G12S
PMID: 32642201
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Proteomics reveals a therapeutic vulnerability via the combined blockade of APE1 and autophagy in lung cancer A549 cells.

Bmc Cancer
ST Pan, J Zhou, F Yang, SF Zhou, T Ren
Publication Date: 2020-07-08

Variant appearance in text: KRAS: G12S
PMID: 32641008
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Germline and Somatic Pharmacogenomics to Refine Rectal Cancer Patients Selection for Neo-Adjuvant Chemoradiotherapy.

Frontiers In Pharmacology
E De Mattia, R Roncato, E Palazzari, G Toffoli, E Cecchin
Publication Date: 2020

Variant appearance in text: KRAS: Gly12Ser
PMID: 32625092
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A potent KRAS macromolecule degrader specifically targeting tumours with mutant KRAS.

Nature Communications
N Bery, A Miller, T Rabbitts
Publication Date: 2020-06-26

Variant appearance in text: KRAS: G12S
PMID: 32591521
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Clinicopathological Characteristics and Mutation Spectrum of Colorectal Adenocarcinoma With Mucinous Component in a Chinese Cohort: Comparison With Classical Adenocarcinoma.

Frontiers In Oncology
J Chen, L Zhou, J Gao, T Lu, J Wang, H Wu, Z Liang
Publication Date: 2020

Variant appearance in text: KRAS: G12S
PMID: 32582557
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Histology and its prognostic effect on KRAS-mutated colorectal carcinomas in Korea.

Oncology Letters
HS Lee, DY Hwang, HS Han
Publication Date: 2020-07

Variant appearance in text: KRAS: G12S
PMID: 32565990
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Complex Oncological Decision-Making Utilizing Fast-and-Frugal Trees in a Community Setting-Role of Academic and Hybrid Modeling.

Journal Of Clinical Medicine
R Salgia, I Mambetsariev, T Tan, A Schwer, DP Pearlstein, H Chehabi, A Baroz, J Fricke, R Pharaon, H Romo, T Waddington, R Babikian, L Buck, P Kulkarni, M Cianfrocca, B Djulbegovic, SK Pal
Publication Date: 2020-06-16

Variant appearance in text: KRAS: G12S
PMID: 32560187
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Anlotinib Exerts Anti-Cancer Effects on KRAS-Mutated Lung Cancer Cell Through Suppressing the MEK/ERK Pathway.

Cancer Management And Research
H Hu, Y Liu, S Tan, XX Xie, J He, F Luo, L Wang
Publication Date: 2020

Variant appearance in text: KRAS: G12S
PMID: 32547195
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A novel sensitive detection method for DNA methylation in circulating free DNA of pancreatic cancer.

Plos One
K Shinjo, K Hara, G Nagae, T Umeda, K Katsushima, M Suzuki, Y Murofushi, Y Umezu, I Takeuchi, S Takahashi, Y Okuno, K Matsuo, H Ito, S Tajima, H Aburatani, K Yamao, Y Kondo
Publication Date: 2020

Variant appearance in text: KRAS: G12S
PMID: 32520974
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Detection of Colorectal Cancer and Advanced Adenoma by Liquid Biopsy (Decalib Study): The ddPCR Challenge.

Cancers
A Junca, G Tachon, C Evrard, C Villalva, E Frouin, L Karayan-Tapon, D Tougeron
Publication Date: 2020-06-06

Variant appearance in text: KRAS: G12S
PMID: 32517177
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An essential role for Argonaute 2 in EGFR-KRAS signaling in pancreatic cancer development.

Nature Communications
S Shankar, JC Tien, RF Siebenaler, S Chugh, VL Dommeti, S Zelenka-Wang, XM Wang, IJ Apel, J Waninger, S Eyunni, A Xu, M Mody, A Goodrum, Y Zhang, JJ Tesmer, R Mannan, X Cao, P Vats, S Pitchiaya, SJ Ellison, J Shi, C Kumar-Sinha, HC Crawford, AM Chinnaiyan
Publication Date: 2020-06-04

Variant appearance in text: KRAS: G12S
PMID: 32499547
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Neuroplastinβ-mediated upregulation of solute carrier family 22 member 18 antisense (SLC22A18AS) plays a crucial role in the epithelial-mesenchymal transition, leading to lung cancer cells' enhanced motility.

Biochemistry And Biophysics Reports
K Bajkowska, IW Sumardika, N Tomonobu, Y Chen, KI Yamamoto, R Kinoshita, H Murata, NL Gede Yoni Komalasari, F Jiang, A Yamauchi, IM Winarsa Ruma, CI Kasano-Camones, Y Inoue, M Sakaguchi
Publication Date: 2020-07

Variant appearance in text: KRAS: G12S
PMID: 32490214
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The Combination of Loss of ALDH1L1 Function and Phenformin Treatment Decreases Tumor Growth in KRAS-Driven Lung Cancer.

Cancers
SH Lee, Y Jeon, JH Kang, H Jang, H Lee, SY Kim
Publication Date: 2020-05-28

Variant appearance in text: KRAS: G12S
PMID: 32481524
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The Quest for Improving Treatment of Cancer of Unknown Primary (CUP) Through Molecularly-Driven Treatments: A Systematic Review.

Frontiers In Oncology
R Lombardo, F Tosi, A Nocerino, K Bencardino, V Gambi, R Ricotta, F Spina, S Siena, A Sartore-Bianchi
Publication Date: 2020

Variant appearance in text: KRAS: G12S
PMID: 32457826
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Small Molecule KRAS Inhibitors: The Future for Targeted Pancreatic Cancer Therapy?

Cancers
J Gillson, Y Ramaswamy, G Singh, AA Gorfe, N Pavlakis, J Samra, A Mittal, S Sahni
Publication Date: 2020-05-24

Variant appearance in text: N/A
PMID: 32456277
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Cisplatin treatment induced interleukin 6 and 8 production alters lung adenocarcinoma cell migration in an oncogenic mutation dependent manner.

Respiratory Research
E Kiss, EHMM Abdelwahab, A Steib, E Papp, Z Torok, L Jakab, G Smuk, V Sarosi, JE Pongracz
Publication Date: 2020-05-20

Variant appearance in text: KRAS: G12S
PMID: 32434541
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NADPH oxidase 1 is highly expressed in human large and small bowel cancers.

Plos One
J Lu, G Jiang, Y Wu, S Antony, JL Meitzler, A Juhasz, H Liu, K Roy, H Makhlouf, R Chuaqui, D Butcher, MM Konaté, JH Doroshow
Publication Date: 2020

Variant appearance in text: KRAS: G12S
PMID: 32428030
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Exosomal long non-coding RNA MSTRG.292666.16 is associated with osimertinib (AZD9291) resistance in non-small cell lung cancer.

Aging
Q Deng, Q Fang, B Xie, H Sun, Y Bao, S Zhou
Publication Date: 2020-05-06

Variant appearance in text: KRAS: G12S
PMID: 32375124
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Digital PCR: A Reliable Tool for Analyzing and Monitoring Hematologic Malignancies.

International Journal Of Molecular Sciences
N Coccaro, G Tota, L Anelli, A Zagaria, G Specchia, F Albano
Publication Date: 2020-04-29

Variant appearance in text: KRAS: G12S
PMID: 32365599
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Spectrum of driver mutations and clinical impact of circulating tumor DNA analysis in non-small cell lung cancer: Analysis of over 8000 cases.

Cancer
PC Mack, KC Banks, CR Espenschied, RA Burich, OA Zill, CE Lee, JW Riess, SA Mortimer, A Talasaz, RB Lanman, DR Gandara
Publication Date: 2020-05-04

Variant appearance in text: KRAS: G12S
PMID: 32365229
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RAS Mutational Status Detection in Tissue, Plasma, and Stool Samples for Colorectal Cancer.

Biomed Research International
L Zhu, Y Wang, Y Zhou, Q Dong, Y Liu, J Zhang
Publication Date: 2020

Variant appearance in text: KRAS: G12S
PMID: 32351996
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Molecular Diagnostic of Solid Tumor Using a Next Generation Sequencing Custom-Designed Multi-Gene Panel.

Diagnostics (Basel, Switzerland)
D de Biase, G Acquaviva, M Visani, V Sanza, CM Argento, A De Leo, T Maloberti, A Pession, G Tallini
Publication Date: 2020-04-23

Variant appearance in text: KRAS: G12S
PMID: 32340363
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[Acquired Drug Resistance Mechanism of Osimertinib in the Targeted Therapy of Non-small Cell Lung Cancer].

Zhongguo Fei Ai Za Zhi = Chinese Journal Of Lung Cancer
Z Zhao, Y Ni, L Li, T Xin
Publication Date: 2020-04-20

Variant appearance in text: KRAS: G12S
PMID: 32316715
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BRAF and KRAS mutations in papillary thyroid carcinoma in the United Arab Emirates.

Plos One
S Al-Salam, C Sharma, B Afandi, K Al Dahmani, AS Al-Zahrani, A Al Shamsi, J Al Kaabi
Publication Date: 2020

Variant appearance in text: KRAS: G12S
PMID: 32315324
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Cancer cell-intrinsic expression of MHC II in lung cancer cell lines is actively restricted by MEK/ERK signaling and epigenetic mechanisms.

Journal For Immunotherapy Of Cancer
AJ Neuwelt, AK Kimball, AM Johnson, BW Arnold, BL Bullock, RE Kaspar, EK Kleczko, JW Kwak, MH Wu, LE Heasley, RC Doebele, HY Li, RA Nemenoff, ET Clambey
Publication Date: 2020-04

Variant appearance in text: KRAS: G12S
PMID: 32312906
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Selective targeting of the oncogenic KRAS G12S mutant allele by CRISPR/Cas9 induces efficient tumor regression.

Theranostics
Q Gao, W Ouyang, B Kang, X Han, Y Xiong, R Ding, Y Li, F Wang, L Huang, L Chen, D Wang, X Dong, Z Zhang, Y Li, B Ze, Y Hou, H Yang, Y Ma, Y Gu, CC Chao
Publication Date: 2020

Variant appearance in text: KRAS: 34G>A; G12S
PMID: 32308773
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Metabolic characterization of colorectal cancer cells harbouring different KRAS mutations in codon 12, 13, 61 and 146 using human SW48 isogenic cell lines.

Metabolomics : Official Journal Of The Metabolomic Society
D Varshavi, D Varshavi, N McCarthy, K Veselkov, HC Keun, JR Everett
Publication Date: 2020-04-16

Variant appearance in text: KRAS: G12S
PMID: 32300895
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RAS/RAF mutations in tumor samples and cell-free DNA from plasma and bone marrow aspirates in multiple myeloma patients.

Journal Of Cancer
Q Li, HJ Huang, J Ma, Y Wang, Z Cao, G Karlin-Neumann, F Janku, Z Liu
Publication Date: 2020

Variant appearance in text: KRAS: G12S
PMID: 32284750
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Multiplexed molecular profiling of lung cancer with malignant pleural effusion using next generation sequencing in Chinese patients.

Oncology Letters
X Ruan, Y Sun, W Wang, J Ye, D Zhang, Z Gong, M Yang
Publication Date: 2020-05

Variant appearance in text: KRAS: G12S
PMID: 32269623
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The Inhibition of Wnt Restrain KRASG12V-Driven Metastasis in Non-Small-Cell Lung Cancer.

Cancers
PS Hung, MH Huang, YY Kuo, JC Yang
Publication Date: 2020-03-31

Variant appearance in text: KRAS: G12S
PMID: 32244355
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Harmonization of Next-Generation Sequencing Procedure in Italian Laboratories: A Multi-Institutional Evaluation of the SiRe® Panel.

Frontiers In Oncology
U Malapelle, F Pepe, P Pisapia, R Sgariglia, M Nacchio, C De Luca, R Lacalamita, S Tommasi, R Pinto, G Palomba, G Palmieri, D Vacirca, M Barberis, I Bottillo, P Grammatico, LR Grillo, V Costa, R Smeraglio, D Bruzzese, G Troncone
Publication Date: 2020

Variant appearance in text: KRAS: G12S
PMID: 32219061
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An enzymatic on/off switch-mediated assay for KRAS hotspot point mutation detection of circulating tumor DNA.

Journal Of Clinical Laboratory Analysis
QL Wang, CL Zhou, YF Yin, L Xiao, Y Wang, K Li
Publication Date: 2020-03-24

Variant appearance in text: KRAS: G12S
PMID: 32207862
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Targeted sequencing analysis of cell-free DNA from metastatic non-small-cell lung cancer patients: clinical and biological implications.

Translational Lung Cancer Research
R Pasquale, L Forgione, C Roma, F Fenizia, F Bergantino, AM Rachiglio, A De Luca, M Gallo, MR Maiello, G Palumbo, A Morabito, R Azzaro, N Normanno
Publication Date: 2020-02

Variant appearance in text: KRAS: Gly12Ser
PMID: 32206554
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Coexisting EGFR and TP53 Mutations in Lung Adenocarcinoma Patients Are Associated With COMP and ITGB8 Upregulation and Poor Prognosis.

Frontiers In Molecular Biosciences
C Zheng, X Li, Y Ren, Z Yin, B Zhou
Publication Date: 2020

Variant appearance in text: N/A
PMID: 32175330
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Analysis of tumor microenvironmental features to refine prognosis by T, N risk group in patients with stage III colon cancer (NCCTG N0147) (Alliance).

Annals Of Oncology : Official Journal Of The European Society For Medical Oncology
H Lee, D Sha, NR Foster, Q Shi, SR Alberts, TC Smyrk, FA Sinicrope
Publication Date: 2020-01-25

Variant appearance in text: KRAS: 34G>A; G12S
PMID: 32165096
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Association of promoter methylation of RASSF1A and KRAS mutations in non-small cell lung carcinoma in Kashmiri population (India).

Heliyon
NU Din Shah, MN Ali, BA Ganai, S Mudassar, MS Khan, J Kour, AA Waza, MT Rasool, AM Lone
Publication Date: 2020-02

Variant appearance in text: KRAS: 34G>A
PMID: 32140600
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Influence of EGFR-activating mutations on sensitivity to tyrosine kinase inhibitors in a KRAS mutant non-small cell lung cancer cell line.

Plos One
Y Tsukumo, M Naito, T Suzuki
Publication Date: 2020

Variant appearance in text: KRAS: G12S
PMID: 32130260
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Identification and Single-Cell Analysis of Viable Circulating Tumor Cells by a Mitochondrion-Specific AIE Bioprobe.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
B Situ, X Ye, Q Zhao, L Mai, Y Huang, S Wang, J Chen, B Li, B He, Y Zhang, J Zou, BZ Tang, X Pan, L Zheng
Publication Date: 2020-02

Variant appearance in text: KRAS: 34G>A; G12S
PMID: 32099764
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Prior acquired resistance to paclitaxel relays diverse EGFR-targeted therapy persistence mechanisms.

Science Advances
MBD Aldonza, J Ku, JY Hong, D Kim, SJ Yu, MS Lee, MC Prayogo, S Tan, D Kim, J Han, SK Lee, SG Im, HS Ryu, Y Kim
Publication Date: 2020-02

Variant appearance in text: KRAS: G12S
PMID: 32083171
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The Prognostic Value of 18F-FDG PET/CT and KRAS Mutation in Colorectal Cancers

Molecular Imaging And Radionuclide Therapy
E Arslan, T Aksoy, RU Gürsu, N Dursun, E Çakar, TF Çermik
Publication Date: 2020-02-17

Variant appearance in text: KRAS: Gly12Ser
PMID: 32079384
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Comparative Study of NGS Platform Ion Torrent Personal Genome Machine and Therascreen Rotor-Gene Q for the Detection of Somatic Variants in Cancer.

High-Throughput
A Lombardi, M Russo, A Luce, F Morgillo, V Tirino, G Misso, E Martinelli, T Troiani, V Desiderio, G Papaccio, F Iovino, G Argenziano, E Moscarella, P Sperlongano, G Galizia, R Addeo, A Necas, A Necasova, F Ciardiello, A Ronchi, M Caraglia, A Grimaldi
Publication Date: 2020-02-11

Variant appearance in text: KRAS: Gly12Ser
PMID: 32054005
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Pattern of nucleotide variants of TP53 and their correlation with the expression of p53 and its downstream proteins in a Sri Lankan cohort of breast and colorectal cancer patients.

Bmc Cancer
V Manoharan, EH Karunanayake, KH Tennekoon, S De Silva, AIA Imthikab, K De Silva, P Angunawela, S Vishwakula, J Lunec
Publication Date: 2020-01-30

Variant appearance in text: N/A
PMID: 32000721
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The current understanding of KRAS protein structure and dynamics.

Computational And Structural Biotechnology Journal
T Pantsar
Publication Date: 2020

Variant appearance in text: KRAS: G12S
PMID: 31988705
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Results of Liquid Biopsy Studies by Next Generation Sequencing in Patients with Advanced Stage Non-small Cell Lung Cancer: Single Center Experience from Turkey.

Balkan Journal Of Medical Genetics : Bjmg
M Buyuksimsek, M Togun, KI Oguz, A Bisgin, I Boga, M Tohumcuoglu, A Ogul, YA Evren, B Sahin, SH Erdem, C Mirili
Publication Date: 2019-12

Variant appearance in text: KRAS: G12S
PMID: 31942412
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Evaluation of KRAS, NRAS and BRAF mutations detection in plasma using an automated system for patients with metastatic colorectal cancer.

Plos One
C Franczak, A Witz, K Geoffroy, J Demange, M Rouyer, M Husson, V Massard, C Gavoille, A Lambert, P Gilson, N Gambier, J Scala-Bertola, JL Merlin, A Harlé
Publication Date: 2020

Variant appearance in text: KRAS: Gly12Ser
PMID: 31940389
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Correlation between clinicopathological features and KRAS, NRAS, and BRAF mutation status in Chinese colorectal cancer patients.

International Journal Of Clinical And Experimental Pathology
X Zhu, X Meng, W Xiang, W Dai, Q Bai, W Sheng, Y Lu, P Qi, L Wu, G Cai, X Zhou
Publication Date: 2018

Variant appearance in text: KRAS: G12S
PMID: 31938404
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Carcinosarcoma colliding osteosarcoma of the pancreas: a rare case report of multiple clonal originated pancreatic tumors.

International Journal Of Clinical And Experimental Pathology
X Zhou, M Li, P Wang, X Teng, L Sun, J Chen, Z Jia
Publication Date: 2018

Variant appearance in text: KRAS: 34G>A
PMID: 31938279
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Not all mutations of KRAS predict poor prognosis in patients with colorectal cancer.

International Journal Of Clinical And Experimental Pathology
W Li, Y Liu, S Cai, C Yang, Z Lin, L Zhou, L Liu, X Cheng, W Zeng
Publication Date: 2019

Variant appearance in text: KRAS: G12S
PMID: 31933906
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ARL4C is associated with initiation and progression of lung adenocarcinoma and represents a therapeutic target.

Cancer Science
K Kimura, S Matsumoto, T Harada, E Morii, I Nagatomo, Y Shintani, A Kikuchi
Publication Date: 2020-01-11

Variant appearance in text: KRAS: G12S
PMID: 31925985
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PROTACs: great opportunities for academia and industry.

Signal Transduction And Targeted Therapy
X Sun, H Gao, Y Yang, M He, Y Wu, Y Song, Y Tong, Y Rao
Publication Date: 2019

Variant appearance in text: KRAS: G12S
PMID: 31885879
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ONECUT2 overexpression promotes RAS-driven lung adenocarcinoma progression.

Scientific Reports
Q Ma, K Wu, H Li, H Li, Y Zhu, G Hu, L Hu, X Kong
Publication Date: 2019-12-27

Variant appearance in text: KRAS: G12S
PMID: 31882655
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KRAS and NRAS mutational gene profile of metastatic colorectal cancer patients in Jordan.

Plos One
M Awidi, N Ababneh, M Shomaf, F Al Fararjeh, L Owaidi, M AlKhatib, B Al Tarawneh, A Awidi
Publication Date: 2019

Variant appearance in text: KRAS: G12S
PMID: 31881025
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Suppression of the SLC7A11/glutathione axis causes synthetic lethality in KRAS-mutant lung adenocarcinoma.

The Journal Of Clinical Investigation
K Hu, K Li, J Lv, J Feng, J Chen, H Wu, F Cheng, W Jiang, J Wang, H Pei, PJ Chiao, Z Cai, Y Chen, M Liu, X Pang
Publication Date: 2019-12-24

Variant appearance in text: KRAS: G12S
PMID: 31874110
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New Frontiers for Molecular Pathology.

Frontiers In Medicine
J Domagala-Kulawik
Publication Date: 2019

Variant appearance in text: N/A
PMID: 31867335
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The Butterfly Effect of RNA Alterations on Transcriptomic Equilibrium.

Cells
N Desi, Y Tay
Publication Date: 2019-12-13

Variant appearance in text: KRAS: G12S
PMID: 31847302
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Ivermectin inhibits HSP27 and potentiates efficacy of oncogene targeting in tumor models.

The Journal Of Clinical Investigation
L Nappi, AH Aguda, NA Nakouzi, B Lelj-Garolla, E Beraldi, N Lallous, M Thi, S Moore, L Fazli, D Battsogt, S Stoffeliene, F Ban, NT Nguyen, N Saxena, E Dueva, F Zhang, T Yamazaki, A Zoubeidi, A Cherkasov, GD Brayer, M Gleave
Publication Date: 2019-12-17

Variant appearance in text: KRAS: G12S
PMID: 31845908
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Ubiquitin-specific protease 22 is critical to in vivo angiogenesis, growth and metastasis of non-small cell lung cancer.

Cell Communication And Signaling : Ccs
K Zhang, L Yang, J Wang, T Sun, Y Guo, R Nelson, TR Tong, R Pangeni, R Salgia, DJ Raz
Publication Date: 2019-12-16

Variant appearance in text: KRAS: G12S
PMID: 31842906
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Assessing the Concordance of Genomic Alterations between Circulating-Free DNA and Tumour Tissue in Cancer Patients.

Cancers
L Jahangiri, T Hurst
Publication Date: 2019-12-04

Variant appearance in text: N/A
PMID: 31817150
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Non-Redundant and Overlapping Oncogenic Readouts of Non-Canonical and Novel Colorectal Cancer KRAS and NRAS Mutants.

Cells
KMM Alcantara, JRP Malapit, RTD Yu, JAMG Garrido, JPT Rigor, AKJ Angeles, EM Cutiongco-de la Paz, RL Garcia
Publication Date: 2019-12-03

Variant appearance in text: KRAS: 34G>A; G12S
PMID: 31816869
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FGF Signalling in the Self-Renewal of Colon Cancer Organoids.

Scientific Reports
J Otte, L Dizdar, B Behrens, W Goering, WT Knoefel, W Wruck, NH Stoecklein, J Adjaye
Publication Date: 2019-11-22

Variant appearance in text: KRAS: G12S
PMID: 31758153
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Circulating tumor DNA as a prognostic indicator in resectable pancreatic ductal adenocarcinoma: A systematic review and meta-analysis.

Scientific Reports
JS Lee, TM Rhee, D Pietrasz, JB Bachet, P Laurent-Puig, SY Kong, E Takai, S Yachida, T Shibata, JW Lee, HC Park, DY Zang, K Jeon, J Lee, M Kim, HS Kim, HJ Kang, YK Lee
Publication Date: 2019-11-18

Variant appearance in text: KRAS: G12S
PMID: 31740696
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Withania Somnifera (Ashwagandha) and Withaferin A: Potential in Integrative Oncology.

International Journal Of Molecular Sciences
R Dutta, R Khalil, R Green, SS Mohapatra, S Mohapatra
Publication Date: 2019-10-25

Variant appearance in text: KRAS: 34G>A
PMID: 31731424
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Accurate detection of KRAS, NRAS and BRAF mutations in metastatic colorectal cancers by bridged nucleic acid-clamp real-time PCR.

Bmc Medical Genomics
Y Nagakubo, Y Hirotsu, K Amemiya, T Oyama, H Mochizuki, M Omata
Publication Date: 2019-11-11

Variant appearance in text: KRAS: G12S
PMID: 31711486
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The prevalence and prognostic value of KRAS co-mutation subtypes in Chinese advanced non-small cell lung cancer patients.

Cancer Medicine
D Cai, C Hu, L Li, S Deng, J Yang, H Han-Zhang, M Li
Publication Date: 2019-11-10

Variant appearance in text: N/A
PMID: 31709742
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Clinical Features and MicroRNA Expression Patterns Between AML Patients With DNMT3A R882 and Frameshift Mutations.

Frontiers In Oncology
L Yang, K Shen, M Zhang, W Zhang, H Cai, L Lin, X Long, S Xing, Y Tang, J Xiong, J Wang, D Li, J Zhou, M Xiao
Publication Date: 2019

Variant appearance in text: KRAS: G12S
PMID: 31709191
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A Comparative Analysis of Individual RAS Mutations in Cancer Biology.

Frontiers In Oncology
C Muñoz-Maldonado, Y Zimmer, M Medová
Publication Date: 2019

Variant appearance in text: KRAS: G12S
PMID: 31681616
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MicroRNA-425-5p Expression Affects BRAF/RAS/MAPK Pathways In Colorectal Cancers.

International Journal Of Medical Sciences
A Angius, G Pira, AM Scanu, P Uva, G Sotgiu, L Saderi, A Manca, C Serra, E Uleri, C Piu, M Caocci, G Ibba, A Zinellu, MR Cesaraccio, F Sanges, MR Muroni, A Dolei, P Cossu-Rocca, MR De Miglio
Publication Date: 2019

Variant appearance in text: KRAS: Gly12Ser
PMID: 31673240
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An integrative pharmacogenomics analysis identifies therapeutic targets in KRAS-mutant lung cancer.

Ebiomedicine
H Wang, Q Lv, Y Xu, Z Cai, J Zheng, X Cheng, Y Dai, PA Jänne, C Ambrogio, J Köhler
Publication Date: 2019-11

Variant appearance in text: KRAS: G12S
PMID: 31668570
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Atypical KRASG12R Mutant Is Impaired in PI3K Signaling and Macropinocytosis in Pancreatic Cancer.

Cancer Discovery
GA Hobbs, NM Baker, AM Miermont, RD Thurman, M Pierobon, TH Tran, AO Anderson, AM Waters, JN Diehl, B Papke, RG Hodge, JE Klomp, CM Goodwin, JM DeLiberty, J Wang, RWS Ng, P Gautam, KL Bryant, D Esposito, SL Campbell, EF Petricoin, DK Simanshu, AJ Aguirre, BM Wolpin, K Wennerberg, U Rudloff, AD Cox, CJ Der
Publication Date: 2019-10-24

Variant appearance in text: KRAS: G12S
PMID: 31649109
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Phenotypic Switching of Naïve T Cells to Immune-Suppressive Treg-Like Cells by Mutant KRAS.

Journal Of Clinical Medicine
A Kalvala, P Wallet, L Yang, C Wang, H Li, A Nam, A Nathan, I Mambetsariev, V Poroyko, H Gao, P Chu, M Sattler, A Bild, ER Manuel, PP Lee, MK Jolly, P Kulkarni, R Salgia
Publication Date: 2019-10-18

Variant appearance in text: KRAS: G12S
PMID: 31635338
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Cobimetinib-induced "dropped head syndrome" and subsequent disease management in an Erdheim-Chester patient.

Clinical Case Reports
AC King, EL Diamond, JS Orozco, HR Morse, LL Ouyang, H Schöder, RK Rampal
Publication Date: 2019-10

Variant appearance in text: KRAS: G12S
PMID: 31624624
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GEFT protein expression in digestive tract malignant tumors and its clinical significance.

Oncology Letters
Y Wang, B Zhang, G Gao, Y Zhang, Q Xia
Publication Date: 2019-11

Variant appearance in text: KRAS: G12S
PMID: 31620201
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Thermodynamics and kinetics guided probe design for uniformly sensitive and specific DNA hybridization without optimization.

Nature Communications
X Chen, N Liu, L Liu, W Chen, N Chen, M Lin, J Xu, X Zhou, H Wang, M Zhao, X Xiao
Publication Date: 2019-10-14

Variant appearance in text: KRAS: G12S
PMID: 31611572
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KRAS G13D sensitivity to neurofibromin-mediated GTP hydrolysis.

Proceedings Of The National Academy Of Sciences Of The United States Of America
D Rabara, TH Tran, S Dharmaiah, RM Stephens, F McCormick, DK Simanshu, M Holderfield
Publication Date: 2019-10-29

Variant appearance in text: N/A
PMID: 31611389
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Genomic profiling of cell-free circulating tumor DNA in patients with colorectal cancer and its fidelity to the genomics of the tumor biopsy.

Journal Of Gastrointestinal Oncology
G Li, D Pavlick, JH Chung, T Bauer, BA Tan, J Peguero, P Ward, A Kallab, J Bufill, A Hoffman, A Sadiq, J Edenfield, J He, M Cooke, J Hughes, B Forcier, M Nahas, P Stephens, SM Ali, AB Schrock, JS Ross, VA Miller, JP Gregg
Publication Date: 2019-10

Variant appearance in text: N/A
PMID: 31602320
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KRAS Mutations Predict Response and Outcome in Advanced Lung Adenocarcinoma Patients Receiving First-Line Bevacizumab and Platinum-Based Chemotherapy.

Cancers
AK Ghimessy, A Gellert, E Schlegl, B Hegedus, E Raso, T Barbai, J Timar, G Ostoros, Z Megyesfalvi, B Gieszer, J Moldvay, F Renyi-Vamos, Z Lohinai, MA Hoda, T Klikovits, W Klepetko, V Laszlo, B Dome
Publication Date: 2019-10-09

Variant appearance in text: KRAS: G12S
PMID: 31600989
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Development of Patient-Derived Preclinical Platform for Metastatic Pancreatic Cancer: PDOX and a Subsequent Organoid Model System Using Percutaneous Biopsy Samples.

Frontiers In Oncology
SI Choi, AR Jeon, MK Kim, YS Lee, JE Im, JW Koh, SS Han, SY Kong, KA Yoon, YH Koh, JH Lee, WJ Lee, SJ Park, EK Hong, SM Woo, YH Kim
Publication Date: 2019

Variant appearance in text: KRAS: G12S
PMID: 31572675
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Variation in nomenclature of somatic variants for selection of oncological therapies: Can we reach a consensus soon?

Human Mutation
C Keppens, V Tack, K Dufraing, E Rouleau, MJL Ligtenberg, E Schuuring, EMC Dequeker
Publication Date: 2019-09-25

Variant appearance in text: KRAS: 34G>A; Gly12Ser
PMID: 31553104
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Co-occurring Alterations in the RAS-MAPK Pathway Limit Response to MET Inhibitor Treatment in MET Exon 14 Skipping Mutation-Positive Lung Cancer.

Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research
JK Rotow, P Gui, W Wu, VM Raymond, RB Lanman, FJ Kaye, N Peled, F Fece de la Cruz, B Nadres, RB Corcoran, I Yeh, BC Bastian, P Starostik, K Newsom, VR Olivas, AM Wolff, JS Fraser, EA Collisson, CE McCoach, DR Camidge, J Pacheco, L Bazhenova, T Li, TG Bivona, CM Blakely
Publication Date: 2019-09-23

Variant appearance in text: KRAS: G12S
PMID: 31548343
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Development of combination therapies to maximize the impact of KRAS-G12C inhibitors in lung cancer.

Science Translational Medicine
M Molina-Arcas, C Moore, S Rana, F van Maldegem, E Mugarza, P Romero-Clavijo, E Herbert, S Horswell, LS Li, MR Janes, DC Hancock, J Downward
Publication Date: 2019-09-18

Variant appearance in text: KRAS: G12S
PMID: 31534020
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Discovery of N-(1-Acryloylazetidin-3-yl)-2-(1H-indol-1-yl)acetamides as Covalent Inhibitors of KRASG12C.

Acs Medicinal Chemistry Letters
Y Shin, JW Jeong, RP Wurz, P Achanta, T Arvedson, MD Bartberger, IDG Campuzano, R Fucini, SK Hansen, J Ingersoll, JS Iwig, JR Lipford, V Ma, DJ Kopecky, J McCarter, T San Miguel, C Mohr, S Sabet, AY Saiki, A Sawayama, S Sethofer, CM Tegley, LP Volak, K Yang, BA Lanman, DA Erlanson, VJ Cee
Publication Date: 2019-09-12

Variant appearance in text: KRAS: G12S
PMID: 31531201
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Lung tumorspheres reveal cancer stem cell-like properties and a score with prognostic impact in resected non-small-cell lung cancer.

Cell Death & Disease
A Herreros-Pomares, JD de-Maya-Girones, S Calabuig-Fariñas, R Lucas, A Martínez, JM Pardo-Sánchez, S Alonso, A Blasco, R Guijarro, M Martorell, E Escorihuela, MD Chiara, E Duréndez, C Gandía, J Forteza, R Sirera, E Jantus-Lewintre, R Farràs, C Camps
Publication Date: 2019-09-10

Variant appearance in text: KRAS: G12S
PMID: 31506430
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Liquid versus tissue biopsy for detecting acquired resistance and tumor heterogeneity in gastrointestinal cancers.

Nature Medicine
AR Parikh, I Leshchiner, L Elagina, L Goyal, C Levovitz, G Siravegna, D Livitz, K Rhrissorrakrai, EE Martin, EE Van Seventer, M Hanna, K Slowik, F Utro, CJ Pinto, A Wong, BP Danysh, FF de la Cruz, IJ Fetter, B Nadres, HA Shahzade, JN Allen, LS Blaszkowsky, JW Clark, B Giantonio, JE Murphy, RD Nipp, E Roeland, DP Ryan, CD Weekes, EL Kwak, JE Faris, JY Wo, F Aguet, I Dey-Guha, M Hazar-Rethinam, D Dias-Santagata, DT Ting, AX Zhu, TS Hong, TR Golub, AJ Iafrate, VA Adalsteinsson, A Bardelli, L Parida, D Juric, G Getz, RB Corcoran
Publication Date: 2019-09

Variant appearance in text: KRAS: G12S
PMID: 31501609
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Alternative transcript annotations:

Transcript cDNA Protein Consequence Exon Intron
ENST00000256078.4 c.34G>A p.Gly12Ser missense_variant 2/6 -
ENST00000311936.3 c.34G>A p.Gly12Ser missense_variant 2/5 -
ENST00000556131.1 c.34G>A p.Gly12Ser missense_variant 2/3 -
ENST00000557334.1 c.34G>A p.Gly12Ser missense_variant 2/3 -
NM_001369786.1 c.34G>A p.Gly12Ser missense_variant 2/6 -
NM_001369787.1 c.34G>A p.Gly12Ser missense_variant 2/5 -
NM_004985.5 c.34G>A p.Gly12Ser missense_variant 2/5 -
NM_033360.4 c.34G>A p.Gly12Ser missense_variant 2/6 -