Publications:

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Crystal structures of trimeric HIV envelope with entry inhibitors BMS-378806 and BMS-626529.

Nature Chemical Biology

Pancera, Marie M; Lai, Yen-Ting YT; Bylund, Tatsiana T; Druz, Aliaksandr A; Narpala, Sandeep S; O'Dell, Sijy S; Schön, Arne A; Bailer, Robert T RT; Chuang, Gwo-Yu GY; Geng, Hui H; Louder, Mark K MK; Rawi, Reda R; Soumana, Djade I DI; Finzi, Andrés A; Herschhorn, Alon A; Madani, Navid N; Sodroski, Joseph J; Freire, Ernesto E; Langley, David R DR; Mascola, John R JR; McDermott, Adrian B AB; Kwong, Peter D PD

Publication Date: 2017-10

Variant appearance in text: CD4: Ser375Ala

PubMed Link: 28825711

Variant Present in the following documents:

• Main text
• nihms894384.pdf

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Antibodies Elicited by Multiple Envelope Glycoprotein Immunogens in Primates Neutralize Primary Human Immunodeficiency Viruses (HIV-1) Sensitized by CD4-Mimetic Compounds.

Journal Of Virology

Madani, Navid N; Princiotto, Amy M AM; Easterhoff, David D; Bradley, Todd T; Luo, Kan K; Williams, Wilton B WB; Liao, Hua-Xin HX; Moody, M Anthony MA; Phad, Ganesh E GE; Vázquez Bernat, Néstor N; Melillo, Bruno B; Santra, Sampa S; Smith, Amos B AB; Karlsson Hedestam, Gunilla B GB; Haynes, Barton B; Sodroski, Joseph J

Publication Date: 2016-05-15

Variant appearance in text: CD4: S375A

PubMed Link: 26962221

Variant Present in the following documents:

• Main text

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Peptide Triazole Inactivators of HIV-1 Utilize a Conserved Two-Cavity Binding Site at the Junction of the Inner and Outer Domains of Env gp120.

Journal Of Medicinal Chemistry

Aneja, Rachna R; Rashad, Adel A AA; Li, Huiyuan H; Kalyana Sundaram, Ramalingam Venkat RV; Duffy, Caitlin C; Bailey, Lauren D LD; Chaiken, Irwin I

Publication Date: 2015-05-14

Variant appearance in text: CD4: S375A

PubMed Link: 25860784

Variant Present in the following documents:

• Main text

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A broad HIV-1 inhibitor blocks envelope glycoprotein transitions critical for entry.

Nature Chemical Biology

Herschhorn, Alon A; Gu, Christopher C; Espy, Nicole N; Richard, Jonathan J; Finzi, Andrés A; Sodroski, Joseph G JG

Publication Date: 2014-10

Variant appearance in text: CD4: S375A

PubMed Link: 25174000

Variant Present in the following documents:

• NIHMS614939-supplement-1.pdf

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A model of peptide triazole entry inhibitor binding to HIV-1 gp120 and the mechanism of bridging sheet disruption.

Biochemistry

Emileh, Ali A; Tuzer, Ferit F; Yeh, Herman H; Umashankara, Muddegowda M; Moreira, Diogo R M DR; Lalonde, Judith M JM; Bewley, Carole A CA; Abrams, Cameron F CF; Chaiken, Irwin M IM

Publication Date: 2013-04-02

Variant appearance in text: CD4: S375A

PubMed Link: 23470147

Variant Present in the following documents:

• Main text

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Spontaneous rearrangement of the β20/β21 strands in simulations of unliganded HIV-1 glycoprotein, gp120.

Biochemistry

Shrivastava, Indira H IH; Wendel, Kaylee K; LaLonde, Judith M JM

Publication Date: 2012-10-02

Variant appearance in text: CD4: S375A

PubMed Link: 22963284

Variant Present in the following documents:

• Main text

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Enhanced dynamics of HIV gp120 glycoprotein by small molecule binding.

Biochemistry

Shrivastava, Indira I; LaLonde, Judith M JM

Publication Date: 2011-05-17

Variant appearance in text: CD4: S375A

PubMed Link: 21488663

Variant Present in the following documents:

• Main text

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Design, synthesis and biological evaluation of small molecule inhibitors of CD4-gp120 binding based on virtual screening.

Bioorganic & Medicinal Chemistry

Lalonde, Judith M JM; Elban, Mark A MA; Courter, Joel R JR; Sugawara, Akihiro A; Soeta, Takahiro T; Madani, Navid N; Princiotto, Amy M AM; Kwon, Young Do YD; Kwong, Peter D PD; Schön, Arne A; Freire, Ernesto E; Sodroski, Joseph J; Smith, Amos B AB

Publication Date: 2011-01-01

Variant appearance in text: CD4: S375A

PubMed Link: 21169023

Variant Present in the following documents:

• Main text

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Fluctuation dynamics analysis of gp120 envelope protein reveals a topologically based communication network.

Proteins

Shrivastava, Indira I; LaLonde, Judith M JM

Publication Date: 2010-11-01

Variant appearance in text: CD4: S375A

PubMed Link: 20718047

Variant Present in the following documents:

• Main text

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Small-molecule CD4 mimics interact with a highly conserved pocket on HIV-1 gp120.

Structure (London, England : 1993)

Madani, Navid N; Schön, Arne A; Princiotto, Amy M AM; Lalonde, Judith M JM; Courter, Joel R JR; Soeta, Takahiro T; Ng, Danny D; Wang, Liping L; Brower, Evan T ET; Xiang, Shi-Hua SH; Kwon, Young Do YD; Huang, Chih-Chin CC; Wyatt, Richard R; Kwong, Peter D PD; Freire, Ernesto E; Smith, Amos B AB; Sodroski, Joseph J

Publication Date: 2008-11-12

Variant appearance in text: CD4: S375A

PubMed Link: 19000821

Variant Present in the following documents:

• Main text

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Localized changes in the gp120 envelope glycoprotein confer resistance to human immunodeficiency virus entry inhibitors BMS-806 and #155.

Journal Of Virology

Madani, Navid N; Perdigoto, Ana Luisa AL; Srinivasan, Kumar K; Cox, Jason M JM; Chruma, Jason J JJ; LaLonde, Judith J; Head, Martha M; Smith, Amos B AB; Sodroski, Joseph G JG

Publication Date: 2004-04

Variant appearance in text: CD4: S375A

PubMed Link: 15016894

Variant Present in the following documents:

• Main text

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