Publications:

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Antiviral Activity and Crystal Structures of HIV-1 gp120 Antagonists.

International Journal Of Molecular Sciences

Curreli, Francesca F; Kwon, Young D YD; Nicolau, Isabella I; Burgos, Giancarla G; Altieri, Andrea A; Kurkin, Alexander V AV; Verardi, Raffaello R; Kwong, Peter D PD; Debnath, Asim K AK

Publication Date: 2022-12-15

Variant appearance in text: CD4: S375W

PubMed Link: 36555641

Variant Present in the following documents:

• Main text
• ijms-23-15999.pdf

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Case Report: The novel hemizygous mutation in the SSR4 gene caused congenital disorder of glycosylation type iy: A case study and literature review.

Frontiers In Genetics

Wang, Jun J; Gou, Xingqing X; Wang, Xiyi X; Zhang, Jing J; Zhao, Nan N; Wang, Xiaohong X

Publication Date: 2022

Variant appearance in text: CD4: 1124C>G

PubMed Link: 36386804

Variant Present in the following documents:

• Table1.xls, sheet 4

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Temsavir Treatment of HIV-1-Infected Cells Decreases Envelope Glycoprotein Recognition by Broadly Neutralizing Antibodies.

Mbio

Boutin, Marianne M; Vézina, Dani D; Ding, Shilei S; Prévost, Jérémie J; Laumaea, Annemarie A; Marchitto, Lorie L; Anand, Sai Priya SP; Medjahed, Halima H; Gendron-Lepage, Gabrielle G; Bourassa, Catherine C; Goyette, Guillaume G; Clark, Andrew A; Richard, Jonathan J; Finzi, Andrés A

Publication Date: 2022-06-28

Variant appearance in text: CD4: S375W

PubMed Link: 35475646

Variant Present in the following documents:

• Main text
• mbio.00577-22.pdf

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Peptide Triazole Thiol Irreversibly Inactivates Metastable HIV-1 Env by Accessing Conformational Triggers Intrinsic to Virus-Cell Entry.

Microorganisms

Ang, Charles Gotuaco CG; Carter, Erik E; Haftl, Ann A; Zhang, Shiyu S; Rashad, Adel A AA; Kutzler, Michele M; Abrams, Cameron F CF; Chaiken, Irwin M IM

Publication Date: 2021-06-12

Variant appearance in text: CD4: S375W

PubMed Link: 34204725

Variant Present in the following documents:

• Main text
• microorganisms-09-01286.pdf

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HIV-1 Env-Dependent Cell Killing by Bifunctional Small-Molecule/Peptide Conjugates.

Acs Chemical Biology

Gaffney, Althea A; Nangarlia, Aakansha A; Ang, Charles G CG; Gossert, Steven S; Rashad Ahmed, Adel Ahmed AA; Hossain, Md Alamgir MA; Abrams, Cameron F CF; Smith, Amos B AB; Chaiken, Irwin I

Publication Date: 2021-01-15

Variant appearance in text: CD4: S375W

PubMed Link: 33410670

Variant Present in the following documents:

• Main text

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Slow Receptor Binding of the Noncytopathic HIV-2UC1 Envs Is Balanced by Long-Lived Activation State and Efficient Fusion Activity.

Cell Reports

Harris, Miranda M; Ratnapriya, Sneha S; Chov, Angela A; Cervera, Héctor H; Block, Alisha A; Gu, Christopher C; Talledge, Nathaniel N; Mansky, Louis M LM; Sodroski, Joseph J; Herschhorn, Alon A

Publication Date: 2020-06-09

Variant appearance in text: CD4: S375W

PubMed Link: 32521274

Variant Present in the following documents:

• Main text

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Long-Acting BMS-378806 Analogues Stabilize the State-1 Conformation of the Human Immunodeficiency Virus Type 1 Envelope Glycoproteins.

Journal Of Virology

Zou, Shitao S; Zhang, Shijian S; Gaffney, Althea A; Ding, Haitao H; Lu, Maolin M; Grover, Jonathan R JR; Farrell, Mark M; Nguyen, Hanh T HT; Zhao, Connie C; Anang, Saumya S; Zhao, Meiqing M; Mohammadi, Mohammadjavad M; Blanchard, Scott C SC; Abrams, Cameron C; Madani, Navid N; Mothes, Walther W; Kappes, John C JC; Smith, Amos B AB; Sodroski, Joseph J

Publication Date: 2020-05-04

Variant appearance in text: CD4: S375W

PubMed Link: 32161177

Variant Present in the following documents:

• Main text

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A New Family of Small-Molecule CD4-Mimetic Compounds Contacts Highly Conserved Aspartic Acid 368 of HIV-1 gp120 and Mediates Antibody-Dependent Cellular Cytotoxicity.

Journal Of Virology

Ding, Shilei S; Grenier, Melissa C MC; Tolbert, William D WD; Vézina, Dani D; Sherburn, Rebekah R; Richard, Jonathan J; Prévost, Jérémie J; Chapleau, Jean-Philippe JP; Gendron-Lepage, Gabrielle G; Medjahed, Halima H; Abrams, Cameron C; Sodroski, Joseph J; Pazgier, Marzena M; Smith, Amos B AB; Finzi, Andrés A

Publication Date: 2019-12-15

Variant appearance in text: CD4: S375W

PubMed Link: 31554684

Variant Present in the following documents:

• Main text

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Synthesis, Antiviral Activity, and Structure-Activity Relationship of 1,3-Benzodioxolyl Pyrrole-Based Entry Inhibitors Targeting the Phe43 Cavity in HIV-1 gp120.

Chemmedchem

Curreli, Francesca F; Belov, Dmitry S DS; Ahmed, Shahad S; Ramesh, Ranjith R RR; Kurkin, Alexander V AV; Altieri, Andrea A; Debnath, Asim K AK

Publication Date: 2018-11-06

Variant appearance in text: CD4: S375W

PubMed Link: 30257071

Variant Present in the following documents:

• Main text

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Bacterially expressed HIV-1 gp120 outer-domain fragment immunogens with improved stability and affinity for CD4-binding site neutralizing antibodies.

The Journal Of Biological Chemistry

Rathore, Ujjwal U; Purwar, Mansi M; Vignesh, Venkada Subramanian VS; Das, Raksha R; Kumar, Aditya Arun AA; Bhattacharyya, Sanchari S; Arendt, Heather H; DeStefano, Joanne J; Wilson, Aaron A; Parks, Christopher C; La Branche, Celia C CC; Montefiori, David C DC; Varadarajan, Raghavan R

Publication Date: 2018-09-28

Variant appearance in text: CD4: S375W

PubMed Link: 30093409

Variant Present in the following documents:

• Main text

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Structure-based lead optimization to improve antiviral potency and ADMET properties of phenyl-1H-pyrrole-carboxamide entry inhibitors targeted to HIV-1 gp120.

European Journal Of Medicinal Chemistry

Curreli, Francesca F; Belov, Dmitry S DS; Kwon, Young Do YD; Ramesh, Ranjith R; Furimsky, Anna M AM; O'Loughlin, Kathleen K; Byrge, Patricia C PC; Iyer, Lalitha V LV; Mirsalis, Jon C JC; Kurkin, Alexander V AV; Altieri, Andrea A; Debnath, Asim K AK

Publication Date: 2018-06-25

Variant appearance in text: CD4: S375W

PubMed Link: 29860061

Variant Present in the following documents:

• Main text

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A Small-Molecule CD4-Mimetic Compound Protects Bone Marrow-Liver-Thymus Humanized Mice From HIV-1 Infection.

The Journal Of Infectious Diseases

Princiotto, Amy M AM; Vrbanac, Vladimir D VD; Melillo, Bruno B; Park, Jongwoo J; Tager, Andrew M AM; Smith, Amos B AB; Sodroski, Joseph J; Madani, Navid N

Publication Date: 2018-07-02

Variant appearance in text: CD4: S375W

PubMed Link: 29617845

Variant Present in the following documents:

• Main text

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The β20-β21 of gp120 is a regulatory switch for HIV-1 Env conformational transitions.

Nature Communications

Herschhorn, Alon A; Gu, Christopher C; Moraca, Francesca F; Ma, Xiaochu X; Farrell, Mark M; Smith, Amos B AB; Pancera, Marie M; Kwong, Peter D PD; Schön, Arne A; Freire, Ernesto E; Abrams, Cameron C; Blanchard, Scott C SC; Mothes, Walther W; Sodroski, Joseph G JG

Publication Date: 2017-10-19

Variant appearance in text: CD4: S375W

PubMed Link: 29051495

Variant Present in the following documents:

• 41467_2017_1119_MOESM1_ESM.pdf

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Crystal structures of trimeric HIV envelope with entry inhibitors BMS-378806 and BMS-626529.

Nature Chemical Biology

Pancera, Marie M; Lai, Yen-Ting YT; Bylund, Tatsiana T; Druz, Aliaksandr A; Narpala, Sandeep S; O'Dell, Sijy S; Schön, Arne A; Bailer, Robert T RT; Chuang, Gwo-Yu GY; Geng, Hui H; Louder, Mark K MK; Rawi, Reda R; Soumana, Djade I DI; Finzi, Andrés A; Herschhorn, Alon A; Madani, Navid N; Sodroski, Joseph J; Freire, Ernesto E; Langley, David R DR; Mascola, John R JR; McDermott, Adrian B AB; Kwong, Peter D PD

Publication Date: 2017-10

Variant appearance in text: CD4: Ser375Trp

PubMed Link: 28825711

Variant Present in the following documents:

• Main text

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Tryptophan 375 stabilizes the outer-domain core of gp120 for HIV vaccine immunogen design.

Vaccine

Hu, Duoyi D; Bowder, Dane D; Wei, Wenzhong W; Thompson, Jesse J; Wilson, Mark A MA; Xiang, Shi-Hua SH

Publication Date: 2017-05-25

Variant appearance in text: CD4: S375W

PubMed Link: 28461065

Variant Present in the following documents:

• Main text
• main.pdf

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Targeting cell surface HIV-1 Env protein to suppress infectious virus formation.

Virus Research

Bastian, Arangassery Rosemary AR; Ang, Charles G CG; Kamanna, Kantharaju K; Shaheen, Farida F; Huang, Yu-Hung YH; McFadden, Karyn K; Duffy, Caitlin C; Bailey, Lauren D LD; Sundaram, Ramalingam Venkat Kalyana RVK; Chaiken, Irwin I

Publication Date: 2017-05-02

Variant appearance in text: CD4: S375W

PubMed Link: 28390972

Variant Present in the following documents:

• Main text

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Influence of the Envelope gp120 Phe 43 Cavity on HIV-1 Sensitivity to Antibody-Dependent Cell-Mediated Cytotoxicity Responses.

Journal Of Virology

Prévost, Jérémie J; Zoubchenok, Daria D; Richard, Jonathan J; Veillette, Maxime M; Pacheco, Beatriz B; Coutu, Mathieu M; Brassard, Nathalie N; Parsons, Matthew S MS; Ruxrungtham, Kiat K; Bunupuradah, Torsak T; Tovanabutra, Sodsai S; Hwang, Kwan-Ki KK; Moody, M Anthony MA; Haynes, Barton F BF; Bonsignori, Mattia M; Sodroski, Joseph J; Kaufmann, Daniel E DE; Shaw, George M GM; Chenine, Agnès L AL; Finzi, Andrés A

Publication Date: 2017-04-01

Variant appearance in text: CD4: S375W

PubMed Link: 28100618

Variant Present in the following documents:

• Main text

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Residues in the gp41 Ectodomain Regulate HIV-1 Envelope Glycoprotein Conformational Transitions Induced by gp120-Directed Inhibitors.

Journal Of Virology

Pacheco, Beatriz B; Alsahafi, Nirmin N; Debbeche, Olfa O; Prévost, Jérémie J; Ding, Shilei S; Chapleau, Jean-Philippe JP; Herschhorn, Alon A; Madani, Navid N; Princiotto, Amy A; Melillo, Bruno B; Gu, Christopher C; Zeng, Xin X; Mao, Youdong Y; Smith, Amos B AB; Sodroski, Joseph J; Finzi, Andrés A

Publication Date: 2017-03-01

Variant appearance in text: CD4: S375W

PubMed Link: 28003492

Variant Present in the following documents:

• Main text

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Histidine 375 Modulates CD4 Binding in HIV-1 CRF01_AE Envelope Glycoproteins.

Journal Of Virology

Zoubchenok, Daria D; Veillette, Maxime M; Prévost, Jérémie J; Sanders-Buell, Eric E; Wagh, Kshitij K; Korber, Bette B; Chenine, Agnès L AL; Finzi, Andrés A

Publication Date: 2017-02-15

Variant appearance in text: CD4: S375W

PubMed Link: 27928014

Variant Present in the following documents:

• Main text

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The N14 anti-afamin antibody Fab: a rare VL1 CDR glycosylation, crystallographic re-sequencing, molecular plasticity and conservative versus enthusiastic modelling.

Acta Crystallographica. Section D, Structural Biology

Naschberger, Andreas A; Fürnrohr, Barbara G BG; Lenac Rovis, Tihana T; Malic, Suzana S; Scheffzek, Klaus K; Dieplinger, Hans H; Rupp, Bernhard B

Publication Date: 2016-12-01

Variant appearance in text: CD4: S375W

PubMed Link: 27917827

Variant Present in the following documents:

• d-72-01267-sup1.xlsx, sheet 1

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Activation and Inactivation of Primary Human Immunodeficiency Virus Envelope Glycoprotein Trimers by CD4-Mimetic Compounds.

Journal Of Virology

Madani, Navid N; Princiotto, Amy M AM; Zhao, Connie C; Jahanbakhshsefidi, Fatemeh F; Mertens, Max M; Herschhorn, Alon A; Melillo, Bruno B; Smith, Amos B AB; Sodroski, Joseph J

Publication Date: 2017-02-01

Variant appearance in text: CD4: S375W

PubMed Link: 27881646

Variant Present in the following documents:

• Main text

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Saturation Mutagenesis of the HIV-1 Envelope CD4 Binding Loop Reveals Residues Controlling Distinct Trimer Conformations.

Plos Pathogens

Duenas-Decamp, Maria M; Jiang, Li L; Bolon, Daniel D; Clapham, Paul R PR

Publication Date: 2016-11

Variant appearance in text: CD4: S375W

PubMed Link: 27820858

Variant Present in the following documents:

• Main text

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Structure of an N276-Dependent HIV-1 Neutralizing Antibody Targeting a Rare V5 Glycan Hole Adjacent to the CD4 Binding Site.

Journal Of Virology

Wibmer, Constantinos Kurt CK; Gorman, Jason J; Anthony, Colin S CS; Mkhize, Nonhlanhla N NN; Druz, Aliaksandr A; York, Talita T; Schmidt, Stephen D SD; Labuschagne, Phillip P; Louder, Mark K MK; Bailer, Robert T RT; Abdool Karim, Salim S SS; Mascola, John R JR; Williamson, Carolyn C; Moore, Penny L PL; Kwong, Peter D PD; Morris, Lynn L

Publication Date: 2016-11-15

Variant appearance in text: CD4: S375W

PubMed Link: 27581986

Variant Present in the following documents:

• Main text
• zjv10220.pdf

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Lineage-Specific Differences between the gp120 Inner Domain Layer 3 of Human Immunodeficiency Virus and That of Simian Immunodeficiency Virus.

Journal Of Virology

Ding, Shilei S; Medjahed, Halima H; Prévost, Jérémie J; Coutu, Mathieu M; Xiang, Shi-Hua SH; Finzi, Andrés A

Publication Date: 2016-11-15

Variant appearance in text: CD4: S375W

PubMed Link: 27535053

Variant Present in the following documents:

• Main text

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Antibodies Elicited by Multiple Envelope Glycoprotein Immunogens in Primates Neutralize Primary Human Immunodeficiency Viruses (HIV-1) Sensitized by CD4-Mimetic Compounds.

Journal Of Virology

Madani, Navid N; Princiotto, Amy M AM; Easterhoff, David D; Bradley, Todd T; Luo, Kan K; Williams, Wilton B WB; Liao, Hua-Xin HX; Moody, M Anthony MA; Phad, Ganesh E GE; Vázquez Bernat, Néstor N; Melillo, Bruno B; Santra, Sampa S; Smith, Amos B AB; Karlsson Hedestam, Gunilla B GB; Haynes, Barton B; Sodroski, Joseph J

Publication Date: 2016-05-15

Variant appearance in text: CD4: S375W

PubMed Link: 26962221

Variant Present in the following documents:

• Main text

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Peptide Triazole Inactivators of HIV-1 Utilize a Conserved Two-Cavity Binding Site at the Junction of the Inner and Outer Domains of Env gp120.

Journal Of Medicinal Chemistry

Aneja, Rachna R; Rashad, Adel A AA; Li, Huiyuan H; Kalyana Sundaram, Ramalingam Venkat RV; Duffy, Caitlin C; Bailey, Lauren D LD; Chaiken, Irwin I

Publication Date: 2015-05-14

Variant appearance in text: CD4: S375W

PubMed Link: 25860784

Variant Present in the following documents:

• Main text

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Effects of the I559P gp41 change on the conformation and function of the human immunodeficiency virus (HIV-1) membrane envelope glycoprotein trimer.

Plos One

Alsahafi, Nirmin N; Debbeche, Olfa O; Sodroski, Joseph J; Finzi, Andrés A

Publication Date: 2015

Variant appearance in text: CD4: S375W

PubMed Link: 25849367

Variant Present in the following documents:

• Main text
• pone.0122111.pdf

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Mechanism of multivalent nanoparticle encounter with HIV-1 for potency enhancement of peptide triazole virus inactivation.

The Journal Of Biological Chemistry

Rosemary Bastian, Arangassery A; Nangarlia, Aakansha A; Bailey, Lauren D LD; Holmes, Andrew A; Kalyana Sundaram, R Venkat RV; Ang, Charles C; Moreira, Diogo R M DR; Freedman, Kevin K; Duffy, Caitlin C; Contarino, Mark M; Abrams, Cameron C; Root, Michael M; Chaiken, Irwin I

Publication Date: 2015-01-02

Variant appearance in text: CD4: S375W

PubMed Link: 25371202

Variant Present in the following documents:

• Main text

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Conformational evaluation of HIV-1 trimeric envelope glycoproteins using a cell-based ELISA assay.

Journal Of Visualized Experiments : Jove

Veillette, Maxime M; Coutu, Mathieu M; Richard, Jonathan J; Batraville, Laurie-Anne LA; Désormeaux, Anik A; Roger, Michel M; Finzi, Andrés A

Publication Date: 2014-09-14

Variant appearance in text: CD4: S375W

PubMed Link: 25286159

Variant Present in the following documents:

• Main text

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CD4-mimetic small molecules sensitize human immunodeficiency virus to vaccine-elicited antibodies.

Journal Of Virology

Madani, Navid N; Princiotto, Amy M AM; Schön, Arne A; LaLonde, Judith J; Feng, Yu Y; Freire, Ernesto E; Park, Jongwoo J; Courter, Joel R JR; Jones, David M DM; Robinson, James J; Liao, Hua-Xin HX; Moody, M Anthony MA; Permar, Sallie S; Haynes, Barton B; Smith, Amos B AB; Wyatt, Richard R; Sodroski, Joseph J

Publication Date: 2014-06

Variant appearance in text: CD4: S375W

PubMed Link: 24696475

Variant Present in the following documents:

• Main text

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Structure-based design, synthesis and validation of CD4-mimetic small molecule inhibitors of HIV-1 entry: conversion of a viral entry agonist to an antagonist.

Accounts Of Chemical Research

Courter, Joel R JR; Madani, Navid N; Sodroski, Joseph J; Schön, Arne A; Freire, Ernesto E; Kwong, Peter D PD; Hendrickson, Wayne A WA; Chaiken, Irwin M IM; LaLonde, Judith M JM; Smith, Amos B AB

Publication Date: 2014-04-15

Variant appearance in text: CD4: S375W

PubMed Link: 24502450

Variant Present in the following documents:

• Main text

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Crystal structures of HIV-1 gp120 envelope glycoprotein in complex with NBD analogues that target the CD4-binding site.

Plos One

Kwon, Young Do YD; LaLonde, Judith M JM; Yang, Yongping Y; Elban, Mark A MA; Sugawara, Akihiro A; Courter, Joel R JR; Jones, David M DM; Smith, Amos B AB; Debnath, Asim K AK; Kwong, Peter D PD

Publication Date: 2014

Variant appearance in text: CD4: S375W

PubMed Link: 24489681

Variant Present in the following documents:

• Main text

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Interaction with cellular CD4 exposes HIV-1 envelope epitopes targeted by antibody-dependent cell-mediated cytotoxicity.

Journal Of Virology

Veillette, Maxime M; Désormeaux, Anik A; Medjahed, Halima H; Gharsallah, Nour-Elhouda NE; Coutu, Mathieu M; Baalwa, Joshua J; Guan, Yongjun Y; Lewis, George G; Ferrari, Guido G; Hahn, Beatrice H BH; Haynes, Barton F BF; Robinson, James E JE; Kaufmann, Daniel E DE; Bonsignori, Mattia M; Sodroski, Joseph J; Finzi, Andrés A

Publication Date: 2014-03

Variant appearance in text: CD4: S375W

PubMed Link: 24352444

Variant Present in the following documents:

• Main text

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Allosteric induction of the CD4-bound conformation of HIV-1 Gp120.

Retrovirology

Roitburd-Berman, Anna A; Dela, Gal G; Kaplan, Gilad G; Lewis, George K GK; Gershoni, Jonathan M JM

Publication Date: 2013-12-05

Variant appearance in text: CD4: S375W

PubMed Link: 24304511

Variant Present in the following documents:

• 1742-4690-10-147.pdf

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Blocking HIV-1 gp120 at the Phe43 cavity: if the extension fits….

Structure (London, England : 1993)

Dey, Barna B; Berger, Edward A EA

Publication Date: 2013-06-04

Variant appearance in text: CD4: S375W

PubMed Link: 23747109

Variant Present in the following documents:

• Main text

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A model of peptide triazole entry inhibitor binding to HIV-1 gp120 and the mechanism of bridging sheet disruption.

Biochemistry

Emileh, Ali A; Tuzer, Ferit F; Yeh, Herman H; Umashankara, Muddegowda M; Moreira, Diogo R M DR; Lalonde, Judith M JM; Bewley, Carole A CA; Abrams, Cameron F CF; Chaiken, Irwin M IM

Publication Date: 2013-04-02

Variant appearance in text: CD4: S375W

PubMed Link: 23470147

Variant Present in the following documents:

• Main text

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Design of an Escherichia coli expressed HIV-1 gp120 fragment immunogen that binds to b12 and induces broad and potent neutralizing antibodies.

The Journal Of Biological Chemistry

Bhattacharyya, Sanchari S; Singh, Pranveer P; Rathore, Ujjwal U; Purwar, Mansi M; Wagner, Denise D; Arendt, Heather H; DeStefano, Joanne J; LaBranche, Celia C CC; Montefiori, David C DC; Phogat, Sanjay S; Varadarajan, Raghavan R

Publication Date: 2013-04-05

Variant appearance in text: CD4: S375W

PubMed Link: 23430741

Variant Present in the following documents:

• Main text

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Escape from human immunodeficiency virus type 1 (HIV-1) entry inhibitors.

Viruses

De Feo, Christopher J CJ; Weiss, Carol D CD

Publication Date: 2012-12

Variant appearance in text: CD4: S375W

PubMed Link: 23342377

Variant Present in the following documents:

• Main text

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Structural plasticity and conformational transitions of HIV envelope glycoprotein gp120.

Plos One

Korkut, Anil A; Hendrickson, Wayne A WA

Publication Date: 2012

Variant appearance in text: CD4: S375W

PubMed Link: 23300605

Variant Present in the following documents:

• Main text

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The highly conserved layer-3 component of the HIV-1 gp120 inner domain is critical for CD4-required conformational transitions.

Journal Of Virology

Désormeaux, Anik A; Coutu, Mathieu M; Medjahed, Halima H; Pacheco, Beatriz B; Herschhorn, Alon A; Gu, Christopher C; Xiang, Shi-Hua SH; Mao, Youdong Y; Sodroski, Joseph J; Finzi, Andrés A

Publication Date: 2013-03

Variant appearance in text: CD4: S375W

PubMed Link: 23255784

Variant Present in the following documents:

• Main text

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CD4 binding determinant mimicry for HIV vaccine design.

Frontiers In Immunology

Nishiyama, Yasuhiro Y; Planque, Stephanie S; Hanson, Carl V CV; Massey, Richard J RJ; Paul, Sudhir S

Publication Date: 2012

Variant appearance in text: CD4: S375W

PubMed Link: 23251137

Variant Present in the following documents:

• Main text

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Optimization of CD4/gp120 inhibitors by thermodynamic-guided alanine-scanning mutagenesis.

Chemical Biology & Drug Design

Liu, Yingyun Y; Schön, Arne A; Freire, Ernesto E

Publication Date: 2013-01

Variant appearance in text: CD4: S375W

PubMed Link: 23066870

Variant Present in the following documents:

• Main text

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Spontaneous rearrangement of the β20/β21 strands in simulations of unliganded HIV-1 glycoprotein, gp120.

Biochemistry

Shrivastava, Indira H IH; Wendel, Kaylee K; LaLonde, Judith M JM

Publication Date: 2012-10-02

Variant appearance in text: CD4: S375W

PubMed Link: 22963284

Variant Present in the following documents:

• Main text

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Lineage-specific differences between human and simian immunodeficiency virus regulation of gp120 trimer association and CD4 binding.

Journal Of Virology

Finzi, Andrés A; Pacheco, Beatriz B; Xiang, Shi-Hua SH; Pancera, Marie M; Herschhorn, Alon A; Wang, Liping L; Zeng, Xing X; Desormeaux, Anik A; Kwong, Peter D PD; Sodroski, Joseph J

Publication Date: 2012-09

Variant appearance in text: CD4: S375W

PubMed Link: 22696649

Variant Present in the following documents:

• Main text

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HIV gp120 H375 is unique to HIV-1 subtype CRF01_AE and confers strong resistance to the entry inhibitor BMS-599793, a candidate microbicide drug.

Antimicrobial Agents And Chemotherapy

Schader, Susan M SM; Colby-Germinario, Susan P SP; Quashie, Peter K PK; Oliveira, Maureen M; Ibanescu, Ruxandra-Ilinca RI; Moisi, Daniela D; Mespléde, Thibault T; Wainberg, Mark A MA

Publication Date: 2012-08

Variant appearance in text: CD4: S375W

PubMed Link: 22615295

Variant Present in the following documents:

• Main text

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MiniCD4 protein resistance mutations affect binding to the HIV-1 gp120 CD4 binding site and decrease entry efficiency.

Retrovirology

Grupping, Katrijn K; Selhorst, Philippe P; Michiels, Johan J; Vereecken, Katleen K; Heyndrickx, Leo L; Kessler, Pascal P; Vanham, Guido G; Martin, Loïc L; Ariën, Kevin K KK

Publication Date: 2012-05-02

Variant appearance in text: CD4: S375W

PubMed Link: 22551420

Variant Present in the following documents:

• 1742-4690-9-36.pdf

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Structure-based design, synthesis, and characterization of dual hotspot small-molecule HIV-1 entry inhibitors.

Journal Of Medicinal Chemistry

LaLonde, Judith M JM; Kwon, Young Do YD; Jones, David M DM; Sun, Alexander W AW; Courter, Joel R JR; Soeta, Takahiro T; Kobayashi, Toyoharu T; Princiotto, Amy M AM; Wu, Xueling X; Schön, Arne A; Freire, Ernesto E; Kwong, Peter D PD; Mascola, John R JR; Sodroski, Joseph J; Madani, Navid N; Smith, Amos B AB

Publication Date: 2012-05-10

Variant appearance in text: CD4: S375W

PubMed Link: 22497421

Variant Present in the following documents:

• Main text

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Unliganded HIV-1 gp120 core structures assume the CD4-bound conformation with regulation by quaternary interactions and variable loops.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Kwon, Young Do YD; Finzi, Andrés A; Wu, Xueling X; Dogo-Isonagie, Cajetan C; Lee, Lawrence K LK; Moore, Lucas R LR; Schmidt, Stephen D SD; Stuckey, Jonathan J; Yang, Yongping Y; Zhou, Tongqing T; Zhu, Jiang J; Vicic, David A DA; Debnath, Asim K AK; Shapiro, Lawrence L; Bewley, Carole A CA; Mascola, John R JR; Sodroski, Joseph G JG; Kwong, Peter D PD

Publication Date: 2012-04-10

Variant appearance in text: CD4: S375W

PubMed Link: 22451932

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Biochemically defined HIV-1 envelope glycoprotein variant immunogens display differential binding and neutralizing specificities to the CD4-binding site.

The Journal Of Biological Chemistry

Feng, Yu Y; McKee, Krisha K; Tran, Karen K; O'Dell, Sijy S; Schmidt, Stephen D SD; Phogat, Adhuna A; Forsell, Mattias N MN; Karlsson Hedestam, Gunilla B GB; Mascola, John R JR; Wyatt, Richard T RT

Publication Date: 2012-02-17

Variant appearance in text: CD4: S375W

PubMed Link: 22167180

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Contribution of intrinsic reactivity of the HIV-1 envelope glycoproteins to CD4-independent infection and global inhibitor sensitivity.

Plos Pathogens

Haim, Hillel H; Strack, Bettina B; Kassa, Aemro A; Madani, Navid N; Wang, Liping L; Courter, Joel R JR; Princiotto, Amy A; McGee, Kathleen K; Pacheco, Beatriz B; Seaman, Michael S MS; Smith, Amos B AB; Sodroski, Joseph J

Publication Date: 2011-06

Variant appearance in text: CD4: S375W

PubMed Link: 21731494

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Enhanced dynamics of HIV gp120 glycoprotein by small molecule binding.

Biochemistry

Shrivastava, Indira I; LaLonde, Judith M JM

Publication Date: 2011-05-17

Variant appearance in text: CD4: S375W

PubMed Link: 21488663

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• Main text

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Conformational and structural features of HIV-1 gp120 underlying the dual receptor antagonism by cross-reactive neutralizing antibody m18.

Biochemistry

Gift, Syna Kuriakose SK; Zentner, Isaac J IJ; Schön, Arne A; McFadden, Karyn K; Umashankara, M M; Rajagopal, Srivats S; Contarino, Mark M; Duffy, Caitlin C; Courter, Joel R JR; Zhang, Mei-Yun MY; Gershoni, Jonathan M JM; Cocklin, Simon S; Dimitrov, Dimiter S DS; Smith, Amos B AB; Freire, Ernesto E; Chaiken, Irwin M IM

Publication Date: 2011-04-12

Variant appearance in text: CD4: S375W

PubMed Link: 21351734

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A mechanism by which binding of the broadly neutralizing antibody b12 unfolds the inner domain α1 helix in an engineered HIV-1 gp120.

Proteins

Emileh, Ali A; Abrams, Cameron F CF

Publication Date: 2011-02

Variant appearance in text: CD4: S375W

PubMed Link: 21117239

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In vivo patterns of resistance to the HIV attachment inhibitor BMS-488043.

Antimicrobial Agents And Chemotherapy

Zhou, Nannan N; Nowicka-Sans, Beata B; Zhang, Sharon S; Fan, Li L; Fang, Jie J; Fang, Hua H; Gong, Yi-Fei YF; Eggers, Betsy B; Langley, David R DR; Wang, Tao T; Kadow, John J; Grasela, Dennis D; Hanna, George J GJ; Alexander, Louis L; Colonno, Richard R; Krystal, Mark M; Lin, Pin-Fang PF

Publication Date: 2011-02

Variant appearance in text: CD4: S375W

PubMed Link: 21078948

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Fluctuation dynamics analysis of gp120 envelope protein reveals a topologically based communication network.

Proteins

Shrivastava, Indira I; LaLonde, Judith M JM

Publication Date: 2010-11-01

Variant appearance in text: CD4: S375W

PubMed Link: 20718047

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Structural basis for broad and potent neutralization of HIV-1 by antibody VRC01.

Science (New York, N.Y.)

Zhou, Tongqing T; Georgiev, Ivelin I; Wu, Xueling X; Yang, Zhi-Yong ZY; Dai, Kaifan K; Finzi, Andrés A; Kwon, Young Do YD; Scheid, Johannes F JF; Shi, Wei W; Xu, Ling L; Yang, Yongping Y; Zhu, Jiang J; Nussenzweig, Michel C MC; Sodroski, Joseph J; Shapiro, Lawrence L; Nabel, Gary J GJ; Mascola, John R JR; Kwong, Peter D PD

Publication Date: 2010-08-13

Variant appearance in text: CD4: Ser375Trp

PubMed Link: 20616231

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Enhanced exposure of human immunodeficiency virus type 1 primary isolate neutralization epitopes through binding of CD4 mimetic compounds.

Journal Of Virology

Yoshimura, Kazuhisa K; Harada, Shigeyoshi S; Shibata, Junji J; Hatada, Makiko M; Yamada, Yuko Y; Ochiai, Chihiro C; Tamamura, Hirokazu H; Matsushita, Shuzo S

Publication Date: 2010-08

Variant appearance in text: CD4: S375W

PubMed Link: 20504942

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Conformational characterization of aberrant disulfide-linked HIV-1 gp120 dimers secreted from overexpressing cells.

Journal Of Virological Methods

Finzi, Andrés A; Pacheco, Beatriz B; Zeng, Xin X; Kwon, Young Do YD; Kwong, Peter D PD; Sodroski, Joseph J

Publication Date: 2010-09

Variant appearance in text: CD4: S375W

PubMed Link: 20471426

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Characterization of a discontinuous epitope of the HIV envelope protein gp120 recognized by a human monoclonal antibody using chemical modification and mass spectrometric analysis.

Journal Of The American Society For Mass Spectrometry

Hager-Braun, Christine C; Hochleitner, Elisabeth O EO; Gorny, Miroslaw K MK; Zolla-Pazner, Susan S; Bienstock, Rachelle J RJ; Tomer, Kenneth B KB

Publication Date: 2010-10

Variant appearance in text: CD4: S375W

PubMed Link: 20434359

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Tamoxifen enhances the Hsp90 molecular chaperone ATPase activity.

Plos One

Zhao, Rongmin R; Leung, Elisa E; Grüner, Stefan S; Schapira, Matthieu M; Houry, Walid A WA

Publication Date: 2010-04-01

Variant appearance in text: CD4: S375W

PubMed Link: 20376192

Variant Present in the following documents:

• pone.0009934.s001.xls, sheet 1

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Topological layers in the HIV-1 gp120 inner domain regulate gp41 interaction and CD4-triggered conformational transitions.

Molecular Cell

Finzi, Andrés A; Xiang, Shi-Hua SH; Pacheco, Beatriz B; Wang, Liping L; Haight, Jessica J; Kassa, Aemro A; Danek, Brenda B; Pancera, Marie M; Kwong, Peter D PD; Sodroski, Joseph J

Publication Date: 2010-03-12

Variant appearance in text: CD4: S375W

PubMed Link: 20227370

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A V3 loop-dependent gp120 element disrupted by CD4 binding stabilizes the human immunodeficiency virus envelope glycoprotein trimer.

Journal Of Virology

Xiang, Shi-Hua SH; Finzi, Andrés A; Pacheco, Beatriz B; Alexander, Kevin K; Yuan, Wen W; Rizzuto, Carlo C; Huang, Chih-Chin CC; Kwong, Peter D PD; Sodroski, Joseph J

Publication Date: 2010-04

Variant appearance in text: CD4: S375W

PubMed Link: 20089638

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Structure of HIV-1 gp120 with gp41-interactive region reveals layered envelope architecture and basis of conformational mobility.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Pancera, Marie M; Majeed, Shahzad S; Ban, Yih-En Andrew YE; Chen, Lei L; Huang, Chih-chin CC; Kong, Leopold L; Kwon, Young Do YD; Stuckey, Jonathan J; Zhou, Tongqing T; Robinson, James E JE; Schief, William R WR; Sodroski, Joseph J; Wyatt, Richard R; Kwong, Peter D PD

Publication Date: 2010-01-19

Variant appearance in text: CD4: S375W

PubMed Link: 20080564

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Epitopes for broad and potent neutralizing antibody responses during chronic infection with human immunodeficiency virus type 1.

Virology

Nandi, Avishek A; Lavine, Christine L CL; Wang, Pengcheng P; Lipchina, Inna I; Goepfert, Paul A PA; Shaw, George M GM; Tomaras, Georgia D GD; Montefiori, David C DC; Haynes, Barton F BF; Easterbrook, Philippa P; Robinson, James E JE; Sodroski, Joseph G JG; Yang, Xinzhen X; ,

Publication Date: 2010-01-20

Variant appearance in text: CD4: S375W

PubMed Link: 19922969

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Identification of a human immunodeficiency virus type 1 envelope glycoprotein variant resistant to cold inactivation.

Journal Of Virology

Kassa, Aemro A; Finzi, Andrés A; Pancera, Marie M; Courter, Joel R JR; Smith, Amos B AB; Sodroski, Joseph J

Publication Date: 2009-05

Variant appearance in text: CD4: S375W

PubMed Link: 19211747

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Human immunodeficiency virus type 1 env trimer immunization of macaques and impact of priming with viral vector or stabilized core protein.

Journal Of Virology

Mörner, Andreas A; Douagi, Iyadh I; Forsell, Mattias N E MN; Sundling, Christopher C; Dosenovic, Pia P; O'Dell, Sijy S; Dey, Barna B; Kwong, Peter D PD; Voss, Gerald G; Thorstensson, Rigmor R; Mascola, John R JR; Wyatt, Richard T RT; Karlsson Hedestam, Gunilla B GB

Publication Date: 2009-01

Variant appearance in text: CD4: S375W

PubMed Link: 19004960

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Small-molecule CD4 mimics interact with a highly conserved pocket on HIV-1 gp120.

Structure (London, England : 1993)

Madani, Navid N; Schön, Arne A; Princiotto, Amy M AM; Lalonde, Judith M JM; Courter, Joel R JR; Soeta, Takahiro T; Ng, Danny D; Wang, Liping L; Brower, Evan T ET; Xiang, Shi-Hua SH; Kwon, Young Do YD; Huang, Chih-Chin CC; Wyatt, Richard R; Kwong, Peter D PD; Freire, Ernesto E; Smith, Amos B AB; Sodroski, Joseph J

Publication Date: 2008-11-12

Variant appearance in text: CD4: S375W

PubMed Link: 19000821

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Structure-activity relationships in the binding of chemically derivatized CD4 to gp120 from human immunodeficiency virus.

Journal Of Medicinal Chemistry

Xie, Hui H; Ng, Danny D; Savinov, Sergey N SN; Dey, Barna B; Kwong, Peter D PD; Wyatt, Richard R; Smith, Amos B AB; Hendrickson, Wayne A WA

Publication Date: 2007-10-04

Variant appearance in text: CD4: S375W

PubMed Link: 17803292

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Characterization of human immunodeficiency virus type 1 monomeric and trimeric gp120 glycoproteins stabilized in the CD4-bound state: antigenicity, biophysics, and immunogenicity.

Journal Of Virology

Dey, Barna B; Pancera, Marie M; Svehla, Krisha K; Shu, Yuuei Y; Xiang, Shi-Hua SH; Vainshtein, Jeffrey J; Li, Yuxing Y; Sodroski, Joseph J; Kwong, Peter D PD; Mascola, John R JR; Wyatt, Richard R

Publication Date: 2007-06

Variant appearance in text: CD4: S375W

PubMed Link: 17360741

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Comparing antigenicity and immunogenicity of engineered gp120.

Journal Of Virology

Selvarajah, Suganya S; Puffer, Bridget B; Pantophlet, Ralph R; Law, Mansun M; Doms, Robert W RW; Burton, Dennis R DR

Publication Date: 2005-10

Variant appearance in text: CD4: S375W

PubMed Link: 16160142

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A high-throughput fluorescence polarization assay specific to the CD4 binding site of HIV-1 glycoproteins based on a fluorescein-labelled CD4 mimic.

The Biochemical Journal

Stricher, François F; Martin, Loïc L; Barthe, Philippe P; Pogenberg, Vivian V; Mechulam, Alain A; Menez, André A; Roumestand, Christian C; Veas, Francisco F; Royer, Catherine C; Vita, Claudio C

Publication Date: 2005-08-15

Variant appearance in text: CD4: S375W

PubMed Link: 15836438

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Stoichiometry of antibody neutralization of human immunodeficiency virus type 1.

Journal Of Virology

Yang, Xinzhen X; Kurteva, Svetla S; Lee, Sandra S; Sodroski, Joseph J

Publication Date: 2005-03

Variant appearance in text: CD4: S375W

PubMed Link: 15731244

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Localized changes in the gp120 envelope glycoprotein confer resistance to human immunodeficiency virus entry inhibitors BMS-806 and #155.

Journal Of Virology

Madani, Navid N; Perdigoto, Ana Luisa AL; Srinivasan, Kumar K; Cox, Jason M JM; Chruma, Jason J JJ; LaLonde, Judith J; Head, Martha M; Smith, Amos B AB; Sodroski, Joseph G JG

Publication Date: 2004-04

Variant appearance in text: CD4: S375W

PubMed Link: 15016894

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Intrapatient alterations in the human immunodeficiency virus type 1 gp120 V1V2 and V3 regions differentially modulate coreceptor usage, virus inhibition by CC/CXC chemokines, soluble CD4, and the b12 and 2G12 monoclonal antibodies.

Journal Of Virology

Nabatov, Alexey A AA; Pollakis, Georgios G; Linnemann, Thomas T; Kliphius, Aletta A; Chalaby, Moustapha I M MI; Paxton, William A WA

Publication Date: 2004-01

Variant appearance in text: CD4: S375W

PubMed Link: 14671134

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Biochemical and genetic characterizations of a novel human immunodeficiency virus type 1 inhibitor that blocks gp120-CD4 interactions.

Journal Of Virology

Guo, Qi Q; Ho, Hsu-Tso HT; Dicker, Ira I; Fan, Li L; Zhou, Nannan N; Friborg, Jacques J; Wang, Tao T; McAuliffe, Brian V BV; Wang, Hwei-Gene Heidi HG; Rose, Ronald E RE; Fang, Hua H; Scarnati, Helen T HT; Langley, David R DR; Meanwell, Nicholas A NA; Abraham, Ralph R; Colonno, Richard J RJ; Lin, Pin-Fang PF

Publication Date: 2003-10

Variant appearance in text: CD4: S375W

PubMed Link: 12970437

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