Publications:

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Evaluation of Circulating and Archived HIV-1 Integrase Drug-Resistance Variants among Patients on Third-Line ART in Cameroon: Implications for Dolutegravir-Containing Regimens in Resource-Limited Settings.

Microbiology Spectrum

Fokam, Joseph J; Ngoufack Jagni Semengue, Ezechiel E; Molimbou, Evariste E; Etame, Naomi-Karell NK; Santoro, Maria Mercedes MM; Takou, Désiré D; Mossiang, Leonella L; Meledie, Alain Patrice AP; Chenwi, Collins Ambe CA; Yagai, Bouba B; Nka, Alex Durand AD; Dambaya, Beatrice B; Teto, Georges G; Ka'e, Aude Christelle AC; Beloumou, Grâce Angong GA; Ndjeyep, Sandrine Claire Djupsa SCD; Fainguem, Nadine N; Abba, Aissatou A; Kengni, Aurelie Minelle Ngueko AMN; Tchouaket, Michel Carlos Tommo MCT; Bouba, Nounouce Pamen NP; Billong, Serge-Clotaire SC; Djubgang, Rina R; Saounde, Edith Temgoua ET; Sosso, Samuel Martin SM; Kouanfack, Charles C; Bissek, Anne-Cecile Zoung-Kanyi AZ; Eben-Moussi, Emmanuel E; Colizzi, Vittorio V; Perno, Carlo-Federico CF; Ceccherini-Silberstein, Francesca F; Ndjolo, Alexis A

Publication Date: 2022-10-19

Variant appearance in text: CD4: V201I

PubMed Link: 36259973

Variant Present in the following documents:

• Main text
• spectrum.03420-22.pdf

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Prevalence of resistance mutations associated with integrase inhibitors in therapy-naive HIV-positive patients in Baoding, Hebei province, China.

Frontiers In Genetics

Fan, Weiguang W; Wang, Xiaodong X; Zhang, Yuchen Y; Meng, Juan J; Su, Miaomiao M; Yang, Xuegang X; Shi, Haoxi H; Shi, Penghui P; Lu, Xinli X

Publication Date: 2022

Variant appearance in text: CD4: V201I

PubMed Link: 36186451

Variant Present in the following documents:

• fgene-13-975397.pdf

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Emergence of Resistance in HIV-1 Integrase With Dolutegravir Treatment in a Pediatric Population From the IMPAACT P1093 Study.

Antimicrobial Agents And Chemotherapy

Vavro, Cindy C; Ruel, Theodore T; Wiznia, Andrew A; Montañez, Nicole N; Nangle, Keith K; Horton, Joseph J; Buchanan, Ann M AM; Stewart, Eugene L EL; Palumbo, Paul P

Publication Date: 2021-10-25

Variant appearance in text: CD4: V201I

PubMed Link: 34694878

Variant Present in the following documents:

• Main text

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Emergence of Resistance in HIV-1 Integrase with Dolutegravir Treatment in a Pediatric Population from the IMPAACT P1093 Study.

Antimicrobial Agents And Chemotherapy

Vavro, Cindy C; Ruel, Theodore T; Wiznia, Andrew A; Montañez, Nicole N; Nangle, Keith K; Horton, Joseph J; Buchanan, Ann M AM; Stewart, Eugene L EL; Palumbo, Paul P

Publication Date: 2022-01-18

Variant appearance in text: CD4: V201I

PubMed Link: 34694878

Variant Present in the following documents:

• Main text

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Variability in HIV-1 Integrase Gene and 3'-Polypurine Tract Sequences in Cameroon Clinical Isolates, and Implications for Integrase Inhibitors Efficacy.

International Journal Of Molecular Sciences

Acharya, Arpan A; Tagny, Claude T CT; Mbanya, Dora D; Fonsah, Julius Y JY; Nchindap, Emilienne E; Kenmogne, Léopoldine L; Jihyun, Ma M; Njamnshi, Alfred K AK; Kanmogne, Georgette D GD

Publication Date: 2020-02-25

Variant appearance in text: CD4: V201I

PubMed Link: 32106437

Variant Present in the following documents:

• Main text

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HIV-1 acquired drug resistance to integrase inhibitors in a cohort of antiretroviral therapy multi-experienced Mexican patients failing to raltegravir: a cross-sectional study.

Aids Research And Therapy

Orta-Resendiz, Aurelio A; Rodriguez-Diaz, Roberto A RA; Angulo-Medina, Luis A LA; Hernandez-Flores, Mario M; Soto-Ramirez, Luis E LE

Publication Date: 2020-02-10

Variant appearance in text: CD4: V201I

PubMed Link: 32041622

Variant Present in the following documents:

• Main text
• 12981_2020_Article_262.pdf

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Rapid Identification and Investigation of an HIV Risk Network Among People Who Inject Drugs -Miami, FL, 2018.

Aids And Behavior

Tookes, Hansel H; Bartholomew, Tyler S TS; Geary, Shana S; Matthias, James J; Poschman, Karalee K; Blackmore, Carina C; Philip, Celeste C; Suarez, Edward E; Forrest, David W DW; Rodriguez, Allan E AE; Kolber, Michael A MA; Knaul, Felicia F; Colucci, Leah L; Spencer, Emma E

Publication Date: 2020-01

Variant appearance in text: CD4: V201I

PubMed Link: 31555932

Variant Present in the following documents:

• Main text

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Noncovalent SUMO-interaction motifs in HIV integrase play important roles in SUMOylation, cofactor binding, and virus replication.

Virology Journal

Zheng, Yingfeng Y; Jayappa, Kallesh Danappa KD; Ao, Zhujun Z; Qiu, Xiangguo X; Su, Ruey-Chyi RC; Yao, Xiaojian X

Publication Date: 2019-04-02

Variant appearance in text: CD4: V201I

PubMed Link: 30940169

Variant Present in the following documents:

• Main text

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Prevalence of resistance to integrase strand-transfer inhibitors (INSTIs) among untreated HIV-1 infected patients in Morocco.

Bmc Research Notes

Alaoui, Najwa N; El Alaoui, Moulay Abdelaziz MA; Touil, Nadia N; El Annaz, Hicham H; Melloul, Marouane M; Tagajdid, Reda R; Hjira, Naoufal N; Boui, Mohamed M; El Fahime, El Mostapha EM; Mrani, Saad S

Publication Date: 2018-06-08

Variant appearance in text: CD4: V201I

PubMed Link: 29884219

Variant Present in the following documents:

• Main text
• 13104_2018_Article_3492.pdf

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Coordinated responses to individual tumor antigens by IgG antibody and CD8+ T cells following cancer vaccination.

Journal For Immunotherapy Of Cancer

Hulett, Tyler W TW; Jensen, Shawn M SM; Wilmarth, Phillip A PA; Reddy, Ashok P AP; Ballesteros-Merino, Carmen C; Afentoulis, Michael E ME; Dubay, Christopher C; David, Larry L LL; Fox, Bernard A BA

Publication Date: 2018-04-05

Variant appearance in text: CD4: V201I

PubMed Link: 29618380

Variant Present in the following documents:

• 40425_2018_331_MOESM1_ESM.xlsx, sheet 4

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Analyses of HIV-1 integrase sequences prior to South African national HIV-treatment program and available of integrase inhibitors in Cape Town, South Africa.

Scientific Reports

Brado, Dominik D; Obasa, Adetayo Emmanuel AE; Ikomey, George Mondinde GM; Cloete, Ruben R; Singh, Kamalendra K; Engelbrecht, Susan S; Neogi, Ujjwal U; Jacobs, Graeme Brendon GB

Publication Date: 2018-03-16

Variant appearance in text: CD4: V201I

PubMed Link: 29549274

Variant Present in the following documents:

• Main text

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HIV-1 strains belonging to large phylogenetic clusters show accelerated escape from integrase inhibitors in cell culture compared with viral isolates from singleton/small clusters.

The Journal Of Antimicrobial Chemotherapy

Brenner, Bluma G BG; Ibanescu, Ruxandra-Ilinca RI; Oliveira, Maureen M; Roger, Michel M; Hardy, Isabelle I; Routy, Jean-Pierre JP; Kyeyune, Fred F; Quiñones-Mateu, Miguel E ME; Wainberg, Mark A MA; ,

Publication Date: 2017-08-01

Variant appearance in text: CD4: V201I

PubMed Link: 28472323

Variant Present in the following documents:

• Main text
• dkx118.pdf

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Effect of HIV-1 Subtype C integrase mutations implied using molecular modeling and docking data.

Bioinformation

Sachithanandham, Jaiprasath J; Konda Reddy, Karnati K; Solomon, King K; David, Shoba S; Kumar Singh, Sanjeev S; Vadhini Ramalingam, Veena V; Alexander Pulimood, Susanne S; Cherian Abraham, Ooriyapadickal O; Rupali, Pricilla P; Sridharan, Gopalan G; Kannangai, Rajesh R

Publication Date: 2016

Variant appearance in text: CD4: V201I

PubMed Link: 28149058

Variant Present in the following documents:

• Main text
• 97320630012221.pdf

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Development of a G118R mutation in HIV-1 integrase following a switch to dolutegravir monotherapy leading to cross-resistance to integrase inhibitors.

The Journal Of Antimicrobial Chemotherapy

Brenner, Bluma G BG; Thomas, Réjean R; Blanco, José Luis JL; Ibanescu, Ruxandra-Ilinca RI; Oliveira, Maureen M; Mesplède, Thibault T; Golubkov, Olga O; Roger, Michel M; Garcia, Federico F; Martinez, Esteban E; Wainberg, Mark A MA

Publication Date: 2016-07

Variant appearance in text: CD4: V201I

PubMed Link: 27029845

Variant Present in the following documents:

• Main text

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Lack of integrase inhibitors associated resistance mutations among HIV-1C isolates.

Journal Of Translational Medicine

Mulu, Andargachew A; Maier, Melanie M; Liebert, Uwe Gerd UG

Publication Date: 2015-12-01

Variant appearance in text: CD4: V201I

PubMed Link: 26626277

Variant Present in the following documents:

• Main text
• 12967_2015_Article_734.pdf

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Mutant MHC class II epitopes drive therapeutic immune responses to cancer.

Nature

Kreiter, Sebastian S; Vormehr, Mathias M; van de Roemer, Niels N; Diken, Mustafa M; Löwer, Martin M; Diekmann, Jan J; Boegel, Sebastian S; Schrörs, Barbara B; Vascotto, Fulvia F; Castle, John C JC; Tadmor, Arbel D AD; Schoenberger, Stephen P SP; Huber, Christoph C; Türeci, Özlem Ö; Sahin, Ugur U

Publication Date: 2015-04-30

Variant appearance in text: CD4: V201I

PubMed Link: 25901682

Variant Present in the following documents:

• Main text

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Effects of raltegravir or elvitegravir resistance signature mutations on the barrier to dolutegravir resistance in vitro.

Antimicrobial Agents And Chemotherapy

Seki, Takahiro T; Suyama-Kagitani, Akemi A; Kawauchi-Miki, Shinobu S; Miki, Shigeru S; Wakasa-Morimoto, Chiaki C; Akihisa, Erika E; Nakahara, Koichiro K; Kobayashi, Masanori M; Underwood, Mark R MR; Sato, Akihiko A; Fujiwara, Tamio T; Yoshinaga, Tomokazu T

Publication Date: 2015-05

Variant appearance in text: CD4: V201I

PubMed Link: 25691633

Variant Present in the following documents:

• Main text

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HIV-1 Genetic Variability and Clinical Implications.

Isrn Microbiology

Santoro, Maria Mercedes MM; Perno, Carlo Federico CF

Publication Date: 2013

Variant appearance in text: CD4: V201I

PubMed Link: 23844315

Variant Present in the following documents:

• Main text

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Broad phenotypic cross-resistance to elvitegravir in HIV-infected patients failing on raltegravir-containing regimens.

Antimicrobial Agents And Chemotherapy

Garrido, Carolina C; Villacian, Jorge J; Zahonero, Natalia N; Pattery, Theresa T; Garcia, Federico F; Gutierrez, Felix F; Caballero, Estrella E; Van Houtte, Margriet M; Soriano, Vincent V; de Mendoza, Carmen C; ,

Publication Date: 2012-06

Variant appearance in text: CD4: V201I

PubMed Link: 22450969

Variant Present in the following documents:

• Main text

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Analysis of transmitted resistance to raltegravir and selective pressure among HIV-1-infected patients on a failing HAART in Sao Paulo, Brazil.

Journal Of Clinical Microbiology

Mantovani, N P NP; Azevedo, R G RG; Rabelato, J T JT; Sanabani, S S; Diaz, R S RS; Komninakis, S V SV

Publication Date: 2012-06

Variant appearance in text: CD4: V201I

PubMed Link: 22403424

Variant Present in the following documents:

• Main text

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Patterns of resistance development with integrase inhibitors in HIV.

Infection And Drug Resistance

Mbisa, Jean L JL; Martin, Supang A SA; Cane, Patricia A PA

Publication Date: 2011

Variant appearance in text: CD4: V201I

PubMed Link: 21694910

Variant Present in the following documents:

• Main text

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Hot spots of integrase genotypic changes leading to HIV-2 resistance to raltegravir.

Antimicrobial Agents And Chemotherapy

Charpentier, Charlotte C; Roquebert, Bénédicte B; Delelis, Olivier O; Larrouy, Lucile L; Matheron, Sophie S; Tubiana, Roland R; Karmochkine, Marina M; Duval, Xavier X; Chêne, Geneviève G; Storto, Alexandre A; Collin, Gilles G; Bénard, Antoine A; Damond, Florence F; Mouscadet, Jean-François JF; Brun-Vézinet, Françoise F; Descamps, Diane D; ,

Publication Date: 2011-03

Variant appearance in text: CD4: V201I

PubMed Link: 21189351

Variant Present in the following documents:

• Main text

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Estonia at the threshold of the fourth decade of the AIDS era in Europe.

Aids Research And Human Retroviruses

Laisaar, Kaja-Triin KT; Avi, Radko R; DeHovitz, Jack J; Uusküla, Anneli A

Publication Date: 2011-08

Variant appearance in text: CD4: V201I

PubMed Link: 21142588

Variant Present in the following documents:

• Main text

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Polymorphisms of HIV-2 integrase and selection of resistance to raltegravir.

Retrovirology

Bercoff, Danielle Perez DP; Triqueneaux, Perrine P; Lambert, Christine C; Oumar, Aboubacar Alassane AA; Ternes, Anne-Marie AM; Dao, Sounkalo S; Goubau, Patrick P; Schmit, Jean-Claude JC; Ruelle, Jean J

Publication Date: 2010-11-29

Variant appearance in text: CD4: V201I

PubMed Link: 21114823

Variant Present in the following documents:

• Main text
• 1742-4690-7-98.pdf

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The HIV-1 integrase mutations Y143C/R are an alternative pathway for resistance to Raltegravir and impact the enzyme functions.

Plos One

Reigadas, Sandrine S; Anies, Guerric G; Masquelier, Bernard B; Calmels, Christina C; Stuyver, Lieven J LJ; Parissi, Vincent V; Fleury, Herve H; Andreola, Marie-Line ML

Publication Date: 2010-04-26

Variant appearance in text: CD4: V201I

PubMed Link: 20436677

Variant Present in the following documents:

• Main text

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Natural polymorphisms of human immunodeficiency virus type 1 integrase and inherent susceptibilities to a panel of integrase inhibitors.

Antimicrobial Agents And Chemotherapy

Low, Andrea A; Prada, Nicole N; Topper, Michael M; Vaida, Florin F; Castor, Delivette D; Mohri, Hiroshi H; Hazuda, Daria D; Muesing, Mark M; Markowitz, Martin M

Publication Date: 2009-10

Variant appearance in text: CD4: V201I

PubMed Link: 19651917

Variant Present in the following documents:

• Main text

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Virological and immunological response in HIV-1-infected patients with multiple treatment failures receiving raltegravir and optimized background therapy, ANRS CO3 Aquitaine Cohort.

The Journal Of Antimicrobial Chemotherapy

Wittkop, Linda L; Breilh, Dominique D; Da Silva, Daniel D; Duffau, Pierre P; Mercié, Patrick P; Raymond, Isabelle I; Anies, Guerric G; Fleury, Hervé H; Saux, Marie-Claude MC; Dabis, Francois F; Fagard, Catherine C; Thiébaut, Rodolphe R; Masquelier, Bernard B; Pellegrin, Isabelle I; ,

Publication Date: 2009-06

Variant appearance in text: CD4: V201I

PubMed Link: 19336453

Variant Present in the following documents:

• Main text

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The G140S mutation in HIV integrases from raltegravir-resistant patients rescues catalytic defect due to the resistance Q148H mutation.

Nucleic Acids Research

Delelis, Olivier O; Malet, Isabelle I; Na, Li L; Tchertanov, Luba L; Calvez, Vincent V; Marcelin, Anne-Genevieve AG; Subra, Frederic F; Deprez, Eric E; Mouscadet, Jean-François JF

Publication Date: 2009-03

Variant appearance in text: CD4: V201I

PubMed Link: 19129221

Variant Present in the following documents:

• Main text

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HIV-1 drug resistance mutations: an updated framework for the second decade of HAART.

Aids Reviews

Shafer, Robert W RW; Schapiro, Jonathan M JM

Publication Date: 2008

Variant appearance in text: CD4: V201I

PubMed Link: 18615118

Variant Present in the following documents:

• Main text

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Abstracts of the 18th European Congress of Clinical Microbiology and Infectious Diseases. Barcelona, Spain. April 19-22, 2008.

Clinical Microbiology And Infection : The Official Publication Of The European Society Of Clinical Microbiology And Infectious Diseases

Publication Date: 2008-05

Variant appearance in text: CD4: V201I

PubMed Link: 18399911

Variant Present in the following documents:

• CLM-14-S1.pdf

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Mutations associated with failure of raltegravir treatment affect integrase sensitivity to the inhibitor in vitro.

Antimicrobial Agents And Chemotherapy

Malet, Isabelle I; Delelis, Olivier O; Valantin, Marc-Antoine MA; Montes, Brigitte B; Soulie, Cathia C; Wirden, Marc M; Tchertanov, Luba L; Peytavin, Gilles G; Reynes, Jacques J; Mouscadet, Jean-François JF; Katlama, Christine C; Calvez, Vincent V; Marcelin, Anne-Geneviève AG

Publication Date: 2008-04

Variant appearance in text: CD4: V201I

PubMed Link: 18227187

Variant Present in the following documents:

• Main text

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