ALOX5AP c.70+2284A>T

Variant ID: 13-31312096-A-T

NM_001629.3(ALOX5AP):c.70+2284A>T

This variant was identified in 42 publications

View GRCh38 version.




Publications:


Relationship between Arachidonate 5-Lipoxygenase-Activating Protein Gene and Peripheral Arterial Disease in Elderly Patients Undergoing General Surgery: A Retrospective Observational Study.

International Journal Of Environmental Research And Public Health
Jin, Sejong S; Choi, Eun-Ji EJ; Choi, Yoon Ji YJ; Min, Won Kee WK; Park, Ju Yeon JY; Yoon, Seung Zhoo SZ
Publication Date: 2023-01-06

Variant appearance in text: rs10507391
PubMed Link: 36673783
Variant Present in the following documents:
  • Main text
  • ijerph-20-01027.pdf
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Establishment and characterization of a new mantle cell lymphoma cell line with a NOTCH2 mutation, Arbo.

Ejhaem
Safa, Firas F; Rasmussen, Terri T; Lobelle-Rich, Patricia P; Collier, Stephanie S; Milligan, Nicholas N; Schmeig, John J; Schmid, Janet J; Wiewiorowski, Carol C; Totaro, Denise D; Brown, Theresa C TC; Satyavarapu, Ishwarya I; Badoo, Melody M; Ungerleider, Nathan N; Flemington, Erik K EK; Safah, Hana H; Saba, Nakhle S NS
Publication Date: 2022-11

Variant appearance in text: rs10507391
PubMed Link: 36467812
Variant Present in the following documents:
  • JHA2-3-1326-s001.xlsx, sheet 1
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The Genetic Factors of the Airway Epithelium Associated with the Pathology of Asthma.

Genes
Ranjbar, Maral M; Whetstone, Christiane E CE; Omer, Hafsa H; Power, Lucy L; Cusack, Ruth P RP; Gauvreau, Gail M GM
Publication Date: 2022-10-15

Variant appearance in text: rs10507391
PubMed Link: 36292755
Variant Present in the following documents:
  • genes-13-01870.pdf
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Large-Scale Targeted Sequencing Study of Ischemic Stroke in the Han Chinese Population.

Journal Of The American Heart Association
Shi, Mengyao M; Kelly, Tanika N TN; Zhu, Zhengbao Z; Li, Changwei C; Shen, Chong C; Sun, Yingxian Y; Wang, Aili A; Shan, Guangliang G; Bu, Xiaoqing X; Guo, Daoxia D; Zhao, Jingbo J; Xu, Tan T; Peng, Hao H; Xu, Tian T; Zhong, Chongke C; Sun, Xiao X; Chen, Jing J; Zhang, Yonghong Y; He, Jiang J
Publication Date: 2022-10-04

Variant appearance in text: rs10507391
PubMed Link: 36193932
Variant Present in the following documents:
  • JAH3-11-e025245.pdf
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Genetic and Epigenetic Regulation of Lipoxygenase Pathways and Reverse Cholesterol Transport in Atherogenesis.

Genes
Kotlyarov, Stanislav S
Publication Date: 2022-08-18

Variant appearance in text: rs10507391
PubMed Link: 36011386
Variant Present in the following documents:
  • Main text
  • genes-13-01474.pdf
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How does race and ethnicity effect the precision treatment of asthma?

Expert Review Of Precision Medicine And Drug Development
Zhang, Ellen E; Levin, Albert M AM; Williams, L Keoki LK
Publication Date: 2019

Variant appearance in text: rs10507391
PubMed Link: 33015363
Variant Present in the following documents:
  • Main text
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Interstitial lung disease in Systemic sclerosis: insights into pathogenesis and evolving therapies.

Mediterranean Journal Of Rheumatology
Ahmed, Sakir S; Pattanaik, Sarit Sekhar SS; Rai, Mohit Kumar MK; Nath, Alok A; Agarwal, Vikas V
Publication Date: 2018-09

Variant appearance in text: rs10507391
PubMed Link: 32185315
Variant Present in the following documents:
  • Main text
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Integrating Multi-Omics Data to Identify Novel Disease Genes and Single-Neucleotide Polymorphisms.

Frontiers In Genetics
Zhao, Sheng S; Jiang, Huijie H; Liang, Zong-Hui ZH; Ju, Hong H
Publication Date: 2019

Variant appearance in text: rs10507391
PubMed Link: 32038707
Variant Present in the following documents:
  • Main text
  • fgene-10-01336.pdf
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Etiology, Risk Factors, and Biomarkers in Systemic Sclerosis with Interstitial Lung Disease.

American Journal Of Respiratory And Critical Care Medicine
Khanna, Dinesh D; Tashkin, Donald P DP; Denton, Christopher P CP; Renzoni, Elisabetta A EA; Desai, Sujal R SR; Varga, John J
Publication Date: 2020-03-15

Variant appearance in text: rs10507391
PubMed Link: 31841044
Variant Present in the following documents:
  • rccm.201903-0563CI_khanna_data_supplement.pdf
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Early and Sustained Increases in Leukotriene B4 Levels Are Associated with Poor Clinical Outcome in Ischemic Stroke Patients.

Neurotherapeutics : The Journal Of The American Society For Experimental Neurotherapeutics
Chan, Su Jing SJ; Ng, Mary P E MPE; Zhao, Hui H; Ng, Geelyn J L GJL; De Foo, Chuan C; Wong, Peter T-H PT; Seet, Raymond C S RCS
Publication Date: 2020-01

Variant appearance in text: rs10507391
PubMed Link: 31520306
Variant Present in the following documents:
  • Main text
  • 13311_2019_Article_787.pdf
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Early and Sustained Increases in Leukotriene B4 Levels Are Associated with Poor Clinical Outcome in Ischemic Stroke Patients.

Neurotherapeutics : The Journal Of The American Society For Experimental Neurotherapeutics
Chan, Su Jing SJ; Ng, Mary P E MPE; Zhao, Hui H; Ng, Geelyn J L GJL; De Foo, Chuan C; Wong, Peter T-H PT; Seet, Raymond C S RCS
Publication Date: 2020-01

Variant appearance in text: rs10507391
PubMed Link: 31520306
Variant Present in the following documents:
  • Main text
  • 13311_2019_Article_787.pdf
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Effect of gene-gene and gene-environment interaction on the risk of first-ever stroke and poststroke death.

Molecular Genetics & Genomic Medicine
Feng, Congrui C; Yang, Yunyun Y; Yang, Shujun S; Tu, Xin X; Wang, Yibo Y; Song, Yiqing Y; Hui, Rutai R; Zhang, Weili W
Publication Date: 2019-08

Variant appearance in text: rs10507391
PubMed Link: 31293107
Variant Present in the following documents:
  • Main text
  • MGG3-7-e846.pdf
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Lack of association between ALOX5AP genetic polymorphisms and risk of ischemic stroke: evidence from meta-analyses.

Neuropsychiatric Disease And Treatment
Zheng, Jing-Hui JH; Ning, Gui-Lan GL; Xu, Wen-Hua WH; Wu, Xin-Cheng XC; Ma, Xiao-Cong XC
Publication Date: 2019

Variant appearance in text: rs10507391
PubMed Link: 30774347
Variant Present in the following documents:
  • Main text
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Genetic variation in the leukotriene pathway is associated with myocardial infarction in the Chinese population.

Lipids In Health And Disease
Li, Yilan Y; Xu, Xueming X; Zhang, Dandan D; Cheng, Wei W; Zhang, Yanan Y; Yu, Bo B; Zhang, Yao Y
Publication Date: 2019-01-24

Variant appearance in text: rs10507391
PubMed Link: 30678701
Variant Present in the following documents:
  • Main text
  • 12944_2019_Article_968.pdf
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Identification of deleterious and regulatory genomic variations in known asthma loci.

Respiratory Research
Neville, Matthew D C MDC; Choi, Jihoon J; Lieberman, Jonathan J; Duan, Qing Ling QL
Publication Date: 2018-12-12

Variant appearance in text: rs10507391
PubMed Link: 30541564
Variant Present in the following documents:
  • Main text
  • 12931_2018_Article_953.pdf
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Lung Involvements in Rheumatic Diseases: Update on the Epidemiology, Pathogenesis, Clinical Features, and Treatment.

Biomed Research International
Ha, You-Jung YJ; Lee, Yun Jong YJ; Kang, Eun Ha EH
Publication Date: 2018

Variant appearance in text: rs10507391
PubMed Link: 29854780
Variant Present in the following documents:
  • Main text
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Weighted Multi-marker Genetic Risk Scores for Incident Coronary Heart Disease among Individuals of African, Latino and East-Asian Ancestry.

Scientific Reports
Iribarren, Carlos C; Lu, Meng M; Jorgenson, Eric E; Martínez, Manuel M; Lluis-Ganella, Carla C; Subirana, Isaac I; Salas, Eduardo E; Elosua, Roberto R
Publication Date: 2018-05-01

Variant appearance in text: rs10507391
PubMed Link: 29717161
Variant Present in the following documents:
  • Main text
  • 41598_2018_Article_25128.pdf
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Genetic predictors of systemic sclerosis-associated interstitial lung disease: a review of recent literature.

European Journal Of Human Genetics : Ejhg
Stock, Carmel J W CJW; Renzoni, Elisabetta A EA
Publication Date: 2018-06

Variant appearance in text: rs10507391
PubMed Link: 29476163
Variant Present in the following documents:
  • Main text
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The β-fibrinogen gene 455G/A polymorphism associated with cardioembolic stroke in atrial fibrillation with low CHA2DS2-VaSc score.

Scientific Reports
Hu, Xiaofeng X; Wang, Junjun J; Li, Yaguo Y; Wu, Jiong J; Qiao, Song S; Xu, Shanhu S; Huang, Jun J; Chen, Linhui L
Publication Date: 2017-12-13

Variant appearance in text: rs10507391
PubMed Link: 29235504
Variant Present in the following documents:
  • Main text
  • 41598_2017_Article_17537.pdf
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A clinical-genetic approach to assessing cardiovascular risk in patients with CKD.

Clinical Kidney Journal
Rodrigo, Emilio E; Pich, Sara S; Subirana, Isaac I; Fernandez-Fresnedo, Gema G; Barreda, Paloma P; Ferrer-Costa, Carles C; M de Francisco, Ángel Luis ÁL; Salas, Eduardo E; Elosua, Roberto R; Arias, Manuel M
Publication Date: 2017-10

Variant appearance in text: rs10507391
PubMed Link: 28979779
Variant Present in the following documents:
  • Main text
  • sfx039.pdf
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Common Polymorphisms in the 5-Lipoxygenase Pathway and Risk of Incident Myocardial Infarction: A Danish Case-Cohort Study.

Plos One
Gammelmark, Anders A; Nielsen, Michael S MS; Lundbye-Christensen, Søren S; Tjønneland, Anne A; Schmidt, Erik B EB; Overvad, Kim K
Publication Date: 2016

Variant appearance in text: rs10507391
PubMed Link: 27893808
Variant Present in the following documents:
  • Main text
  • pone.0167217.pdf
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A tagging ALOX5AP polymorphism and risk of ischemic stroke in a northeastern Chinese Han population.

International Journal Of Clinical And Experimental Medicine
Qu, Zhengyi Z; Su, Fang F; Zhu, Yulan Y; Zhang, Shuangyan S; Zhao, Hong H; Li, Yongnan Y; Qiao, Zhenkui Z; Wang, Hongcai H
Publication Date: 2015

Variant appearance in text: rs10507391
PubMed Link: 26885075
Variant Present in the following documents:
  • Main text
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Genetics of coronary artery disease and myocardial infarction.

World Journal Of Cardiology
Dai, Xuming X; Wiernek, Szymon S; Evans, James P JP; Runge, Marschall S MS
Publication Date: 2016-01-26

Variant appearance in text: rs10507391
PubMed Link: 26839654
Variant Present in the following documents:
  • Main text
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Association of ALOX5AP with ischemic stroke in eastern Chinese.

World Journal Of Emergency Medicine
Wang, Yao Y; Wang, Gan-Nan GN; Sun, Hao H; Chen, Chen C; Xiao, Hang H; Zhang, Jin-Song JS
Publication Date: 2012

Variant appearance in text: rs10507391
PubMed Link: 25215047
Variant Present in the following documents:
  • Main text
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Interrelationships between ALOX5AP polymorphisms, serum leukotriene B4 level and risk of acute coronary syndrome.

Plos One
He, Guoping G; Ye, Shan S; Hui, Jingjiao J; Shen, Dandan D; Qi, Chuanping C; Xu, Lianhong L; Qian, Yichao Y
Publication Date: 2014

Variant appearance in text: rs10507391
PubMed Link: 25210744
Variant Present in the following documents:
  • Main text
  • pone.0106596.pdf
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Role of interactions in pharmacogenetic studies: leukotrienes in asthma.

Pharmacogenomics
Via, Marc M; Tcheurekdjian, Haig H; González Burchard, Esteban E
Publication Date: 2013-06

Variant appearance in text: rs10507391
PubMed Link: 23746186
Variant Present in the following documents:
  • Main text
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Variants of the arachidonate 5-lipoxygenase-activating protein (ALOX5AP) gene and risk of ischemic stroke in Han Chinese of eastern China.

Journal Of Biomedical Research
Wang, Gannan G; Wang, Yao Y; Sun, Hao H; Cao, Weijuan W; Zhang, Jing J; Xiao, Hang H; Zhang, Jinsong J
Publication Date: 2011-09

Variant appearance in text: rs10507391
PubMed Link: 23554707
Variant Present in the following documents:
  • Main text
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Leukotriene A4 hydrolase haplotype, diet and atherosclerosis: a twin study.

Atherosclerosis
Zhao, Jinying J; Goldberg, Jack J; Vaccarino, Viola V
Publication Date: 2013-01

Variant appearance in text: rs10507391
PubMed Link: 23153620
Variant Present in the following documents:
  • Main text
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Association of ALOX5AP gene single nucleotide polymorphisms and cerebral infarction in the Han population of northern China.

Bmc Medical Genetics
Zhang, Shuang-yan SY; Xu, Mei-ling ML; Zhang, Cui-e CE; Qu, Zheng-yi ZY; Zhang, Bin-bin BB; Zheng, Zu-yan ZY; Zhang, Li-ming LM
Publication Date: 2012-07-31

Variant appearance in text: rs10507391
PubMed Link: 22849376
Variant Present in the following documents:
  • Main text
  • 1471-2350-13-61.pdf
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No association of ALOX5AP polymorphisms with risk of MRI-defined brain infarcts.

Neurobiology Of Aging
Barral, Sandra S; Fernández-Cadenas, Israel I; Bis, Joshua C JC; Montaner, Joan J; Ikram, Arfan M AM; Launer, Lenore J LJ; Fornage, Myriam M; Schmidt, Helena H; Brickman, Adam M AM; Seshadri, Sudha S; Mayeux, Richard R
Publication Date: 2012-03

Variant appearance in text: rs10507391
PubMed Link: 22074807
Variant Present in the following documents:
  • Main text
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Large-scale gene-centric analysis identifies novel variants for coronary artery disease.

Plos Genetics
,
Publication Date: 2011-09

Variant appearance in text: rs10507391
PubMed Link: 21966275
Variant Present in the following documents:
  • pgen.1002260.s008.pdf
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Associations between gene polymorphisms in fatty acid metabolism pathway and preterm delivery in a US urban black population.

Human Genetics
Liu, Xin X; Wang, Guoying G; Hong, Xiumei X; Tsai, Hui-Ju HJ; Liu, Rong R; Zhang, Shanchun S; Wang, Hongjian H; Pearson, Colleen C; Ortiz, Katherin K; Wang, Deli D; Hirsch, Emmet E; Zuckerman, Barry B; Wang, Xiaobin X
Publication Date: 2012-03

Variant appearance in text: rs10507391
PubMed Link: 21847588
Variant Present in the following documents:
  • Main text
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Genetic contribution of the leukotriene pathway to coronary artery disease.

Human Genetics
Hartiala, Jaana J; Li, Dalin D; Conti, David V DV; Vikman, Susanna S; Patel, Yesha Y; Tang, W H Wilson WH; Brennan, Marie-Louise ML; Newman, John W JW; Stephensen, Charles B CB; Armstrong, Patrice P; Hazen, Stanley L SL; Allayee, Hooman H
Publication Date: 2011-06

Variant appearance in text: rs10507391
PubMed Link: 21293878
Variant Present in the following documents:
  • Main text
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Assessment of LD matrix measures for the analysis of biological pathway association.

Statistical Applications In Genetics And Molecular Biology
Crosslin, David R DR; Qin, Xuejun X; Hauser, Elizabeth R ER
Publication Date: 2010

Variant appearance in text: rs10507391
PubMed Link: 20887274
Variant Present in the following documents:
  • Main text
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ALOX5AP and LTA4H polymorphisms modify augmentation of bronchodilator responsiveness by leukotriene modifiers in Latinos.

The Journal Of Allergy And Clinical Immunology
Tcheurekdjian, Haig H; Via, Marc M; De Giacomo, Anthony A; Corvol, Harriet H; Eng, Celeste C; Thyne, Shannon S; Chapela, Rocio R; Rodriguez-Cintron, William W; Rodriguez-Santana, Jose R JR; Avila, Pedro C PC; Burchard, Esteban González EG; ,
Publication Date: 2010-10

Variant appearance in text: rs10507391
PubMed Link: 20810156
Variant Present in the following documents:
  • Main text
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Human lipoxygenase pathway gene variation and association with markers of subclinical atherosclerosis in the diabetes heart study.

Mediators Of Inflammation
Burdon, Kathryn P KP; Rudock, Megan E ME; Lehtinen, Allison B AB; Langefeld, Carl D CD; Bowden, Donald W DW; Register, Thomas C TC; Liu, Yongmei Y; Freedman, Barry I BI; Carr, J Jeffrey JJ; Hedrick, Catherine C CC; Rich, Stephen S SS
Publication Date: 2010

Variant appearance in text: rs10507391
PubMed Link: 20592751
Variant Present in the following documents:
  • Main text
  • MI2010-170153.pdf
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The role of LTA4H and ALOX5AP genes in the risk for asthma in Latinos.

Clinical And Experimental Allergy : Journal Of The British Society For Allergy And Clinical Immunology
Via, M M; De Giacomo, A A; Corvol, H H; Eng, C C; Seibold, M A MA; Gillett, C C; Galanter, J J; Sen, S S; Tcheurekdjian, H H; Chapela, R R; Rodríguez-Santana, J R JR; Rodríguez-Cintrón, W W; Thyne, S S; Avila, P C PC; Choudhry, S S; González Burchard, E E; ,
Publication Date: 2010-04

Variant appearance in text: rs10507391
PubMed Link: 20067482
Variant Present in the following documents:
  • Main text
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Genetics and pharmacogenetics of the leukotriene pathway.

The Journal Of Allergy And Clinical Immunology
Tantisira, Kelan G KG; Drazen, Jeffrey M JM
Publication Date: 2009-09

Variant appearance in text: rs10507391
PubMed Link: 19665766
Variant Present in the following documents:
  • Main text
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Sex-specific association of depression and a haplotype in leukotriene A4 hydrolase gene.

Psychosomatic Medicine
Zhao, Jinying J; Quyyumi, Arshed A AA; Patel, Riyaz R; Zafari, A Maziar AM; Veledar, Emir E; Onufrak, Stephen S; Shallenberger, Lucy H LH; Jones, Linda L; Vaccarino, Viola V
Publication Date: 2009-09

Variant appearance in text: rs10507391
PubMed Link: 19622707
Variant Present in the following documents:
  • Main text
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Genetic effects in the leukotriene biosynthesis pathway and association with atherosclerosis.

Human Genetics
Crosslin, David R DR; Shah, Svati H SH; Nelson, Sarah C SC; Haynes, Carol S CS; Connelly, Jessica J JJ; Gadson, Shera S; Goldschmidt-Clermont, Pascal J PJ; Vance, Jeffery M JM; Rose, Jason J; Granger, Chris B CB; Seo, David D; Gregory, Simon G SG; Kraus, William E WE; Hauser, Elizabeth R ER
Publication Date: 2009-03

Variant appearance in text: rs10507391
PubMed Link: 19130089
Variant Present in the following documents:
  • Main text
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Common polymorphisms of ALOX5 and ALOX5AP and risk of coronary artery disease.

Human Genetics
Assimes, Themistocles L TL; Knowles, Joshua W JW; Priest, James R JR; Basu, Analabha A; Volcik, Kelly A KA; Southwick, Audrey A; Tabor, Holly K HK; Hartiala, Jaana J; Allayee, Hooman H; Grove, Megan L ML; Tabibiazar, Raymond R; Sidney, Stephen S; Fortmann, Stephen P SP; Go, Alan A; Hlatky, Mark M; Iribarren, Carlos C; Boerwinkle, Eric E; Myers, Richard R; Risch, Neil N; Quertermous, Thomas T
Publication Date: 2008-05

Variant appearance in text: rs10507391
PubMed Link: 18369664
Variant Present in the following documents:
  • Main text
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Framingham Heart Study 100K project: genome-wide associations for cardiovascular disease outcomes.

Bmc Medical Genetics
Larson, Martin G MG; Atwood, Larry D LD; Benjamin, Emelia J EJ; Cupples, L Adrienne LA; D'Agostino, Ralph B RB; Fox, Caroline S CS; Govindaraju, Diddahally R DR; Guo, Chao-Yu CY; Heard-Costa, Nancy L NL; Hwang, Shih-Jen SJ; Murabito, Joanne M JM; Newton-Cheh, Christopher C; O'Donnell, Christopher J CJ; Seshadri, Sudha S; Vasan, Ramachandran S RS; Wang, Thomas J TJ; Wolf, Philip A PA; Levy, Daniel D
Publication Date: 2007-09-19

Variant appearance in text: rs10507391
PubMed Link: 17903304
Variant Present in the following documents:
  • Main text
  • 1471-2350-8-S1-S5.pdf
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Variants associated with common disease are not unusually differentiated in frequency across populations.

American Journal Of Human Genetics
Lohmueller, Kirk E KE; Mauney, Matthew M MM; Reich, David D; Braverman, John M JM
Publication Date: 2006-01

Variant appearance in text: rs10507391
PubMed Link: 16385456
Variant Present in the following documents:
  • Main text
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