Acute myeloid leukemia stratifies as two clinically relevant sphingolipidomic subtypes.
Biorxiv : The Preprint Server For Biology
Paudel, B Bishal BB; Tan, Su-Fern SF; Fox, Todd E TE; Ung, Johnson J; Shaw, Jeremy J; Dunton, Wendy W; Lee, Irene I; Sharma, Arati A; Viny, Aaron D AD; Barth, Brian M BM; Tallman, Martin S MS; Cabot, Myles M; Garrett-Bakelman, Francine E FE; Levine, Ross L RL; Kester, Mark M; Claxton, David D; Feith, David J DJ; Janes, Kevin A KA; Loughran, Thomas P TP
Workflow enabling deepscale immunopeptidome, proteome, ubiquitylome, phosphoproteome, and acetylome analyses of sample-limited tissues.
Nature Communications
Abelin, Jennifer G JG; Bergstrom, Erik J EJ; Rivera, Keith D KD; Taylor, Hannah B HB; Klaeger, Susan S; Xu, Charles C; Verzani, Eva K EK; Jackson White, C C; Woldemichael, Hilina B HB; Virshup, Maya M; Olive, Meagan E ME; Maynard, Myranda M; Vartany, Stephanie A SA; Allen, Joseph D JD; Phulphagar, Kshiti K; Harry Kane, M M; Rachimi, Suzanna S; Mani, D R DR; Gillette, Michael A MA; Satpathy, Shankha S; Clauser, Karl R KR; Udeshi, Namrata D ND; Carr, Steven A SA
Inflammatory bone marrow signaling in pediatric acute myeloid leukemia distinguishes patients with poor outcomes.
Nature Communications
Bolouri, Hamid H; Ries, Rhonda E RE; Wiedeman, Alice E AE; Hylkema, Tiffany T; Scheiding, Sheila S; Gersuk, Vivian H VH; O'Brien, Kimberly K; Nguyen, Quynh-Anh QA; Smith, Jenny L JL; Alice Long, S S; Meshinchi, Soheil S
Genomic landscape of patients with FLT3-mutated acute myeloid leukemia (AML) treated within the CALGB 10603/RATIFY trial.
Leukemia
Jahn, Nikolaus N; Jahn, Ekaterina E; Saadati, Maral M; Bullinger, Lars L; Larson, Richard A RA; Ottone, Tiziana T; Amadori, Sergio S; Prior, Thomas W TW; Brandwein, Joseph M JM; Appelbaum, Frederick R FR; Medeiros, Bruno C BC; Tallman, Martin S MS; Ehninger, Gerhard G; Heuser, Michael M; Ganser, Arnold A; Pallaud, Celine C; Gathmann, Insa I; Krzykalla, Julia J; Benner, Axel A; Bloomfield, Clara D CD; Thiede, Christian C; Stone, Richard M RM; Döhner, Hartmut H; Döhner, Konstanze K
Clonal hematopoiesis is not significantly associated with COVID-19 disease severity.
Blood
Zhou, Yifan Y; Shalhoub, Ruba R; Rogers, Stephanie N SN; Yu, Shiqin S; Gu, Muxin M; Fabre, Margarete A MA; Quiros, Pedro M PM; Shin, Tae-Hoon TH; Diangson, Arch A; Deng, Wenhan W; Anand, Shubha S; Lu, Wenhua W; Cullen, Matthew M; Godfrey, Anna L AL; Preller, Jacobus J; Hadjadj, Jerome J; Jouanguy, Emmanuelle E; Cobat, Aurélie A; Abel, Laurent L; Rieux-Laucat, Frederic F; Terrier, Benjamin B; Fischer, Alain A; Novik, Lara L; Gordon, Ingelise J IJ; Strom, Larisa L; Gaudinski, Martin R MR; Lisco, Andrea A; Sereti, Irini I; Gniadek, Thomas J TJ; Biondi, Andrea A; Bonfanti, Paolo P; Imberti, Luisa L; Dalgard, Clifton L CL; Zhang, Yu Y; Dobbs, Kerry K; Su, Helen C HC; Notarangelo, Luigi D LD; Wu, Colin O CO; Openshaw, Peter J M PJM; Semple, Malcolm G MG; Mallat, Ziad Z; Baillie, Kenneth K; Dunbar, Cynthia E CE; Vassiliou, George S GS
Genome-wide analyses of 200,453 individuals yield new insights into the causes and consequences of clonal hematopoiesis.
Nature Genetics
Kar, Siddhartha P SP; Quiros, Pedro M PM; Gu, Muxin M; Jiang, Tao T; Mitchell, Jonathan J; Langdon, Ryan R; Iyer, Vivek V; Barcena, Clea C; Vijayabaskar, M S MS; Fabre, Margarete A MA; Carter, Paul P; Petrovski, Slavé S; Burgess, Stephen S; Vassiliou, George S GS
BMX kinase mediates gilteritinib resistance in FLT3-mutated AML through microenvironmental factors.
Blood Advances
Buelow, Daelynn R DR; Bhatnagar, Bhavana B; Orwick, Shelley J SJ; Jeon, Jae Yoon JY; Eisenmann, Eric D ED; Stromatt, Jack C JC; Pabla, Navjot Singh NS; Blachly, James S JS; Baker, Sharyn D SD; Blaser, Bradley W BW
Integrated Genomic Analysis Identifies UBTF Tandem Duplications as a Recurrent Lesion in Pediatric Acute Myeloid Leukemia.
Blood Cancer Discovery
Umeda, Masayuki M; Ma, Jing J; Huang, Benjamin J BJ; Hagiwara, Kohei K; Westover, Tamara T; Abdelhamed, Sherif S; Barajas, Juan M JM; Thomas, Melvin E ME; Walsh, Michael P MP; Song, Guangchun G; Tian, Liqing L; Liu, Yanling Y; Chen, Xiaolong X; Kolekar, Pandurang P; Tran, Quang Q; Foy, Scott G SG; Maciaszek, Jamie L JL; Kleist, Andrew B AB; Leonti, Amanda R AR; Ju, Bengsheng B; Easton, John J; Wu, Huiyun H; Valentine, Virginia V; Valentine, Marcus B MB; Liu, Yen-Chun YC; Ries, Rhonda E RE; Smith, Jenny L JL; Parganas, Evan E; Iacobucci, Ilaria I; Hiltenbrand, Ryan R; Miller, Jonathan J; Myers, Jason R JR; Rampersaud, Evadnie E; Rahbarinia, Delaram D; Rusch, Michael M; Wu, Gang G; Inaba, Hiroto H; Wang, Yi-Cheng YC; Alonzo, Todd A TA; Downing, James R JR; Mullighan, Charles G CG; Pounds, Stanley S; Babu, M Madan MM; Zhang, Jinghui J; Rubnitz, Jeffrey E JE; Meshinchi, Soheil S; Ma, Xiaotu X; Klco, Jeffery M JM
Whole-transcriptome analysis in acute lymphoblastic leukemia: a report from the DFCI ALL Consortium Protocol 16-001.
Blood Advances
Tran, Thai Hoa TH; Langlois, Sylvie S; Meloche, Caroline C; Caron, Maxime M; Saint-Onge, Pascal P; Rouette, Alexandre A; Bataille, Alain R AR; Jimenez-Cortes, Camille C; Sontag, Thomas T; Bittencourt, Henrique H; Laverdière, Caroline C; Lavallée, Vincent-Philippe VP; Leclerc, Jean-Marie JM; Cole, Peter D PD; Gennarini, Lisa M LM; Kahn, Justine M JM; Kelly, Kara M KM; Michon, Bruno B; Santiago, Raoul R; Stevenson, Kristen E KE; Welch, Jennifer J G JJG; Schroeder, Kaitlin M KM; Koch, Victoria V; Cellot, Sonia S; Silverman, Lewis B LB; Sinnett, Daniel D
Focal disruption of DNA methylation dynamics at enhancers in IDH-mutant AML cells.
Leukemia
Wilson, Elisabeth R ER; Helton, Nichole M NM; Heath, Sharon E SE; Fulton, Robert S RS; Payton, Jacqueline E JE; Welch, John S JS; Walter, Matthew J MJ; Westervelt, Peter P; DiPersio, John F JF; Link, Daniel C DC; Miller, Christopher A CA; Ley, Timothy J TJ; Spencer, David H DH
Immunosuppression and outcomes in adult patients with de novo acute myeloid leukemia with normal karyotypes.
Proceedings Of The National Academy Of Sciences Of The United States Of America
Ferraro, Francesca F; Miller, Christopher A CA; Christensen, Keegan A KA; Helton, Nichole M NM; O'Laughlin, Margaret M; Fronick, Catrina C CC; Fulton, Robert S RS; Kohlschmidt, Jessica J; Eisfeld, Ann-Kathrin AK; Bloomfield, Clara D CD; Ramakrishnan, Sai Mukund SM; Day, Ryan B RB; Wartman, Lukas D LD; Uy, Geoffrey L GL; Welch, John S JS; Christopher, Matthew J MJ; Heath, Sharon E SE; Baty, Jack D JD; Schuelke, Matthew J MJ; Payton, Jacqueline E JE; Spencer, David H DH; Rettig, Michael P MP; Link, Daniel C DC; Walter, Matthew J MJ; Westervelt, Peter P; DiPersio, John F JF; Ley, Timothy J TJ
Immunosuppression and outcomes in adult patients with de novo acute myeloid leukemia with normal karyotypes.
Proceedings Of The National Academy Of Sciences Of The United States Of America
Ferraro, Francesca F; Miller, Christopher A CA; Christensen, Keegan A KA; Helton, Nichole M NM; O'Laughlin, Margaret M; Fronick, Catrina C CC; Fulton, Robert S RS; Kohlschmidt, Jessica J; Eisfeld, Ann-Kathrin AK; Bloomfield, Clara D CD; Ramakrishnan, Sai Mukund SM; Day, Ryan B RB; Wartman, Lukas D LD; Uy, Geoffrey L GL; Welch, John S JS; Christopher, Matthew J MJ; Heath, Sharon E SE; Baty, Jack D JD; Schuelke, Matthew J MJ; Payton, Jacqueline E JE; Spencer, David H DH; Rettig, Michael P MP; Link, Daniel C DC; Walter, Matthew J MJ; Westervelt, Peter P; DiPersio, John F JF; Ley, Timothy J TJ
Targeted Therapy of Papillary Thyroid Cancer: A Comprehensive Genomic Analysis.
Frontiers In Endocrinology
Hescheler, Daniel A DA; Riemann, Burkhard B; Hartmann, Milan J M MJM; Michel, Maximilian M; Faust, Michael M; Bruns, Christiane J CJ; Alakus, Hakan H; Chiapponi, Costanza C
Enhancer recruitment of transcription repressors RUNX1 and TLE3 by mis-expressed FOXC1 blocks differentiation in acute myeloid leukemia.
Cell Reports
Simeoni, Fabrizio F; Romero-Camarero, Isabel I; Camera, Francesco F; Amaral, Fabio M R FMR; Sinclair, Oliver J OJ; Papachristou, Evangelia K EK; Spencer, Gary J GJ; Lie-A-Ling, Michael M; Lacaud, Georges G; Wiseman, Daniel H DH; Carroll, Jason S JS; Somervaille, Tim C P TCP
Spatially interacting phosphorylation sites and mutations in cancer.
Nature Communications
Huang, Kuan-Lin KL; Scott, Adam D AD; Zhou, Daniel Cui DC; Wang, Liang-Bo LB; Weerasinghe, Amila A; Elmas, Abdulkadir A; Liu, Ruiyang R; Wu, Yige Y; Wendl, Michael C MC; Wyczalkowski, Matthew A MA; Baral, Jessika J; Sengupta, Sohini S; Lai, Chin-Wen CW; Ruggles, Kelly K; Payne, Samuel H SH; Raphael, Benjamin B; Fenyö, David D; Chen, Ken K; Mills, Gordon G; Ding, Li L
Integration of intra-sample contextual error modeling for improved detection of somatic mutations from deep sequencing.
Science Advances
Abelson, Sagi S; Zeng, Andy G X AGX; Nofech-Mozes, Ido I; Wang, Ting Ting TT; Ng, Stanley W K SWK; Minden, Mark D MD; Pugh, Trevor J TJ; Awadalla, Philip P; Shlush, Liran I LI; Murphy, Tracy T; Chan, Steven M SM; Dick, John E JE; Bratman, Scott V SV
TP-0903 is active in models of drug-resistant acute myeloid leukemia.
Jci Insight
Jeon, Jae Yoon JY; Buelow, Daelynn R DR; Garrison, Dominique A DA; Niu, Mingshan M; Eisenmann, Eric D ED; Huang, Kevin M KM; Zavorka Thomas, Megan E ME; Weber, Robert H RH; Whatcott, Clifford J CJ; Warner, Steve L SL; Orwick, Shelley J SJ; Carmichael, Bridget B; Stahl, Emily E; Brinton, Lindsey T LT; Lapalombella, Rosa R; Blachly, James S JS; Hertlein, Erin E; Byrd, John C JC; Bhatnagar, Bhavana B; Baker, Sharyn D SD
Targeted nanopore sequencing for the identification of ABCB1 promoter translocations in cancer.
Bmc Cancer
Williams, Mark S MS; Basma, Naseer J NJ; Amaral, Fabio M R FMR; Williams, Gillian G; Weightman, John P JP; Breitwieser, Wolfgang W; Nelson, Louisa L; Taylor, Stephen S SS; Wiseman, Daniel H DH; Somervaille, Tim C P TCP
mTOR Signaling and SREBP Activity Increase FADS2 Expression and Can Activate Sapienate Biosynthesis.
Cell Reports
Triki, Mouna M; Rinaldi, Gianmarco G; Planque, Melanie M; Broekaert, Dorien D; Winkelkotte, Alina M AM; Maier, Carina R CR; Janaki Raman, Sudha S; Vandekeere, Anke A; Van Elsen, Joke J; Orth, Martin F MF; Grünewald, Thomas G P TGP; Schulze, Almut A; Fendt, Sarah-Maria SM
Venetoclax induces rapid elimination of NPM1 mutant measurable residual disease in combination with low-intensity chemotherapy in acute myeloid leukaemia.
British Journal Of Haematology
Tiong, Ing S IS; Dillon, Richard R; Ivey, Adam A; Teh, Tse-Chieh TC; Nguyen, Phillip P; Cummings, Nicholas N; Taussig, David C DC; Latif, Annie-Louise AL; Potter, Nicola E NE; Runglall, Manohursingh M; Russell, Nigel H NH; Raj, Kavita K; Schwarer, Anthony P AP; Fong, Chun Yew CY; Grigg, Andrew P AP; Wei, Andrew H AH
High incidence of FLT3 mutations in follicular thyroid cancer: potential therapeutic target in patients with advanced disease stage.
Therapeutic Advances In Medical Oncology
Borowczyk, Martyna M; Szczepanek-Parulska, Ewelina E; Dębicki, Szymon S; Budny, Bartłomiej B; Janicka-Jedyńska, Małgorzata M; Gil, Lidia L; Verburg, Frederik A FA; Filipowicz, Dorota D; Wrotkowska, Elżbieta E; Majchrzycka, Blanka B; Marszałek, Andrzej A; Ziemnicka, Katarzyna K; Ruchała, Marek M
Publication Date: 2020
Variant appearance in text: FLT3: 2505T>G; D835E; rs121913487
Targeting AML-associated FLT3 mutations with a type I kinase inhibitor.
The Journal Of Clinical Investigation
Jones, LaQuita M LM; Melgar, Katelyn K; Bolanos, Lyndsey L; Hueneman, Kathleen K; Walker, Morgan M MM; Jiang, Jian-Kang JK; Wilson, Kelli M KM; Zhang, Xiaohu X; Shen, Jian J; Jiang, Fan F; Sutter, Patrick P; Wang, Amy A; Xu, Xin X; Tawa, Gregory J GJ; Hoyt, Scott B SB; Wunderlich, Mark M; O'Brien, Eric E; Perentesis, John P JP; Starczynowski, Daniel T DT; Thomas, Craig J CJ
Acute myeloid leukemia immunopeptidome reveals HLA presentation of mutated nucleophosmin.
Plos One
Narayan, Rupa R; Olsson, Niclas N; Wagar, Lisa E LE; Medeiros, Bruno C BC; Meyer, Everett E; Czerwinski, Debra D; Khodadoust, Michael S MS; Zhang, Lichao L; Schultz, Liora L; Davis, Mark M MM; Elias, Joshua E JE; Levy, Ron R
The TP53 Apoptotic Network Is a Primary Mediator of Resistance to BCL2 Inhibition in AML Cells.
Cancer Discovery
Nechiporuk, Tamilla T; Kurtz, Stephen E SE; Nikolova, Olga O; Liu, Tingting T; Jones, Courtney L CL; D'Alessandro, Angelo A; Culp-Hill, Rachel R; d'Almeida, Amanda A; Joshi, Sunil K SK; Rosenberg, Mara M; Tognon, Cristina E CE; Danilov, Alexey V AV; Druker, Brian J BJ; Chang, Bill H BH; McWeeney, Shannon K SK; Tyner, Jeffrey W JW
Functional genomic landscape of acute myeloid leukaemia.
Nature
Tyner, Jeffrey W JW; Tognon, Cristina E CE; Bottomly, Daniel D; Wilmot, Beth B; Kurtz, Stephen E SE; Savage, Samantha L SL; Long, Nicola N; Schultz, Anna Reister AR; Traer, Elie E; Abel, Melissa M; Agarwal, Anupriya A; Blucher, Aurora A; Borate, Uma U; Bryant, Jade J; Burke, Russell R; Carlos, Amy A; Carpenter, Richie R; Carroll, Joseph J; Chang, Bill H BH; Coblentz, Cody C; d'Almeida, Amanda A; Cook, Rachel R; Danilov, Alexey A; Dao, Kim-Hien T KT; Degnin, Michie M; Devine, Deirdre D; Dibb, James J; Edwards, David K DK; Eide, Christopher A CA; English, Isabel I; Glover, Jason J; Henson, Rachel R; Ho, Hibery H; Jemal, Abdusebur A; Johnson, Kara K; Johnson, Ryan R; Junio, Brian B; Kaempf, Andy A; Leonard, Jessica J; Lin, Chenwei C; Liu, Selina Qiuying SQ; Lo, Pierrette P; Loriaux, Marc M MM; Luty, Samuel S; Macey, Tara T; MacManiman, Jason J; Martinez, Jacqueline J; Mori, Motomi M; Nelson, Dylan D; Nichols, Ceilidh C; Peters, Jill J; Ramsdill, Justin J; Rofelty, Angela A; Schuff, Robert R; Searles, Robert R; Segerdell, Erik E; Smith, Rebecca L RL; Spurgeon, Stephen E SE; Sweeney, Tyler T; Thapa, Aashis A; Visser, Corinne C; Wagner, Jake J; Watanabe-Smith, Kevin K; Werth, Kristen K; Wolf, Joelle J; White, Libbey L; Yates, Amy A; Zhang, Haijiao H; Cogle, Christopher R CR; Collins, Robert H RH; Connolly, Denise C DC; Deininger, Michael W MW; Drusbosky, Leylah L; Hourigan, Christopher S CS; Jordan, Craig T CT; Kropf, Patricia P; Lin, Tara L TL; Martinez, Micaela E ME; Medeiros, Bruno C BC; Pallapati, Rachel R RR; Pollyea, Daniel A DA; Swords, Ronan T RT; Watts, Justin M JM; Weir, Scott J SJ; Wiest, David L DL; Winters, Ryan M RM; McWeeney, Shannon K SK; Druker, Brian J BJ