High Detection Rate of HIV Drug Resistance Mutations among Patients Who Fail Combined Antiretroviral Therapy in Manaus, Brazil.
Biomed Research International
Chaves, Yury Oliveira YO; Pereira, Flávio Ribeiro FR; de Souza Pinheiro, Rebeca R; Batista, Diego Rafael Lima DRL; da Silva Balieiro, Antônio Alcirley AA; de Lacerda, Marcus Vinicius Guimarães MVG; Nogueira, Paulo Afonso PA; Guimarães, Monick Lindenmeyer ML
Efficacy and safety of the long-acting fusion inhibitor albuvirtide in antiretroviral-experienced adults with human immunodeficiency virus-1: interim analysis of the randomized, controlled, phase 3, non-inferiority TALENT study.
HSV-2 Infection as a Potential Cofactor for HIV Disease Progression and Selection of Drug Resistance Mutations in Adults under WHO-Recommended First-Line Antiretroviral Therapy: A Multicentric, Cross-Sectional Study in Cameroon, Central African Republic, Chad, and Gabon.
HIV-1 acquired drug resistance to integrase inhibitors in a cohort of antiretroviral therapy multi-experienced Mexican patients failing to raltegravir: a cross-sectional study.
Aids Research And Therapy
Orta-Resendiz, Aurelio A; Rodriguez-Diaz, Roberto A RA; Angulo-Medina, Luis A LA; Hernandez-Flores, Mario M; Soto-Ramirez, Luis E LE
Increasing proportions of HIV-1 non-B subtypes and of NNRTI resistance between 2013 and 2016 in Germany: Results from the national molecular surveillance of new HIV-diagnoses.
Plos One
Hauser, Andrea A; Hofmann, Alexandra A; Meixenberger, Karolin K; Altmann, Britta B; Hanke, Kirsten K; Bremer, Viviane V; Bartmeyer, Barbara B; Bannert, Norbert N
Collaborative update of a rule-based expert system for HIV-1 genotypic resistance test interpretation.
Plos One
Paredes, Roger R; Tzou, Philip L PL; van Zyl, Gert G; Barrow, Geoff G; Camacho, Ricardo R; Carmona, Sergio S; Grant, Philip M PM; Gupta, Ravindra K RK; Hamers, Raph L RL; Harrigan, P Richard PR; Jordan, Michael R MR; Kantor, Rami R; Katzenstein, David A DA; Kuritzkes, Daniel R DR; Maldarelli, Frank F; Otelea, Dan D; Wallis, Carole L CL; Schapiro, Jonathan M JM; Shafer, Robert W RW
Antiviral Activity, Safety, and Exposure-Response Relationships of GSK3532795, a Second-Generation Human Immunodeficiency Virus Type 1 Maturation Inhibitor, Administered as Monotherapy or in Combination With Atazanavir With or Without Ritonavir in a Phase 2a Randomized, Dose-Ranging, Controlled Trial (AI468002).
Clinical Infectious Diseases : An Official Publication Of The Infectious Diseases Society Of America
Hwang, Carey C; Schürmann, Dirk D; Sobotha, Christian C; Boffito, Marta M; Sevinsky, Heather H; Ray, Neelanjana N; Ravindran, Palanikumar P; Xiao, Hong H; Keicher, Christian C; Hüser, Andreas A; Krystal, Mark M; Dicker, Ira B IB; Grasela, Dennis D; Lataillade, Max M
An update to the HIV-TRePS system: the development and evaluation of new global and local computational models to predict HIV treatment outcomes, with or without a genotype.
The Journal Of Antimicrobial Chemotherapy
Revell, Andrew D AD; Wang, Dechao D; Wood, Robin R; Morrow, Carl C; Tempelman, Hugo H; Hamers, Raph L RL; Reiss, Peter P; van Sighem, Ard I AI; Nelson, Mark M; Montaner, Julio S G JS; Lane, H Clifford HC; Larder, Brendan A BA; ,
Tenofovir alafenamide as part of a salvage regimen in a patient with multi-drug resistant HIV and tenofovir-DF-associated renal tubulopathy.
Antiviral Therapy
Mikula, James M JM; Manion, Maura M MM; Maldarelli, Frank F; Suarez, Lucila M LM; Norman-Wheeler, Jaha F JF; Ober, Alex G AG; Dewar, Robin L RL; Kopp, Jeffrey B JB; Lane, H Clifford HC; Pau, Alice K AK
Potent in vitro antiviral activity of Cistus incanus extract against HIV and Filoviruses targets viral envelope proteins.
Scientific Reports
Rebensburg, Stephanie S; Helfer, Markus M; Schneider, Martha M; Koppensteiner, Herwig H; Eberle, Josef J; Schindler, Michael M; Gürtler, Lutz L; Brack-Werner, Ruth R
High prevalence of PI resistance in patients failing second-line ART in Vietnam.
The Journal Of Antimicrobial Chemotherapy
Thao, Vu Phuong VP; Quang, Vo Minh VM; Day, Jeremy N JN; Chinh, Nguyen Tran NT; Shikuma, Cecilia M CM; Farrar, Jeremy J; Van Vinh Chau, Nguyen N; Thwaites, Guy E GE; Dunstan, Sarah J SJ; Le, Thuy T
C-5-Modified Tetrahydropyrano-Tetrahydofuran-Derived Protease Inhibitors (PIs) Exert Potent Inhibition of the Replication of HIV-1 Variants Highly Resistant to Various PIs, including Darunavir.
Journal Of Virology
Aoki, Manabu M; Hayashi, Hironori H; Yedidi, Ravikiran S RS; Martyr, Cuthbert D CD; Takamatsu, Yuki Y; Aoki-Ogata, Hiromi H; Nakamura, Teruya T; Nakata, Hirotomo H; Das, Debananda D; Yamagata, Yuriko Y; Ghosh, Arun K AK; Mitsuya, Hiroaki H
Cobicistat-boosted darunavir in HIV-1-infected adults: week 48 results of a Phase IIIb, open-label single-arm trial.
Aids Research And Therapy
Tashima, Karen K; Crofoot, Gordon G; Tomaka, Frank L FL; Kakuda, Thomas N TN; Brochot, Anne A; Van de Casteele, Tom T; Opsomer, Magda M; Garner, William W; Margot, Nicolas N; Custodio, Joseph M JM; Fordyce, Marshall W MW; Szwarcberg, Javier J
HIV Drug Resistance Profiles and Clinical Outcomes in Patients with Viremia Maintained at Very Low Levels.
World Journal Of Aids
Jordan, Michael R MR; Winsett, Julie J; Tiro, Aileen A; Bau, Vuth V; Berbara, Rony S RS; Rowley, Christopher C; Bellosillo, Nobel N; Wanke, Christine C; Coakley, Eoin P EP
Persistence of frequently transmitted drug-resistant HIV-1 variants can be explained by high viral replication capacity.
Retrovirology
Pingen, Marieke M; Wensing, Annemarie M J AM; Fransen, Katrien K; De Bel, Annelies A; de Jong, Dorien D; Hoepelman, Andy I M AI; Magiorkinis, Emmanouil E; Paraskevis, Dimitrios D; Lunar, Maja M MM; Poljak, Mario M; Nijhuis, Monique M; Boucher, Charles A B CA; ,
Trends and correlates of HIV-1 resistance among subjects failing an antiretroviral treatment over the 2003-2012 decade in Italy.
Bmc Infectious Diseases
Franzetti, Marco M; Violin, Michela M; Antinori, Andrea A; De Luca, Andrea A; Ceccherini-Silberstein, Francesca F; Gianotti, Nicola N; Torti, Carlo C; Bonora, Stefano S; Zazzi, Maurizio M; Balotta, Claudia C
Natural polymorphisms and unusual mutations in HIV-1 protease with potential antiretroviral resistance: a bioinformatic analysis.
Bmc Bioinformatics
Mata-Munguía, Carlos C; Escoto-Delgadillo, Martha M; Torres-Mendoza, Blanca B; Flores-Soto, Mario M; Vázquez-Torres, Mildred M; Gálvez-Gastelum, Francisco F; Viniegra-Osorio, Arturo A; Castillero-Manzano, Marcelo M; Vázquez-Valls, Eduardo E
The evolution of HIV-1 group M genetic variability in Southern Cameroon is characterized by several emerging recombinant forms of CRF02_AG and viruses with drug resistance mutations.
Journal Of Medical Virology
Agyingi, Lucy L; Mayr, Luzia M LM; Kinge, Thompson T; Orock, George Enow GE; Ngai, Johnson J; Asaah, Bladine B; Mpoame, Mbida M; Hewlett, Indira I; Nyambi, Phillipe P
Added value of deep sequencing relative to population sequencing in heavily pre-treated HIV-1-infected subjects.
Plos One
Codoñer, Francisco M FM; Pou, Christian C; Thielen, Alexander A; García, Federico F; Delgado, Rafael R; Dalmau, David D; Álvarez-Tejado, Miguel M; Ruiz, Lidia L; Clotet, Bonaventura B; Paredes, Roger R
Rapid development of antiretroviral drug resistance mutations in HIV-infected children less than two years of age initiating protease inhibitor-based therapy in South Africa.
Aids Research And Human Retroviruses
Taylor, Barbara S BS; Hunt, Gillian G; Abrams, Elaine J EJ; Coovadia, Ashraf A; Meyers, Tammy T; Sherman, Gayle G; Strehlau, Renate R; Morris, Lynn L; Kuhn, Louise L
Prevalence and clinical significance of HIV drug resistance mutations by ultra-deep sequencing in antiretroviral-naïve subjects in the CASTLE study.
Plos One
Lataillade, Max M; Chiarella, Jennifer J; Yang, Rong R; Schnittman, Steven S; Wirtz, Victoria V; Uy, Jonathan J; Seekins, Daniel D; Krystal, Mark M; Mancini, Marco M; McGrath, Donnie D; Simen, Birgitte B; Egholm, Michael M; Kozal, Michael M
Drug resistance mutations in HIV-infected patients in the Spanish drug resistance database failing tipranavir and darunavir therapy.
Antimicrobial Agents And Chemotherapy
Poveda, Eva E; Anta, Lourdes L; Blanco, José Luis JL; Casado, José Luis JL; Gutiérrez, Félix F; García, Federico F; Gómez-Sirvent, Juan Luis JL; Iribarren, José Antonio JA; Soriano, Vincent V; de Mendoza, Carmen C; ,
Use of different inhibitory quotients to predict early virological response to tipranavir in antiretroviral-experienced human immunodeficiency virus-infected patients.
Antimicrobial Agents And Chemotherapy
Morello, Judit J; De Mendoza, Carmen C; Soriano, Vincent V; Anta, Lourdes L; González-Pardo, Gema G; Corral, Angélica A; Blanco, Francisco F; Jiménez-Nácher, Inmaculada I; González-Lahoz, Juan J; Rodríguez-Novoa, Sonia S
Emergence of multiclass drug-resistance in HIV-2 in antiretroviral-treated individuals in Senegal: implications for HIV-2 treatment in resouce-limited West Africa.
Clinical Infectious Diseases : An Official Publication Of The Infectious Diseases Society Of America
Gottlieb, Geoffrey S GS; Badiane, Ndeye Mery Dia NM; Hawes, Stephen E SE; Fortes, Louise L; Toure, Macoumba M; Ndour, Cheikh T CT; Starling, Alison K AK; Traore, Fatou F; Sall, Fatima F; Wong, Kim G KG; Cherne, Stephen L SL; Anderson, Donovan J DJ; Dye, Stefanie A SA; Smith, Robert A RA; Mullins, James I JI; Kiviat, Nancy B NB; Sow, Papa Salif PS; ,
GRL-02031, a novel nonpeptidic protease inhibitor (PI) containing a stereochemically defined fused cyclopentanyltetrahydrofuran potent against multi-PI-resistant human immunodeficiency virus type 1 in vitro.
Antimicrobial Agents And Chemotherapy
Koh, Yasuhiro Y; Das, Debananda D; Leschenko, Sofiya S; Nakata, Hirotomo H; Ogata-Aoki, Hiromi H; Amano, Masayuki M; Nakayama, Maki M; Ghosh, Arun K AK; Mitsuya, Hiroaki H
Two cases of multidrug-resistant human immunodeficiency virus infection treated with atazanavir and lopinavir/ritonavir combination therapy.
Journal Of Korean Medical Science
Choi, Heekyoung H; Jeong, Su Jin SJ; Lee, Han Sung HS; Chin, Bum Sik BS; Choi, Suk Hoon SH; Han, Sang Hoon SH; Kim, Myung Soo MS; Kim, Chang Oh CO; Choi, Jun Yong JY; Song, Young Goo YG; Kim, June Myung JM
Tipranavir-ritonavir genotypic resistance score in protease inhibitor-experienced patients.
Antimicrobial Agents And Chemotherapy
Marcelin, Anne-Genevieve AG; Masquelier, Bernard B; Descamps, Diane D; Izopet, Jacques J; Charpentier, Charlotte C; Alloui, Chakib C; Bouvier-Alias, Magali M; Signori-Schmuck, Anne A; Montes, Brigitte B; Chaix, Marie-Laure ML; Amiel, Corinne C; Santos, Georges Dos GD; Ruffault, Annick A; Barin, Francis F; Peytavin, Gilles G; Lavignon, Marc M; Flandre, Philippe P; Calvez, Vincent V
Selecting anti-HIV therapies based on a variety of genomic and clinical factors.
Bioinformatics (Oxford, England)
Rosen-Zvi, Michal M; Altmann, Andre A; Prosperi, Mattia M; Aharoni, Ehud E; Neuvirth, Hani H; Sönnerborg, Anders A; Schülter, Eugen E; Struck, Daniel D; Peres, Yardena Y; Incardona, Francesca F; Kaiser, Rolf R; Zazzi, Maurizio M; Lengauer, Thomas T
HIV type 2 protease, reverse transcriptase, and envelope viral variation in the PBMC and genital tract of ARV-naive women in Senegal.
Aids Research And Human Retroviruses
Gottlieb, Geoffrey S GS; Hawes, Stephen E SE; Wong, Kim G KG; Raugi, Dana N DN; Agne, Habibatou D HD; Critchlow, Cathy W CW; Kiviat, Nancy B NB; Sow, Papa Salif PS
Tipranavir (TPV) genotypic inhibitory quotient predicts virological response at 48 weeks to TPV-based salvage regimens.
Antimicrobial Agents And Chemotherapy
de Requena, Daniel Gonzalez DG; Bonora, Stefano S; Calcagno, Andrea A; D'Avolio, Antonio A; Siccardi, Marco M; Fontana, Silvia S; Milia, Maria Grazia MG; Sciandra, Mauro M; Garazzino, Silvia S; Di Garbo, Antonio A; Baietto, Lorena L; Trentini, Laura L; Di Perri, Giovanni G
Evolution of human immunodeficiency virus type 1 protease genotypes and phenotypes in vivo under selective pressure of the protease inhibitor ritonavir.
Journal Of Virology
Resch, Wolfgang W; Parkin, Neil N; Watkins, Terri T; Harris, Janera J; Swanstrom, Ronald R