Publications:

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Distinct Molecular Landscape of Epstein-Barr Virus Associated Pulmonary Lymphoepithelioma-Like Carcinoma Revealed by Genomic Sequencing.

Cancers

SL Chau, JH Tong, C Chow, JS Kwan, RW Lung, LY Chung, EK Tin, SS Wong, AH Cheung, RW Lau, CS Ng, TS Mok, KW Lo, KF To

Publication Date: 2020-07-27

Variant appearance in text: AKT1: E17K

PMID: 32726920

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The Roles of Common Variation and Somatic Mutation in Cancer Pharmacogenomics.

Oncology And Therapy

HT Chan, YM Chin, SK Low

Publication Date: 2019-06

Variant appearance in text: AKT1: E17K

PMID: 32700193

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Detection of somatic TP53 mutation in surgically resected small-cell lung cancer by targeted exome sequencing: association with longer relapse-free survival.

Heliyon

H Yokouchi, H Nishihara, T Harada, S Yamazaki, H Kikuchi, S Oizumi, H Uramoto, F Tanaka, M Harada, K Akie, F Sugaya, Y Fujita, K Takamura, T Kojima, M Higuchi, O Honjo, Y Minami, N Watanabe, M Nishimura, H Suzuki, H Dosaka-Akita, H Isobe

Publication Date: 2020-07

Variant appearance in text: AKT1: E17K

PMID: 32685741

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Cross-species oncogenic signatures of breast cancer in canine mammary tumors.

Nature Communications

TM Kim, IS Yang, BJ Seung, S Lee, D Kim, YJ Ha, MK Seo, KK Kim, HS Kim, JH Cheong, JH Sur, H Nam, S Kim

Publication Date: 2020-07-17

Variant appearance in text: AKT1: E17K

PMID: 32680987

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Brief CommunicationCirculating tumor DNA is present in the most aggressive meningiomas.

Neuro-Oncology Advances

T Graillon, C Roche, N Basset, G Mougel, M Meyer, K Farah, S Boissonneau, S Fuentes, E Tabouret, C Campello, R Appay, D Figarella-Branger, O Chinot, H Dufour, P Romanet, A Barlier

Publication Date: 2020

Variant appearance in text: AKT1: 49G>A; Glu17Lys

PMID: 32642718

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Histomolecular characterization of intracranial meningiomas developed in patients exposed to high-dose cyproterone acetate: an antiandrogen treatment.

Neuro-Oncology Advances

S Portet, R Naoufal, G Tachon, A Simonneau, A Chalant, A Naar, S Milin, B Bataille, L Karayan-Tapon

Publication Date: 2019

Variant appearance in text: AKT1: E17K

PMID: 32642646

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The PI3K-AKT-mTOR Pathway and Prostate Cancer: At the Crossroads of AR, MAPK, and WNT Signaling.

International Journal Of Molecular Sciences

BY Shorning, MS Dass, MJ Smalley, HB Pearson

Publication Date: 2020-06-25

Variant appearance in text: AKT: E17K

PMID: 32630372

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Biomarkers in Triple-Negative Breast Cancer: State-of-the-Art and Future Perspectives.

International Journal Of Molecular Sciences

S Cocco, M Piezzo, A Calabrese, D Cianniello, R Caputo, VD Lauro, G Fusco, GD Gioia, M Licenziato, M Laurentiis

Publication Date: 2020-06-27

Variant appearance in text: AKT: E17K

PMID: 32605126

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Whole Exome Sequencing of Multi-Regional Biopsies from Metastatic Lesions to Evaluate Actionable Truncal Mutations Using a Single-Pass Percutaneous Technique.

Cancers

V Heong, D Tay, SE Goh, B Wee, TZ Tan, R Soo, B Pang, D Lim, A Gopinathan, S Ow, CE Chee, BC Goh, SC Lee, WP Yong, A Wong, MFM Omar, R Soong, DS Tan

Publication Date: 2020-06-17

Variant appearance in text: AKT1: E17K

PMID: 32560395

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Detection of ctDNA with Personalized Molecular Barcode NGS and Its Clinical Significance in Patients with Early Breast Cancer.

Translational Oncology

T Yoshinami, N Kagara, D Motooka, S Nakamura, T Miyake, T Tanei, Y Naoi, M Shimoda, K Shimazu, SJ Kim, S Noguchi

Publication Date: 2020-05-27

Variant appearance in text: AKT1: E17K

PMID: 32473569

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Genomic and Transcriptomic Characteristics According to Size of Papillary Thyroid Microcarcinoma.

Cancers

YS Song, BH Kang, S Lee, SK Yoo, YS Choi, J Park, DY Park, KE Lee, JS Seo, YJ Park

Publication Date: 2020-05-25

Variant appearance in text: AKT1: E17K

PMID: 32466217

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The Quest for Improving Treatment of Cancer of Unknown Primary (CUP) Through Molecularly-Driven Treatments: A Systematic Review.

Frontiers In Oncology

R Lombardo, F Tosi, A Nocerino, K Bencardino, V Gambi, R Ricotta, F Spina, S Siena, A Sartore-Bianchi

Publication Date: 2020

Variant appearance in text: AKT1: E17K

PMID: 32457826

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Inhibitors in AKTion: ATP-competitive vs allosteric.

Biochemical Society Transactions

G Lazaro, E Kostaras, I Vivanco

Publication Date: 2020-05-26

Variant appearance in text: AKT: E17K

PMID: 32453400

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A systematic molecular and pharmacologic evaluation of AKT inhibitors reveals new insight into their biological activity.

British Journal Of Cancer

E Kostaras, T Kaserer, G Lazaro, SF Heuss, A Hussain, P Casado, A Hayes, C Yandim, N Palaskas, Y Yu, B Schwartz, F Raynaud, YL Chung, PR Cutillas, I Vivanco

Publication Date: 2020-05-22

Variant appearance in text: AKT: E17K

PMID: 32439931

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Integrative Analysis of the Genes Induced by the Intestine Microbiota of Infant Born to Term and Breastfed.

Bioinformatics And Biology Insights

B Nouadi, Y Sbaoui, M El Messal, F Bennis, F Chegdani

Publication Date: 2020

Variant appearance in text: AKT1: E17K

PMID: 32425510

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Pharmacogenomic Testing to Guide Personalized Cancer Medicine Decisions in Private Oncology Practice: A Case Study.

Frontiers In Oncology

G Astras, CI Papagiannopoulos, KA Kyritsis, C Markitani, IS Vizirianakis

Publication Date: 2020

Variant appearance in text: AKT1: 49G>A

PMID: 32411592

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Exomes of Ductal Luminal Breast Cancer Patients from Southwest Colombia: Gene Mutational Profile and Related Expression Alterations.

Biomolecules

C Cortes-Urrea, F Bueno-Gutiérrez, M Solarte, M Guevara-Burbano, F Tobar-Tosse, PE Vélez-Varela, JC Bonilla, G Barreto, J Velasco-Medina, PA Moreno, JL Rivas

Publication Date: 2020-04-30

Variant appearance in text: rs121434592

PMID: 32365829

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Role of PI3K/AKT pathway in cancer: the framework of malignant behavior.

Molecular Biology Reports

N Jiang, Q Dai, X Su, J Fu, X Feng, J Peng

Publication Date: 2020-04-24

Variant appearance in text: AKT1: E17K

PMID: 32333246

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Allelic heterogeneity of Proteus syndrome.

Cold Spring Harbor Molecular Case Studies

A Buser, MJ Lindhurst, HC Kondolf, MR Yourick, KM Keppler-Noreuil, JC Sapp, LG Biesecker

Publication Date: 2020-04-23

Variant appearance in text: AKT1: 49G>A

PMID: 32327430

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Targeted next generation sequencing identifies somatic mutations in a cohort of Egyptian breast cancer patients.

Journal Of Advanced Research

A Nassar, M Abouelhoda, O Mansour, SA Loutfy, MM Hafez, M Gomaa, A Bahnassy, AS El-Din Youssef, MM Lotfy, H Ismail, OS Ahmed, AA Abou-Bakr, AN Zekri

Publication Date: 2020-07

Variant appearance in text: AKT1: 49G>A

PMID: 32322420

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Use of an Integrated Pan-Cancer Oncology Enrichment Next-Generation Sequencing Assay to Measure Tumour Mutational Burden and Detect Clinically Actionable Variants.

Molecular Diagnosis & Therapy

V Pestinger, M Smith, T Sillo, JM Findlay, JF Laes, G Martin, G Middleton, P Taniere, AD Beggs

Publication Date: 2020-04-18

Variant appearance in text: AKT: E17K

PMID: 32306292

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The role of ubiquitination in tumorigenesis and targeted drug discovery.

Signal Transduction And Targeted Therapy

L Deng, T Meng, L Chen, W Wei, P Wang

Publication Date: 2020-02-29

Variant appearance in text: AKT: E17K

PMID: 32296023

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Ovarian mucinous tumors with mural nodules: immunohistochemical and molecular analysis of 3 cases.

Diagnostic Pathology

Y Shao, Q Liu, H Shi, B Lu

Publication Date: 2020-04-14

Variant appearance in text: AKT1: E17K

PMID: 32290854

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Comparison of commercially available whole-genome sequencing kits for variant detection in circulating cell-free DNA.

Scientific Reports

F Mauger, C Horgues, M Pierre-Jean, N Oussada, L Mesrob, JF Deleuze

Publication Date: 2020-04-10

Variant appearance in text: AKT1: E17K

PMID: 32277101

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Multiplexed molecular profiling of lung cancer with malignant pleural effusion using next generation sequencing in Chinese patients.

Oncology Letters

X Ruan, Y Sun, W Wang, J Ye, D Zhang, Z Gong, M Yang

Publication Date: 2020-05

Variant appearance in text: AKT1: E17K

PMID: 32269623

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KLF4K409Q-mutated meningiomas show enhanced hypoxia signaling and respond to mTORC1 inhibitor treatment.

Acta Neuropathologica Communications

N von Spreckelsen, N Waldt, R Poetschke, C Kesseler, H Dohmen, HK Jiao, A Nemeth, S Schob, C Scherlach, IE Sandalcioglu, M Deckert, F Angenstein, B Krischek, P Stavrinou, M Timmer, M Remke, E Kirches, R Goldbrunner, EA Chiocca, S Huettelmaier, T Acker, C Mawrin

Publication Date: 2020-04-03

Variant appearance in text: AKT1: E17K

PMID: 32245394

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Recent Improvements in Genomic and Transcriptomic Understanding of Anaplastic and Poorly Differentiated Thyroid Cancers.

Endocrinology And Metabolism (Seoul, Korea)

SK Yoo, YS Song, YJ Park, JS Seo

Publication Date: 2020-03

Variant appearance in text: AKT1: E17K

PMID: 32207263

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A phase I dose-escalation study of enzalutamide in combination with the AKT inhibitor AZD5363 (capivasertib) in patients with metastatic castration-resistant prostate cancer.

Annals Of Oncology : Official Journal Of The European Society For Medical Oncology

MP Kolinsky, P Rescigno, D Bianchini, Z Zafeiriou, N Mehra, J Mateo, V Michalarea, R Riisnaes, M Crespo, I Figueiredo, S Miranda, D Nava Rodrigues, P Flohr, N Tunariu, U Banerji, R Ruddle, A Sharp, J Welti, M Lambros, S Carreira, FI Raynaud, KE Swales, S Plymate, J Luo, H Tovey, N Porta, R Slade, L Leonard, E Hall, JS de Bono

Publication Date: 2020-02-21

Variant appearance in text: AKT: E17K

PMID: 32205016

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The role of ubiquitination in tumorigenesis and targeted drug discovery.

Signal Transduction And Targeted Therapy

L Deng, T Meng, L Chen, W Wei, P Wang

Publication Date: 2020

Variant appearance in text: AKT: E17K

PMID: 32140262

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Control of Akt activity and substrate phosphorylation in cells.

Iubmb Life

I Yudushkin

Publication Date: 2020-03-03

Variant appearance in text: AKT: E17K

PMID: 32125765

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Novel pathogenic alterations in pediatric and adult desmoid-type fibromatosis - A systematic analysis of 204 cases.

Scientific Reports

M Trautmann, J Rehkämper, H Gevensleben, J Becker, E Wardelmann, W Hartmann, I Grünewald, S Huss

Publication Date: 2020-02-25

Variant appearance in text: AKT1: E17K

PMID: 32099073

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A Rapid Robust Method for Subgrouping Non-NF2 Meningiomas According to Genotype and Detection of Lower Levels of M2 Macrophages in AKT1 E17K Mutated Tumours.

International Journal Of Molecular Sciences

CL Adams, E Ercolano, S Ferluga, A Sofela, F Dave, C Negroni, KM Kurian, DA Hilton, CO Hanemann

Publication Date: 2020-02-13

Variant appearance in text: AKT1: 49G>A; E17K

PMID: 32070062

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The paradox of cancer genes in non-malignant conditions: implications for precision medicine.

Genome Medicine

JJ Adashek, S Kato, SM Lippman, R Kurzrock

Publication Date: 2020-02-17

Variant appearance in text: AKT: E17K

PMID: 32066498

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NOTCH target gene HES5 mediates oncogenic and tumor suppressive functions in hepatocarcinogenesis.

Oncogene

S Luiken, A Fraas, M Bieg, R Sugiyanto, B Goeppert, S Singer, C Ploeger, G Warsow, JU Marquardt, C Sticht, C De La Torre, S Pusch, A Mehrabi, N Gretz, M Schlesner, R Eils, P Schirmacher, T Longerich, S Roessler

Publication Date: 2020-02-13

Variant appearance in text: AKT: E17K

PMID: 32055024

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Targeting non-small cell lung cancer: driver mutation beyond epidermal growth factor mutation and anaplastic lymphoma kinase fusion.

Therapeutic Advances In Medical Oncology

QS Chu

Publication Date: 2020

Variant appearance in text: AKT: E17K

PMID: 32047535

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Response to mTOR and PI3K inhibitors in enzalutamide-resistant luminal androgen receptor triple-negative breast cancer patient-derived xenografts.

Theranostics

F Coussy, M Lavigne, L de Koning, RE Botty, F Nemati, A Naguez, G Bataillon, B Ouine, A Dahmani, E Montaudon, P Painsec, S Chateau-Joubert, F Laetitia, T Larcher, S Vacher, W Chemlali, A Briaux, S Melaabi, AV Salomon, JM Guinebretiere, I Bieche, E Marangoni

Publication Date: 2020

Variant appearance in text: AKT1: E17K

PMID: 32042320

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Cell fitness screens reveal a conflict between LINE-1 retrotransposition and DNA replication.

Nature Structural & Molecular Biology

D Ardeljan, JP Steranka, C Liu, Z Li, MS Taylor, LM Payer, M Gorbounov, JS Sarnecki, V Deshpande, RH Hruban, JD Boeke, D Fenyö, PH Wu, A Smogorzewska, AJ Holland, KH Burns

Publication Date: 2020-02

Variant appearance in text: AKT1: E17K

PMID: 32042151

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Is There a Role for Dual PI3K/mTOR Inhibitors for Patients Affected with Lymphoma?

International Journal Of Molecular Sciences

C Tarantelli, A Lupia, A Stathis, F Bertoni

Publication Date: 2020-02-05

Variant appearance in text: AKT: E17K

PMID: 32033478

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Gene Prioritization through Consensus Strategy, Enrichment Methodologies Analysis, and Networking for Osteosarcoma Pathogenesis.

International Journal Of Molecular Sciences

A Cabrera-Andrade, A López-Cortés, G Jaramillo-Koupermann, C Paz-Y-Miño, Y Pérez-Castillo, CR Munteanu, H González-Díaz, A Pazos, E Tejera

Publication Date: 2020-02-05

Variant appearance in text: AKT: E17K

PMID: 32033398

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Clinical report: one year of treatment of Proteus syndrome with miransertib (ARQ 092).

Cold Spring Harbor Molecular Case Studies

LG Biesecker, M Edwards, S O'Donnell, P Doherty, T MacDougall, K Tith, J Kazakin, B Schwartz

Publication Date: 2020-02

Variant appearance in text: AKT1: 49G>A; rs121434592

PMID: 32014856

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Circulating tumor DNA analysis in the era of precision oncology.

Oncotarget

R Said, N Guibert, GR Oxnard, AM Tsimberidou

Publication Date: 2020-01-14

Variant appearance in text: AKT1: E17K

PMID: 32010431

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PIK3CA gene mutations in the helical domain correlate with high tumor mutation burden and poor prognosis in metastatic breast carcinomas with late-line therapies.

Aging

Y Tang, J Li, N Xie, X Yang, L Liu, H Wu, C Tian, Y He, X Wang, Q He, ZY Hu, Q Ouyang

Publication Date: 2020-01-24

Variant appearance in text: AKT1: E17K

PMID: 31980592

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Recent Advances in Meningioma Immunogenetics.

Frontiers In Oncology

M Al-Rashed, K Foshay, M Abedalthagafi

Publication Date: 2019

Variant appearance in text: AKT1: E17K

PMID: 31970090

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A case report of Proteus syndrome (PS).

Bmc Medical Genetics

X Zeng, X Wen, X Liang, L Wang, L Xu

Publication Date: 2020-01-21

Variant appearance in text: AKT1: Glu17Lys

PMID: 31964351

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Mutation Status and Epithelial Differentiation Stratify Recurrence Risk in Chordoid Meningioma-A Multicenter Study with High Prognostic Relevance.

Cancers

MM Georgescu, A Nanda, Y Li, BC Mobley, PL Faust, JM Raisanen, A Olar

Publication Date: 2020-01-17

Variant appearance in text: AKT1: E17K

PMID: 31963394

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Genome-wide DNA copy number profiling and bioinformatics analysis of ovarian cancer reveals key genes and pathways associated with distinct invasive/migratory capabilities.

Aging

G Liu, G Ruan, M Huang, L Chen, P Sun

Publication Date: 2020-01-02

Variant appearance in text: AKT1: E17K

PMID: 31895688

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Overview of the relevance of PI3K pathway in HR-positive breast cancer.

Annals Of Oncology : Official Journal Of The European Society For Medical Oncology

N Vasan, E Toska, M Scaltriti

Publication Date: 2019-12-01

Variant appearance in text: AKT: E17K

PMID: 31859348

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Phase 1 Dose Escalation Study of the Allosteric AKT Inhibitor BAY 1125976 in Advanced Solid Cancer-Lack of Association between Activating AKT Mutation and AKT Inhibition-Derived Efficacy.

Cancers

A Schneeweiss, D Hess, M Joerger, A Varga, S Moulder, AM Tsimberidou, C Ma, SA Hurvitz, C Rentzsch, M Rudolph, S Thiele, O Boix, G Wilkinson, E Lagkadinou, M Ocker

Publication Date: 2019-12-10

Variant appearance in text: AKT: E17K

PMID: 31835495

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Combing the Cancer Genome for Novel Kinase Drivers and New Therapeutic Targets.

Cancers

P Torres-Ayuso, J Brognard

Publication Date: 2019-12-07

Variant appearance in text: AKT: E17K

PMID: 31817861

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Hyperprogressive Disease In Cervical Small Cell Carcinoma Treated By Immune Checkpoint Inhibitor.

Oncotargets And Therapy

Z Xu, L Chen, L Zheng, Q Yang, M Chen, J Wang, G Zhu, Z Chen, J Sun

Publication Date: 2019

Variant appearance in text: AKT1: E17K

PMID: 31802899

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MiRNA therapeutics based on logic circuits of biological pathways.

Bmc Bioinformatics

V Boscaino, A Fiannaca, L La Paglia, M La Rosa, R Rizzo, A Urso

Publication Date: 2019-11-22

Variant appearance in text: AKT1: 49G>A

PMID: 31757209

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Distinct functions of AKT isoforms in breast cancer: a comprehensive review.

Cell Communication And Signaling : Ccs

N Hinz, M Jücker

Publication Date: 2019-11-21

Variant appearance in text: AKT: E17K

PMID: 31752925

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The Role of Merlin/NF2 Loss in Meningioma Biology.

Cancers

S Lee, PJ Karas, CC Hadley, JC Bayley V, AB Khan, A Jalali, AD Sweeney, TJ Klisch, AJ Patel

Publication Date: 2019-10-24

Variant appearance in text: AKT: E17K

PMID: 31652973

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Response to Mammalian Target of Rapamycin-Based Therapy and Incidental Finding of Lynch Syndrome in a Patient With Solid Pseudopapillary Neoplasm of the Pancreas With AKT1_E17K Mutation.

Jco Precision Oncology

B Cuglievan, V Subbiah, H Wang, A Morani, F Meric-Bernstam, V Holla, CE Herzog

Publication Date: 2018

Variant appearance in text: AKT1: E17K

PMID: 31650099

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Epigenetic modifiers DNMT3A and BCOR are recurrently mutated in CYLD cutaneous syndrome.

Nature Communications

HR Davies, K Hodgson, E Schwalbe, J Coxhead, N Sinclair, X Zou, S Cockell, A Husain, S Nik-Zainal, N Rajan

Publication Date: 2019-10-17

Variant appearance in text: AKT1: E17K

PMID: 31624251

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Towards precision oncology in advanced prostate cancer.

Nature Reviews. Urology

SY Ku, ME Gleave, H Beltran

Publication Date: 2019-11

Variant appearance in text: AKT1: E17K

PMID: 31591549

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Prognostic and Predictive Implications of PTEN in Breast Cancer: Unfulfilled Promises but Intriguing Perspectives.

Cancers

L Carbognin, F Miglietta, I Paris, MV Dieci

Publication Date: 2019-09-19

Variant appearance in text: AKT: E17K

PMID: 31546901

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Molecular Alterations in Thyroid Cancer: From Bench to Clinical Practice.

Genes

E Tirrò, F Martorana, C Romano, SR Vitale, G Motta, S Di Gregorio, M Massimino, MS Pennisi, S Stella, A Puma, F Gianì, M Russo, L Manzella, P Vigneri

Publication Date: 2019-09-13

Variant appearance in text: AKT: E17K

PMID: 31540307

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Allosteric AKT Inhibitors Target Synthetic Lethal Vulnerabilities in E-Cadherin-Deficient Cells.

Cancers

N Bougen-Zhukov, Y Nouri, T Godwin, M Taylor, C Hakkaart, A Single, T Brew, E Permina, A Chen, MA Black, P Guilford

Publication Date: 2019-09-13

Variant appearance in text: AKT: E17K

PMID: 31540244

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Intraventricular meningiomas frequently harbor NF2 mutations but lack common genetic alterations in TRAF7, AKT1, SMO, KLF4, PIK3CA, and TERT.

Acta Neuropathologica Communications

G Jungwirth, R Warta, C Beynon, F Sahm, A von Deimling, A Unterberg, C Herold-Mende, C Jungk

Publication Date: 2019-08-30

Variant appearance in text: AKT: E17K

PMID: 31470906

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Targeted therapies for non-HPV-related head and neck cancer: challenges and opportunities in the context of predictive, preventive, and personalized medicine.

The Epma Journal

LA Shahoumi, WA Yeudall

Publication Date: 2019-09

Variant appearance in text: AKT: E17K

PMID: 31462945

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Next-generation sequencing for the general cancer patient.

Clinical Advances In Hematology & Oncology : H&O

M Avila, F Meric-Bernstam

Publication Date: 2019-08

Variant appearance in text: AKT1: E17K

PMID: 31449513

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Molecular heterogeneity of the cerebriform connective tissue nevus in mosaic overgrowth syndromes.

Cold Spring Harbor Molecular Case Studies

KM Keppler-Noreuil, J Burton-Akright, MJ Lindhurst, J Shwetar, JC Sapp, T Darling, LG Biesecker

Publication Date: 2019-08

Variant appearance in text: AKT1: 49G>A; Glu17Lys

PMID: 31371346

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Blood-based monitoring identifies acquired and targetable driver HER2 mutations in endocrine-resistant metastatic breast cancer.

Npj Precision Oncology

AJ Medford, TD Dubash, D Juric, L Spring, A Niemierko, N Vidula, J Peppercorn, S Isakoff, BA Reeves, JA LiCausi, B Wesley, G Malvarosa, M Yuen, BS Wittner, MS Lawrence, AJ Iafrate, L Ellisen, B Moy, M Toner, S Maheswaran, DA Haber, A Bardia

Publication Date: 2019

Variant appearance in text: AKT1: E17K

PMID: 31341951

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Molecular profiling and molecular classification of endometrioid ovarian carcinomas.

Gynecologic Oncology

P Cybulska, ADC Paula, J Tseng, MM Leitao, A Bashashati, DG Huntsman, TM Nazeran, C Aghajanian, NR Abu-Rustum, DF DeLair, SP Shah, B Weigelt

Publication Date: 2019-09

Variant appearance in text: AKT1: E17K

PMID: 31340883

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Safety and tolerability of CFI-400945, a first-in-class, selective PLK4 inhibitor in advanced solid tumours: a phase 1 dose-escalation trial.

British Journal Of Cancer

ZW Veitch, DW Cescon, T Denny, LM Yonemoto, G Fletcher, R Brokx, P Sampson, SW Li, TJ Pugh, J Bruce, MR Bray, DJ Slamon, TW Mak, ZA Wainberg, PL Bedard

Publication Date: 2019-08

Variant appearance in text: AKT1: E17K

PMID: 31303643

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Oncogene Amplification in Growth Factor Signaling Pathways Renders Cancers Dependent on Membrane Lipid Remodeling.

Cell Metabolism

J Bi, TA Ichu, C Zanca, H Yang, W Zhang, Y Gu, S Chowdhry, A Reed, S Ikegami, KM Turner, W Zhang, GR Villa, S Wu, O Quehenberger, WH Yong, HI Kornblum, JN Rich, TF Cloughesy, WK Cavenee, FB Furnari, BF Cravatt, PS Mischel

Publication Date: 2019-09-03

Variant appearance in text: AKT: E17K

PMID: 31303424

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A functional genetic screen defines the AKT-induced senescence signaling network.

Cell Death And Differentiation

KT Chan, S Blake, H Zhu, J Kang, AS Trigos, PB Madhamshettiwar, J Diesch, L Paavolainen, P Horvath, RD Hannan, AJ George, E Sanij, KM Hannan, KJ Simpson, RB Pearson

Publication Date: 2019-07-08

Variant appearance in text: AKT: E17K

PMID: 31285545

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PI3K-AKT-mTOR and NFκB Pathways in Ovarian Cancer: Implications for Targeted Therapeutics.

Cancers

A Ghoneum, N Said

Publication Date: 2019-07-05

Variant appearance in text: AKT1: E17K

PMID: 31284467

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Phase II trial of AKT inhibitor MK-2206 in patients with advanced breast cancer who have tumors with PIK3CA or AKT mutations, and/or PTEN loss/PTEN mutation.

Breast Cancer Research : Bcr

Y Xing, NU Lin, MA Maurer, H Chen, A Mahvash, A Sahin, A Akcakanat, Y Li, V Abramson, J Litton, M Chavez-MacGregor, V Valero, SA Piha-Paul, D Hong, KA Do, E Tarco, D Riall, AK Eterovic, GM Wulf, LC Cantley, GB Mills, LA Doyle, E Winer, GN Hortobagyi, AM Gonzalez-Angulo, F Meric-Bernstam

Publication Date: 2019-07-05

Variant appearance in text: AKT: E17K

PMID: 31277699

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STK11 p.G270W: A Novel Mutation Detected in a Case of MSI High Mixed Medullary-Mucinous Carcinoma of the Transverse Colon.

Cancer Genomics & Proteomics

M Shahid, D Wang, J Saller, E Ryzhova, D Qin, A Magliocco, D Coppola

Publication Date: 2019

Variant appearance in text: AKT1: E17K

PMID: 31243107

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Prospective Comprehensive Genomic Profiling of Primary and Metastatic Prostate Tumors.

Jco Precision Oncology

JH Chung, N Dewal, E Sokol, P Mathew, R Whitehead, SZ Millis, GM Frampton, G Bratslavsky, SK Pal, RJ Lee, A Necchi, JP Gregg, P Lara, ES Antonarakis, VA Miller, JS Ross, SM Ali, N Agarwal

Publication Date: 2019

Variant appearance in text: AKT: E17K

PMID: 31218271

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Analysis of the Clinical Relevance of Histological Classification of Benign Epithelial Salivary Gland Tumours.

Advances In Therapy

H Hellquist, A Paiva-Correia, V Vander Poorten, M Quer, JC Hernandez-Prera, S Andreasen, P Zbären, A Skalova, A Rinaldo, A Ferlito

Publication Date: 2019-08

Variant appearance in text: AKT1: Glu17Lys

PMID: 31209701

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Comprehensive validation of liquid-based cytology specimens for next-generation sequencing in cancer genome analysis.

Plos One

T Akahane, T Yamaguchi, Y Kato, S Yokoyama, T Hamada, Y Nishida, M Higashi, H Nishihara, S Suzuki, S Ueno, A Tanimoto

Publication Date: 2019

Variant appearance in text: AKT1: Glu17Lys

PMID: 31199826

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A mouse model of Proteus syndrome.

Human Molecular Genetics

MJ Lindhurst, LR Brinster, HC Kondolf, JJ Shwetar, MR Yourick, H Shiferaw, KM Keppler-Noreuil, G Elliot, C Rivas, L Garrett, J Gomez-Rodriguez, NJ Sebire, SM Hewitt, PL Schwartzberg, LG Biesecker

Publication Date: 2019-09-01

Variant appearance in text: AKT: E17K

PMID: 31194862

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The deubiquitinase Otub1 controls the activation of CD8+ T cells and NK cells by regulating IL-15-mediated priming.

Nature Immunology

X Zhou, J Yu, X Cheng, B Zhao, GC Manyam, L Zhang, K Schluns, P Li, J Wang, SC Sun

Publication Date: 2019-07

Variant appearance in text: AKT: E17K

PMID: 31182807

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Characterization of frequently mutated cancer genes in Chinese breast tumors: a comparison of Chinese and TCGA cohorts.

Annals Of Translational Medicine

G Zhang, Y Wang, B Chen, L Guo, L Cao, C Ren, L Wen, K Li, M Jia, C Li, H Mok, X Chen, G Wei, J Lin, Z Zhang, T Hou, H Han-Zhang, C Liu, H Liu, J Liu, CM Balch, F Meric-Bernstam, N Liao

Publication Date: 2019-04

Variant appearance in text: AKT1: E17K

PMID: 31168460

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Activated Signaling Pathways and Targeted Therapies in Desmoid-Type Fibromatosis: A Literature Review.

Frontiers In Oncology

MJM Timbergen, R Smits, DJ Grünhagen, C Verhoef, S Sleijfer, EAC Wiemer

Publication Date: 2019

Variant appearance in text: AKT: E17K

PMID: 31165043

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Tamoxifen withdrawal in women with progressive metastatic breast cancer: a case series of six patients.

International Cancer Conference Journal

K Hagio, M Baba, N Ishida, T Oshino, R Kasahara, M Nara, H Yamashita

Publication Date: 2018-10

Variant appearance in text: AKT1: E17K

PMID: 31149534

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AKT1E17K Activates Focal Adhesion Kinase and Promotes Melanoma Brain Metastasis.

Molecular Cancer Research : Mcr

DA Kircher, KA Trombetti, MR Silvis, GL Parkman, GM Fischer, SN Angel, CM Stehn, SC Strain, AH Grossmann, KL Duffy, KM Boucher, M McMahon, MA Davies, MC Mendoza, MW VanBrocklin, SL Holmen

Publication Date: 2019-09

Variant appearance in text: AKT: E17K

PMID: 31138602

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ALPK1 hotspot mutation as a driver of human spiradenoma and spiradenocarcinoma.

Nature Communications

M Rashid, M van der Horst, T Mentzel, F Butera, I Ferreira, A Pance, A Rütten, B Luzar, Z Marusic, N de Saint Aubain, JS Ko, SD Billings, S Chen, M Abi Daoud, J Hewinson, S Louzada, PW Harms, G Cerretelli, CD Robles-Espinoza, RM Patel, L van der Weyden, C Bakal, JL Hornick, MJ Arends, T Brenn, DJ Adams

Publication Date: 2019-05-17

Variant appearance in text: AKT1: E17K

PMID: 31101826

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A Comparison of DNA Mutation and Copy Number Profiles of Primary Breast Cancers and Paired Brain Metastases for Identifying Clinically Relevant Genetic Alterations in Brain Metastases.

Cancers

M Tyran, N Carbuccia, S Garnier, A Guille, J Adelaïde, P Finetti, J Toulzian, P Viens, A Tallet, A Goncalves, P Metellus, D Birnbaum, M Chaffanet, F Bertucci

Publication Date: 2019-05-13

Variant appearance in text: AKT1: E17K

PMID: 31086113

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The Pathogenesis of Port Wine Stain and Sturge Weber Syndrome: Complex Interactions between Genetic Alterations and Aberrant MAPK and PI3K Activation.

International Journal Of Molecular Sciences

V Nguyen, M Hochman, MC Mihm, JS Nelson, W Tan

Publication Date: 2019-05-07

Variant appearance in text: AKT: E17K

PMID: 31067686

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BRIP-1 germline mutation and its role in colon cancer: presentation of two case reports and review of literature.

Bmc Medical Genetics

M Ali, CD Delozier, U Chaudhary

Publication Date: 2019-05-07

Variant appearance in text: AKT1: E17K

PMID: 31064327

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Intratumoral Adaptive Immunosuppression and Type 17 Immunity in Mismatch Repair Proficient Colorectal Tumors.

Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research

NJ Llosa, B Luber, AJ Tam, KN Smith, N Siegel, AH Awan, H Fan, T Oke, J Zhang, J Domingue, EL Engle, CA Roberts, BR Bartlett, LK Aulakh, ED Thompson, JM Taube, JN Durham, CL Sears, DT Le, LA Diaz, DM Pardoll, H Wang, RA Anders, F Housseau

Publication Date: 2019-09-01

Variant appearance in text: AKT1: E17K

PMID: 31061070

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Multilaboratory Assessment of a New Reference Material for Quality Assurance of Cell-Free Tumor DNA Measurements.

The Journal Of Molecular Diagnostics : Jmd

HJ He, EV Stein, Y Konigshofer, T Forbes, FL Tomson, R Garlick, E Yamada, T Godfrey, T Abe, K Tamura, M Borges, M Goggins, S Elmore, ML Gulley, JL Larson, L Ringel, BC Haynes, C Karlovich, PM Williams, A Garnett, A Ståhlberg, S Filges, L Sorbara, MR Young, S Srivastava, KD Cole

Publication Date: 2019-07

Variant appearance in text: AKT1: 49G>A; E17K

PMID: 31055023

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Therapeutic Potency of PI3K Pharmacological Inhibitors of Gastrointestinal Cancer.

Middle East Journal Of Digestive Diseases

K Hashemzadeh, MH Jokar, S Sedighi, M Moradzadeh

Publication Date: 2019-01

Variant appearance in text: AKT: E17K

PMID: 31049177

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Clinical validation of the tempus xT next-generation targeted oncology sequencing assay.

Oncotarget

N Beaubier, R Tell, D Lau, JR Parsons, S Bush, J Perera, S Sorrells, T Baker, A Chang, J Michuda, C Iguartua, S MacNeil, K Shah, P Ellis, K Yeatts, B Mahon, T Taxter, M Bontrager, A Khan, R Huether, E Lefkofsky, KP White

Publication Date: 2019-03-22

Variant appearance in text: AKT1: E17K

PMID: 31040929

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Basket Trials for Intractable Cancer.

Frontiers In Oncology

BD Qin, XD Jiao, K Liu, Y Wu, X He, J Liu, WX Qin, Z Wang, YS Zang

Publication Date: 2019

Variant appearance in text: AKT: E17K

PMID: 31032221

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The PTEN⁻PI3K Axis in Cancer.

Biomolecules

A Papa, PP Pandolfi

Publication Date: 2019-04-17

Variant appearance in text: AKT: E17K

PMID: 30999672

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Alternative transcript annotations:

Transcript	cDNA	Protein	Consequence	Exon	Intron
ENST00000349310.3	c.49G>A	p.Glu17Lys	missense_variant,splice_region_variant	4/15	-
ENST00000402615.2	c.49G>A	p.Glu17Lys	missense_variant,splice_region_variant	3/14	-
ENST00000407796.2	c.49G>A	p.Glu17Lys	missense_variant,splice_region_variant	3/14	-
ENST00000554581.1	c.49G>A	p.Glu17Lys	missense_variant,splice_region_variant	2/13	-
ENST00000554848.1	c.49G>A	p.Glu17Lys	missense_variant,splice_region_variant	3/14	-
ENST00000555380.1	c.-138G>A	-	splice_region_variant,5_prime_UTR_variant	2/5	-
ENST00000555528.1	c.49G>A	p.Glu17Lys	missense_variant,splice_region_variant	3/14	-
ENST00000555926.1	c.49G>A	p.Glu17Lys	missense_variant,splice_region_variant	4/5	-
NM_001014431.2	c.49G>A	p.Glu17Lys	missense_variant,splice_region_variant	3/14	-
NM_001014432.1	c.49G>A	p.Glu17Lys	missense_variant,splice_region_variant	4/15	-
NM_005163.2	c.49G>A	p.Glu17Lys	missense_variant,splice_region_variant	3/14	-