Publications:

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LRRK2 Phosphorylation, More Than an Epiphenomenon.

Frontiers In Neuroscience

Marchand, Antoine A; Drouyer, Matthieu M; Sarchione, Alessia A; Chartier-Harlin, Marie-Christine MC; Taymans, Jean-Marc JM

Publication Date: 2020

Variant appearance in text: LRRK2: T1343G

PubMed Link: 32612495

Variant Present in the following documents:

• Main text
• fnins-14-00527.pdf

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Understanding the GTPase Activity of LRRK2: Regulation, Function, and Neurotoxicity.

Advances In Neurobiology

Nguyen, An Phu Tran AP; Moore, Darren J DJ

Publication Date: 2017

Variant appearance in text: LRRK2: T1343G

PubMed Link: 28353279

Variant Present in the following documents:

• Main text

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Protective LRRK2 R1398H Variant Enhances GTPase and Wnt Signaling Activity.

Frontiers In Molecular Neuroscience

Nixon-Abell, Jonathon J; Berwick, Daniel C DC; Grannó, Simone S; Spain, Victoria A VA; Blackstone, Craig C; Harvey, Kirsten K

Publication Date: 2016

Variant appearance in text: LRRK2: T1343G

PubMed Link: 27013965

Variant Present in the following documents:

• Main text
• fnmol-09-00018.pdf

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GTPase activity and neuronal toxicity of Parkinson's disease-associated LRRK2 is regulated by ArfGAP1.

Plos Genetics

Stafa, Klodjan K; Trancikova, Alzbeta A; Webber, Philip J PJ; Glauser, Liliane L; West, Andrew B AB; Moore, Darren J DJ

Publication Date: 2012

Variant appearance in text: LRRK2: T1343G

PubMed Link: 22363216

Variant Present in the following documents:

• Main text

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Models for LRRK2-Linked Parkinsonism.

Parkinson'S Disease

Li, Tianxia T; Yang, Dejun D; Sushchky, Sarah S; Liu, Zhaohui Z; Smith, Wanli W WW

Publication Date: 2011

Variant appearance in text: LRRK2: T1343G

PubMed Link: 21603132

Variant Present in the following documents:

• Main text
• PD2011-942412.pdf

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GTPase activity plays a key role in the pathobiology of LRRK2.

Plos Genetics

Xiong, Yulan Y; Coombes, Candice E CE; Kilaru, Austin A; Li, Xiaojie X; Gitler, Aaron D AD; Bowers, William J WJ; Dawson, Valina L VL; Dawson, Ted M TM; Moore, Darren J DJ

Publication Date: 2010-04-08

Variant appearance in text: LRRK2: T1343G

PubMed Link: 20386743

Variant Present in the following documents:

• Main text

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The Parkinson's disease kinase LRRK2 autophosphorylates its GTPase domain at multiple sites.

Biochemical And Biophysical Research Communications

Greggio, Elisa E; Taymans, Jean-Marc JM; Zhen, Eugene Yuejun EY; Ryder, John J; Vancraenenbroeck, Renée R; Beilina, Alexandra A; Sun, Peng P; Deng, Junpeng J; Jaffe, Howard H; Baekelandt, Veerle V; Merchant, Kalpana K; Cookson, Mark R MR

Publication Date: 2009-11-20

Variant appearance in text: LRRK2: T1343G

PubMed Link: 19733152

Variant Present in the following documents:

• Main text

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Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Deng, Junpeng J; Lewis, Patrick A PA; Greggio, Elisa E; Sluch, Eli E; Beilina, Alexandra A; Cookson, Mark R MR

Publication Date: 2008-02-05

Variant appearance in text: LRRK2: T1343G

PubMed Link: 18230735

Variant Present in the following documents:

• Main text

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