Publications:

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The E3 ligase TRIM1 ubiquitinates LRRK2 and controls its localization, degradation, and toxicity.

The Journal Of Cell Biology

Stormo, Adrienne E D AED; Shavarebi, Farbod F; FitzGibbon, Molly M; Earley, Elizabeth M EM; Ahrendt, Hannah H; Lum, Lotus S LS; Verschueren, Erik E; Swaney, Danielle L DL; Skibinski, Gaia G; Ravisankar, Abinaya A; van Haren, Jeffrey J; Davis, Emily J EJ; Johnson, Jeffrey R JR; Von Dollen, John J; Balen, Carson C; Porath, Jacob J; Crosio, Claudia C; Mirescu, Christian C; Iaccarino, Ciro C; Dauer, William T WT; Nichols, R Jeremy RJ; Wittmann, Torsten T; Cox, Timothy C TC; Finkbeiner, Steve S; Krogan, Nevan J NJ; Oakes, Scott A SA; Hiniker, Annie A

Publication Date: 2022-04-04

Variant appearance in text: LRRK2: Ser910Ala

PubMed Link: 35266954

Variant Present in the following documents:

• Main text
• JCB_202010065.pdf

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Physiological and pathological functions of LRRK2: implications from substrate proteins.

Neuronal Signaling

Araki, Miho M; Ito, Genta G; Tomita, Taisuke T

Publication Date: 2018-12

Variant appearance in text: LRRK2: S910A

PubMed Link: 32714591

Variant Present in the following documents:

• Main text
• ns-02-ns20180005.pdf

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LRRK2 Phosphorylation, More Than an Epiphenomenon.

Frontiers In Neuroscience

Marchand, Antoine A; Drouyer, Matthieu M; Sarchione, Alessia A; Chartier-Harlin, Marie-Christine MC; Taymans, Jean-Marc JM

Publication Date: 2020

Variant appearance in text: LRRK2: S910A

PubMed Link: 32612495

Variant Present in the following documents:

• Main text

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Guilt-by-Association - Functional Insights Gained From Studying the LRRK2 Interactome.

Frontiers In Neuroscience

Gloeckner, Christian Johannes CJ; Porras, Pablo P

Publication Date: 2020

Variant appearance in text: LRRK2: S910A

PubMed Link: 32508578

Variant Present in the following documents:

• Main text
• fnins-14-00485.pdf

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Inhibition of LRRK2 or Casein Kinase 1 Results in LRRK2 Protein Destabilization.

Molecular Neurobiology

De Wit, T T; Baekelandt, V V; Lobbestael, E E

Publication Date: 2019-08

Variant appearance in text: LRRK2: S910A

PubMed Link: 30592011

Variant Present in the following documents:

• 12035_2018_Article_1449.pdf

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Nigrostriatal pathology with reduced astrocytes in LRRK2 S910/S935 phosphorylation deficient knockin mice.

Neurobiology Of Disease

Zhao, Ye Y; Keshiya, Shikara S; Atashrazm, Farzaneh F; Gao, Jianqun J; Ittner, Lars M LM; Alessi, Dario R DR; Halliday, Glenda M GM; Fu, Yuhong Y; Dzamko, Nicolas N

Publication Date: 2018-12

Variant appearance in text: LRRK2: S910A

PubMed Link: 30194047

Variant Present in the following documents:

• Main text

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Detection of endogenous S1292 LRRK2 autophosphorylation in mouse tissue as a readout for kinase activity.

Npj Parkinson'S Disease

Kluss, Jillian H JH; Conti, Melissa M MM; Kaganovich, Alice A; Beilina, Aleksandra A; Melrose, Heather L HL; Cookson, Mark R MR; Mamais, Adamantios A

Publication Date: 2018

Variant appearance in text: LRRK2: S910A

PubMed Link: 29707617

Variant Present in the following documents:

• Main text
• 41531_2018_Article_49.pdf

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Pharmacological LRRK2 kinase inhibition induces LRRK2 protein destabilization and proteasomal degradation.

Scientific Reports

Lobbestael, E E; Civiero, L L; De Wit, T T; Taymans, J-M JM; Greggio, E E; Baekelandt, V V

Publication Date: 2016-09-23

Variant appearance in text: LRRK2: S910A

PubMed Link: 27658356

Variant Present in the following documents:

• Main text
• srep33897.pdf

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Phos-tag analysis of Rab10 phosphorylation by LRRK2: a powerful assay for assessing kinase function and inhibitors.

The Biochemical Journal

Ito, Genta G; Katsemonova, Kristina K; Tonelli, Francesca F; Lis, Pawel P; Baptista, Marco A S MA; Shpiro, Natalia N; Duddy, Graham G; Wilson, Steve S; Ho, Philip Wing-Lok PW; Ho, Shu-Leong SL; Reith, Alastair D AD; Alessi, Dario R DR

Publication Date: 2016-09-01

Variant appearance in text: LRRK2: S910A

PubMed Link: 27474410

Variant Present in the following documents:

• Main text
• bj4732671.pdf

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Phosphorylation of LRRK2 by casein kinase 1α regulates trans-Golgi clustering via differential interaction with ARHGEF7.

Nature Communications

Chia, Ruth R; Haddock, Sara S; Beilina, Alexandra A; Rudenko, Iakov N IN; Mamais, Adamantios A; Kaganovich, Alice A; Li, Yan Y; Kumaran, Ravindran R; Nalls, Michael A MA; Cookson, Mark R MR

Publication Date: 2014-12-15

Variant appearance in text: LRRK2: S910A

PubMed Link: 25500533

Variant Present in the following documents:

• Main text
• NIHMS641836-supplement-1.pdf
• nihms641836.pdf

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Arsenite stress down-regulates phosphorylation and 14-3-3 binding of leucine-rich repeat kinase 2 (LRRK2), promoting self-association and cellular redistribution.

The Journal Of Biological Chemistry

Mamais, Adamantios A; Chia, Ruth R; Beilina, Alexandra A; Hauser, David N DN; Hall, Christine C; Lewis, Patrick A PA; Cookson, Mark R MR; Bandopadhyay, Rina R

Publication Date: 2014-08-01

Variant appearance in text: LRRK2: S910A

PubMed Link: 24942733

Variant Present in the following documents:

• Main text
• zbc21386.pdf

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Identification of protein phosphatase 1 as a regulator of the LRRK2 phosphorylation cycle.

The Biochemical Journal

Lobbestael, Evy E; Zhao, Jing J; Rudenko, Iakov N IN; Beylina, Aleksandra A; Gao, Fangye F; Wetter, Justin J; Beullens, Monique M; Bollen, Mathieu M; Cookson, Mark R MR; Baekelandt, Veerle V; Nichols, R Jeremy RJ; Taymans, Jean-Marc JM

Publication Date: 2013-11-15

Variant appearance in text: LRRK2: S910A

PubMed Link: 23937259

Variant Present in the following documents:

• Main text

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Screening for novel LRRK2 inhibitors using a high-throughput TR-FRET cellular assay for LRRK2 Ser935 phosphorylation.

Plos One

Hermanson, Spencer B SB; Carlson, Coby B CB; Riddle, Steven M SM; Zhao, Jing J; Vogel, Kurt W KW; Nichols, R Jeremy RJ; Bi, Kun K

Publication Date: 2012

Variant appearance in text: LRRK2: Ser910Ala

PubMed Link: 22952710

Variant Present in the following documents:

• Main text
• pone.0043580.pdf

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14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization.

The Biochemical Journal

Nichols, R Jeremy RJ; Dzamko, Nicolas N; Morrice, Nicholas A NA; Campbell, David G DG; Deak, Maria M; Ordureau, Alban A; Macartney, Thomas T; Tong, Youren Y; Shen, Jie J; Prescott, Alan R AR; Alessi, Dario R DR

Publication Date: 2010-09-15

Variant appearance in text: LRRK2: S910A

PubMed Link: 20642453

Variant Present in the following documents:

• Main text
• bj4300393.pdf

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