CD4 c.1123_1124delinsAG ;(p.S375R)

Variant ID: 12-6926463-TC-AG

NM_000616.4(CD4):c.1123_1124delinsAG;(p.S375R)

This variant was identified in 3 publications

View GRCh38 version.




Publications:


Structural basis for highly effective HIV-1 neutralization by CD4-mimetic miniproteins revealed by 1.5 Å cocrystal structure of gp120 and M48U1.

Structure (London, England : 1993)
Acharya, Priyamvada P; Luongo, Timothy S TS; Louder, Mark K MK; McKee, Krisha K; Yang, Yongping Y; Kwon, Young Do YD; Mascola, John R JR; Kessler, Pascal P; Martin, Loïc L; Kwong, Peter D PD
Publication Date: 2013-06-04

Variant appearance in text: CD4: S375R
PubMed Link: 23707685
Variant Present in the following documents:
  • Main text
View BVdb publication page



M48U1 CD4 mimetic has a sustained inhibitory effect on cell-associated HIV-1 by attenuating virion infectivity through gp120 shedding.

Retrovirology
Selhorst, Philippe P; Grupping, Katrijn K; Tong, Tommy T; Crooks, Ema T ET; Martin, Loïc L; Vanham, Guido G; Binley, James M JM; Ariën, Kevin K KK
Publication Date: 2013-02-01

Variant appearance in text: CD4: S375R
PubMed Link: 23375046
Variant Present in the following documents:
  • Main text
  • 1742-4690-10-12.pdf
View BVdb publication page



MiniCD4 protein resistance mutations affect binding to the HIV-1 gp120 CD4 binding site and decrease entry efficiency.

Retrovirology
Grupping, Katrijn K; Selhorst, Philippe P; Michiels, Johan J; Vereecken, Katleen K; Heyndrickx, Leo L; Kessler, Pascal P; Vanham, Guido G; Martin, Loïc L; Ariën, Kevin K KK
Publication Date: 2012-05-02

Variant appearance in text: CD4: S375R
PubMed Link: 22551420
Variant Present in the following documents:
  • 1742-4690-9-36.pdf
View BVdb publication page