CD4 c.680T>G ;(p.F227C)

Variant ID: 12-6925294-T-G

NM_000616.4(CD4):c.680T>G;(p.F227C)

This variant was identified in 37 publications

View GRCh38 version.




Publications:


Circulating messenger RNA variants as a potential biomarker for surveillance of hepatocellular carcinoma.

Frontiers In Oncology
Block, Timothy T; Zezulinski, Daniel D; Kaplan, David E DE; Lu, Jingqiao J; Zanine, Samantha S; Zhan, Tingting T; Doria, Cataldo C; Sayeed, Aejaz A
Publication Date: 2022

Variant appearance in text: rs11064419
PubMed Link: 36582804
Variant Present in the following documents:
  • Table_6.xlsx, sheet 1
View BVdb publication page



Differences in Antiretroviral Adherence Behaviors, Treatment Success, and Eligibility for Long-Acting Injectable Treatment between Patients Who Acquired HIV in Childhood vs. Those Who Acquired It in Adolescence/Early Adulthood.

Journal Of Personalized Medicine
Marcellin, Anthony A; Martel-Laferrière, Valérie V; Genest, Anne-Geneviève AG; Lebouché, Bertrand B; Marcotte, Suzanne S
Publication Date: 2022-08-27

Variant appearance in text: CD4: F227C
PubMed Link: 36143175
Variant Present in the following documents:
  • Main text
  • jpm-12-01390.pdf
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High Prevalence of Doravirine Resistance in HIV-1-Infected Patients with Virological Failure to an NNRTI-Based Single-Tablet Regimen.

Infection And Drug Resistance
Tsai, Hung-Chin HC; Chen, I-Tzu IT; Chang, Hui-Min HM; Lee, Susan Shin-Jung SS; Chen, Yao-Shen YS
Publication Date: 2022

Variant appearance in text: CD4: F227C
PubMed Link: 35899084
Variant Present in the following documents:
  • Main text
  • idr-15-3857.pdf
View BVdb publication page



High efficacy of switching to bictegravir/emtricitabine/tenofovir alafenamide in people with suppressed HIV and preexisting M184V/I.

Aids (London, England)
Sax, Paul E PE; Andreatta, Kristen K; Molina, Jean-Michel JM; Daar, Eric S ES; Hagins, Debbie D; Acosta, Rima R; D'Antoni, Michelle L ML; Chang, Silvia S; Martin, Ross R; Liu, Hui H; Blair, Christiana C; McNicholl, Ian I; Gallant, Joel J; Collins, Sean E SE; Martin, Hal H; White, Kirsten L KL
Publication Date: 2022-09-01

Variant appearance in text: CD4: F227C
PubMed Link: 35466963
Variant Present in the following documents:
  • aids-36-1511.pdf
View BVdb publication page



HIV: how to manage heavily treatment-experienced patients.

Drugs In Context
Spivack, Stephanie S; Pagkalinawan, Stephen S; Samuel, Rafik R; Koren, David E DE
Publication Date: 2022

Variant appearance in text: CD4: F227C
PubMed Link: 35310298
Variant Present in the following documents:
  • Main text
  • dic-2021-9-1.pdf
View BVdb publication page



Phase 2 Open-Label Study of Long-Term Safety, Tolerability, and Antiviral Activity of Rilpivirine in Antiretroviral-Naive Adolescents Living with HIV-1.

Antimicrobial Agents And Chemotherapy
Lombaard, Johan J; Ssali, Francis F; Thanyawee, Puthanakit P; Fourie, Jan J; Vanveggel, Simon S; Linthicum, Cornelia C; Van Eygen, Veerle V; Van Solingen-Ristea, Rodica R
Publication Date: 2022-02-15

Variant appearance in text: CD4: F227C
PubMed Link: 34871089
Variant Present in the following documents:
  • Main text
  • aac.00916-21.pdf
View BVdb publication page



Single oral doses of MK-8507, a novel non-nucleoside reverse transcriptase inhibitor, suppress HIV-1 RNA for a week.

Journal Of Acquired Immune Deficiency Syndromes (1999)
Schürmann, Dirk D; Rudd, Deanne Jackson DJ; Schaeffer, Andrea A; De Lepeleire, Inge I; Friedman, Evan J EJ; Robberechts, Martine M; Zhang, Saijuan S; Liu, Yang Y; Kandala, Bhargava B; Keicher, Christian C; Däumer, Martin M; Hofmann, Jörg J; Grobler, Jay A JA; Stoch, S Aubrey SA; Iwamoto, Marian M; Ankrom, Wendy W
Publication Date: 2021-10-13

Variant appearance in text: CD4: F227C
PubMed Link: 34654041
Variant Present in the following documents:
  • Main text
View BVdb publication page



Single Oral Doses of MK-8507, a Novel Non-Nucleoside Reverse Transcriptase Inhibitor, Suppress HIV-1 RNA for a Week.

Journal Of Acquired Immune Deficiency Syndromes (1999)
Schürmann, Dirk D; Jackson Rudd, Deanne D; Schaeffer, Andrea A; De Lepeleire, Inge I; Friedman, Evan J EJ; Robberechts, Martine M; Zhang, Saijuan S; Liu, Yang Y; Kandala, Bhargava B; Keicher, Christian C; Däumer, Martin M; Hofmann, Jörg J; Grobler, Jay A JA; Stoch, S Aubrey SA; Iwamoto, Marian M; Ankrom, Wendy W
Publication Date: 2022-02-01

Variant appearance in text: CD4: F227C
PubMed Link: 34654041
Variant Present in the following documents:
  • Main text
View BVdb publication page



Evaluation of HIV Transmission Clusters among Natives and Foreigners Living in Italy.

Viruses
Fabeni, Lavinia L; Santoro, Maria Mercedes MM; Lorenzini, Patrizia P; Rusconi, Stefano S; Gianotti, Nicola N; Costantini, Andrea A; Sarmati, Loredana L; Antinori, Andrea A; Ceccherini-Silberstein, Francesca F; d'Arminio Monforte, Antonella A; Saracino, Annalisa A; Girardi, Enrico E; On Behalf Of The Icona Foundation Study Cohort,
Publication Date: 2020-07-23

Variant appearance in text: CD4: F227C
PubMed Link: 32718024
Variant Present in the following documents:
  • Main text
  • viruses-12-00791.pdf
View BVdb publication page



Doravirine and Its Potential in the Treatment of HIV: An Evidence-Based Review of the Emerging Data.

Hiv/Aids (Auckland, N.Z.)
Rock, Alexander E AE; Lerner, Jeremy J; Badowski, Melissa E ME
Publication Date: 2020

Variant appearance in text: CD4: F227C
PubMed Link: 32606994
Variant Present in the following documents:
  • Main text
  • hiv-12-201.pdf
View BVdb publication page



Pharmaceutical, clinical, and resistance information on doravirine, a novel non-nucleoside reverse transcriptase inhibitor for the treatment of HIV-1 infection.

Drugs In Context
Pham, Hanh Thi HT; Xiao, Meng A MA; Principe, Miguel Av MA; Wong, Alexander A; Mesplède, Thibault T
Publication Date: 2020

Variant appearance in text: CD4: F227C
PubMed Link: 32180823
Variant Present in the following documents:
  • Main text
View BVdb publication page



Switching to Doravirine/Lamivudine/Tenofovir Disoproxil Fumarate (DOR/3TC/TDF) Maintains HIV-1 Virologic Suppression Through 48 Weeks: Results of the DRIVE-SHIFT Trial.

Journal Of Acquired Immune Deficiency Syndromes (1999)
Johnson, Margaret M; Kumar, Princy P; Molina, Jean-Michel JM; Rizzardini, Giuliano G; Cahn, Pedro P; Bickel, Markus M; Mallolas, Josep J; Zhou, Yan Y; Morais, Cristiana C; Kumar, Sushma S; Sklar, Peter P; Hanna, George J GJ; Hwang, Carey C; Greaves, Wayne W; ,
Publication Date: 2019-08-01

Variant appearance in text: CD4: F227C
PubMed Link: 30985556
Variant Present in the following documents:
  • Main text
View BVdb publication page



Provir/Latitude 45 study: A step towards a multi-epitopic CTL vaccine designed on archived HIV-1 DNA and according to dominant HLA I alleles.

Plos One
Tumiotto, Camille C; Alves, Bruna M BM; Recordon-Pinson, Patricia P; Jourdain, Marine M; Bellecave, Pantxika P; Guidicelli, Gwenda-Line GL; Visentin, Jonathan J; Bonnet, Fabrice F; Hessamfar, Mojdan M; Neau, Didier D; Sanchez, Jorge J; Brander, Christian C; Sajadi, Mohammad M; Eyzaguirre, Lindsay L; Soares, Esmeralda A EA; Routy, Jean-Pierre JP; Soares, Marcelo A MA; Fleury, Hervé H
Publication Date: 2019

Variant appearance in text: CD4: F227C
PubMed Link: 30811489
Variant Present in the following documents:
  • pone.0212347.pdf
View BVdb publication page



Resistance Analysis of Bictegravir-Emtricitabine-Tenofovir Alafenamide in HIV-1 Treatment-Naive Patients through 48 Weeks.

Antimicrobial Agents And Chemotherapy
Acosta, Rima K RK; Willkom, Madeleine M; Martin, Ross R; Chang, Silvia S; Wei, Xuelian X; Garner, William W; Lutz, Justin J; Majeed, Sophia S; SenGupta, Devi D; Martin, Hal H; Quirk, Erin E; White, Kirsten L KL
Publication Date: 2019-05

Variant appearance in text: CD4: F227C
PubMed Link: 30803969
Variant Present in the following documents:
  • Main text
View BVdb publication page



Prevalence of Rilpivirine and Etravirine Resistance Mutations in HIV-1 Subtype C-Infected Patients Failing Nevirapine or Efavirenz-Based Combination Antiretroviral Therapy in Botswana.

Aids Research And Human Retroviruses
Diphoko, Thabo T; Gaseitsiwe, Simani S; Kasvosve, Ishmael I; Moyo, Sikhulile S; Okatch, Harriet H; Musonda, Rosemary R; Wainberg, Mark M; Makhema, Joseph J; Marlink, Richard R; Novitsky, Vladimir V; Essex, Max M
Publication Date: 2018-08

Variant appearance in text: CD4: F227C
PubMed Link: 29732907
Variant Present in the following documents:
  • Main text
View BVdb publication page



Genetic variation in human drug-related genes.

Genome Medicine
Schärfe, Charlotta Pauline Irmgard CPI; Tremmel, Roman R; Schwab, Matthias M; Kohlbacher, Oliver O; Marks, Debora Susan DS
Publication Date: 2017-12-22

Variant appearance in text: rs11064419
PubMed Link: 29273096
Variant Present in the following documents:
  • 13073_2017_502_MOESM2_ESM.xlsx, sheet 2
View BVdb publication page



Virological response and resistance among HIV-infected children receiving long-term antiretroviral therapy without virological monitoring in Uganda and Zimbabwe: Observational analyses within the randomised ARROW trial.

Plos Medicine
Szubert, Alexander J AJ; Prendergast, Andrew J AJ; Spyer, Moira J MJ; Musiime, Victor V; Musoke, Philippa P; Bwakura-Dangarembizi, Mutsa M; Nahirya-Ntege, Patricia P; Thomason, Margaret J MJ; Ndashimye, Emmanuel E; Nkanya, Immaculate I; Senfuma, Oscar O; Mudenge, Boniface B; Klein, Nigel N; Gibb, Diana M DM; Walker, A Sarah AS; ,
Publication Date: 2017-11

Variant appearance in text: CD4: F227C
PubMed Link: 29136032
Variant Present in the following documents:
  • pmed.1002432.s008.pdf
  • pmed.1002432.s006.pdf
View BVdb publication page



Role of Rilpivirine and Etravirine in Efavirenz and Nevirapine-Based Regimens Failure in a Resource-Limited Country: A Cross- Sectional Study.

Plos One
Teeranaipong, Phairote P; Sirivichayakul, Sunee S; Mekprasan, Suwanna S; Ohata, Pirapon June PJ; Avihingsanon, Anchalee A; Ruxrungtham, Kiat K; Putcharoen, Opass O
Publication Date: 2016

Variant appearance in text: CD4: F227C
PubMed Link: 27120449
Variant Present in the following documents:
  • Main text
  • pone.0154221.pdf
View BVdb publication page



Treatment options after virological failure of first-line tenofovir-based regimens in South Africa: an analysis by deep sequencing.

Aids (London, England)
Casadellà, Maria M; Noguera-Julian, Marc M; Sunpath, Henry H; Gordon, Michelle M; Rodriguez, Cristina C; Parera, Mariona M; Kuritzkes, Daniel R DR; Marconi, Vincent C VC; Paredes, Roger R
Publication Date: 2016-04-24

Variant appearance in text: CD4: F227C
PubMed Link: 26807968
Variant Present in the following documents:
  • Main text
View BVdb publication page



Emergent HIV-1 Drug Resistance Mutations Were Not Present at Low-Frequency at Baseline in Non-Nucleoside Reverse Transcriptase Inhibitor-Treated Subjects in the STaR Study.

Viruses
Porter, Danielle P DP; Daeumer, Martin M; Thielen, Alexander A; Chang, Silvia S; Martin, Ross R; Cohen, Cal C; Miller, Michael D MD; White, Kirsten L KL
Publication Date: 2015-12-07

Variant appearance in text: CD4: F227C
PubMed Link: 26690199
Variant Present in the following documents:
  • Main text
  • viruses-07-02943.pdf
View BVdb publication page



Reproducible Analysis of Post-Translational Modifications in Proteomes--Application to Human Mutations.

Plos One
Holehouse, Alex S AS; Naegle, Kristen M KM
Publication Date: 2015

Variant appearance in text: rs11064419
PubMed Link: 26659599
Variant Present in the following documents:
  • pone.0144692.s002.xlsx, sheet 1
View BVdb publication page



Resistance to reverse transcriptase inhibitors used in the treatment and prevention of HIV-1 infection.

Future Microbiology
Sluis-Cremer, Nicolas N; Wainberg, Mark A MA; Schinazi, Raymond F RF
Publication Date: 2015

Variant appearance in text: CD4: F227C
PubMed Link: 26517190
Variant Present in the following documents:
  • Main text
View BVdb publication page



In vitro resistance selection with doravirine (MK-1439), a novel nonnucleoside reverse transcriptase inhibitor with distinct mutation development pathways.

Antimicrobial Agents And Chemotherapy
Feng, Meizhen M; Wang, Deping D; Grobler, Jay A JA; Hazuda, Daria J DJ; Miller, Michael D MD; Lai, Ming-Tain MT
Publication Date: 2015-01

Variant appearance in text: CD4: F227C
PubMed Link: 25385110
Variant Present in the following documents:
  • Main text
View BVdb publication page



Drug resistance in non-B subtype HIV-1: impact of HIV-1 reverse transcriptase inhibitors.

Viruses
Singh, Kamalendra K; Flores, Jacqueline A JA; Kirby, Karen A KA; Neogi, Ujjwal U; Sonnerborg, Anders A; Hachiya, Atsuko A; Das, Kalyan K; Arnold, Eddy E; McArthur, Carole C; Parniak, Michael M; Sarafianos, Stefan G SG
Publication Date: 2014-09-24

Variant appearance in text: CD4: F227C
PubMed Link: 25254383
Variant Present in the following documents:
  • Main text
View BVdb publication page



Antiretroviral therapy: current drugs.

Infectious Disease Clinics Of North America
Pau, Alice K AK; George, Jomy M JM
Publication Date: 2014-09

Variant appearance in text: CD4: F227C
PubMed Link: 25151562
Variant Present in the following documents:
  • Main text
View BVdb publication page



The emerging profile of cross-resistance among the nonnucleoside HIV-1 reverse transcriptase inhibitors.

Viruses
Sluis-Cremer, Nicolas N
Publication Date: 2014-07-31

Variant appearance in text: CD4: F227C
PubMed Link: 25089538
Variant Present in the following documents:
  • Main text
View BVdb publication page



Rilpivirine resistance-associated mutations among antiretroviral-naive patients infected with HIV-1 in Asia.

Journal Of Acquired Immune Deficiency Syndromes (1999)
Sungkanuparph, Somnuek S; Jiamsakul, Awachana A; Kiertiburanakul, Sasisopin S; Sirivichayakul, Sunee S; Praparattanapan, Jutarat J; Kantor, Rami R; ,
Publication Date: 2013-03-01

Variant appearance in text: CD4: F227C
PubMed Link: 23924642
Variant Present in the following documents:
  • Main text
View BVdb publication page



Trends in Genotypic HIV-1 Antiretroviral Resistance between 2006 and 2012 in South African Patients Receiving First- and Second-Line Antiretroviral Treatment Regimens.

Plos One
Van Zyl, Gert U GU; Liu, Tommy F TF; Claassen, Mathilda M; Engelbrecht, Susan S; de Oliveira, Tulio T; Preiser, Wolfgang W; Wood, Natasha T NT; Travers, Simon S; Shafer, Robert W RW
Publication Date: 2013

Variant appearance in text: CD4: F227C
PubMed Link: 23840622
Variant Present in the following documents:
  • Main text
View BVdb publication page



Triple-combination rilpivirine, emtricitabine, and tenofovir (Complera™/Eviplera™) in the treatment of HIV infection.

Patient Preference And Adherence
Bernardini, Claudia C; Maggiolo, Franco F
Publication Date: 2013

Variant appearance in text: CD4: F227C
PubMed Link: 23814462
Variant Present in the following documents:
  • Main text
View BVdb publication page



Combination therapies, effectiveness, and adherence in patients with HIV infection: clinical utility of a single tablet of emtricitabine, rilpivirine, and tenofovir.

Hiv/Aids (Auckland, N.Z.)
Wainberg, Mark A MA
Publication Date: 2013

Variant appearance in text: CD4: F227C
PubMed Link: 23413112
Variant Present in the following documents:
  • Main text
View BVdb publication page



High viremia and low level of transmitted drug resistance in anti-retroviral therapy-naïve perinatally-infected children and adolescents with HIV-1 subtype C infection.

Bmc Infectious Diseases
Neogi, Ujjwal U; Sahoo, Pravat Nalini PN; De Costa, Ayesha A; Shet, Anita A
Publication Date: 2012-11-22

Variant appearance in text: CD4: F227C
PubMed Link: 23171203
Variant Present in the following documents:
  • Main text
  • 1471-2334-12-317.pdf
View BVdb publication page



Comparison of predicted susceptibility between genotype and virtual phenotype HIV drug resistance interpretation systems among treatment-naive HIV-infected patients in Asia: TASER-M cohort analysis.

Bmc Research Notes
Jiamsakul, Awachana A; Kantor, Rami R; Li, Patrick C K PC; Sirivichayakul, Sunee S; Sirisanthana, Thira T; Kantipong, Pacharee P; Lee, Christopher K C CK; Kamarulzaman, Adeeba A; Ratanasuwan, Winai W; Ditangco, Rossana R; Singtoroj, Thida T; Sungkanuparph, Somnuek S; ,
Publication Date: 2012-10-24

Variant appearance in text: CD4: F227C
PubMed Link: 23095645
Variant Present in the following documents:
  • Main text
View BVdb publication page



Low-frequency nevirapine resistance at multiple sites may predict treatment failure in infants on nevirapine-based treatment.

Journal Of Acquired Immune Deficiency Syndromes (1999)
Lehman, Dara A DA; Wamalwa, Dalton C DC; McCoy, Connor O CO; Matsen, Frederick A FA; Langat, Agnes A; Chohan, Bhavna H BH; Benki-Nugent, Sarah S; Custers-Allen, Rebecca R; Bushman, Frederic D FD; John-Stewart, Grace C GC; Overbaugh, Julie J
Publication Date: 2012-07-01

Variant appearance in text: CD4: F227C
PubMed Link: 22395670
Variant Present in the following documents:
  • Main text
View BVdb publication page



Identification of HIV inhibitors guided by free energy perturbation calculations.

Current Pharmaceutical Design
Acevedo, Orlando O; Ambrose, Zandrea Z; Flaherty, Patrick T PT; Aamer, Hadega H; Jain, Prashi P; Sambasivarao, Somisetti V SV
Publication Date: 2012

Variant appearance in text: CD4: F227C
PubMed Link: 22316150
Variant Present in the following documents:
  • Main text
View BVdb publication page



Profile of etravirine for the treatment of HIV infection.

Therapeutics And Clinical Risk Management
Tseng, Alice A; Macarthur, Rodger D RD
Publication Date: 2010-02-02

Variant appearance in text: CD4: F227C
PubMed Link: 20169036
Variant Present in the following documents:
  • Main text
  • tcrm-6-049.pdf
View BVdb publication page



Factors associated with virological response to etravirine in nonnucleoside reverse transcriptase inhibitor-experienced HIV-1-infected patients.

Antimicrobial Agents And Chemotherapy
Marcelin, Anne-Genevieve AG; Flandre, Philippe P; Descamps, Diane D; Morand-Joubert, Laurence L; Charpentier, Charlotte C; Izopet, Jacques J; Trabaud, Mary-Anne MA; Saoudin, Henia H; Delaugerre, Constance C; Tamalet, Catherine C; Cottalorda, Jacqueline J; Bouvier-Alias, Magali M; Bettinger, Dominique D; Dos Santos, Georges G; Ruffault, Annick A; Alloui, Chakib C; Henquell, Cecile C; Rogez, Sylvie S; Barin, Francis F; Signori-Schmuck, Anne A; Vallet, Sophie S; Masquelier, Bernard B; Calvez, Vincent V; ,
Publication Date: 2010-01

Variant appearance in text: CD4: F227C
PubMed Link: 19901096
Variant Present in the following documents:
  • Main text
View BVdb publication page



HIV-1 drug resistance mutations: an updated framework for the second decade of HAART.

Aids Reviews
Shafer, Robert W RW; Schapiro, Jonathan M JM
Publication Date: 2008

Variant appearance in text: CD4: F227C
PubMed Link: 18615118
Variant Present in the following documents:
  • Main text
View BVdb publication page