CD4 c.1123_1125delinsCAT ;(p.S375H)

Variant ID: 12-6926463-TCG-CAT

NM_000616.4(CD4):c.1123_1125delinsCAT;(p.S375H)

This variant was identified in 16 publications

View GRCh38 version.




Publications:


Antiviral Activity and Crystal Structures of HIV-1 gp120 Antagonists.

International Journal Of Molecular Sciences
Curreli, Francesca F; Kwon, Young D YD; Nicolau, Isabella I; Burgos, Giancarla G; Altieri, Andrea A; Kurkin, Alexander V AV; Verardi, Raffaello R; Kwong, Peter D PD; Debnath, Asim K AK
Publication Date: 2022-12-15

Variant appearance in text: CD4: S375H
PubMed Link: 36555641
Variant Present in the following documents:
  • Main text
  • ijms-23-15999.pdf
View BVdb publication page



Week 96 Genotypic and Phenotypic Results of the Fostemsavir Phase 3 BRIGHTE Study in Heavily Treatment-Experienced Adults Living with Multidrug-Resistant HIV-1.

Antimicrobial Agents And Chemotherapy
Gartland, Margaret M; Cahn, Pedro P; DeJesus, Edwin E; Diaz, Ricardo Sobhie RS; Grossberg, Robert R; Kozal, Michael M; Kumar, Princy P; Molina, Jean-Michel JM; Mendo Urbina, Fernando F; Wang, Marcia M; Du, Fangfang F; Chabria, Shiven S; Clark, Andrew A; Garside, Louise L; Krystal, Mark M; Mannino, Frank F; Pierce, Amy A; Ackerman, Peter P; Lataillade, Max M
Publication Date: 2022-06-21

Variant appearance in text: CD4: S375H
PubMed Link: 35502922
Variant Present in the following documents:
  • Main text
  • aac.01751-21.pdf
View BVdb publication page



Efficacy and Safety Profile of Fostemsavir for the Treatment of People with Human Immunodeficiency Virus-1 (HIV-1): Current Evidence and Place in Therapy.

Drug Design, Development And Therapy
Muccini, Camilla C; Canetti, Diana D; Castagna, Antonella A; Spagnuolo, Vincenzo V
Publication Date: 2022

Variant appearance in text: CD4: S375H
PubMed Link: 35115764
Variant Present in the following documents:
  • Main text
  • dddt-16-297.pdf
View BVdb publication page



Clinical evidence for a lack of cross-resistance between temsavir and ibalizumab or maraviroc.

Aids (London, England)
Rose, Ronald R; Gartland, Margaret M; Li, Zhufang Z; Zhou, Nannan N; Cockett, Mark M; Beloor, Jagadish J; Lataillade, Max M; Ackerman, Peter P; Krystal, Mark M
Publication Date: 2022-01-01

Variant appearance in text: CD4: S375H
PubMed Link: 34628442
Variant Present in the following documents:
  • Main text
  • aids-36-011.pdf
View BVdb publication page



Clinical evidence for a lack of cross-resistance between temsavir and ibalizumab or maraviroc.

Aids (London, England)
Rose, Ronald R; Gartland, Margaret M; Li, Zhufang Z; Zhou, Nannan N; Cockett, Mark M; Beloor, Jagadish J; Lataillade, Max M; Ackerman, Peter P; Krystal, Mark M
Publication Date: 2022-01-01

Variant appearance in text: CD4: S375H
PubMed Link: 34628442
Variant Present in the following documents:
  • Main text
  • aids-36-011.pdf
View BVdb publication page



Susceptibility of global HIV-1 clinical isolates to fostemsavir using the PhenoSense® Entry assay.

The Journal Of Antimicrobial Chemotherapy
Gartland, Margaret M; Zhou, Nannan N; Stewart, Eugene E; Pierce, Amy A; Clark, Andrew A; Ackerman, Peter P; Llamoso, Cyril C; Lataillade, Max M; Krystal, Mark M
Publication Date: 2021-02-11

Variant appearance in text: CD4: S375H
PubMed Link: 33241285
Variant Present in the following documents:
  • Main text
  • dkaa474.pdf
View BVdb publication page



The HIV-1 Env gp120 Inner Domain Shapes the Phe43 Cavity and the CD4 Binding Site.

Mbio
Prévost, Jérémie J; Tolbert, William D WD; Medjahed, Halima H; Sherburn, Rebekah T RT; Madani, Navid N; Zoubchenok, Daria D; Gendron-Lepage, Gabrielle G; Gaffney, Althea E AE; Grenier, Melissa C MC; Kirk, Sharon S; Vergara, Natasha N; Han, Changze C; Mann, Brendan T BT; Chénine, Agnès L AL; Ahmed, Adel A; Chaiken, Irwin I; Kirchhoff, Frank F; Hahn, Beatrice H BH; Haim, Hillel H; Abrams, Cameron F CF; Smith, Amos B AB; Sodroski, Joseph J; Pazgier, Marzena M; Finzi, Andrés A
Publication Date: 2020-05-26

Variant appearance in text: CD4: S375H
PubMed Link: 32457241
Variant Present in the following documents:
  • Main text
View BVdb publication page



Synthesis, Antiviral Activity, and Structure-Activity Relationship of 1,3-Benzodioxolyl Pyrrole-Based Entry Inhibitors Targeting the Phe43 Cavity in HIV-1 gp120.

Chemmedchem
Curreli, Francesca F; Belov, Dmitry S DS; Ahmed, Shahad S; Ramesh, Ranjith R RR; Kurkin, Alexander V AV; Altieri, Andrea A; Debnath, Asim K AK
Publication Date: 2018-11-06

Variant appearance in text: CD4: S375H
PubMed Link: 30257071
Variant Present in the following documents:
  • Main text
View BVdb publication page



Structure-based lead optimization to improve antiviral potency and ADMET properties of phenyl-1H-pyrrole-carboxamide entry inhibitors targeted to HIV-1 gp120.

European Journal Of Medicinal Chemistry
Curreli, Francesca F; Belov, Dmitry S DS; Kwon, Young Do YD; Ramesh, Ranjith R; Furimsky, Anna M AM; O'Loughlin, Kathleen K; Byrge, Patricia C PC; Iyer, Lalitha V LV; Mirsalis, Jon C JC; Kurkin, Alexander V AV; Altieri, Andrea A; Debnath, Asim K AK
Publication Date: 2018-06-25

Variant appearance in text: CD4: S375H
PubMed Link: 29860061
Variant Present in the following documents:
  • Main text
View BVdb publication page



Crystal structures of trimeric HIV envelope with entry inhibitors BMS-378806 and BMS-626529.

Nature Chemical Biology
Pancera, Marie M; Lai, Yen-Ting YT; Bylund, Tatsiana T; Druz, Aliaksandr A; Narpala, Sandeep S; O'Dell, Sijy S; Schön, Arne A; Bailer, Robert T RT; Chuang, Gwo-Yu GY; Geng, Hui H; Louder, Mark K MK; Rawi, Reda R; Soumana, Djade I DI; Finzi, Andrés A; Herschhorn, Alon A; Madani, Navid N; Sodroski, Joseph J; Freire, Ernesto E; Langley, David R DR; Mascola, John R JR; McDermott, Adrian B AB; Kwong, Peter D PD
Publication Date: 2017-10

Variant appearance in text: CD4: Ser375His
PubMed Link: 28825711
Variant Present in the following documents:
  • Main text
  • nihms894384.pdf
View BVdb publication page



Histidine 375 Modulates CD4 Binding in HIV-1 CRF01_AE Envelope Glycoproteins.

Journal Of Virology
Zoubchenok, Daria D; Veillette, Maxime M; Prévost, Jérémie J; Sanders-Buell, Eric E; Wagh, Kshitij K; Korber, Bette B; Chenine, Agnès L AL; Finzi, Andrés A
Publication Date: 2017-02-15

Variant appearance in text: CD4: S375H
PubMed Link: 27928014
Variant Present in the following documents:
  • Main text
View BVdb publication page



Saturation Mutagenesis of the HIV-1 Envelope CD4 Binding Loop Reveals Residues Controlling Distinct Trimer Conformations.

Plos Pathogens
Duenas-Decamp, Maria M; Jiang, Li L; Bolon, Daniel D; Clapham, Paul R PR
Publication Date: 2016-11

Variant appearance in text: CD4: S375H
PubMed Link: 27820858
Variant Present in the following documents:
  • Main text
  • ppat.1005988.pdf
View BVdb publication page



Synthesis, antiviral activity and resistance of a novel small molecule HIV-1 entry inhibitor.

Bioorganic & Medicinal Chemistry
Curreli, Francesca F; Haque, Kashfia K; Xie, Lihua L; Qiu, Qian Q; Xu, Jinfeng J; Yong, Weizhong W; Tong, Xiaohe X; Debnath, Asim K AK
Publication Date: 2015-12-15

Variant appearance in text: CD4: S375H
PubMed Link: 26602829
Variant Present in the following documents:
  • Main text
View BVdb publication page



Peptide Triazole Inactivators of HIV-1 Utilize a Conserved Two-Cavity Binding Site at the Junction of the Inner and Outer Domains of Env gp120.

Journal Of Medicinal Chemistry
Aneja, Rachna R; Rashad, Adel A AA; Li, Huiyuan H; Kalyana Sundaram, Ramalingam Venkat RV; Duffy, Caitlin C; Bailey, Lauren D LD; Chaiken, Irwin I
Publication Date: 2015-05-14

Variant appearance in text: CD4: S375H
PubMed Link: 25860784
Variant Present in the following documents:
  • Main text
View BVdb publication page



Activity of the HIV-1 attachment inhibitor BMS-626529, the active component of the prodrug BMS-663068, against CD4-independent viruses and HIV-1 envelopes resistant to other entry inhibitors.

Antimicrobial Agents And Chemotherapy
Li, Zhufang Z; Zhou, Nannan N; Sun, Yongnian Y; Ray, Neelanjana N; Lataillade, Max M; Hanna, George J GJ; Krystal, Mark M
Publication Date: 2013-09

Variant appearance in text: CD4: S375H
PubMed Link: 23774428
Variant Present in the following documents:
  • Main text
View BVdb publication page



HIV gp120 H375 is unique to HIV-1 subtype CRF01_AE and confers strong resistance to the entry inhibitor BMS-599793, a candidate microbicide drug.

Antimicrobial Agents And Chemotherapy
Schader, Susan M SM; Colby-Germinario, Susan P SP; Quashie, Peter K PK; Oliveira, Maureen M; Ibanescu, Ruxandra-Ilinca RI; Moisi, Daniela D; Mespléde, Thibault T; Wainberg, Mark A MA
Publication Date: 2012-08

Variant appearance in text: CD4: S375H
PubMed Link: 22615295
Variant Present in the following documents:
  • Main text
View BVdb publication page



Intrapatient alterations in the human immunodeficiency virus type 1 gp120 V1V2 and V3 regions differentially modulate coreceptor usage, virus inhibition by CC/CXC chemokines, soluble CD4, and the b12 and 2G12 monoclonal antibodies.

Journal Of Virology
Nabatov, Alexey A AA; Pollakis, Georgios G; Linnemann, Thomas T; Kliphius, Aletta A; Chalaby, Moustapha I M MI; Paxton, William A WA
Publication Date: 2004-01

Variant appearance in text: CD4: S375H
PubMed Link: 14671134
Variant Present in the following documents:
  • Main text
View BVdb publication page