Publications:

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Week 96 Genotypic and Phenotypic Results of the Fostemsavir Phase 3 BRIGHTE Study in Heavily Treatment-Experienced Adults Living with Multidrug-Resistant HIV-1.

Antimicrobial Agents And Chemotherapy

Gartland, Margaret M; Cahn, Pedro P; DeJesus, Edwin E; Diaz, Ricardo Sobhie RS; Grossberg, Robert R; Kozal, Michael M; Kumar, Princy P; Molina, Jean-Michel JM; Mendo Urbina, Fernando F; Wang, Marcia M; Du, Fangfang F; Chabria, Shiven S; Clark, Andrew A; Garside, Louise L; Krystal, Mark M; Mannino, Frank F; Pierce, Amy A; Ackerman, Peter P; Lataillade, Max M

Publication Date: 2022-06-21

Variant appearance in text: CD4: S375T

PubMed Link: 35502922

Variant Present in the following documents:

• Main text
• aac.01751-21.pdf

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Efficacy and Safety Profile of Fostemsavir for the Treatment of People with Human Immunodeficiency Virus-1 (HIV-1): Current Evidence and Place in Therapy.

Drug Design, Development And Therapy

Muccini, Camilla C; Canetti, Diana D; Castagna, Antonella A; Spagnuolo, Vincenzo V

Publication Date: 2022

Variant appearance in text: CD4: S375T

PubMed Link: 35115764

Variant Present in the following documents:

• Main text
• dddt-16-297.pdf

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Clinical evidence for a lack of cross-resistance between temsavir and ibalizumab or maraviroc.

Aids (London, England)

Rose, Ronald R; Gartland, Margaret M; Li, Zhufang Z; Zhou, Nannan N; Cockett, Mark M; Beloor, Jagadish J; Lataillade, Max M; Ackerman, Peter P; Krystal, Mark M

Publication Date: 2022-01-01

Variant appearance in text: CD4: S375T

PubMed Link: 34628442

Variant Present in the following documents:

• Main text
• aids-36-011.pdf

View BVdb publication page

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Clinical evidence for a lack of cross-resistance between temsavir and ibalizumab or maraviroc.

Aids (London, England)

Rose, Ronald R; Gartland, Margaret M; Li, Zhufang Z; Zhou, Nannan N; Cockett, Mark M; Beloor, Jagadish J; Lataillade, Max M; Ackerman, Peter P; Krystal, Mark M

Publication Date: 2022-01-01

Variant appearance in text: CD4: S375T

PubMed Link: 34628442

Variant Present in the following documents:

• Main text
• aids-36-011.pdf

View BVdb publication page

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The HIV-1 Env gp120 Inner Domain Shapes the Phe43 Cavity and the CD4 Binding Site.

Mbio

Prévost, Jérémie J; Tolbert, William D WD; Medjahed, Halima H; Sherburn, Rebekah T RT; Madani, Navid N; Zoubchenok, Daria D; Gendron-Lepage, Gabrielle G; Gaffney, Althea E AE; Grenier, Melissa C MC; Kirk, Sharon S; Vergara, Natasha N; Han, Changze C; Mann, Brendan T BT; Chénine, Agnès L AL; Ahmed, Adel A; Chaiken, Irwin I; Kirchhoff, Frank F; Hahn, Beatrice H BH; Haim, Hillel H; Abrams, Cameron F CF; Smith, Amos B AB; Sodroski, Joseph J; Pazgier, Marzena M; Finzi, Andrés A

Publication Date: 2020-05-26

Variant appearance in text: CD4: S375T

PubMed Link: 32457241

Variant Present in the following documents:

• Main text

View BVdb publication page

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Harnessing calcineurin-FK506-FKBP12 crystal structures from invasive fungal pathogens to develop antifungal agents.

Nature Communications

Juvvadi, Praveen R PR; Fox, David D; Bobay, Benjamin G BG; Hoy, Michael J MJ; Gobeil, Sophie M C SMC; Venters, Ronald A RA; Chang, Zanetta Z; Lin, Jackie J JJ; Averette, Anna Floyd AF; Cole, D Christopher DC; Barrington, Blake C BC; Wheaton, Joshua D JD; Ciofani, Maria M; Trzoss, Michael M; Li, Xiaoming X; Lee, Soo Chan SC; Chen, Ying-Lien YL; Mutz, Mitchell M; Spicer, Leonard D LD; Schumacher, Maria A MA; Heitman, Joseph J; Steinbach, William J WJ

Publication Date: 2019-09-19

Variant appearance in text: CD4: S375T

PubMed Link: 31537789

Variant Present in the following documents:

• Main text

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Neutralization Synergy between HIV-1 Attachment Inhibitor Fostemsavir and Anti-CD4 Binding Site Broadly Neutralizing Antibodies against HIV.

Journal Of Virology

Zhang, Yijun Y; Chapman, James H JH; Ulcay, Asim A; Sutton, Richard E RE

Publication Date: 2019-02-15

Variant appearance in text: CD4: S375T

PubMed Link: 30518644

Variant Present in the following documents:

• Main text

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Viral Drug Resistance Through 48 Weeks, in a Phase 2b, Randomized, Controlled Trial of the HIV-1 Attachment Inhibitor Prodrug, Fostemsavir.

Journal Of Acquired Immune Deficiency Syndromes (1999)

Lataillade, Max M; Zhou, Nannan N; Joshi, Samit R SR; Lee, Sangil S; Stock, David A DA; Hanna, George J GJ; Krystal, Mark M; ,

Publication Date: 2018-03-01

Variant appearance in text: CD4: S375T

PubMed Link: 29206721

Variant Present in the following documents:

• Main text
• qai-77-299.pdf

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Saturation Mutagenesis of the HIV-1 Envelope CD4 Binding Loop Reveals Residues Controlling Distinct Trimer Conformations.

Plos Pathogens

Duenas-Decamp, Maria M; Jiang, Li L; Bolon, Daniel D; Clapham, Paul R PR

Publication Date: 2016-11

Variant appearance in text: CD4: S375T

PubMed Link: 27820858

Variant Present in the following documents:

• Main text
• ppat.1005988.pdf

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HIV gp120 H375 is unique to HIV-1 subtype CRF01_AE and confers strong resistance to the entry inhibitor BMS-599793, a candidate microbicide drug.

Antimicrobial Agents And Chemotherapy

Schader, Susan M SM; Colby-Germinario, Susan P SP; Quashie, Peter K PK; Oliveira, Maureen M; Ibanescu, Ruxandra-Ilinca RI; Moisi, Daniela D; Mespléde, Thibault T; Wainberg, Mark A MA

Publication Date: 2012-08

Variant appearance in text: CD4: S375T

PubMed Link: 22615295

Variant Present in the following documents:

• Main text

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In vivo patterns of resistance to the HIV attachment inhibitor BMS-488043.

Antimicrobial Agents And Chemotherapy

Zhou, Nannan N; Nowicka-Sans, Beata B; Zhang, Sharon S; Fan, Li L; Fang, Jie J; Fang, Hua H; Gong, Yi-Fei YF; Eggers, Betsy B; Langley, David R DR; Wang, Tao T; Kadow, John J; Grasela, Dennis D; Hanna, George J GJ; Alexander, Louis L; Colonno, Richard R; Krystal, Mark M; Lin, Pin-Fang PF

Publication Date: 2011-02

Variant appearance in text: CD4: S375T

PubMed Link: 21078948

Variant Present in the following documents:

• Main text

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