Risk Factors of Drug Resistance and the Potential Risk of HIV-1 Transmission of Patients with ART Virological Failure: A Population-Based Study in Sichuan, China.
Infection And Drug Resistance
Zhou, Chang C; Kang, Rui R; Liang, Shu S; Fei, Teng T; Li, Yiping Y; Su, Ling L; Li, Ling L; Ye, Li L; Zhang, Yan Y; Yuan, Dan D
Prevalence of human immunodeficiency virus-1 drug-resistant mutations among adults on first- and second-line antiretroviral therapy in a resource-limited health facility in Busia County, Kenya.
The Pan African Medical Journal
Makwaga, Olipher O; Adhiambo, Maureen M; Mulama, David Hughes DH; Muoma, John J; Adungo, Ferdinard F; Wanjiku, Humphrey H; Ongaya, Asiko A; Maitha, Geoffrey Mutisya GM; Mwau, Matilu M
Identification of an Antiretroviral Small Molecule That Appears To Be a Host-Targeting Inhibitor of HIV-1 Assembly.
Journal Of Virology
Reed, Jonathan C JC; Solas, Dennis D; Kitaygorodskyy, Anatoliy A; Freeman, Beverly B; Ressler, Dylan T B DTB; Phuong, Daryl J DJ; Swain, J Victor JV; Matlack, Kent K; Hurt, Clarence R CR; Lingappa, Vishwanath R VR; Lingappa, Jaisri R JR
Patterns of acquired HIV-1 drug resistance mutations and predictors of virological failure in Moshi, Northern Tanzania.
Plos One
Mziray, Shabani Ramadhani SR; Kumburu, Happiness H HH; Assey, Hellen B HB; Sonda, Tolbert B TB; Mahande, Michael J MJ; Msuya, Sia E SE; Kiwelu, Ireen E IE
HSV-2 Infection as a Potential Cofactor for HIV Disease Progression and Selection of Drug Resistance Mutations in Adults under WHO-Recommended First-Line Antiretroviral Therapy: A Multicentric, Cross-Sectional Study in Cameroon, Central African Republic, Chad, and Gabon.
First case of Dolutegravir and Darunavir/r multi drug-resistant HIV-1 in Cameroon following exposure to Raltegravir: lessons and implications in the era of transition to Dolutegravir-based regimens.
Drug Resistance Mutation Frequency of Single-Genome Amplification-Derived HIV-1 Polymerase Genomes in the Cerebrospinal Fluid and Plasma of HIV-1-Infected Individuals under Nonsuppressive Therapy.
Journal Of Virology
St Bernard, Leslie L; Abolade, Jeremy J; Mohri, Hiroshi H; Markowitz, Martin M; Evering, Teresa H TH
Outcomes of Integrase Inhibitor-based Antiretroviral Therapy in a Clinical Cohort of Treatment-experienced Children, Adolescents and Young Adults With HIV Infection.
The Pediatric Infectious Disease Journal
Levy, Matthew E ME; Griffith, Caleb C; Ellenberger, Nicole N; Monroe, Anne K AK; Castel, Amanda D AD; Rakhmanina, Natella N; ,
High prevalence of integrase mutation L74I in West African HIV-1 subtypes prior to integrase inhibitor treatment.
The Journal Of Antimicrobial Chemotherapy
El Bouzidi, Kate K; Kemp, Steven A SA; Datir, Rawlings P RP; Murtala-Ibrahim, Fati F; Aliyu, Ahmad A; Kwaghe, Vivian V; Frampton, Dan D; Roy, Sunando S; Breuer, Judith J; Sabin, Caroline A CA; Ogbanufe, Obinna O; Charurat, Man E ME; Bonsall, David D; Golubchik, Tanya T; Fraser, Christophe C; Dakum, Patrick P; Ndembi, Nicaise N; Gupta, Ravindra K RK
Evaluating an enhanced adherence intervention among HIV positive adolescents failing atazanavir/ritonavir-based second line antiretroviral treatment at a public health clinic.
Journal Of Aids And Hiv Research (Online)
Chawana, Tariro Dianah TD; Katzenstein, David D; Nathoo, Kusum K; Ngara, Bernard B; Nhachi, Charles Fungai Brian CFB
Adoptive lymphocyte transfer to an HIV-infected progressor from an elite controller.
Jci Insight
Migueles, Stephen A SA; Chairez, Cheryl C; Lin, Siying S; Gavil, Noah V NV; Rosenthal, Danielle M DM; Pooran, Milad M; Natarajan, Ven V; Rupert, Adam A; Dewar, Robin R; Rehman, Tauseef T; Sherman, Brad T BT; Adelsberger, Joseph J; Leitman, Susan F SF; Stroncek, David D; Morse, Caryn G CG; Connors, Mark M; Lane, H Clifford HC; Kovacs, Joseph A JA
Characterization of minority HIV-1 drug resistant variants in the United Kingdom following the verification of a deep sequencing-based HIV-1 genotyping and tropism assay.
Aids Research And Therapy
Silver, Nicholas N; Paynter, Mary M; McAllister, Georgina G; Atchley, Maureen M; Sayir, Christine C; Short, John J; Winner, Dane D; Alouani, David J DJ; Sharkey, Freddie H FH; Bergefall, Kicki K; Templeton, Kate K; Carrington, David D; Quiñones-Mateu, Miguel E ME
2018 update to the HIV-TRePS system: the development of new computational models to predict HIV treatment outcomes, with or without a genotype, with enhanced usability for low-income settings.
The Journal Of Antimicrobial Chemotherapy
Revell, Andrew D AD; Wang, Dechao D; Perez-Elias, Maria-Jesus MJ; Wood, Robin R; Cogill, Dolphina D; Tempelman, Hugo H; Hamers, Raph L RL; Reiss, Peter P; van Sighem, Ard I AI; Rehm, Catherine A CA; Pozniak, Anton A; Montaner, Julio S G JSG; Lane, H Clifford HC; Larder, Brendan A BA; ,
HIV drug resistance patterns in pregnant women using next generation sequence in Mozambique.
Plos One
Rupérez, María M; Noguera-Julian, Marc M; González, Raquel R; Maculuve, Sonia S; Bellido, Rocío R; Vala, Anifa A; Rodríguez, Cristina C; Sevene, Esperança E; Paredes, Roger R; Menéndez, Clara C
Design of Highly Potent, Dual-Acting and Central-Nervous-System-Penetrating HIV-1 Protease Inhibitors with Excellent Potency against Multidrug-Resistant HIV-1 Variants.
Chemmedchem
Ghosh, Arun K AK; Rao, Kalapala Venkateswara KV; Nyalapatla, Prasanth R PR; Kovela, Satish S; Brindisi, Margherita M; Osswald, Heather L HL; Sekhara Reddy, Bhavanam B; Agniswamy, Johnson J; Wang, Yuan-Fang YF; Aoki, Manabu M; Hattori, Shin-Ichiro SI; Weber, Irene T IT; Mitsuya, Hiroaki H
Human Immunodeficiency Virus Antiretroviral Resistance and Transmission in Mother-Infant Pairs Enrolled in a Large Perinatal Study.
Clinical Infectious Diseases : An Official Publication Of The Infectious Diseases Society Of America
Yeganeh, Nava N; Kerin, Tara T; Ank, Bonnie B; Watts, D Heather DH; Camarca, Margaret M; Joao, Esau C EC; Pilotto, Jose Henrique JH; Veloso, Valdilea G VG; Bryson, Yvonne Y; Gray, Glenda G; Theron, Gerhard G; Dickover, Ruth R; Morgado, Mariza G MG; Santos, Breno B; Kreitchmann, Regis R; Mofenson, Lynne L; Nielsen-Saines, Karin K
Collaborative update of a rule-based expert system for HIV-1 genotypic resistance test interpretation.
Plos One
Paredes, Roger R; Tzou, Philip L PL; van Zyl, Gert G; Barrow, Geoff G; Camacho, Ricardo R; Carmona, Sergio S; Grant, Philip M PM; Gupta, Ravindra K RK; Hamers, Raph L RL; Harrigan, P Richard PR; Jordan, Michael R MR; Kantor, Rami R; Katzenstein, David A DA; Kuritzkes, Daniel R DR; Maldarelli, Frank F; Otelea, Dan D; Wallis, Carole L CL; Schapiro, Jonathan M JM; Shafer, Robert W RW
High levels of virological failure with major genotypic resistance mutations in HIV-1-infected children after 5 years of care according to WHO-recommended 1st-line and 2nd-line antiretroviral regimens in the Central African Republic: A cross-sectional study.
Medicine
Mossoro-Kpinde, Christian Diamant CD; Gody, Jean-Chrysostome JC; Mboumba Bouassa, Ralph-Sydney RS; Mbitikon, Olivia O; Jenabian, Mohammad-Ali MA; Robin, Leman L; Matta, Mathieu M; Zeitouni, Kamal K; Longo, Jean De Dieu JD; Costiniuk, Cecilia C; Grésenguet, Gérard G; Touré Kane, Ndèye Coumba NC; Bélec, Laurent L
From antiretroviral therapy access to provision of third line regimens: evidence of HIV Drug resistance mutations to first and second line regimens among Ugandan adults.
Bmc Research Notes
Namakoola, Ivan I; Kasamba, Ivan I; Mayanja, Billy N BN; Kazooba, Patrick P; Lutaakome, Joseph J; Lyagoba, Fred F; Kapaata, Anne A AA; Kaleebu, Pontiano P; Munderi, Paula P; ,
Antiviral Activity of Bictegravir (GS-9883), a Novel Potent HIV-1 Integrase Strand Transfer Inhibitor with an Improved Resistance Profile.
Antimicrobial Agents And Chemotherapy
Tsiang, Manuel M; Jones, Gregg S GS; Goldsmith, Joshua J; Mulato, Andrew A; Hansen, Derek D; Kan, Elaine E; Tsai, Luong L; Bam, Rujuta A RA; Stepan, George G; Stray, Kirsten M KM; Niedziela-Majka, Anita A; Yant, Stephen R SR; Yu, Helen H; Kukolj, George G; Cihlar, Tomas T; Lazerwith, Scott E SE; White, Kirsten L KL; Jin, Haolun H
An update to the HIV-TRePS system: the development and evaluation of new global and local computational models to predict HIV treatment outcomes, with or without a genotype.
The Journal Of Antimicrobial Chemotherapy
Revell, Andrew D AD; Wang, Dechao D; Wood, Robin R; Morrow, Carl C; Tempelman, Hugo H; Hamers, Raph L RL; Reiss, Peter P; van Sighem, Ard I AI; Nelson, Mark M; Montaner, Julio S G JS; Lane, H Clifford HC; Larder, Brendan A BA; ,
Epidemiological, Clinical and Antiretroviral Susceptibility Characterization of Human Immunodeficiency Virus Subtypes B and Non-B in Pernambuco, Northeast Brazil.
Plos One
Lima, Kledoaldo K; de Souza Leal, Élcio É; Cavalcanti, Ana Maria Salustiano AM; Salustiano, Daniela Medeiros DM; de Medeiros, Luzidalva Barbosa LB; da Silva, Sirleide Pereira SP; Lacerda, Heloísa Ramos HR
Improved darunavir genotypic mutation score predicting treatment response for patients infected with HIV-1 subtype B and non-subtype B receiving a salvage regimen.
The Journal Of Antimicrobial Chemotherapy
De Luca, Andrea A; Flandre, Philippe P; Dunn, David D; Zazzi, Maurizio M; Wensing, Annemarie A; Santoro, Maria Mercedes MM; Günthard, Huldrych F HF; Wittkop, Linda L; Kordossis, Theodoros T; Garcia, Federico F; Castagna, Antonella A; Cozzi-Lepri, Alessandro A; Churchill, Duncan D; De Wit, Stéphane S; Brockmeyer, Norbert H NH; Imaz, Arkaitz A; Mussini, Cristina C; Obel, Niels N; Perno, Carlo Federico CF; Roca, Bernardino B; Reiss, Peter P; Schülter, Eugen E; Torti, Carlo C; van Sighem, Ard A; Zangerle, Robert R; Descamps, Diane D; ,
High prevalence of PI resistance in patients failing second-line ART in Vietnam.
The Journal Of Antimicrobial Chemotherapy
Thao, Vu Phuong VP; Quang, Vo Minh VM; Day, Jeremy N JN; Chinh, Nguyen Tran NT; Shikuma, Cecilia M CM; Farrar, Jeremy J; Van Vinh Chau, Nguyen N; Thwaites, Guy E GE; Dunstan, Sarah J SJ; Le, Thuy T
Clinical, Virologic, Immunologic Outcomes and Emerging HIV Drug Resistance Patterns in Children and Adolescents in Public ART Care in Zimbabwe.
Plos One
Makadzange, A T AT; Higgins-Biddle, M M; Chimukangara, B B; Birri, R R; Gordon, M M; Mahlanza, T T; McHugh, G G; van Dijk, J H JH; Bwakura-Dangarembizi, M M; Ndung'u, T T; Masimirembwa, C C; Phelps, B B; Amzel, A A; Ojikutu, B O BO; Walker, B D BD; Ndhlovu, C E CE
C-5-Modified Tetrahydropyrano-Tetrahydofuran-Derived Protease Inhibitors (PIs) Exert Potent Inhibition of the Replication of HIV-1 Variants Highly Resistant to Various PIs, including Darunavir.
Journal Of Virology
Aoki, Manabu M; Hayashi, Hironori H; Yedidi, Ravikiran S RS; Martyr, Cuthbert D CD; Takamatsu, Yuki Y; Aoki-Ogata, Hiromi H; Nakamura, Teruya T; Nakata, Hirotomo H; Das, Debananda D; Yamagata, Yuriko Y; Ghosh, Arun K AK; Mitsuya, Hiroaki H
The ASSURE study: HIV-1 suppression is maintained with bone and renal biomarker improvement 48 weeks after ritonavir discontinuation and randomized switch to abacavir/lamivudine + atazanavir.
Hiv Medicine
Wohl, D A DA; Bhatti, L L; Small, C B CB; Edelstein, H H; Zhao, H H HH; Margolis, D A DA; DeJesus, E E; Weinberg, W G WG; Ross, L L LL; Shaefer, M S MS
Lopinavir/Ritonavir Monotherapy as Second-line Antiretroviral Treatment in Resource-Limited Settings: Week 104 Analysis of AIDS Clinical Trials Group (ACTG) A5230.
Clinical Infectious Diseases : An Official Publication Of The Infectious Diseases Society Of America
Kumarasamy, Nagalingeswaran N; Aga, Evgenia E; Ribaudo, Heather J HJ; Wallis, Carole L CL; Katzenstein, David A DA; Stevens, Wendy S WS; Norton, Michael R MR; Klingman, Karin L KL; Hosseinipour, Mina C MC; Crump, John A JA; Supparatpinyo, Khuanchai K; Badal-Faesen, Sharlaa S; Bartlett, John A JA
Pharmacokinetics of Etravirine Combined with Atazanavir/Ritonavir and a Nucleoside Reverse Transcriptase Inhibitor in Antiretroviral Treatment-Experienced, HIV-1-Infected Patients.
Aids Research And Treatment
Orrell, Catherine C; Felizarta, Franco F; Nell, André A; Kakuda, Thomas N TN; Lavreys, Ludo L; Nijs, Steven S; Tambuyzer, Lotke L; Van Solingen-Ristea, Rodica R; Tomaka, Frank L FL
Complexity and dynamics of HIV-1 chemokine receptor usage in a multidrug-resistant adolescent.
Aids Research And Human Retroviruses
Cavarelli, Mariangela M; Mainetti, Lara L; Pignataro, Angela Rosa AR; Bigoloni, Alba A; Tolazzi, Monica M; Galli, Andrea A; Nozza, Silvia S; Castagna, Antonella A; Sampaolo, Michela M; Boeri, Enzo E; Scarlatti, Gabriella G
Drug resistance among newly diagnosed HIV-infected children in the era of more efficacious antiretroviral prophylaxis.
Aids (London, England)
Kuhn, Louise L; Hunt, Gillian G; Technau, Karl-Günter KG; Coovadia, Ashraf A; Ledwaba, Johanna J; Pickerill, Sam S; Penazzato, Martina M; Bertagnolio, Silvia S; Mellins, Claude A CA; Black, Vivian V; Morris, Lynn L; Abrams, Elaine J EJ
GRL-04810 and GRL-05010, difluoride-containing nonpeptidic HIV-1 protease inhibitors (PIs) that inhibit the replication of multi-PI-resistant HIV-1 in vitro and possess favorable lipophilicity that may allow blood-brain barrier penetration.
Antimicrobial Agents And Chemotherapy
Salcedo Gómez, Pedro Miguel PM; Amano, Masayuki M; Yashchuk, Sofiya S; Mizuno, Akira A; Das, Debananda D; Ghosh, Arun K AK; Mitsuya, Hiroaki H
Trends in Genotypic HIV-1 Antiretroviral Resistance between 2006 and 2012 in South African Patients Receiving First- and Second-Line Antiretroviral Treatment Regimens.
Plos One
Van Zyl, Gert U GU; Liu, Tommy F TF; Claassen, Mathilda M; Engelbrecht, Susan S; de Oliveira, Tulio T; Preiser, Wolfgang W; Wood, Natasha T NT; Travers, Simon S; Shafer, Robert W RW
Attenuated and replication-competent vaccinia virus strains M65 and M101 with distinct biology and immunogenicity as potential vaccine candidates against pathogens.
Journal Of Virology
Sánchez-Sampedro, Lucas L; Gómez, Carmen Elena CE; Mejías-Pérez, Ernesto E; Pérez-Jiménez, Eva E; Oliveros, Juan Carlos JC; Esteban, Mariano M
HIV-1 amino acid changes among participants with virologic failure: associations with first-line efavirenz or atazanavir plus ritonavir and disease status.
The Journal Of Infectious Diseases
Mollan, Katie K; Daar, Eric S ES; Sax, Paul E PE; Balamane, Maya M; Collier, Ann C AC; Fischl, Margaret A MA; Lalama, Christina M CM; Bosch, Ronald J RJ; Tierney, Camlin C; Katzenstein, David D; ,
Darunavir is a good third-line antiretroviral agent for HIV type 1-infected patients failing second-line protease inhibitor-based regimens in South India.
Aids Research And Human Retroviruses
Saravanan, Shanmugam S; Madhavan, Vidya V; Balakrishnan, Pachamuthu P; Smith, Davey M DM; Solomon, Sunil Suhas SS; Sivamalar, Sathasivam S; Poongulali, Selvamuthu S; Kumarasamy, Nagalingeswaran N; Schooley, Robert T RT; Solomon, Suniti S; Kantor, Rami R
Minor protease inhibitor mutations at baseline do not increase the risk for a virological failure in HIV-1 subtype B infected patients.
Plos One
Scherrer, Alexandra U AU; Ledergerber, Bruno B; von Wyl, Viktor V; Böni, Jürg J; Yerly, Sabine S; Klimkait, Thomas T; Cellerai, Cristina C; Furrer, Hansjakob H; Calmy, Alexandra A; Cavassini, Matthias M; Elzi, Luigia L; Vernazza, Pietro L PL; Bernasconi, Enos E; Günthard, Huldrych F HF; ,