Novel aptamer to von Willebrand factor A1 domain (TAGX-0004) shows total inhibition of thrombus formation superior to ARC1779 and comparable to caplacizumab.
DNA binds to a specific site of the adhesive blood-protein von Willebrand factor guided by electrostatic interactions.
Nucleic Acids Research
Sandoval-Pérez, Angélica A; Berger, Ricarda M L RML; Garaizar, Adiran A; Farr, Stephen E SE; Brehm, Maria A MA; König, Gesa G; Schneider, Stefan W SW; Collepardo-Guevara, Rosana R; Huck, Volker V; Rädler, Joachim O JO; Aponte-Santamaría, Camilo C
von Willebrand factor binding to myosin assists in coagulation.
Blood Advances
Flood, Veronica H VH; Slobodianuk, Tricia L TL; Keesler, Daniel D; Lohmeier, Hannah K HK; Fahs, Scot S; Zhang, Liyun L; Simpson, Pippa P; Montgomery, Robert R RR