Pathak, Pragya P; Alexander, Krista K KK; Helton, Leah G LG; Kentros, Michalis M; LeClair, Timothy J TJ; Zhang, Xiaojuan X; Ho, Franz Y FY; Moore, Timothy T TT; Hall, Scotty S; Guaitoli, Giambattista G; Gloeckner, Christian Johannes CJ; Kortholt, Arjan A; Rideout, Hardy H; Kennedy, Eileen J EJ
Mutations in LRRK2 linked to Parkinson disease sequester Rab8a to damaged lysosomes and regulate transferrin-mediated iron uptake in microglia.
Plos Biology
Mamais, Adamantios A; Kluss, Jillian H JH; Bonet-Ponce, Luis L; Landeck, Natalie N; Langston, Rebekah G RG; Smith, Nathan N; Beilina, Alexandra A; Kaganovich, Alice A; Ghosh, Manik C MC; Pellegrini, Laura L; Kumaran, Ravindran R; Papazoglou, Ioannis I; Heaton, George R GR; Bandopadhyay, Rina R; Maio, Nunziata N; Kim, Changyoun C; LaVoie, Matthew J MJ; Gershlick, David C DC; Cookson, Mark R MR
Mutations in LRRK2 linked to Parkinson disease sequester Rab8a to damaged lysosomes and regulate transferrin-mediated iron uptake in microglia.
Plos Biology
Mamais, Adamantios A; Kluss, Jillian H JH; Bonet-Ponce, Luis L; Landeck, Natalie N; Langston, Rebekah G RG; Smith, Nathan N; Beilina, Alexandra A; Kaganovich, Alice A; Ghosh, Manik C MC; Pellegrini, Laura L; Kumaran, Ravindran R; Papazoglou, Ioannis I; Heaton, George R GR; Bandopadhyay, Rina R; Maio, Nunziata N; Kim, Changyoun C; LaVoie, Matthew J MJ; Gershlick, David C DC; Cookson, Mark R MR
Preclinical modeling of chronic inhibition of the Parkinson's disease associated kinase LRRK2 reveals altered function of the endolysosomal system in vivo.
Molecular Neurodegeneration
Kluss, Jillian H JH; Mazza, Melissa Conti MC; Li, Yan Y; Manzoni, Claudia C; Lewis, Patrick A PA; Cookson, Mark R MR; Mamais, Adamantios A
LRRK2 mediates tubulation and vesicle sorting from lysosomes.
Science Advances
Bonet-Ponce, Luis L; Beilina, Alexandra A; Williamson, Chad D CD; Lindberg, Eric E; Kluss, Jillian H JH; Saez-Atienzar, Sara S; Landeck, Natalie N; Kumaran, Ravindran R; Mamais, Adamantios A; Bleck, Christopher K E CKE; Li, Yan Y; Cookson, Mark R MR
LRRK2 mediates tubulation and vesicle sorting from lysosomes.
Science Advances
Bonet-Ponce, Luis L; Beilina, Alexandra A; Williamson, Chad D CD; Lindberg, Eric E; Kluss, Jillian H JH; Saez-Atienzar, Sara S; Landeck, Natalie N; Kumaran, Ravindran R; Mamais, Adamantios A; Bleck, Christopher K E CKE; Li, Yan Y; Cookson, Mark R MR
The Current State-of-the Art of LRRK2-Based Biomarker Assay Development in Parkinson's Disease.
Frontiers In Neuroscience
Rideout, Hardy J HJ; Chartier-Harlin, Marie-Christine MC; Fell, Matthew J MJ; Hirst, Warren D WD; Huntwork-Rodriguez, Sarah S; Leyns, Cheryl E G CEG; Mabrouk, Omar S OS; Taymans, Jean-Marc JM
The Parkinson's Disease Protein LRRK2 Interacts with the GARP Complex to Promote Retrograde Transport to the trans-Golgi Network.
Cell Reports
Beilina, Alexandra A; Bonet-Ponce, Luis L; Kumaran, Ravindran R; Kordich, Jennifer J JJ; Ishida, Morié M; Mamais, Adamantios A; Kaganovich, Alice A; Saez-Atienzar, Sara S; Gershlick, David C DC; Roosen, Dorien A DA; Pellegrini, Laura L; Malkov, Vlad V; Fell, Matthew J MJ; Harvey, Kirsten K; Bonifacino, Juan S JS; Moore, Darren J DJ; Cookson, Mark R MR
RAB8, RAB10 and RILPL1 contribute to both LRRK2 kinase-mediated centrosomal cohesion and ciliogenesis deficits.
Human Molecular Genetics
Lara Ordónez, Antonio Jesús AJ; Fernández, Belén B; Fdez, Elena E; Romo-Lozano, María M; Madero-Pérez, Jesús J; Lobbestael, Evy E; Baekelandt, Veerle V; Aiastui, Ana A; López de Munaín, Adolfo A; Melrose, Heather L HL; Civiero, Laura L; Hilfiker, Sabine S
The dynamic switch mechanism that leads to activation of LRRK2 is embedded in the DFGψ motif in the kinase domain.
Proceedings Of The National Academy Of Sciences Of The United States Of America
Schmidt, Sven H SH; Knape, Matthias J MJ; Boassa, Daniela D; Mumdey, Natascha N; Kornev, Alexandr P AP; Ellisman, Mark H MH; Taylor, Susan S SS; Herberg, Friedrich W FW
Differences in Stability, Activity and Mutation Effects Between Human and Mouse Leucine-Rich Repeat Kinase 2.
Neurochemical Research
Langston, Rebekah G RG; Rudenko, Iakov N IN; Kumaran, Ravindran R; Hauser, David N DN; Kaganovich, Alice A; Ponce, Luis Bonet LB; Mamais, Adamantios A; Ndukwe, Kelechi K; Dillman, Allissa A AA; Al-Saif, Amr M AM; Beilina, Aleksandra A; Cookson, Mark R MR
Leucine-rich repeat kinase 2 interacts with p21-activated kinase 6 to control neurite complexity in mammalian brain.
Journal Of Neurochemistry
Civiero, Laura L; Cirnaru, Maria Daniela MD; Beilina, Alexandra A; Rodella, Umberto U; Russo, Isabella I; Belluzzi, Elisa E; Lobbestael, Evy E; Reyniers, Lauran L; Hondhamuni, Geshanthi G; Lewis, Patrick A PA; Van den Haute, Chris C; Baekelandt, Veerle V; Bandopadhyay, Rina R; Bubacco, Luigi L; Piccoli, Giovanni G; Cookson, Mark R MR; Taymans, Jean-Marc JM; Greggio, Elisa E
Phosphorylation of LRRK2 by casein kinase 1α regulates trans-Golgi clustering via differential interaction with ARHGEF7.
Nature Communications
Chia, Ruth R; Haddock, Sara S; Beilina, Alexandra A; Rudenko, Iakov N IN; Mamais, Adamantios A; Kaganovich, Alice A; Li, Yan Y; Kumaran, Ravindran R; Nalls, Michael A MA; Cookson, Mark R MR