CD4 c.375G>T ;(p.L125F)

Variant ID: 12-6923926-G-T

NM_000616.4(CD4):c.375G>T;(p.L125F)

This variant was identified in 5 publications

View GRCh38 version.




Publications:


HIV-1 gp41 Residues Modulate CD4-Induced Conformational Changes in the Envelope Glycoprotein and Evolution of a Relaxed Conformation of gp120.

Journal Of Virology
Keller, Paul W PW; Morrison, Orrianne O; Vassell, Russell R; Weiss, Carol D CD
Publication Date: 2018-08-15

Variant appearance in text: CD4: L125F
PubMed Link: 29875245
Variant Present in the following documents:
  • Main text
View BVdb publication page



Stabilization of the gp120 V3 loop through hydrophobic interactions reduces the immunodominant V3-directed non-neutralizing response to HIV-1 envelope trimers.

The Journal Of Biological Chemistry
de Taeye, Steven W SW; de la Peña, Alba Torrents AT; Vecchione, Andrea A; Scutigliani, Enzo E; Sliepen, Kwinten K; Burger, Judith A JA; van der Woude, Patricia P; Schorcht, Anna A; Schermer, Edith E EE; van Gils, Marit J MJ; LaBranche, Celia C CC; Montefiori, David C DC; Wilson, Ian A IA; Moore, John P JP; Ward, Andrew B AB; Sanders, Rogier W RW
Publication Date: 2018-02-02

Variant appearance in text: CD4: L125F
PubMed Link: 29222332
Variant Present in the following documents:
  • Main text
  • zbc1688.pdf
View BVdb publication page



Structure/Function Studies Involving the V3 Region of the HIV-1 Envelope Delineate Multiple Factors That Affect Neutralization Sensitivity.

Journal Of Virology
Zolla-Pazner, Susan S; Cohen, Sandra Sharpe SS; Boyd, David D; Kong, Xiang-Peng XP; Seaman, Michael M; Nussenzweig, Michel M; Klein, Florian F; Overbaugh, Julie J; Totrov, Max M
Publication Date: 2016-01-15

Variant appearance in text: CD4: L125F
PubMed Link: 26491157
Variant Present in the following documents:
  • Main text
  • zjv636.pdf
View BVdb publication page



Resistance to N-peptide fusion inhibitors correlates with thermodynamic stability of the gp41 six-helix bundle but not HIV entry kinetics.

Retrovirology
De Feo, Christopher J CJ; Wang, Wei W; Hsieh, Meng-Lun ML; Zhuang, Min M; Vassell, Russell R; Weiss, Carol D CD
Publication Date: 2014-10-02

Variant appearance in text: CD4: L125F
PubMed Link: 25274545
Variant Present in the following documents:
  • Main text
  • 12977_2014_Article_86.pdf
View BVdb publication page



Trimeric, coiled-coil extension on peptide fusion inhibitor of HIV-1 influences selection of resistance pathways.

The Journal Of Biological Chemistry
Zhuang, Min M; Wang, Wei W; De Feo, Christopher J CJ; Vassell, Russell R; Weiss, Carol D CD
Publication Date: 2012-03-09

Variant appearance in text: CD4: L125F
PubMed Link: 22235115
Variant Present in the following documents:
  • Main text
View BVdb publication page