BRCA2 c.4648G>T ;(p.E1550*)

Variant ID: 13-32913140-G-T

NM_000059.3(BRCA2):c.4648G>T;(p.E1550*)

This variant was identified in 18 publications

View GRCh38 version.




Publications:


Whole-exome Sequencing of Nigerian Prostate Tumors from the Prostate Cancer Transatlantic Consortium (CaPTC) Reveals DNA Repair Genes Associated with African Ancestry.

Cancer Research Communications
White, Jason A JA; Kaninjing, Ernest T ET; Adeniji, Kayode A KA; Jibrin, Paul P; Obafunwa, John O JO; Ogo, Chidiebere N CN; Mohammed, Faruk F; Popoola, Ademola A; Fatiregun, Omolara A OA; Oluwole, Olabode P OP; Karanam, Balasubramanyam B; Elhussin, Isra I; Ambs, Stefan S; Tang, Wei W; Davis, Melissa M; Polak, Paz P; Campbell, Moray J MJ; Brignole, Kathryn R KR; Rotimi, Solomon O SO; Dean-Colomb, Windy W; Odedina, Folake T FT; Martin, Damali N DN; Yates, Clayton C
Publication Date: 2022-09

Variant appearance in text: BRCA2: 4648G>T; E1550*; rs80358695
PubMed Link: 36922933
Variant Present in the following documents:
  • crc-22-0136-s01.xlsx, sheet 1
View BVdb publication page



Network expansion of genetic associations defines a pleiotropy map of human cell biology.

Nature Genetics
Barrio-Hernandez, Inigo I; Schwartzentruber, Jeremy J; Shrivastava, Anjali A; Del-Toro, Noemi N; Gonzalez, Asier A; Zhang, Qian Q; Mountjoy, Edward E; Suveges, Daniel D; Ochoa, David D; Ghoussaini, Maya M; Bradley, Glyn G; Hermjakob, Henning H; Orchard, Sandra S; Dunham, Ian I; Anderson, Carl A CA; Porras, Pablo P; Beltrao, Pedro P
Publication Date: 2023-02-23

Variant appearance in text: BRCA2: 4648G>T; Glu1550Ter
PubMed Link: 36823319
Variant Present in the following documents:
  • 41588_2023_1327_MOESM4_ESM.xlsx, sheet 6
View BVdb publication page



Genomic and transcriptomic analyses identify a prognostic gene signature and predict response to therapy in pleural and peritoneal mesothelioma.

Cell Reports. Medicine
Nair, Nishanth Ulhas NU; Jiang, Qun Q; Wei, Jun Stephen JS; Misra, Vikram Alexander VA; Morrow, Betsy B; Kesserwan, Chimene C; Hermida, Leandro C LC; Lee, Joo Sang JS; Mian, Idrees I; Zhang, Jingli J; Lebensohn, Alexandra A; Miettinen, Markku M; Sengupta, Manjistha M; Khan, Javed J; Ruppin, Eytan E; Hassan, Raffit R
Publication Date: 2023-02-08

Variant appearance in text: BRCA2: 4648G>T; Glu1550Ter; rs80358695
PubMed Link: 36773602
Variant Present in the following documents:
  • mmc2.xlsx, sheet 1
View BVdb publication page



Analysis of single-nucleotide polymorphisms in genes associated with triple-negative breast cancer.

Frontiers In Genetics
G, Vigneshwaran V; Hasan, Qurratulain Annie QA; Kumar, Rahul R; Eranki, Avinash A
Publication Date: 2022

Variant appearance in text: rs80358695
PubMed Link: 36561320
Variant Present in the following documents:
  • Table2.xlsx, sheet 3
View BVdb publication page



Tissue and liquid biopsy profiling reveal convergent tumor evolution and therapy evasion in breast cancer.

Nature Communications
Sivakumar, Smruthy S; Jin, Dexter X DX; Tukachinsky, Hanna H; Murugesan, Karthikeyan K; McGregor, Kimberly K; Danziger, Natalie N; Pavlick, Dean D; Gjoerup, Ole O; Ross, Jeffrey S JS; Harmon, Robert R; Chung, Jon J; Decker, Brennan B; Dennis, Lucas L; Frampton, Garrett M GM; Molinero, Luciana L; Oesterreich, Steffi S; Venstrom, Jeffrey M JM; Oxnard, Geoffrey R GR; Hegde, Priti S PS; Sokol, Ethan S ES
Publication Date: 2022-12-05

Variant appearance in text: BRCA2: E1550*
PubMed Link: 36470901
Variant Present in the following documents:
  • 41467_2022_35245_MOESM4_ESM.xlsx, sheet 13
View BVdb publication page



Copy number variants as modifiers of breast cancer risk for BRCA1/BRCA2 pathogenic variant carriers.

Communications Biology
Hakkaart, Christopher C; Pearson, John F JF; Marquart, Louise L; Dennis, Joe J; Wiggins, George A R GAR; Barnes, Daniel R DR; Robinson, Bridget A BA; Mace, Peter D PD; Aittomäki, Kristiina K; Andrulis, Irene L IL; Arun, Banu K BK; Azzollini, Jacopo J; Balmaña, Judith J; Barkardottir, Rosa B RB; Belhadj, Sami S; Berger, Lieke L; Blok, Marinus J MJ; Boonen, Susanne E SE; Borde, Julika J; Bradbury, Angela R AR; Brunet, Joan J; Buys, Saundra S SS; Caligo, Maria A MA; Campbell, Ian I; Chung, Wendy K WK; Claes, Kathleen B M KBM; , ; , ; Collonge-Rame, Marie-Agnès MA; Cook, Jackie J; Cosgrove, Casey C; Couch, Fergus J FJ; Daly, Mary B MB; Dandiker, Sita S; Davidson, Rosemarie R; de la Hoya, Miguel M; de Putter, Robin R; Delnatte, Capucine C; Dhawan, Mallika M; Diez, Orland O; Ding, Yuan Chun YC; Domchek, Susan M SM; Donaldson, Alan A; Eason, Jacqueline J; Easton, Douglas F DF; Ehrencrona, Hans H; Engel, Christoph C; Evans, D Gareth DG; Faust, Ulrike U; Feliubadaló, Lidia L; Fostira, Florentia F; Friedman, Eitan E; Frone, Megan M; Frost, Debra D; Garber, Judy J; Gayther, Simon A SA; Gehrig, Andrea A; Gesta, Paul P; Godwin, Andrew K AK; Goldgar, David E DE; Greene, Mark H MH; Hahnen, Eric E; Hake, Christopher R CR; Hamann, Ute U; Hansen, Thomas V O TVO; Hauke, Jan J; Hentschel, Julia J; Herold, Natalie N; Honisch, Ellen E; Hulick, Peter J PJ; Imyanitov, Evgeny N EN; , ; , ; , ; Isaacs, Claudine C; Izatt, Louise L; Izquierdo, Angel A; Jakubowska, Anna A; James, Paul A PA; Janavicius, Ramunas R; John, Esther M EM; Joseph, Vijai V; Karlan, Beth Y BY; Kemp, Zoe Z; Kirk, Judy J; Konstantopoulou, Irene I; Koudijs, Marco M; Kwong, Ava A; Laitman, Yael Y; Lalloo, Fiona F; Lasset, Christine C; Lautrup, Charlotte C; Lazaro, Conxi C; Legrand, Clémentine C; Leslie, Goska G; Lesueur, Fabienne F; Mai, Phuong L PL; Manoukian, Siranoush S; Mari, Véronique V; Martens, John W M JWM; McGuffog, Lesley L; Mebirouk, Noura N; Meindl, Alfons A; Miller, Austin A; Montagna, Marco M; Moserle, Lidia L; Mouret-Fourme, Emmanuelle E; Musgrave, Hannah H; Nambot, Sophie S; Nathanson, Katherine L KL; Neuhausen, Susan L SL; Nevanlinna, Heli H; Yie, Joanne Ngeow Yuen JNY; Nguyen-Dumont, Tu T; Nikitina-Zake, Liene L; Offit, Kenneth K; Olah, Edith E; Olopade, Olufunmilayo I OI; Osorio, Ana A; Ott, Claus-Eric CE; Park, Sue K SK; Parsons, Michael T MT; Pedersen, Inge Sokilde IS; Peixoto, Ana A; Perez-Segura, Pedro P; Peterlongo, Paolo P; Pocza, Timea T; Radice, Paolo P; Ramser, Juliane J; Rantala, Johanna J; Rodriguez, Gustavo C GC; Rønlund, Karina K; Rosenberg, Efraim H EH; Rossing, Maria M; Schmutzler, Rita K RK; Shah, Payal D PD; Sharif, Saba S; Sharma, Priyanka P; Side, Lucy E LE; Simard, Jacques J; Singer, Christian F CF; Snape, Katie K; Steinemann, Doris D; Stoppa-Lyonnet, Dominique D; Sutter, Christian C; Tan, Yen Yen YY; Teixeira, Manuel R MR; Teo, Soo Hwang SH; Thomassen, Mads M; Thull, Darcy L DL; Tischkowitz, Marc M; Toland, Amanda E AE; Trainer, Alison H AH; Tripathi, Vishakha V; Tung, Nadine N; van Engelen, Klaartje K; van Rensburg, Elizabeth J EJ; Vega, Ana A; Viel, Alessandra A; Walker, Lisa L; Weitzel, Jeffrey N JN; Wevers, Marike R MR; Chenevix-Trench, Georgia G; Spurdle, Amanda B AB; Antoniou, Antonis C AC; Walker, Logan C LC
Publication Date: 2022-10-06

Variant appearance in text: BRCA2: 4648G>T; Glu1550X
PubMed Link: 36203093
Variant Present in the following documents:
  • 42003_2022_3978_MOESM4_ESM.xlsx, sheet 14
View BVdb publication page



BRCA2-DSS1 interaction is dispensable for RAD51 recruitment at replication-induced and meiotic DNA double strand breaks.

Nature Communications
Mishra, Arun Prakash AP; Hartford, Suzanne A SA; Sahu, Sounak S; Klarmann, Kimberly K; Chittela, Rajani Kant RK; Biswas, Kajal K; Jeon, Albert B AB; Martin, Betty K BK; Burkett, Sandra S; Southon, Eileen E; Reid, Susan S; Albaugh, Mary E ME; Karim, Baktiar B; Tessarollo, Lino L; Keller, Jonathan R JR; Sharan, Shyam K SK
Publication Date: 2022-04-01

Variant appearance in text: BRCA2: Glu1550Ter
PubMed Link: 35365640
Variant Present in the following documents:
  • Main text
  • 41467_2022_Article_29409.pdf
View BVdb publication page



Evidence for accelerated aging in mammary epithelia of women carrying germline BRCA1 or BRCA2 mutations.

Nature Aging
Shalabi, Sundus F SF; Miyano, Masaru M; Sayaman, Rosalyn W RW; Lopez, Jennifer C JC; Jokela, Tiina A TA; Todhunter, Michael E ME; Hinz, Stefan S; Garbe, James C JC; Stampfer, Martha R MR; Kessenbrock, Kai K; Seewaldt, Victoria E VE; LaBarge, Mark A MA
Publication Date: 2021-09

Variant appearance in text: BRCA2: 4648G>T; Glu1550X
PubMed Link: 35187501
Variant Present in the following documents:
  • NIHMS1772753-supplement-Supplementary_Tables_1_12.xlsx, sheet 2
View BVdb publication page



Population-based estimates of breast cancer risk for carriers of pathogenic variants identified by gene-panel testing.

Npj Breast Cancer
Southey, Melissa C MC; Dowty, James G JG; Riaz, Moeen M; Steen, Jason A JA; Renault, Anne-Laure AL; Tucker, Katherine K; Kirk, Judy J; James, Paul P; Winship, Ingrid I; Pachter, Nicholas N; Poplawski, Nicola N; Grist, Scott S; Park, Daniel J DJ; Pope, Bernard J BJ; Mahmood, Khalid K; Hammet, Fleur F; Mahmoodi, Maryam M; Tsimiklis, Helen H; Theys, Derrick D; Rewse, Amanda A; Willis, Amanda A; Morrow, April A; Speechly, Catherine C; Harris, Rebecca R; Sebra, Robert R; Schadt, Eric E; Lacaze, Paul P; McNeil, John J JJ; Giles, Graham G GG; Milne, Roger L RL; Hopper, John L JL; Nguyen-Dumont, Tú T
Publication Date: 2021-12-09

Variant appearance in text: BRCA2: 4648G>T; Glu1550Ter
PubMed Link: 34887416
Variant Present in the following documents:
  • 41523_2021_360_MOESM1_ESM.pdf
View BVdb publication page



Population-based estimates of breast cancer risk for carriers of pathogenic variants identified by gene-panel testing.

Npj Breast Cancer
Southey, Melissa C MC; Dowty, James G JG; Riaz, Moeen M; Steen, Jason A JA; Renault, Anne-Laure AL; Tucker, Katherine K; Kirk, Judy J; James, Paul P; Winship, Ingrid I; Pachter, Nicholas N; Poplawski, Nicola N; Grist, Scott S; Park, Daniel J DJ; Pope, Bernard J BJ; Mahmood, Khalid K; Hammet, Fleur F; Mahmoodi, Maryam M; Tsimiklis, Helen H; Theys, Derrick D; Rewse, Amanda A; Willis, Amanda A; Morrow, April A; Speechly, Catherine C; Harris, Rebecca R; Sebra, Robert R; Schadt, Eric E; Lacaze, Paul P; McNeil, John J JJ; Giles, Graham G GG; Milne, Roger L RL; Hopper, John L JL; Nguyen-Dumont, Tú T
Publication Date: 2021-12-09

Variant appearance in text: BRCA2: 4648G>T; Glu1550Ter
PubMed Link: 34887416
Variant Present in the following documents:
  • 41523_2021_360_MOESM1_ESM.pdf
View BVdb publication page



A computational and structural analysis of germline and somatic variants affecting the DDR mechanism, and their impact on human diseases.

Scientific Reports
Magraner-Pardo, Lorena L; Laskowski, Roman A RA; Pons, Tirso T; Thornton, Janet M JM
Publication Date: 2021-07-12

Variant appearance in text: BRCA2: 4648G>T; E1550X; rs80358695
PubMed Link: 34253785
Variant Present in the following documents:
  • 41598_2021_93715_MOESM2_ESM.xlsx, sheet 7
View BVdb publication page



Prostate Cancer Risk by BRCA2 Genomic Regions.

European Urology
Nyberg, Tommy T; Frost, Debra D; Barrowdale, Daniel D; Evans, D Gareth DG; Bancroft, Elizabeth E; Adlard, Julian J; Ahmed, Munaza M; Barwell, Julian J; Brady, Angela F AF; Brewer, Carole C; Cook, Jackie J; Davidson, Rosemarie R; Donaldson, Alan A; Eason, Jacqueline J; Gregory, Helen H; Henderson, Alex A; Izatt, Louise L; Kennedy, M John MJ; Miller, Claire C; Morrison, Patrick J PJ; Murray, Alex A; Ong, Kai-Ren KR; Porteous, Mary M; Pottinger, Caroline C; Rogers, Mark T MT; Side, Lucy L; Snape, Katie K; Tripathi, Vishakha V; Walker, Lisa L; Tischkowitz, Marc M; Eeles, Rosalind R; Easton, Douglas F DF; Antoniou, Antonis C AC
Publication Date: 2020-10

Variant appearance in text: BRCA2: 4648G>T; Glu1550*
PubMed Link: 32532514
Variant Present in the following documents:
  • mmc1.pdf
View BVdb publication page



Prediction of the functional impact of missense variants in BRCA1 and BRCA2 with BRCA-ML.

Npj Breast Cancer
Hart, Steven N SN; Polley, Eric C EC; Shimelis, Hermella H; Yadav, Siddhartha S; Couch, Fergus J FJ
Publication Date: 2020

Variant appearance in text: BRCA2: 4648G>T; Glu1550X
PubMed Link: 32377563
Variant Present in the following documents:
  • 41523_2020_159_MOESM3_ESM.xlsx, sheet 1
View BVdb publication page



Clinical outcome of breast cancer in carriers of BRCA1 and BRCA2 mutations according to molecular subtypes.

Scientific Reports
De Talhouet, Solene S; Peron, Julien J; Vuilleumier, Aurelie A; Friedlaender, Alex A; Viassolo, Valeria V; Ayme, Aurélie A; Bodmer, Alexandre A; Treilleux, Isabelle I; Lang, Noemie N; Tille, Jean- Christophe JC; Chappuis, Pierre O PO; Buisson, Adrien A; Giraud, Sophie S; Lasset, Christine C; Bonadona, Valerie V; Trédan, Olivier O; Labidi-Galy, S Intidhar SI
Publication Date: 2020-04-27

Variant appearance in text: BRCA2: 4648G>T; Glu1550*
PubMed Link: 32341426
Variant Present in the following documents:
  • 41598_2020_63759_MOESM1_ESM.pdf
View BVdb publication page



Pan-urologic cancer genomic subtypes that transcend tissue of origin.

Nature Communications
Chen, Fengju F; Zhang, Yiqun Y; Bossé, Dominick D; Lalani, Aly-Khan A AA; Hakimi, A Ari AA; Hsieh, James J JJ; Choueiri, Toni K TK; Gibbons, Don L DL; Ittmann, Michael M; Creighton, Chad J CJ
Publication Date: 2017-08-04

Variant appearance in text: rs80358695
PubMed Link: 28775315
Variant Present in the following documents:
  • 41467_2017_289_MOESM7_ESM.xlsx, sheet 1
View BVdb publication page



Sources of discordance among germ-line variant classifications in ClinVar.

Genetics In Medicine : Official Journal Of The American College Of Medical Genetics
Yang, Shan S; Lincoln, Stephen E SE; Kobayashi, Yuya Y; Nykamp, Keith K; Nussbaum, Robert L RL; Topper, Scott S
Publication Date: 2017-10

Variant appearance in text: BRCA2: 4648G>T; Glu1550Ter
PubMed Link: 28569743
Variant Present in the following documents:
  • gim201760x7.xlsx, sheet 2
View BVdb publication page



Development of primary early-onset colorectal cancers due to biallelic mutations of the FANCD1/BRCA2 gene.

European Journal Of Human Genetics : Ejhg
Degrolard-Courcet, Emilie E; Sokolowska, Joanna J; Padeano, Marie-Martine MM; Guiu, Séverine S; Bronner, Myriam M; Chery, Carole C; Coron, Fanny F; Lepage, Côme C; Chapusot, Caroline C; Loustalot, Catherine C; Jouve, Jean-Louis JL; Hatem, Cyril C; Ferrant, Emmanuelle E; Martin, Laurent L; Coutant, Charles C; Baurand, Amandine A; Couillault, Gérard G; Delignette, Alexandra A; El Chehadeh, Salima S; Lizard, Sarab S; Arnould, Laurent L; Fumoleau, Pierre P; Callier, Patrick P; Mugneret, Francine F; Philippe, Christophe C; Frebourg, Thierry T; Jonveaux, Philippe P; Faivre, Laurence L
Publication Date: 2014-08

Variant appearance in text: BRCA2: 4648G>T
PubMed Link: 24301060
Variant Present in the following documents:
  • Main text
View BVdb publication page



A comprehensive functional characterization of BRCA2 variants associated with Fanconi anemia using mouse ES cell-based assay.

Blood
Biswas, Kajal K; Das, Ranabir R; Alter, Blanche P BP; Kuznetsov, Sergey G SG; Stauffer, Stacey S; North, Susan L SL; Burkett, Sandra S; Brody, Lawrence C LC; Meyer, Stefan S; Byrd, R Andrew RA; Sharan, Shyam K SK
Publication Date: 2011-09-01

Variant appearance in text: BRCA2: E1550X
PubMed Link: 21719596
Variant Present in the following documents:
  • Main text
View BVdb publication page



Clinical and molecular features associated with biallelic mutations in FANCD1/BRCA2.

Journal Of Medical Genetics
Alter, Blanche P BP; Rosenberg, Philip S PS; Brody, Lawrence C LC
Publication Date: 2007-01

Variant appearance in text: BRCA2: E1550X
PubMed Link: 16825431
Variant Present in the following documents:
  • Main text
View BVdb publication page