Nasal vaccination with the 40-kilodalton outer membrane protein of Porphyromonas gingivalis and a nontoxic chimeric enterotoxin adjuvant induces long-term protective immunity with reduced levels of immunoglobulin E antibodies.
Enterotoxin-based mucosal adjuvants alter antigen trafficking and induce inflammatory responses in the nasal tract.
Infection And Immunity
van Ginkel, Frederik W FW; Jackson, Raymond J RJ; Yoshino, Naoto N; Hagiwara, Yukari Y; Metzger, Daniel J DJ; Connell, Terry D TD; Vu, Hong L HL; Martin, Michael M; Fujihashi, Kohtaro K; McGhee, Jerry R JR