Publications:

Understanding and predicting the functional consequences of missense mutations in BRCA1 and BRCA2.

Scientific Reports

Aljarf, Raghad R; Shen, Mengyuan M; Pires, Douglas E V DEV; Ascher, David B DB

Publication Date: 2022-06-21

Variant appearance in text: BRCA2: A1527S

PubMed Link: 35729312

Variant Present in the following documents:

• 41598_2022_13508_MOESM2_ESM.xlsx, sheet 1

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Prediction of the functional impact of missense variants in BRCA1 and BRCA2 with BRCA-ML.

Npj Breast Cancer

Hart, Steven N SN; Polley, Eric C EC; Shimelis, Hermella H; Yadav, Siddhartha S; Couch, Fergus J FJ

Publication Date: 2020

Variant appearance in text: BRCA2: 4579G>T; Ala1527Ser

PubMed Link: 32377563

Variant Present in the following documents:

• 41523_2020_159_MOESM3_ESM.xlsx, sheet 1

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Comprehensive annotation of BRCA1 and BRCA2 missense variants by functionally validated sequence-based computational prediction models.

Genetics In Medicine : Official Journal Of The American College Of Medical Genetics

Hart, Steven N SN; Hoskin, Tanya T; Shimelis, Hermela H; Moore, Raymond M RM; Feng, Bingjian B; Thomas, Abigail A; Lindor, Noralane M NM; Polley, Eric C EC; Goldgar, David E DE; Iversen, Edwin E; Monteiro, Alvaro N A ANA; Suman, Vera J VJ; Couch, Fergus J FJ

Publication Date: 2019-01

Variant appearance in text: BRCA2: A1527S

PubMed Link: 29884841

Variant Present in the following documents:

• NIHMS953431-supplement-Table_S2.xls, sheet 1

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Structure-activity relationship of the peptide binding-motif mediating the BRCA2:RAD51 protein-protein interaction.

Febs Letters

Scott, Duncan E DE; Marsh, May M; Blundell, Tom L TL; Abell, Chris C; Hyvönen, Marko M

Publication Date: 2016-04

Variant appearance in text: BRCA2: A1527S

PubMed Link: 26992456

Variant Present in the following documents:

• Main text
• FEB2-590-1094.pdf

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Design of potent inhibitors of human RAD51 recombinase based on BRC motifs of BRCA2 protein: modeling and experimental validation of a chimera peptide.

Journal Of Medicinal Chemistry

Nomme, Julian J; Renodon-Cornière, Axelle A; Asanomi, Yuya Y; Sakaguchi, Kazuyasu K; Stasiak, Alicja Z AZ; Stasiak, Andrzej A; Norden, Bengt B; Tran, Vinh V; Takahashi, Masayuki M

Publication Date: 2010-08-12

Variant appearance in text: BRCA2: Ala1527Ser

PubMed Link: 20684611

Variant Present in the following documents:

• Main text
• jm1002974.pdf

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