Publications:

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Splice-Switching Antisense Oligonucleotides Reduce LRRK2 Kinase Activity in Human LRRK2 Transgenic Mice.

Molecular Therapy. Nucleic Acids

JA Korecka, R Thomas, AJ Hinrich, AM Moskites, ZK Macbain, PJ Hallett, O Isacson, ML Hastings

Publication Date: 2020-06-27

Variant appearance in text: LRRK2: G2019S

PMID: 32736291

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LRRK2 and Protein Aggregation in Parkinson's Disease: Insights From Animal Models.

Frontiers In Neuroscience

DJ Dues, DJ Moore

Publication Date: 2020

Variant appearance in text: LRRK2: G2019S

PMID: 32733200

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Translation Regulation by eIF2α Phosphorylation and mTORC1 Signaling Pathways in Non-Communicable Diseases (NCDs).

International Journal Of Molecular Sciences

TJ Rios-Fuller, M Mahe, B Walters, D Abbadi, S Pérez-Baos, A Gadi, JJ Andrews, O Katsara, CT Vincent, RJ Schneider

Publication Date: 2020-07-26

Variant appearance in text: LRRK2: G2019S

PMID: 32722591

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Comprehensive Genomic Analysis Reveals the Prognostic Role of LRRK2 Copy-Number Variations in Human Malignancies.

Genes

G Lopez, G Lazzeri, A Rappa, G Isimbaldi, FM Cribiù, E Guerini-Rocco, S Ferrero, V Vaira, A Di Fonzo

Publication Date: 2020-07-24

Variant appearance in text: LRRK2: G2019S

PMID: 32722212

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The class II histone deacetylases as therapeutic targets for Parkinson's disease.

Neuronal Signaling

M Mazzocchi, LM Collins, AM Sullivan, GW O'Keeffe

Publication Date: 2020-06

Variant appearance in text: LRRK2: G2019S

PMID: 32714601

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Mitochondrial quality control and neurodegenerative diseases.

Neuronal Signaling

F Gao, J Zhang

Publication Date: 2018-12

Variant appearance in text: LRRK2: G2019S

PMID: 32714594

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Physiological and pathological functions of LRRK2: implications from substrate proteins.

Neuronal Signaling

M Araki, G Ito, T Tomita

Publication Date: 2018-12

Variant appearance in text: LRRK2: G2019S

PMID: 32714591

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Oxidative Stress and Neuroinflammation Potentiate Each Other to Promote Progression of Dopamine Neurodegeneration.

Oxidative Medicine And Cellular Longevity

J He, G Zhu, G Wang, F Zhang

Publication Date: 2020

Variant appearance in text: LRRK2: G2019S

PMID: 32714488

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Association Between Glucocerebrosidase Mutations and Parkinson's Disease in Ireland.

Frontiers In Neurology

DA Olszewska, A McCarthy, AI Soto-Beasley, RL Walton, B Magennis, RL McLaughlin, O Hardiman, OA Ross, T Lynch

Publication Date: 2020

Variant appearance in text: LRRK2: G2019S

PMID: 32714263

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Distinct Roles for RAB10 and RAB29 in Pathogenic LRRK2-Mediated Endolysosomal Trafficking Alterations.

Cells

P Rivero-Ríos, M Romo-Lozano, B Fernández, E Fdez, S Hilfiker

Publication Date: 2020-07-17

Variant appearance in text: LRRK2: G2019S

PMID: 32709066

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Classification of α-synuclein-induced changes in the AAV α-synuclein rat model of Parkinson's disease using electrophysiological measurements of visual processing.

Scientific Reports

FG Østergaard, MM Himmelberg, B Laursen, HR Siebner, AR Wade, KV Christensen

Publication Date: 2020-07-17

Variant appearance in text: LRRK2: G2019S

PMID: 32681050

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Contactin-1 Is Required for Peripheral Innervation and Immune Homeostasis Within the Intestinal Mucosa.

Frontiers In Immunology

M Veny, D Grases, K Kucharova, WW Lin, J Nguyen, S Huang, CF Ware, B Ranscht, JR Šedý

Publication Date: 2020

Variant appearance in text: LRRK2: G2019S

PMID: 32676079

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Abnormal Mitochondrial Quality Control in Neurodegenerative Diseases.

Frontiers In Cellular Neuroscience

X Yan, B Wang, Y Hu, S Wang, X Zhang

Publication Date: 2020

Variant appearance in text: LRRK2: G2019S

PMID: 32655368

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The Role of Oxidative Stress in Parkinson's Disease.

Antioxidants (Basel, Switzerland)

KH Chang, CM Chen

Publication Date: 2020-07-08

Variant appearance in text: LRRK2: G2019S

PMID: 32650609

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Studying the Pathophysiology of Parkinson's Disease Using Zebrafish.

Biomedicines

LM Barnhill, H Murata, JM Bronstein

Publication Date: 2020-07-07

Variant appearance in text: LRRK2: G2019S

PMID: 32645821

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LRRK2 mediates axon development by regulating Frizzled3 phosphorylation and growth cone-growth cone communication.

Proceedings Of The National Academy Of Sciences Of The United States Of America

K Onishi, R Tian, B Feng, Y Liu, J Wang, Y Li, Y Zou

Publication Date: 2020-07-08

Variant appearance in text: LRRK2: G2019S

PMID: 32641508

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Parkinson's Disease Research on the African Continent: Obstacles and Opportunities.

Frontiers In Neurology

MCJ Dekker, T Coulibaly, S Bardien, OA Ross, J Carr, M Komolafe

Publication Date: 2020

Variant appearance in text: LRRK2: G2019S

PMID: 32636796

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Dopaminergic neurodegeneration induced by Parkinson's disease-linked G2019S LRRK2 is dependent on kinase and GTPase activity.

Proceedings Of The National Academy Of Sciences Of The United States Of America

APT Nguyen, E Tsika, K Kelly, N Levine, X Chen, AB West, S Boularand, P Barneoud, DJ Moore

Publication Date: 2020-07-06

Variant appearance in text: LRRK2: G2019S

PMID: 32631998

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Epigenetics in Lewy Body Diseases: Impact on Gene Expression, Utility as a Biomarker, and Possibilities for Therapy.

International Journal Of Molecular Sciences

A Urbizu, K Beyer

Publication Date: 2020-07-02

Variant appearance in text: LRRK2: G2019S

PMID: 32630630

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Dietary Antioxidants and Parkinson's Disease.

Antioxidants (Basel, Switzerland)

HA Park, AC Ellis

Publication Date: 2020-07-01

Variant appearance in text: LRRK2: G2019S

PMID: 32630250

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Negative Symptoms of Schizophrenia and Dopaminergic Transmission: Translational Models and Perspectives Opened by iPSC Techniques.

Frontiers In Neuroscience

G Collo, A Mucci, GM Giordano, E Merlo Pich, S Galderisi

Publication Date: 2020

Variant appearance in text: LRRK2: G2019S

PMID: 32625059

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LRRK2 and α-Synuclein: Distinct or Synergistic Players in Parkinson's Disease?

Frontiers In Neuroscience

DM O'Hara, G Pawar, SK Kalia, LV Kalia

Publication Date: 2020

Variant appearance in text: LRRK2: G2019S

PMID: 32625052

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LRRK2 Phosphorylation, More Than an Epiphenomenon.

Frontiers In Neuroscience

A Marchand, M Drouyer, A Sarchione, MC Chartier-Harlin, JM Taymans

Publication Date: 2020

Variant appearance in text: LRRK2: G2019S

PMID: 32612495

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Molecular mechanism of Fast Endophilin-Mediated Endocytosis.

The Biochemical Journal

A Casamento, E Boucrot

Publication Date: 2020-06-26

Variant appearance in text: LRRK2: Gly2019Ser

PMID: 32589750

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MAP/ERK Signaling in Developing Cognitive and Emotional Function and Its Effect on Pathological and Neurodegenerative Processes.

International Journal Of Molecular Sciences

H Albert-Gascó, F Ros-Bernal, E Castillo-Gómez, FE Olucha-Bordonau

Publication Date: 2020-06-23

Variant appearance in text: LRRK2: G2019S

PMID: 32586047

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Circulating Inflammatory miRNAs Associated with Parkinson's Disease Pathophysiology.

Biomolecules

SR Oliveira, PA Dionísio, L Correia Guedes, N Gonçalves, M Coelho, MM Rosa, JD Amaral, JJ Ferreira, CMP Rodrigues

Publication Date: 2020-06-23

Variant appearance in text: LRRK2: G2019S

PMID: 32585840

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Translation Imaging in Parkinson's Disease: Focus on Neuroinflammation.

Frontiers In Aging Neuroscience

S Belloli, M Morari, V Murtaj, S Valtorta, RM Moresco, MC Gilardi

Publication Date: 2020

Variant appearance in text: LRRK2: G2019S

PMID: 32581765

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LRRK2-Related Parkinson's Disease Due to Altered Endolysosomal Biology With Variable Lewy Body Pathology: A Hypothesis.

Frontiers In Neuroscience

P Rivero-Ríos, M Romo-Lozano, R Fasiczka, Y Naaldijk, S Hilfiker

Publication Date: 2020

Variant appearance in text: LRRK2: G2019S

PMID: 32581693

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The Future of Targeted Gene-Based Treatment Strategies and Biomarkers in Parkinson's Disease.

Biomolecules

A Polissidis, L Petropoulou-Vathi, M Nakos-Bimpos, HJ Rideout

Publication Date: 2020-06-16

Variant appearance in text: LRRK2: G2019S

PMID: 32560161

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Kinase inhibition of G2019S-LRRK2 enhances autolysosome formation and function to reduce endogenous alpha-synuclein intracellular inclusions.

Cell Death Discovery

J Obergasteiger, G Frapporti, G Lamonaca, S Pizzi, A Picard, AA Lavdas, F Pischedda, G Piccoli, S Hilfiker, E Lobbestael, V Baekelandt, AA Hicks, C Corti, PP Pramstaller, M Volta

Publication Date: 2020

Variant appearance in text: LRRK2: G2019S

PMID: 32550012

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Toxicity of Necrostatin-1 in Parkinson's Disease Models.

Antioxidants (Basel, Switzerland)

E Alegre-Cortés, A Muriel-González, S Canales-Cortés, E Uribe-Carretero, G Martínez-Chacón, A Aiastui, A López de Munain, M Niso-Santano, RA Gonzalez-Polo, JM Fuentes, SMS Yakhine-Diop

Publication Date: 2020-06-15

Variant appearance in text: LRRK2: G2019S

PMID: 32549347

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Innovative Approaches for Slowing Disease Progression in Parkinson's Disease: Takeaways from the 14th Annual International Society for Central Nervous System Clinical Trials and Methodology Scientific Meeting.

Innovations In Clinical Neuroscience

M Javidnia, M Frasier, I Shoulson, I Turkoz, K Budur

Publication Date: 2020-01-01

Variant appearance in text: LRRK2: G2019S

PMID: 32547841

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Recent Developments in Microfluidic Technologies for Central Nervous System Targeted Studies.

Pharmaceutics

MI Teixeira, MH Amaral, PC Costa, CM Lopes, DA Lamprou

Publication Date: 2020-06-11

Variant appearance in text: LRRK2: G2019S

PMID: 32545276

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In vitro Models of Neurodegenerative Diseases.

Frontiers In Cell And Developmental Biology

A Slanzi, G Iannoto, B Rossi, E Zenaro, G Constantin

Publication Date: 2020

Variant appearance in text: LRRK2: G2019S

PMID: 32528949

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Quantitative Measurements of LRRK2 in Human Cerebrospinal Fluid Demonstrates Increased Levels in G2019S Patients.

Frontiers In Neuroscience

OS Mabrouk, S Chen, AL Edwards, M Yang, WD Hirst, DL Graham

Publication Date: 2020

Variant appearance in text: LRRK2: G2019S

PMID: 32523511

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"LRRK2: Autophagy and Lysosomal Activity".

Frontiers In Neuroscience

M Madureira, N Connor-Robson, R Wade-Martins

Publication Date: 2020

Variant appearance in text: LRRK2: G2019S

PMID: 32523507

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Metabolic syndrome does not influence the phenotype of LRRK2 and GBA related Parkinson's disease.

Scientific Reports

A Thaler, S Shenhar-Tsarfaty, Y Shaked, T Gurevich, N Omer, A Bar-Shira, M Gana-Weisz, O Goldstein, M Kestenbaum, JM Cedarbaum, A Orr-Urtreger, N Giladi, A Mirelman

Publication Date: 2020-06-09

Variant appearance in text: LRRK2: G2019S

PMID: 32518334

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Neuron-autonomous susceptibility to induced synuclein aggregation is exacerbated by endogenous Lrrk2 mutations and ameliorated by Lrrk2 genetic knock-out.

Brain Communications

S MacIsaac, T Quevedo Melo, Y Zhang, M Volta, MJ Farrer, AJ Milnerwood

Publication Date: 2020

Variant appearance in text: LRRK2: G2019S

PMID: 32510053

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Midbrain Organoids: A New Tool to Investigate Parkinson's Disease.

Frontiers In Cell And Developmental Biology

LM Smits, JC Schwamborn

Publication Date: 2020

Variant appearance in text: LRRK2: G2019S

PMID: 32509785

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Guilt-by-Association - Functional Insights Gained From Studying the LRRK2 Interactome.

Frontiers In Neuroscience

CJ Gloeckner, P Porras

Publication Date: 2020

Variant appearance in text: LRRK2: G2019S

PMID: 32508578

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LRRK2 at the Interface Between Peripheral and Central Immune Function in Parkinson's.

Frontiers In Neuroscience

RL Wallings, MK Herrick, MG Tansey

Publication Date: 2020

Variant appearance in text: LRRK2: G2019S

PMID: 32508566

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LRRK2 Kinase Inhibition Rescues Deficits in Lysosome Function Due to Heterozygous GBA1 Expression in Human iPSC-Derived Neurons.

Frontiers In Neuroscience

A Sanyal, HS Novis, E Gasser, S Lin, MJ LaVoie

Publication Date: 2020

Variant appearance in text: LRRK2: G2019S

PMID: 32499675

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Long-Term Outcomes of Genetic Parkinson's Disease.

Journal Of Movement Disorders

JO Aasly

Publication Date: 2020-05

Variant appearance in text: LRRK2: G2019S

PMID: 32498494

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Fluctuation Imaging of LRRK2 Reveals that the G2019S Mutation Alters Spatial and Membrane Dynamics.

Molecules (Basel, Switzerland)

BJ Sanstrum, BMSS Goo, DZY Holden, DD Delgado, TPN Nguyen, KD Lee, NG James

Publication Date: 2020-05-31

Variant appearance in text: LRRK2: G2019S

PMID: 32486414

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Sleep Spindles and Fragmented Sleep as Prodromal Markers in a Preclinical Model of LRRK2-G2019S Parkinson's Disease.

Frontiers In Neurology

LM Crown, MJ Bartlett, JL Wiegand, AJ Eby, EJ Monroe, K Gies, L Wohlford, MJ Fell, T Falk, SL Cowen

Publication Date: 2020

Variant appearance in text: LRRK2: G2019S

PMID: 32477237

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The effect of LRRK2 loss-of-function variants in humans.

Nature Medicine

N Whiffin, IM Armean, A Kleinman, JL Marshall, EV Minikel, JK Goodrich, NM Quaife, JB Cole, Q Wang, KJ Karczewski, BB Cummings, L Francioli, K Laricchia, A Guan, B Alipanahi, P Morrison, MAS Baptista, KM Merchant, , , JS Ware, AS Havulinna, B Iliadou, JJ Lee, GN Nadkarni, C Whiteman, , M Daly, T Esko, C Hultman, RJF Loos, L Milani, A Palotie, C Pato, M Pato, D Saleheen, PF Sullivan, J Alföldi, P Cannon, DG MacArthur

Publication Date: 2020-05-27

Variant appearance in text: LRRK2: G2019S

PMID: 32461697

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A brief history of organoids.

American Journal Of Physiology. Cell Physiology

C Corrò, L Novellasdemunt, VSW Li

Publication Date: 2020-05-27

Variant appearance in text: LRRK2: G2019S

PMID: 32459504

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Clinical and Imaging Markers of Prodromal Parkinson's Disease.

Frontiers In Neurology

E Hustad, JO Aasly

Publication Date: 2020

Variant appearance in text: LRRK2: G2019S

PMID: 32457695

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Sequential screening nominates the Parkinson's disease associated kinase LRRK2 as a regulator of Clathrin-mediated endocytosis.

Neurobiology Of Disease

GR Heaton, N Landeck, A Mamais, MA Nalls, J Nixon-Abell, R Kumaran, A Beilina, L Pelligrini, Y Li, , K Harvey, MR Cookson

Publication Date: 2020-05-17

Variant appearance in text: LRRK2: G2019S

PMID: 32434048

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Iroquois Homeobox Protein 2 Identified as a Potential Biomarker for Parkinson's Disease.

International Journal Of Molecular Sciences

H Sim, JE Lee, HM Yoo, S Cho, H Lee, A Baek, J Kim, H Seo, MN Kweon, HG Kim, YJ Jeon, MY Son, J Kim

Publication Date: 2020-05-14

Variant appearance in text: LRRK2: Gly2019Ser

PMID: 32422864

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Multiple-Hit Hypothesis in Parkinson's Disease: LRRK2 and Inflammation.

Frontiers In Neuroscience

D Cabezudo, V Baekelandt, E Lobbestael

Publication Date: 2020

Variant appearance in text: LRRK2: G2019S

PMID: 32410948

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Substantia nigra hyperechogenicity in Parkinson disease patients with leucine-rich repeat kinase 2 variants in the Chinese Han population.

Chinese Medical Journal

K Li, CC Gu, JR Zhang, H Jin, YL Ge, J Chen, YP Yang, F Wang, CJ Mao, YC Zhang, CF Liu

Publication Date: 2020-05-11

Variant appearance in text: LRRK2: G2019S

PMID: 32404696

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Autophagy in Neurodegenerative Diseases: A Hunter for Aggregates.

International Journal Of Molecular Sciences

H Park, JH Kang, S Lee

Publication Date: 2020-05-10

Variant appearance in text: LRRK2: G2019S

PMID: 32397599

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Modeling Parkinson's Disease With the Alpha-Synuclein Protein.

Frontiers In Pharmacology

M Gómez-Benito, N Granado, P García-Sanz, A Michel, M Dumoulin, R Moratalla

Publication Date: 2020

Variant appearance in text: LRRK2: G2019S

PMID: 32390826

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CSF total and oligomeric α-Synuclein along with TNF-α as risk biomarkers for Parkinson's disease: a study in LRRK2 mutation carriers.

Translational Neurodegeneration

NK Majbour, JO Aasly, E Hustad, MA Thomas, NN Vaikath, N Elkum, WDJ van de Berg, T Tokuda, B Mollenhauer, HW Berendse, OMA El-Agnaf

Publication Date: 2020-05-06

Variant appearance in text: LRRK2: G2019S

PMID: 32375873

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Genetic perspective on the synergistic connection between vesicular transport, lysosomal and mitochondrial pathways associated with Parkinson's disease pathogenesis.

Acta Neuropathologica Communications

S Smolders, C Van Broeckhoven

Publication Date: 2020-05-06

Variant appearance in text: LRRK2: Gly2019Ser

PMID: 32375870

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The Parkinson's Disease Protein LRRK2 Interacts with the GARP Complex to Promote Retrograde Transport to the trans-Golgi Network.

Cell Reports

A Beilina, L Bonet-Ponce, R Kumaran, JJ Kordich, M Ishida, A Mamais, A Kaganovich, S Saez-Atienzar, DC Gershlick, DA Roosen, L Pellegrini, V Malkov, MJ Fell, K Harvey, JS Bonifacino, DJ Moore, MR Cookson

Publication Date: 2020-05-05

Variant appearance in text: LRRK2: G2019S

PMID: 32375042

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Mitochondrial Homeostasis and Signaling in Parkinson's Disease.

Frontiers In Aging Neuroscience

A Scorziello, D Borzacchiello, MJ Sisalli, R Di Martino, M Morelli, A Feliciello

Publication Date: 2020

Variant appearance in text: LRRK2: G2019S

PMID: 32372945

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Alpha-Synuclein and LRRK2 in Synaptic Autophagy: Linking Early Dysfunction to Late-Stage Pathology in Parkinson's Disease.

Cells

G Lamonaca, M Volta

Publication Date: 2020-04-30

Variant appearance in text: LRRK2: G2019S

PMID: 32365906

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LRRK2 Is Recruited to Phagosomes and Co-recruits RAB8 and RAB10 in Human Pluripotent Stem Cell-Derived Macrophages.

Stem Cell Reports

H Lee, R Flynn, I Sharma, E Haberman, PJ Carling, FJ Nicholls, M Stegmann, J Vowles, W Haenseler, R Wade-Martins, WS James, SA Cowley

Publication Date: 2020-04-15

Variant appearance in text: LRRK2: G2019S

PMID: 32359446

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Modeling Neurodegenerative Disorders in Drosophila melanogaster.

International Journal Of Molecular Sciences

H Bolus, K Crocker, G Boekhoff-Falk, S Chtarbanova

Publication Date: 2020-04-26

Variant appearance in text: LRRK2: G2019S

PMID: 32357532

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Investigating lymphocyte populations in patients with Parkinson's disease.

Annals Of Translational Medicine

N Dzamko

Publication Date: 2020-03

Variant appearance in text: LRRK2: G2019S

PMID: 32355720

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Genetic predispositions of Parkinson's disease revealed in patient-derived brain cells.

Npj Parkinson'S Disease

J Tran, H Anastacio, C Bardy

Publication Date: 2020

Variant appearance in text: LRRK2: G2019S

PMID: 32352027

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C. elegans and Neurodegeneration In Caenorhabditis Elegans: Anatomy, Life Cycles and Biological Functions.

Advances In Medicine And Biology

EJ Martinez-Finley, S Chakraborty, S Caito, S Fretham, M Aschner

Publication Date: 2012

Variant appearance in text: LRRK2: G2019S

PMID: 32346495

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Ultrasensitive RT-QuIC assay with high sensitivity and specificity for Lewy body-associated synucleinopathies.

Acta Neuropathologica

M Rossi, N Candelise, S Baiardi, S Capellari, G Giannini, CD Orrù, E Antelmi, A Mammana, AG Hughson, G Calandra-Buonaura, A Ladogana, G Plazzi, P Cortelli, B Caughey, P Parchi

Publication Date: 2020-04-27

Variant appearance in text: LRRK2: G2019S

PMID: 32342188

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Identification of biomarkers associated with Parkinson's disease by gene expression profiling studies and bioinformatics analysis.

Aims Neuroscience

MG Krokidis

Publication Date: 2019

Variant appearance in text: LRRK2: Gly2019Ser

PMID: 32341987

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Imaging dopamine function and microglia in asymptomatic LRRK2 mutation carriers.

Journal Of Neurology

M Gersel Stokholm, A Garrido, E Tolosa, M Serradell, A Iranzo, K Østergaard, P Borghammer, A Møller, P Parbo, K Stær, DJ Brooks, MJ Martí, N Pavese

Publication Date: 2020-04-21

Variant appearance in text: LRRK2: G2019S

PMID: 32318850

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Binding of the Human 14-3-3 Isoforms to Distinct Sites in the Leucine-Rich Repeat Kinase 2.

Frontiers In Neuroscience

JT Manschwetus, M Wallbott, A Fachinger, C Obergruber, S Pautz, D Bertinetti, SH Schmidt, FW Herberg

Publication Date: 2020

Variant appearance in text: LRRK2: G2019S

PMID: 32317922

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SARS-CoV-2: at the crossroad between aging and neurodegeneration.

Movement Disorders : Official Journal Of The Movement Disorder Society

A Lippi, R Domingues, C Setz, TF Outeiro, A Krisko

Publication Date: 2020-04-15

Variant appearance in text: LRRK2: G2019S

PMID: 32291797

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Origins of Parkinson's Disease in Brain Development: Insights From Early and Persistent Effects of LRRK2-G2019S on Striatal Circuits.

Frontiers In Neuroscience

GW Huntley, DL Benson

Publication Date: 2020

Variant appearance in text: LRRK2: G2019S

PMID: 32273839

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CAV-2-Mediated GFP and LRRK2G2019S Expression in the Macaca fascicularis Brain.

Frontiers In Molecular Neuroscience

C di Caudo, I Martínez-Valbuena, IC Mundiñano, A Gennetier, M Hernandez, M Carmona-Abellan, I Marcilla Garcia, EJ Kremer, R Luquin

Publication Date: 2020

Variant appearance in text: LRRK2: G2019S

PMID: 32269512

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Biological links between traumatic brain injury and Parkinson's disease.

Acta Neuropathologica Communications

V Delic, KD Beck, KCH Pang, BA Citron

Publication Date: 2020-04-07

Variant appearance in text: LRRK2: G2019S

PMID: 32264976

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Modeling Parkinson's Disease Using Induced Pluripotent Stem Cells.

Stem Cells International

X Hu, C Mao, L Fan, H Luo, Z Hu, S Zhang, Z Yang, H Zheng, H Sun, Y Fan, J Yang, C Shi, Y Xu

Publication Date: 2020

Variant appearance in text: LRRK2: G2019S

PMID: 32256606

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The Emerging Functions of LRRK2 and Rab GTPases in the Endolysosomal System.

Frontiers In Neuroscience

T Kuwahara, T Iwatsubo

Publication Date: 2020

Variant appearance in text: LRRK2: G2019S

PMID: 32256311

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Historical Perspective: Models of Parkinson's Disease.

International Journal Of Molecular Sciences

SJ Chia, EK Tan, YX Chao

Publication Date: 2020-04-02

Variant appearance in text: LRRK2: G2019S

PMID: 32252301

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Missing heritability in Parkinson's disease: the emerging role of non-coding genetic variation.

Journal Of Neural Transmission (Vienna, Austria : 1996)

J Ohnmacht, P May, L Sinkkonen, R Krüger

Publication Date: 2020-04-04

Variant appearance in text: LRRK2: G2019S

PMID: 32248367

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Clinicopathologic and genetic features of multiple system atrophy with Lewy body disease.

Brain Pathology (Zurich, Switzerland)

S Koga, F Li, N Zhao, SF Roemer, TJ Ferman, AI Wernick, RL Walton, AH Faroqi, NR Graff-Radford, WP Cheshire, OA Ross, DW Dickson

Publication Date: 2020-03-30

Variant appearance in text: LRRK2: G2019S

PMID: 32232888

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PINK1-dependent phosphorylation of Serine111 within the SF3 motif of Rab GTPases impairs effector interactions and LRRK2 mediated phosphorylation at Threonine72.

The Biochemical Journal

S Vieweg, K Mulholland, B Brauning, N Kacharia, YC Lai, R Toth, PK Singh, I Volpi, M Sattler, M Groll, A Itzen, MMK Muqit

Publication Date: 2020-03-30

Variant appearance in text: LRRK2: G2019S

PMID: 32227113

View BVdb publication page

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Association Between Parkinson's Disease and Melanoma: Putting the Pieces Together.

Frontiers In Aging Neuroscience

Q Ye, Y Wen, N Al-Kuwari, X Chen

Publication Date: 2020

Variant appearance in text: LRRK2: G2019S

PMID: 32210791

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Proteostasis of α-Synuclein and Its Role in the Pathogenesis of Parkinson's Disease.

Frontiers In Cellular Neuroscience

D Han, W Zheng, X Wang, Z Chen

Publication Date: 2020

Variant appearance in text: LRRK2: G2019S

PMID: 32210767

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Leucine Rich Repeat Kinase 2 and Innate Immunity.

Frontiers In Neuroscience

D Ahmadi Rastegar, N Dzamko

Publication Date: 2020

Variant appearance in text: LRRK2: G2019S

PMID: 32210756

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Allosteric modulation of the GTPase activity of a bacterial LRRK2 homologue by conformation-specific Nanobodies.

The Biochemical Journal

M Leemans, C Galicia, E Deyaert, E Daems, L Krause, J Paesmans, E Pardon, J Steyaert, A Kortholt, F Sobott, D Klostermeier, W Versées

Publication Date: 2020-03-13

Variant appearance in text: LRRK2: G2019S

PMID: 32167135

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LRRK2 Mutations and Asian Disease-Associated Variants in the First Parkinson's Disease Cohort from Kazakhstan.

Parkinson'S Disease

R Kaiyrzhanov, A Aitkulova, C Shashkin, N Zharkinbekova, M Rizig, E Zholdybayeva, Z Jarmukhanov, V Akhmetzhanov, G Kaishibayeva, T Khaibullin, A Karimova, S Akshulakov, A Bralov, N Kissamedenov, Z Seidinova, A Taskinbayeva, A Muratbaikyzy, H Houlden

Publication Date: 2020

Variant appearance in text: LRRK2: 6055G>A; Gly2019Ser; rs34637584

PMID: 32148752

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Initiation and propagation of α-synuclein aggregation in the nervous system.

Molecular Neurodegeneration

BA Hijaz, LA Volpicelli-Daley

Publication Date: 2020-03-06

Variant appearance in text: LRRK2: G2019S

PMID: 32143659

View BVdb publication page

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Alternative transcript annotations:

Transcript	cDNA	Protein	Consequence	Exon	Intron
ENST00000298910.7	c.6055G>A	p.Gly2019Ser	missense_variant	41/51	-
ENST00000430804.1	c.*2728G>A	-	3_prime_UTR_variant,NMD_transcript_variant	20/30	-
ENST00000479187.1	n.2736G>A	-	non_coding_transcript_exon_variant	18/26	-
NM_198578.4	c.6055G>A	p.Gly2019Ser	missense_variant	41/51	-