Fine-mapping, trans-ancestral and genomic analyses identify causal variants, cells, genes and drug targets for type 1 diabetes.
Nature Genetics
Robertson, Catherine C CC; Inshaw, Jamie R J JRJ; Onengut-Gumuscu, Suna S; Chen, Wei-Min WM; Santa Cruz, David Flores DF; Yang, Hanzhi H; Cutler, Antony J AJ; Crouch, Daniel J M DJM; Farber, Emily E; Bridges, S Louis SL; Edberg, Jeffrey C JC; Kimberly, Robert P RP; Buckner, Jane H JH; Deloukas, Panos P; Divers, Jasmin J; Dabelea, Dana D; Lawrence, Jean M JM; Marcovina, Santica S; Shah, Amy S AS; Greenbaum, Carla J CJ; Atkinson, Mark A MA; Gregersen, Peter K PK; Oksenberg, Jorge R JR; Pociot, Flemming F; Rewers, Marian J MJ; Steck, Andrea K AK; Dunger, David B DB; , ; Wicker, Linda S LS; Concannon, Patrick P; Todd, John A JA; Rich, Stephen S SS
Fine-mapping, trans-ancestral and genomic analyses identify causal variants, cells, genes and drug targets for type 1 diabetes.
Nature Genetics
Robertson, Catherine C CC; Inshaw, Jamie R J JRJ; Onengut-Gumuscu, Suna S; Chen, Wei-Min WM; Santa Cruz, David Flores DF; Yang, Hanzhi H; Cutler, Antony J AJ; Crouch, Daniel J M DJM; Farber, Emily E; Bridges, S Louis SL; Edberg, Jeffrey C JC; Kimberly, Robert P RP; Buckner, Jane H JH; Deloukas, Panos P; Divers, Jasmin J; Dabelea, Dana D; Lawrence, Jean M JM; Marcovina, Santica S; Shah, Amy S AS; Greenbaum, Carla J CJ; Atkinson, Mark A MA; Gregersen, Peter K PK; Oksenberg, Jorge R JR; Pociot, Flemming F; Rewers, Marian J MJ; Steck, Andrea K AK; Dunger, David B DB; , ; Wicker, Linda S LS; Concannon, Patrick P; Todd, John A JA; Rich, Stephen S SS
Type 1 diabetes: genes associated with disease development.
Central-European Journal Of Immunology
Klak, Marta M; Gomółka, Magdalena M; Kowalska, Patrycja P; Cichoń, Justyna J; Ambrożkiewicz, Filip F; Serwańska-Świętek, Marta M; Berman, Andrzej A; Wszoła, Michał M
Clinical and genetic correlates of islet-autoimmune signatures in juvenile-onset type 1 diabetes.
Diabetologia
Claessens, Laura A LA; Wesselius, Joris J; van Lummel, Menno M; Laban, Sandra S; Mulder, Flip F; Mul, Dick D; Nikolic, Tanja T; Aanstoot, Henk-Jan HJ; Koeleman, Bobby P C BPC; Roep, Bart O BO
Identification of infants with increased type 1 diabetes genetic risk for enrollment into Primary Prevention Trials-GPPAD-02 study design and first results.
Pediatric Diabetes
Winkler, Christiane C; Haupt, Florian F; Heigermoser, Martin M; Zapardiel-Gonzalo, Jose J; Ohli, Jasmin J; Faure, Theresa T; Kalideri, Evdokia E; Hommel, Angela A; Delivani, Petrina P; Berner, Reinhard R; Kordonouri, Olga O; Roloff, Frank F; von dem Berge, Thekla T; Lange, Karin K; Oltarzewski, Mariusz M; Glab, Ryszard R; Szypowska, Agnieszka A; Snape, Matthew D MD; Vatish, Manu M; Todd, John A JA; Larsson, Helena E HE; Ramelius, Anita A; Kördel, Jeanette Å JÅ; Casteels, Kristina K; Paulus, Jasmin J; Ziegler, Anette G AG; Bonifacio, Ezio E; ,
Impact of the Polymorphism of the PACRG and CD80 Genes on the Development of the Different Stages of Tuberculosis Infection.
Iranian Journal Of Medical Sciences
Bragina, Elena Yu EY; Babushkina, Nadezhda P NP; Garaeva, Anna F AF; Rudko, Alexey A AA; Tsitrikov, Dmitry Yu DY; Gomboeva, Densema E DE; Freidin, Maxim B MB
Genetic Contribution to the Divergence in Type 1 Diabetes Risk Between Children From the General Population and Children From Affected Families.
Diabetes
Hippich, Markus M; Beyerlein, Andreas A; Hagopian, William A WA; Krischer, Jeffrey P JP; Vehik, Kendra K; Knoop, Jan J; Winker, Christiane C; Toppari, Jorma J; Lernmark, Åke Å; Rewers, Marian J MJ; Steck, Andrea K AK; She, Jin-Xiong JX; Akolkar, Beena B; Robertson, Catherine C CC; Onengut-Gumuscu, Suna S; Rich, Stephen S SS; Bonifacio, Ezio E; Ziegler, Anette-G AG; , ; ,
Large-Scale Exome-wide Association Analysis Identifies Loci for White Blood Cell Traits and Pleiotropy with Immune-Mediated Diseases.
American Journal Of Human Genetics
Tajuddin, Salman M SM; Schick, Ursula M UM; Eicher, John D JD; Chami, Nathalie N; Giri, Ayush A; Brody, Jennifer A JA; Hill, W David WD; Kacprowski, Tim T; Li, Jin J; Lyytikäinen, Leo-Pekka LP; Manichaikul, Ani A; Mihailov, Evelin E; O'Donoghue, Michelle L ML; Pankratz, Nathan N; Pazoki, Raha R; Polfus, Linda M LM; Smith, Albert Vernon AV; Schurmann, Claudia C; Vacchi-Suzzi, Caterina C; Waterworth, Dawn M DM; Evangelou, Evangelos E; Yanek, Lisa R LR; Burt, Amber A; Chen, Ming-Huei MH; van Rooij, Frank J A FJ; Floyd, James S JS; Greinacher, Andreas A; Harris, Tamara B TB; Highland, Heather M HM; Lange, Leslie A LA; Liu, Yongmei Y; Mägi, Reedik R; Nalls, Mike A MA; Mathias, Rasika A RA; Nickerson, Deborah A DA; Nikus, Kjell K; Starr, John M JM; Tardif, Jean-Claude JC; Tzoulaki, Ioanna I; Velez Edwards, Digna R DR; Wallentin, Lars L; Bartz, Traci M TM; Becker, Lewis C LC; Denny, Joshua C JC; Raffield, Laura M LM; Rioux, John D JD; Friedrich, Nele N; Fornage, Myriam M; Gao, He H; Hirschhorn, Joel N JN; Liewald, David C M DC; Rich, Stephen S SS; Uitterlinden, Andre A; Bastarache, Lisa L; Becker, Diane M DM; Boerwinkle, Eric E; de Denus, Simon S; Bottinger, Erwin P EP; Hayward, Caroline C; Hofman, Albert A; Homuth, Georg G; Lange, Ethan E; Launer, Lenore J LJ; Lehtimäki, Terho T; Lu, Yingchang Y; Metspalu, Andres A; O'Donnell, Chris J CJ; Quarells, Rakale C RC; Richard, Melissa M; Torstenson, Eric S ES; Taylor, Kent D KD; Vergnaud, Anne-Claire AC; Zonderman, Alan B AB; Crosslin, David R DR; Deary, Ian J IJ; Dörr, Marcus M; Elliott, Paul P; Evans, Michele K MK; Gudnason, Vilmundur V; Kähönen, Mika M; Psaty, Bruce M BM; Rotter, Jerome I JI; Slater, Andrew J AJ; Dehghan, Abbas A; White, Harvey D HD; Ganesh, Santhi K SK; Loos, Ruth J F RJ; Esko, Tõnu T; Faraday, Nauder N; Wilson, James G JG; Cushman, Mary M; Johnson, Andrew D AD; Edwards, Todd L TL; Zakai, Neil A NA; Lettre, Guillaume G; Reiner, Alex P AP; Auer, Paul L PL
Mechanisms and Disease Associations of Haplotype-Dependent Allele-Specific DNA Methylation.
American Journal Of Human Genetics
Do, Catherine C; Lang, Charles F CF; Lin, John J; Darbary, Huferesh H; Krupska, Izabela I; Gaba, Aulona A; Petukhova, Lynn L; Vonsattel, Jean-Paul JP; Gallagher, Mary P MP; Goland, Robin S RS; Clynes, Raphael A RA; Dwork, Andrew A; Kral, John G JG; Monk, Catherine C; Christiano, Angela M AM; Tycko, Benjamin B
Genetic Risk Score Modelling for Disease Progression in New-Onset Type 1 Diabetes Patients: Increased Genetic Load of Islet-Expressed and Cytokine-Regulated Candidate Genes Predicts Poorer Glycemic Control.
Journal Of Diabetes Research
Brorsson, Caroline A CA; Nielsen, Lotte B LB; Andersen, Marie Louise ML; Kaur, Simranjeet S; Bergholdt, Regine R; Hansen, Lars L; Mortensen, Henrik B HB; Pociot, Flemming F; Størling, Joachim J; ,
Shared Genetic Basis for Type 1 Diabetes, Islet Autoantibodies, and Autoantibodies Associated With Other Immune-Mediated Diseases in Families With Type 1 Diabetes.
Role of Type 1 Diabetes-Associated SNPs on Risk of Autoantibody Positivity in the TEDDY Study.
Diabetes
Törn, Carina C; Hadley, David D; Lee, Hye-Seung HS; Hagopian, William W; Lernmark, Åke Å; Simell, Olli O; Rewers, Marian M; Ziegler, Anette A; Schatz, Desmond D; Akolkar, Beena B; Onengut-Gumuscu, Suna S; Chen, Wei-Min WM; Toppari, Jorma J; Mykkänen, Juha J; Ilonen, Jorma J; Rich, Stephen S SS; She, Jin-Xiong JX; Steck, Andrea K AK; Krischer, Jeffrey J; ,
Improving prediction of type 1 diabetes by testing non-HLA genetic variants in addition to HLA markers.
Pediatric Diabetes
Steck, Andrea K AK; Dong, Fran F; Wong, Randall R; Fouts, Alexandra A; Liu, Edwin E; Romanos, Jihane J; Wijmenga, Cisca C; Norris, Jill M JM; Rewers, Marian J MJ
Effects of non-HLA gene polymorphisms on development of islet autoimmunity and type 1 diabetes in a population with high-risk HLA-DR,DQ genotypes.
Diabetes
Steck, Andrea K AK; Wong, Randall R; Wagner, Brandie B; Johnson, Kelly K; Liu, Edwin E; Romanos, Jihane J; Wijmenga, Cisca C; Norris, Jill M JM; Eisenbarth, George S GS; Rewers, Marian J MJ
Confirmation of novel type 1 diabetes risk loci in families.
Diabetologia
Cooper, J D JD; Howson, J M M JM; Smyth, D D; Walker, N M NM; Stevens, H H; Yang, J H M JH; She, J-X JX; Eisenbarth, G S GS; Rewers, M M; Todd, J A JA; Akolkar, B B; Concannon, P P; Erlich, H A HA; Julier, C C; Morahan, G G; Nerup, J J; Nierras, C C; Pociot, F F; Rich, S S SS; ,
A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci.
Plos Genetics
Bradfield, Jonathan P JP; Qu, Hui-Qi HQ; Wang, Kai K; Zhang, Haitao H; Sleiman, Patrick M PM; Kim, Cecilia E CE; Mentch, Frank D FD; Qiu, Haijun H; Glessner, Joseph T JT; Thomas, Kelly A KA; Frackelton, Edward C EC; Chiavacci, Rosetta M RM; Imielinski, Marcin M; Monos, Dimitri S DS; Pandey, Rahul R; Bakay, Marina M; Grant, Struan F A SF; Polychronakos, Constantin C; Hakonarson, Hakon H
Tests for genetic interactions in type 1 diabetes: linkage and stratification analyses of 4,422 affected sib-pairs.
Diabetes
Morahan, Grant G; Mehta, Munish M; James, Ian I; Chen, Wei-Min WM; Akolkar, Beena B; Erlich, Henry A HA; Hilner, Joan E JE; Julier, Cécile C; Nerup, Jørn J; Nierras, Concepcion C; Pociot, Flemming F; Todd, John A JA; Rich, Stephen S SS; ,
Mapping of numerous disease-associated expression polymorphisms in primary peripheral blood CD4+ lymphocytes.
Human Molecular Genetics
Murphy, Amy A; Chu, Jen-Hwa JH; Xu, Mousheng M; Carey, Vincent J VJ; Lazarus, Ross R; Liu, Andy A; Szefler, Stanley J SJ; Strunk, Robert R; Demuth, Karen K; Castro, Mario M; Hansel, Nadia N NN; Diette, Gregory B GB; Vonakis, Becky M BM; Adkinson, N Franklin NF; Klanderman, Barbara J BJ; Senter-Sylvia, Jody J; Ziniti, John J; Lange, Christoph C; Pastinen, Tomi T; Raby, Benjamin A BA
Pociot, Flemming F; Akolkar, Beena B; Concannon, Patrick P; Erlich, Henry A HA; Julier, Cécile C; Morahan, Grant G; Nierras, Concepcion R CR; Todd, John A JA; Rich, Stephen S SS; Nerup, Jørn J
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.
Nature Genetics
Barrett, Jeffrey C JC; Clayton, David G DG; Concannon, Patrick P; Akolkar, Beena B; Cooper, Jason D JD; Erlich, Henry A HA; Julier, Cécile C; Morahan, Grant G; Nerup, Jørn J; Nierras, Concepcion C; Plagnol, Vincent V; Pociot, Flemming F; Schuilenburg, Helen H; Smyth, Deborah J DJ; Stevens, Helen H; Todd, John A JA; Walker, Neil M NM; Rich, Stephen S SS; ,