A common mechanism by which type 2A von Willebrand disease mutations enhance ADAMTS13 proteolysis revealed with a von Willebrand factor A2 domain FRET construct.
Plos One
Lynch, Christopher J CJ; Cawte, Adam D AD; Millar, Carolyn M CM; Rueda, David D; Lane, David A DA
Leukocyte proteases cleave von Willebrand factor at or near the ADAMTS13 cleavage site.
Blood
Raife, Thomas J TJ; Cao, Wenjing W; Atkinson, Bonnie S BS; Bedell, Bruce B; Montgomery, Robert R RR; Lentz, Steven R SR; Johnson, George F GF; Zheng, X Long XL