Coding and Noncoding Variation in LRRK2 and Parkinson's Disease Risk.
Movement Disorders : Official Journal Of The Movement Disorder Society
Lake, Julie J; Reed, Xylena X; Langston, Rebekah G RG; Nalls, Mike A MA; Gan-Or, Ziv Z; Cookson, Mark R MR; Singleton, Andrew B AB; Blauwendraat, Cornelis C; Leonard, Hampton L HL; ,
Differences in MTHFR and LRRK2 variant's association with sporadic Parkinson's disease in Mexican Mestizos correlated to Native American ancestry.
Npj Parkinson'S Disease
Romero-Gutiérrez, Elizabeth E; Vázquez-Cárdenas, Paola P; Moreno-Macías, Hortensia H; Salas-Pacheco, José J; Tusié-Luna, Teresa T; Arias-Carrión, Oscar O
Phenome-wide association studies across large population cohorts support drug target validation.
Nature Communications
Diogo, Dorothée D; Tian, Chao C; Franklin, Christopher S CS; Alanne-Kinnunen, Mervi M; March, Michael M; Spencer, Chris C A CCA; Vangjeli, Ciara C; Weale, Michael E ME; Mattsson, Hannele H; Kilpeläinen, Elina E; Sleiman, Patrick M A PMA; Reilly, Dermot F DF; McElwee, Joshua J; Maranville, Joseph C JC; Chatterjee, Arnaub K AK; Bhandari, Aman A; Nguyen, Khanh-Dung H KH; Estrada, Karol K; Reeve, Mary-Pat MP; Hutz, Janna J; Bing, Nan N; John, Sally S; MacArthur, Daniel G DG; Salomaa, Veikko V; Ripatti, Samuli S; Hakonarson, Hakon H; Daly, Mark J MJ; Palotie, Aarno A; Hinds, David A DA; Donnelly, Peter P; Fox, Caroline S CS; Day-Williams, Aaron G AG; Plenge, Robert M RM; Runz, Heiko H
Evaluation of the interaction between LRRK2 and PARK16 loci in determining risk of Parkinson's disease: analysis of a large multicenter study.
Neurobiology Of Aging
Wang, Lisa L; Heckman, Michael G MG; Aasly, Jan O JO; Annesi, Grazia G; Bozi, Maria M; Chung, Sun Ju SJ; Clarke, Carl C; Crosiers, David D; Eckstein, Gertrud G; Garraux, Gaetan G; Hadjigeorgiou, Georgios M GM; Hattori, Nobu N; Jeon, Beom B; Kim, Yun J YJ; Kubo, Masato M; Lesage, Suzanne S; Lin, Juei Jueng JJ; Lynch, Timothy T; Lichtner, Peter P; Mellick, George D GD; Mok, Vincent V; Morrison, Karin E KE; Quattrone, Aldo A; Satake, Wataru W; Silburn, Peter A PA; Stefanis, Leonidas L; Stockton, Joanne D JD; Tan, Eng King EK; Toda, Tatsushi T; Brice, Alexis A; Van Broeckhoven, Christine C; Uitti, Ryan J RJ; Wirdefeldt, Karin K; Wszolek, Zbigniew Z; Xiromerisiou, Georgia G; Maraganore, Demetrius M DM; Gasser, Thomas T; Krüger, Rejko R; Farrer, Matthew J MJ; Ross, Owen A OA; Sharma, Manu M; ,
Heritability and genomics of gene expression in peripheral blood.
Nature Genetics
Wright, Fred A FA; Sullivan, Patrick F PF; Brooks, Andrew I AI; Zou, Fei F; Sun, Wei W; Xia, Kai K; Madar, Vered V; Jansen, Rick R; Chung, Wonil W; Zhou, Yi-Hui YH; Abdellaoui, Abdel A; Batista, Sandra S; Butler, Casey C; Chen, Guanhua G; Chen, Ting-Huei TH; D'Ambrosio, David D; Gallins, Paul P; Ha, Min Jin MJ; Hottenga, Jouke Jan JJ; Huang, Shunping S; Kattenberg, Mathijs M; Kochar, Jaspreet J; Middeldorp, Christel M CM; Qu, Ani A; Shabalin, Andrey A; Tischfield, Jay J; Todd, Laura L; Tzeng, Jung-Ying JY; van Grootheest, Gerard G; Vink, Jacqueline M JM; Wang, Qi Q; Wang, Wei W; Wang, Weibo W; Willemsen, Gonneke G; Smit, Johannes H JH; de Geus, Eco J EJ; Yin, Zhaoyu Z; Penninx, Brenda W J H BW; Boomsma, Dorret I DI
GWAS risk factors in Parkinson's disease: LRRK2 coding variation and genetic interaction with PARK16.
American Journal Of Neurodegenerative Disease
Soto-Ortolaza, Alexandra I AI; Heckman, Michael G MG; Labbé, Catherine C; Serie, Daniel J DJ; Puschmann, Andreas A; Rayaprolu, Sruti S; Strongosky, Audrey A; Boczarska-Jedynak, Magdalena M; Opala, Grzegorz G; Krygowska-Wajs, Anna A; Barcikowska, Maria M; Czyzewski, Krzysztof K; Lynch, Timothy T; Uitti, Ryan J RJ; Wszolek, Zbigniew K ZK; Ross, Owen A OA
Assessment of Parkinson's disease risk loci in Greece.
Neurobiology Of Aging
Kara, Eleanna E; Xiromerisiou, Georgia G; Spanaki, Cleanthe C; Bozi, Maria M; Koutsis, Georgios G; Panas, Marios M; Dardiotis, Efthimios E; Ralli, Styliani S; Bras, Jose J; Letson, Christopher C; Edsall, Connor C; Pliner, Hannah H; Arepalli, Sampath S; Kalinderi, Kallirhoe K; Fidani, Liana L; Bostantjopoulou, Sevasti S; Keller, Margaux F MF; Wood, Nicholas W NW; Hardy, John J; Houlden, Henry H; Stefanis, Leonidas L; Plaitakis, Andreas A; Hernandez, Dena D; Hadjigeorgiou, Georgios M GM; Nalls, Mike A MA; Singleton, Andrew B AB
Fine-mapping, gene expression and splicing analysis of the disease associated LRRK2 locus.
Plos One
Trabzuni, Daniah D; Ryten, Mina M; Emmett, Warren W; Ramasamy, Adaikalavan A; Lackner, Karl J KJ; Zeller, Tanja T; Walker, Robert R; Smith, Colin C; Lewis, Patrick A PA; Mamais, Adamantios A; de Silva, Rohan R; Vandrovcova, Jana J; , ; Hernandez, Dena D; Nalls, Michael A MA; Sharma, Manu M; Garnier, Sophie S; Lesage, Suzanne S; Simon-Sanchez, Javier J; Gasser, Thomas T; Heutink, Peter P; Brice, Alexis A; Singleton, Andrew A; Cai, Huaibin H; Schadt, Eric E; Wood, Nicholas W NW; Bandopadhyay, Rina R; Weale, Michael E ME; Hardy, John J; Plagnol, Vincent V
Risk prediction for complex diseases: application to Parkinson disease.
Genetics In Medicine : Official Journal Of The American College Of Medical Genetics
Hall, Taryn O TO; Wan, Jia Y JY; Mata, Ignacio F IF; Kerr, Kathleen F KF; Snapinn, Katherine W KW; Samii, Ali A; Roberts, John W JW; Agarwal, Pinky P; Zabetian, Cyrus P CP; Edwards, Karen L KL
Common variation in the LRRK2 gene is a risk factor for Parkinson's disease.
Movement Disorders : Official Journal Of The Movement Disorder Society
Mata, Ignacio F IF; Checkoway, Harvey H; Hutter, Carolyn M CM; Samii, Ali A; Roberts, John W JW; Kim, Hojoong M HM; Agarwal, Pinky P; Alvarez, Victoria V; Ribacoba, Renee R; Pastor, Pau P; Lorenzo-Betancor, Oswaldo O; Infante, Jon J; Sierra, María M; Gómez-Garre, Pilar P; Mir, Pablo P; Ritz, Beate B; Rhodes, Shannon L SL; Colcher, Amy A; Van Deerlin, Vivianna V; Chung, Kathryn A KA; Quinn, Joseph F JF; Yearout, Dora D; Martinez, Erica E; Farin, Federico M FM; Wan, Jia Y JY; Edwards, Karen L KL; Zabetian, Cyrus P CP
Using genome-wide complex trait analysis to quantify 'missing heritability' in Parkinson's disease.
Human Molecular Genetics
Keller, Margaux F MF; Saad, Mohamad M; Bras, Jose J; Bettella, Francesco F; Nicolaou, Nayia N; Simón-Sánchez, Javier J; Mittag, Florian F; Büchel, Finja F; Sharma, Manu M; Gibbs, J Raphael JR; Schulte, Claudia C; Moskvina, Valentina V; Durr, Alexandra A; Holmans, Peter P; Kilarski, Laura L LL; Guerreiro, Rita R; Hernandez, Dena G DG; Brice, Alexis A; Ylikotila, Pauli P; Stefánsson, Hreinn H; Majamaa, Kari K; Morris, Huw R HR; Williams, Nigel N; Gasser, Thomas T; Heutink, Peter P; Wood, Nicholas W NW; Hardy, John J; Martinez, Maria M; Singleton, Andrew B AB; Nalls, Michael A MA; , ; ,
Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDGene database.
Plos Genetics
Lill, Christina M CM; Roehr, Johannes T JT; McQueen, Matthew B MB; Kavvoura, Fotini K FK; Bagade, Sachin S; Schjeide, Brit-Maren M BM; Schjeide, Leif M LM; Meissner, Esther E; Zauft, Ute U; Allen, Nicole C NC; Liu, Tian T; Schilling, Marcel M; Anderson, Kari J KJ; Beecham, Gary G; Berg, Daniela D; Biernacka, Joanna M JM; Brice, Alexis A; DeStefano, Anita L AL; Do, Chuong B CB; Eriksson, Nicholas N; Factor, Stewart A SA; Farrer, Matthew J MJ; Foroud, Tatiana T; Gasser, Thomas T; Hamza, Taye T; Hardy, John A JA; Heutink, Peter P; Hill-Burns, Erin M EM; Klein, Christine C; Latourelle, Jeanne C JC; Maraganore, Demetrius M DM; Martin, Eden R ER; Martinez, Maria M; Myers, Richard H RH; Nalls, Michael A MA; Pankratz, Nathan N; Payami, Haydeh H; Satake, Wataru W; Scott, William K WK; Sharma, Manu M; Singleton, Andrew B AB; Stefansson, Kari K; Toda, Tatsushi T; Tung, Joyce Y JY; Vance, Jeffery J; Wood, Nick W NW; Zabetian, Cyrus P CP; , ; , ; , ; , ; Young, Peter P; Tanzi, Rudolph E RE; Khoury, Muin J MJ; Zipp, Frauke F; Lehrach, Hans H; Ioannidis, John P A JP; Bertram, Lars L
No association between Parkinson disease alleles and the risk of melanoma.
Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology
Meng, Shasha S; Song, Fengju F; Chen, Honglei H; Gao, Xiang X; Amos, Christopher I CI; Lee, Jeffrey E JE; Wei, Qingyi Q; Qureshi, Abrar A AA; Han, Jiali J
Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's disease.
Plos Genetics
Do, Chuong B CB; Tung, Joyce Y JY; Dorfman, Elizabeth E; Kiefer, Amy K AK; Drabant, Emily M EM; Francke, Uta U; Mountain, Joanna L JL; Goldman, Samuel M SM; Tanner, Caroline M CM; Langston, J William JW; Wojcicki, Anne A; Eriksson, Nicholas N
Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy.
Nature Genetics
Höglinger, Günter U GU; Melhem, Nadine M NM; Dickson, Dennis W DW; Sleiman, Patrick M A PM; Wang, Li-San LS; Klei, Lambertus L; Rademakers, Rosa R; de Silva, Rohan R; Litvan, Irene I; Riley, David E DE; van Swieten, John C JC; Heutink, Peter P; Wszolek, Zbigniew K ZK; Uitti, Ryan J RJ; Vandrovcova, Jana J; Hurtig, Howard I HI; Gross, Rachel G RG; Maetzler, Walter W; Goldwurm, Stefano S; Tolosa, Eduardo E; Borroni, Barbara B; Pastor, Pau P; , ; Cantwell, Laura B LB; Han, Mi Ryung MR; Dillman, Allissa A; van der Brug, Marcel P MP; Gibbs, J Raphael JR; Cookson, Mark R MR; Hernandez, Dena G DG; Singleton, Andrew B AB; Farrer, Matthew J MJ; Yu, Chang-En CE; Golbe, Lawrence I LI; Revesz, Tamas T; Hardy, John J; Lees, Andrew J AJ; Devlin, Bernie B; Hakonarson, Hakon H; Müller, Ulrich U; Schellenberg, Gerard D GD
Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies.
Lancet (London, England)
, ; Nalls, Michael A MA; Plagnol, Vincent V; Hernandez, Dena G DG; Sharma, Manu M; Sheerin, Una-Marie UM; Saad, Mohamad M; Simón-Sánchez, J J; Schulte, Claudia C; Lesage, Suzanne S; Sveinbjörnsdóttir, Sigurlaug S; Stefánsson, Kári K; Martinez, Maria M; Hardy, John J; Heutink, Peter P; Brice, Alexis A; Gasser, Thomas T; Singleton, Andrew B AB; Wood, Nicholas W NW