BRCA2 c.4963_4964delinsCT ;(p.Y1655L)

Variant ID: 13-32913455-TA-CT

NM_000059.3(BRCA2):c.4963_4964delinsCT;(p.Y1655L)

This variant was identified in 4 publications

View GRCh38 version.




Publications:


Olaparib-Resistant BRCA2MUT Ovarian Cancer Cells with Restored BRCA2 Abrogate Olaparib-Induced DNA Damage and G2/M Arrest Controlled by the ATR/CHK1 Pathway for Survival.

Cells
Biegała, Łukasz Ł; Gajek, Arkadiusz A; Marczak, Agnieszka A; Rogalska, Aneta A
Publication Date: 2023-03-29

Variant appearance in text: BRCA2: Y1655L
PubMed Link: 37048111
Variant Present in the following documents:
  • Main text
  • cells-12-01038.pdf
View BVdb publication page



Preclinical models of epithelial ovarian cancer: practical considerations and challenges for a meaningful application.

Cellular And Molecular Life Sciences : Cmls
Ciucci, Alessandra A; Buttarelli, Marianna M; Fagotti, Anna A; Scambia, Giovanni G; Gallo, Daniela D
Publication Date: 2022-06-16

Variant appearance in text: BRCA2: Tyr1655Leu
PubMed Link: 35705879
Variant Present in the following documents:
  • Main text
  • 18_2022_Article_4395.pdf
View BVdb publication page



BRCA1/2 mutation analysis in 41 ovarian cell lines reveals only one functionally deleterious BRCA1 mutation.

Molecular Oncology
Stordal, Britta B; Timms, Kirsten K; Farrelly, Angela A; Gallagher, Danielle D; Busschots, Steven S; Renaud, Mickaël M; Thery, Julien J; Williams, Deborah D; Potter, Jennifer J; Tran, Thanh T; Korpanty, Greg G; Cremona, Mattia M; Carey, Mark M; Li, Jie J; Li, Yang Y; Aslan, Ozlem O; O'Leary, John J JJ; Mills, Gordon B GB; Hennessy, Bryan T BT
Publication Date: 2013-06

Variant appearance in text: BRCA2: Y1655L
PubMed Link: 23415752
Variant Present in the following documents:
  • Main text
View BVdb publication page



Functional restoration of BRCA2 protein by secondary BRCA2 mutations in BRCA2-mutated ovarian carcinoma.

Cancer Research
Sakai, Wataru W; Swisher, Elizabeth M EM; Jacquemont, Céline C; Chandramohan, Kurapaty Venkatapoorna KV; Couch, Fergus J FJ; Langdon, Simon P SP; Wurz, Kaitlyn K; Higgins, Jake J; Villegas, Emily E; Taniguchi, Toshiyasu T
Publication Date: 2009-08-15

Variant appearance in text: BRCA2: Y1655L
PubMed Link: 19654294
Variant Present in the following documents:
  • Main text
View BVdb publication page