TPH2 c.608+9108T>C

Variant ID: 12-72352543-T-C

NM_173353.3(TPH2):c.608+9108T>C

This variant was identified in 33 publications

View GRCh38 version.




Publications:


Impact of genetic variants within serotonin turnover enzymes on human cerebral monoamine oxidase A in vivo.

Translational Psychiatry
Spies, Marie M; Murgaš, Matej M; Vraka, Chrysoula C; Philippe, Cecile C; Gryglewski, Gregor G; Nics, Lukas L; Balber, Theresa T; Baldinger-Melich, Pia P; Hartmann, Annette M AM; Rujescu, Dan D; Hacker, Marcus M; Winkler-Pjrek, Edda E; Winkler, Dietmar D; Lanzenberger, Rupert R
Publication Date: 2023-06-15

Variant appearance in text: rs1386494
PubMed Link: 37322010
Variant Present in the following documents:
  • Main text
  • 41398_2023_Article_2506.pdf
View BVdb publication page



Early antidepressant treatment response prediction in major depression using clinical and TPH2 DNA methylation features based on machine learning approaches.

Bmc Psychiatry
Chen, Bingwei B; Jiao, Zhigang Z; Shen, Tian T; Fan, Ru R; Chen, Yuqi Y; Xu, Zhi Z
Publication Date: 2023-05-01

Variant appearance in text: rs1386494
PubMed Link: 37127594
Variant Present in the following documents:
  • Main text
  • 12888_2023_Article_4791.pdf
View BVdb publication page



Genetic regulation of newborn telomere length is mediated and modified by DNA methylation.

Frontiers In Genetics
Wang, Congrong C; Alfano, Rossella R; Reimann, Brigitte B; Hogervorst, Janneke J; Bustamante, Mariona M; De Vivo, Immaculata I; Plusquin, Michelle M; Nawrot, Tim S TS; Martens, Dries S DS
Publication Date: 2022

Variant appearance in text: rs1386494
PubMed Link: 36267401
Variant Present in the following documents:
  • Main text
  • fgene-13-934277.pdf
View BVdb publication page



The interplay of pineal hormones and socioeconomic status leading to colorectal cancer disparity.

Translational Oncology
Haynes, Talaijha T; Oprea-Ilies, Gabriela G; Manne, Upender U; Singh, Rajesh R; Singh, Shailesh S; Mir, Hina H
Publication Date: 2022-01-03

Variant appearance in text: rs1386494
PubMed Link: 34990909
Variant Present in the following documents:
  • Main text
  • main.pdf
View BVdb publication page



The interplay of pineal hormones and socioeconomic status leading to colorectal cancer disparity.

Translational Oncology
Haynes, Talaijha T; Oprea-Ilies, Gabriela G; Manne, Upender U; Singh, Rajesh R; Singh, Shailesh S; Mir, Hina H
Publication Date: 2022-02

Variant appearance in text: rs1386494
PubMed Link: 34990909
Variant Present in the following documents:
  • Main text
  • main.pdf
View BVdb publication page



The 5-HTTLPR-rs25531 S-A-S-A Haplotype and Chronic Stress Moderate the Association Between Acute Stress and Internalizing Mental Disorders Among HIV+ Children and Adolescents in Uganda.

Frontiers In Genetics
Kalungi, Allan A; Womersley, Jacqueline S JS; Kinyanda, Eugene E; Joloba, Moses L ML; Ssembajjwe, Wilber W; Nsubuga, Rebecca N RN; Seedat, Soraya S; Hemmings, Sian M J SMJ
Publication Date: 2021

Variant appearance in text: rs1386494
PubMed Link: 33968131
Variant Present in the following documents:
  • Main text
View BVdb publication page



TPH-2 Gene Polymorphism in Major Depressive Disorder Patients With Early-Wakening Symptom.

Frontiers In Neuroscience
Tao, Shiwan S; Chattun, Mohammad Ridwan MR; Yan, Rui R; Geng, Jiting J; Zhu, Rongxin R; Shao, Junneng J; Lu, Qing Q; Yao, Zhijian Z
Publication Date: 2018

Variant appearance in text: rs1386494
PubMed Link: 30519155
Variant Present in the following documents:
  • Main text
  • fnins-12-00827.pdf
View BVdb publication page



Association between single nucleotide polymorphisms of TPH1 and TPH2 genes, and depressive disorders.

Journal Of Cellular And Molecular Medicine
Wigner, Paulina P; Czarny, Piotr P; Synowiec, Ewelina E; Bijak, Michał M; Białek, Katarzyna K; Talarowska, Monika M; Galecki, Piotr P; Szemraj, Janusz J; Sliwinski, Tomasz T
Publication Date: 2018-03

Variant appearance in text: TPH2: 608+9108T>C; rs1386494
PubMed Link: 29314569
Variant Present in the following documents:
  • Main text
  • JCMM-22-1778.pdf
View BVdb publication page



The Life Span Model of Suicide and Its Neurobiological Foundation.

Frontiers In Neuroscience
Ludwig, Birgit B; Roy, Bhaskar B; Wang, Qingzhong Q; Birur, Badari B; Dwivedi, Yogesh Y
Publication Date: 2017

Variant appearance in text: rs1386494
PubMed Link: 28261051
Variant Present in the following documents:
  • Main text
  • fnins-11-00074.pdf
View BVdb publication page



Association of tryptophan hydroxylase-2 polymorphisms with oppositional defiant disorder in a Chinese Han population.

Behavioral And Brain Functions : Bbf
Wang, Chang-Hong CH; Liu, Cong C; Cong, En-Zhao EZ; Xu, Gai-Ling GL; Lv, Ting-Ting TT; Zhang, Ying-Li YL; Ning, Qiu-Fen QF; Wang, Ji-Kang JK; Nie, Hui-Yao HY; Li, Yan Y
Publication Date: 2016-11-21

Variant appearance in text: rs1386494
PubMed Link: 27871272
Variant Present in the following documents:
  • Main text
View BVdb publication page



Sex differences modulating serotonergic polymorphisms implicated in the mechanistic pathways of risk for depression and related disorders.

Journal Of Neuroscience Research
Perry, LeeAnn M LM; Goldstein-Piekarski, Andrea N AN; Williams, Leanne M LM
Publication Date: 2017-01-02

Variant appearance in text: rs1386494
PubMed Link: 27870440
Variant Present in the following documents:
  • Main text
View BVdb publication page



Genetic Association Studies of Suicidal Behavior: A Review of the Past 10 Years, Progress, Limitations, and Future Directions.

Frontiers In Psychiatry
Mirkovic, Bojan B; Laurent, Claudine C; Podlipski, Marc-Antoine MA; Frebourg, Thierry T; Cohen, David D; Gerardin, Priscille P
Publication Date: 2016

Variant appearance in text: rs1386494
PubMed Link: 27721799
Variant Present in the following documents:
  • Main text
View BVdb publication page



TPH-2 Polymorphisms Interact with Early Life Stress to Influence Response to Treatment with Antidepressant Drugs.

The International Journal Of Neuropsychopharmacology
Xu, Zhi Z; Reynolds, Gavin P GP; Yuan, Yonggui Y; Shi, Yanyan Y; Pu, Mengjia M; Zhang, Zhijun Z
Publication Date: 2016-11

Variant appearance in text: rs1386494
PubMed Link: 27521242
Variant Present in the following documents:
  • Main text
  • pyw070.pdf
View BVdb publication page



Association Study of Genotype by Depressive Response during Tryptophan Depletion in Subjects Recovered from Major Depression.

Molecular Neuropsychiatry
Moreno, Francisco A FA; Erickson, Robert P RP; Garriock, Holly A HA; Gelernter, Joel J; Mintz, Jim J; Oas-Terpstra, Jennifer J; Davies, Marilyn A MA; Delgado, Pedro L PL
Publication Date: 2015-10

Variant appearance in text: rs1386494
PubMed Link: 26528486
Variant Present in the following documents:
  • Main text
View BVdb publication page



The neurobiology of suicide - A Review of post-mortem studies.

Journal Of Molecular Psychiatry
Furczyk, Karolina K; Schutová, Barbora B; Michel, Tanja M TM; Thome, Johannes J; Büttner, Andreas A
Publication Date: 2013

Variant appearance in text: rs1386494
PubMed Link: 25408895
Variant Present in the following documents:
  • Main text
View BVdb publication page



Research in China on the molecular genetics of schizophrenia.

Shanghai Archives Of Psychiatry
Cui, Donghong D; Jiang, Kaida K
Publication Date: 2012-08

Variant appearance in text: rs1386494
PubMed Link: 25324626
Variant Present in the following documents:
  • sap-24-04-187.pdf
View BVdb publication page



Association between serotonin cumulative genetic score and the Behavioral Approach System (BAS): Moderation by early life environment.

Personality And Individual Differences
Pearson, Rahel R; McGeary, John E JE; Beevers, Christopher G CG
Publication Date: 2014-11-01

Variant appearance in text: rs1386494
PubMed Link: 25264393
Variant Present in the following documents:
  • Main text
View BVdb publication page



Toward a biosignature for suicide.

The American Journal Of Psychiatry
Oquendo, Maria A MA; Sullivan, Gregory M GM; Sudol, Katherin K; Baca-Garcia, Enrique E; Stanley, Barbara H BH; Sublette, M Elizabeth ME; Mann, J John JJ
Publication Date: 2014-12-01

Variant appearance in text: rs1386494
PubMed Link: 25263730
Variant Present in the following documents:
  • Main text
View BVdb publication page



Association of TPH-1 and TPH-2 gene polymorphisms with suicidal behavior: a systematic review and meta-analysis.

Bmc Psychiatry
González-Castro, Thelma Beatriz TB; Juárez-Rojop, Isela I; López-Narváez, María Lilia ML; Tovilla-Zárate, Carlos Alfonso CA
Publication Date: 2014-07-08

Variant appearance in text: rs1386494
PubMed Link: 25005534
Variant Present in the following documents:
  • Main text
  • 1471-244X-14-196.pdf
View BVdb publication page



Social disadvantage, genetic sensitivity, and children's telomere length.

Proceedings Of The National Academy Of Sciences Of The United States Of America
Mitchell, Colter C; Hobcraft, John J; McLanahan, Sara S SS; Siegel, Susan Rutherford SR; Berg, Arthur A; Brooks-Gunn, Jeanne J; Garfinkel, Irwin I; Notterman, Daniel D
Publication Date: 2014-04-22

Variant appearance in text: rs1386494
PubMed Link: 24711381
Variant Present in the following documents:
  • Main text
View BVdb publication page



5-HTTLPR, HTR1A, and HTR2A cumulative genetic score interacts with mood reactivity to predict mood-congruent gaze bias.

Cognitive, Affective & Behavioral Neuroscience
Disner, Seth G SG; McGeary, John E JE; Wells, Tony T TT; Ellis, Alissa J AJ; Beevers, Christopher G CG
Publication Date: 2014-12

Variant appearance in text: rs1386494
PubMed Link: 24643765
Variant Present in the following documents:
  • Main text
View BVdb publication page



Personalized medicine in psychiatry: problems and promises.

Bmc Medicine
Ozomaro, Uzoezi U; Wahlestedt, Claes C; Nemeroff, Charles B CB
Publication Date: 2013-05-16

Variant appearance in text: rs1386494
PubMed Link: 23680237
Variant Present in the following documents:
  • Main text
  • 1741-7015-11-132.pdf
View BVdb publication page



The role of the serotonergic system at the interface of aggression and suicide.

Neuroscience
Bortolato, M M; Pivac, N N; Muck Seler, D D; Nikolac Perkovic, M M; Pessia, M M; Di Giovanni, G G
Publication Date: 2013-04-16

Variant appearance in text: rs1386494
PubMed Link: 23333677
Variant Present in the following documents:
  • Main text
View BVdb publication page



A survey of putative anxiety-associated genes in panic disorder patients with and without bladder symptoms.

Psychiatric Genetics
Subaran, Ryan L RL; Talati, Ardesheer A; Hamilton, Steven P SP; Adams, Phillip P; Weissman, Myrna M MM; Fyer, Abby J AJ; Hodge, Susan E SE
Publication Date: 2012-12

Variant appearance in text: rs1386494
PubMed Link: 23018769
Variant Present in the following documents:
  • Main text
View BVdb publication page



TPH2 gene polymorphisms and major depression--a meta-analysis.

Plos One
Gao, Jin J; Pan, Zhenglun Z; Jiao, Zhian Z; Li, Feng F; Zhao, Guoqing G; Wei, Qianqian Q; Pan, Fang F; Evangelou, Evangelos E
Publication Date: 2012

Variant appearance in text: rs1386494
PubMed Link: 22693556
Variant Present in the following documents:
  • Main text
View BVdb publication page



Genetic factors modulating the response to stimulant drugs in humans.

Current Topics In Behavioral Neurosciences
Hart, Amy B AB; de Wit, Harriet H; Palmer, Abraham A AA
Publication Date: 2012

Variant appearance in text: rs1386494
PubMed Link: 22261702
Variant Present in the following documents:
  • Main text
View BVdb publication page



Tryptophan research in panic disorder.

International Journal Of Tryptophan Research : Ijtr
Maron, Eduard E; Shlik, Jakov J; Nutt, David J DJ
Publication Date: 2008

Variant appearance in text: rs1386494
PubMed Link: 22084577
Variant Present in the following documents:
  • Main text
View BVdb publication page



The genetic basis of panic disorder.

Journal Of Korean Medical Science
Na, Hae-Ran HR; Kang, Eun-Ho EH; Lee, Jae-Hon JH; Yu, Bum-Hee BH
Publication Date: 2011-06

Variant appearance in text: rs1386494
PubMed Link: 21655053
Variant Present in the following documents:
  • Main text
  • jkms-26-701.pdf
View BVdb publication page



Association of polymorphisms in HTR2A, HTR1A and TPH2 genes with suicide attempts in alcohol dependence: a preliminary report.

Psychiatry Research
Wrzosek, Małgorzata M; Łukaszkiewicz, Jacek J; Wrzosek, Michał M; Serafin, Piotr P; Jakubczyk, Andrzej A; Klimkiewicz, Anna A; Matsumoto, Halina H; Brower, Kirk J KJ; Wojnar, Marcin M
Publication Date: 2011-11-30

Variant appearance in text: rs1386494
PubMed Link: 21621273
Variant Present in the following documents:
  • Main text
View BVdb publication page



Pharmacogenetics of antidepressant response.

Journal Of Psychiatry & Neuroscience : Jpn
Porcelli, Stefano S; Drago, Antonio A; Fabbri, Chiara C; Gibiino, Sara S; Calati, Raffaella R; Serretti, Alessandro A
Publication Date: 2011-03

Variant appearance in text: rs1386494
PubMed Link: 21172166
Variant Present in the following documents:
  • Main text
View BVdb publication page



Epistasis between IL1A, IL1B, TNF, HTR2A, 5-HTTLPR and TPH2 variations does not impact alcohol dependence disorder features.

International Journal Of Environmental Research And Public Health
Drago, Antonio A; Liappas, Ioannis I; Petio, Carmine C; Albani, Diego D; Forloni, Gianluigi G; Malitas, Petros P; Piperi, Christina C; Politis, Antonis A; Tzavellas, Elias O EO; Zisaki, Katerina K KK; Prato, Francesca F; Batelli, Sara S; Polito, Letizia L; De Ronchi, Diana D; Paparrigopoulos, Thomas T; Kalofoutis, Anastasios A; Serretti, Alessandro A
Publication Date: 2009-07

Variant appearance in text: rs1386494
PubMed Link: 19742166
Variant Present in the following documents:
  • Main text
View BVdb publication page



Cohort profile: risk patterns and processes for psychopathology emerging during adolescence: the ROOTS project.

International Journal Of Epidemiology
Goodyer, Ian M IM; Croudace, Tim T; Dunn, Valerie V; Herbert, Joe J; Jones, Peter B PB
Publication Date: 2010-04

Variant appearance in text: rs1386494
PubMed Link: 19359258
Variant Present in the following documents:
  • Main text
View BVdb publication page



Examination of association of genes in the serotonin system to autism.

Neurogenetics
Anderson, B M BM; Schnetz-Boutaud, N C NC; Bartlett, J J; Wotawa, A M AM; Wright, H H HH; Abramson, R K RK; Cuccaro, M L ML; Gilbert, J R JR; Pericak-Vance, M A MA; Haines, J L JL
Publication Date: 2009-07

Variant appearance in text: rs1386494
PubMed Link: 19184136
Variant Present in the following documents:
  • Main text
View BVdb publication page



Number of risk genotypes is a risk factor for major depressive disorder: a case control study.

Behavioral And Brain Functions : Bbf
Garriock, Holly A HA; Delgado, Pedro P; Kling, Mitchel A MA; Carpenter, Linda L LL; Burke, Michael M; Burke, William J WJ; Schwartz, Thomas T; Marangell, Lauren B LB; Husain, Mustafa M; Erickson, Robert P RP; Moreno, Francisco A FA
Publication Date: 2006-07-05

Variant appearance in text: rs1386494
PubMed Link: 16822313
Variant Present in the following documents:
  • Main text
  • 1744-9081-2-24.pdf
View BVdb publication page