Publications:

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Olaparib-Resistant BRCA2MUT Ovarian Cancer Cells with Restored BRCA2 Abrogate Olaparib-Induced DNA Damage and G2/M Arrest Controlled by the ATR/CHK1 Pathway for Survival.

Cells

Biegała, Łukasz Ł; Gajek, Arkadiusz A; Marczak, Agnieszka A; Rogalska, Aneta A

Publication Date: 2023-03-29

Variant appearance in text: BRCA2: 4965C>T; Y1655Y

PubMed Link: 37048111

Variant Present in the following documents:

• Main text
• cells-12-01038.pdf

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Predictive mutation signature of immunotherapy benefits in NSCLC based on machine learning algorithms.

Frontiers In Immunology

Liu, Zhichao Z; Lin, Guo G; Yan, Zeping Z; Li, Linduo L; Wu, Xingchen X; Shi, Jingrong J; He, Jianxing J; Zhao, Lei L; Liang, Hengrui H; Wang, Wei W

Publication Date: 2022

Variant appearance in text: BRCA2: 4965C>T; Y1655Y

PubMed Link: 36238300

Variant Present in the following documents:

• Table_1.xlsx, sheet 4

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EPHA5 mutation was associated with adverse outcome of atezolizumab treatment in late-stage non-small cell lung cancers.

Bmc Pulmonary Medicine

Li, Zhenxiang Z; Zhou, Qing Q; Wang, Qi Q; Wang, Haiyong H; Yue, Weiming W

Publication Date: 2022-09-19

Variant appearance in text: BRCA2: 4965C>T; Y1655Y

PubMed Link: 36123678

Variant Present in the following documents:

• 12890_2022_2161_MOESM2_ESM.xlsx, sheet 1

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WRN helicase safeguards deprotected replication forks in BRCA2-mutated cancer cells.

Nature Communications

Datta, Arindam A; Biswas, Kajal K; Sommers, Joshua A JA; Thompson, Haley H; Awate, Sanket S; Nicolae, Claudia M CM; Thakar, Tanay T; Moldovan, George-Lucian GL; Shoemaker, Robert H RH; Sharan, Shyam K SK; Brosh, Robert M RM

Publication Date: 2021-11-12

Variant appearance in text: BRCA2: Y1655Y

PubMed Link: 34772932

Variant Present in the following documents:

• Main text
• 41467_2021_Article_26811.pdf

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WRN helicase safeguards deprotected replication forks in BRCA2-mutated cancer cells.

Nature Communications

Datta, Arindam A; Biswas, Kajal K; Sommers, Joshua A JA; Thompson, Haley H; Awate, Sanket S; Nicolae, Claudia M CM; Thakar, Tanay T; Moldovan, George-Lucian GL; Shoemaker, Robert H RH; Sharan, Shyam K SK; Brosh, Robert M RM

Publication Date: 2021-11-12

Variant appearance in text: BRCA2: Y1655Y

PubMed Link: 34772932

Variant Present in the following documents:

• Main text
• 41467_2021_Article_26811.pdf

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NADP+ is an endogenous PARP inhibitor in DNA damage response and tumor suppression.

Nature Communications

Bian, Chunjing C; Zhang, Chao C; Luo, Tao T; Vyas, Aditi A; Chen, Shih-Hsun SH; Liu, Chao C; Kassab, Muzaffer Ahmad MA; Yang, Ying Y; Kong, Mei M; Yu, Xiaochun X

Publication Date: 2019-02-11

Variant appearance in text: BRCA2: Y1655Y

PubMed Link: 30741937

Variant Present in the following documents:

• Main text
• 41467_2019_Article_8530.pdf

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Ovarian Cancers Harbor Defects in Nonhomologous End Joining Resulting in Resistance to Rucaparib.

Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research

McCormick, Aiste A; Donoghue, Peter P; Dixon, Michelle M; O'Sullivan, Richard R; O'Donnell, Rachel L RL; Murray, James J; Kaufmann, Angelika A; Curtin, Nicola J NJ; Edmondson, Richard J RJ

Publication Date: 2017-04-15

Variant appearance in text: BRCA2: Y1655Y

PubMed Link: 27702817

Variant Present in the following documents:

• Main text

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Ovarian cancer cell line panel (OCCP): clinical importance of in vitro morphological subtypes.

Plos One

Beaufort, Corine M CM; Helmijr, Jean C A JC; Piskorz, Anna M AM; Hoogstraat, Marlous M; Ruigrok-Ritstier, Kirsten K; Besselink, Nicolle N; Murtaza, Muhammed M; van IJcken, Wilfred F J WF; Heine, Anouk A J AA; Smid, Marcel M; Koudijs, Marco J MJ; Brenton, James D JD; Berns, Els M J J EM; Helleman, Jozien J

Publication Date: 2014

Variant appearance in text: BRCA2: Y1655Y

PubMed Link: 25230021

Variant Present in the following documents:

• pone.0103988.s007.xlsx, sheet 1

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BRCA1/2 mutation analysis in 41 ovarian cell lines reveals only one functionally deleterious BRCA1 mutation.

Molecular Oncology

Stordal, Britta B; Timms, Kirsten K; Farrelly, Angela A; Gallagher, Danielle D; Busschots, Steven S; Renaud, Mickaël M; Thery, Julien J; Williams, Deborah D; Potter, Jennifer J; Tran, Thanh T; Korpanty, Greg G; Cremona, Mattia M; Carey, Mark M; Li, Jie J; Li, Yang Y; Aslan, Ozlem O; O'Leary, John J JJ; Mills, Gordon B GB; Hennessy, Bryan T BT

Publication Date: 2013-06

Variant appearance in text: BRCA2: Y1655Y

PubMed Link: 23415752

Variant Present in the following documents:

• Main text

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Loss of BRCA1-A complex function in RAP80 null tumor cells.

Plos One

Bian, Chunjing C; Wu, Rong R; Cho, Kathleen K; Yu, Xiaochun X

Publication Date: 2012

Variant appearance in text: BRCA2: Y1655Y

PubMed Link: 22792303

Variant Present in the following documents:

• Main text
• pone.0040406.pdf

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Secondary mutations of BRCA1/2 and drug resistance.

Cancer Science

Dhillon, Kiranjit K KK; Swisher, Elizabeth M EM; Taniguchi, Toshiyasu T

Publication Date: 2011-04

Variant appearance in text: BRCA2: Y1655Y

PubMed Link: 21205087

Variant Present in the following documents:

• Main text

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Functional restoration of BRCA2 protein by secondary BRCA2 mutations in BRCA2-mutated ovarian carcinoma.

Cancer Research

Sakai, Wataru W; Swisher, Elizabeth M EM; Jacquemont, Céline C; Chandramohan, Kurapaty Venkatapoorna KV; Couch, Fergus J FJ; Langdon, Simon P SP; Wurz, Kaitlyn K; Higgins, Jake J; Villegas, Emily E; Taniguchi, Toshiyasu T

Publication Date: 2009-08-15

Variant appearance in text: BRCA2: Y1655Y

PubMed Link: 19654294

Variant Present in the following documents:

• Main text

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