Variant ID: 14-105246551-C-T

NM_005163.2(AKT1):c.49G>A;(p.Glu17Lys)

This variant was identified in 551 publications




Publications:


Distinct Molecular Landscape of Epstein-Barr Virus Associated Pulmonary Lymphoepithelioma-Like Carcinoma Revealed by Genomic Sequencing.

Cancers
SL Chau, JH Tong, C Chow, JS Kwan, RW Lung, LY Chung, EK Tin, SS Wong, AH Cheung, RW Lau, CS Ng, TS Mok, KW Lo, KF To
Publication Date: 2020-07-27

Variant appearance in text: AKT1: E17K
PMID: 32726920
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The Roles of Common Variation and Somatic Mutation in Cancer Pharmacogenomics.

Oncology And Therapy
HT Chan, YM Chin, SK Low
Publication Date: 2019-06

Variant appearance in text: AKT1: E17K
PMID: 32700193
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Detection of somatic TP53 mutation in surgically resected small-cell lung cancer by targeted exome sequencing: association with longer relapse-free survival.

Heliyon
H Yokouchi, H Nishihara, T Harada, S Yamazaki, H Kikuchi, S Oizumi, H Uramoto, F Tanaka, M Harada, K Akie, F Sugaya, Y Fujita, K Takamura, T Kojima, M Higuchi, O Honjo, Y Minami, N Watanabe, M Nishimura, H Suzuki, H Dosaka-Akita, H Isobe
Publication Date: 2020-07

Variant appearance in text: AKT1: E17K
PMID: 32685741
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Cross-species oncogenic signatures of breast cancer in canine mammary tumors.

Nature Communications
TM Kim, IS Yang, BJ Seung, S Lee, D Kim, YJ Ha, MK Seo, KK Kim, HS Kim, JH Cheong, JH Sur, H Nam, S Kim
Publication Date: 2020-07-17

Variant appearance in text: AKT1: E17K
PMID: 32680987
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Brief CommunicationCirculating tumor DNA is present in the most aggressive meningiomas.

Neuro-Oncology Advances
T Graillon, C Roche, N Basset, G Mougel, M Meyer, K Farah, S Boissonneau, S Fuentes, E Tabouret, C Campello, R Appay, D Figarella-Branger, O Chinot, H Dufour, P Romanet, A Barlier
Publication Date: 2020

Variant appearance in text: AKT1: 49G>A; Glu17Lys
PMID: 32642718
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Histomolecular characterization of intracranial meningiomas developed in patients exposed to high-dose cyproterone acetate: an antiandrogen treatment.

Neuro-Oncology Advances
S Portet, R Naoufal, G Tachon, A Simonneau, A Chalant, A Naar, S Milin, B Bataille, L Karayan-Tapon
Publication Date: 2019

Variant appearance in text: AKT1: E17K
PMID: 32642646
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The PI3K-AKT-mTOR Pathway and Prostate Cancer: At the Crossroads of AR, MAPK, and WNT Signaling.

International Journal Of Molecular Sciences
BY Shorning, MS Dass, MJ Smalley, HB Pearson
Publication Date: 2020-06-25

Variant appearance in text: AKT: E17K
PMID: 32630372
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Biomarkers in Triple-Negative Breast Cancer: State-of-the-Art and Future Perspectives.

International Journal Of Molecular Sciences
S Cocco, M Piezzo, A Calabrese, D Cianniello, R Caputo, VD Lauro, G Fusco, GD Gioia, M Licenziato, M Laurentiis
Publication Date: 2020-06-27

Variant appearance in text: AKT: E17K
PMID: 32605126
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Whole Exome Sequencing of Multi-Regional Biopsies from Metastatic Lesions to Evaluate Actionable Truncal Mutations Using a Single-Pass Percutaneous Technique.

Cancers
V Heong, D Tay, SE Goh, B Wee, TZ Tan, R Soo, B Pang, D Lim, A Gopinathan, S Ow, CE Chee, BC Goh, SC Lee, WP Yong, A Wong, MFM Omar, R Soong, DS Tan
Publication Date: 2020-06-17

Variant appearance in text: AKT1: E17K
PMID: 32560395
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Detection of ctDNA with Personalized Molecular Barcode NGS and Its Clinical Significance in Patients with Early Breast Cancer.

Translational Oncology
T Yoshinami, N Kagara, D Motooka, S Nakamura, T Miyake, T Tanei, Y Naoi, M Shimoda, K Shimazu, SJ Kim, S Noguchi
Publication Date: 2020-05-27

Variant appearance in text: AKT1: E17K
PMID: 32473569
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Genomic and Transcriptomic Characteristics According to Size of Papillary Thyroid Microcarcinoma.

Cancers
YS Song, BH Kang, S Lee, SK Yoo, YS Choi, J Park, DY Park, KE Lee, JS Seo, YJ Park
Publication Date: 2020-05-25

Variant appearance in text: AKT1: E17K
PMID: 32466217
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The Quest for Improving Treatment of Cancer of Unknown Primary (CUP) Through Molecularly-Driven Treatments: A Systematic Review.

Frontiers In Oncology
R Lombardo, F Tosi, A Nocerino, K Bencardino, V Gambi, R Ricotta, F Spina, S Siena, A Sartore-Bianchi
Publication Date: 2020

Variant appearance in text: AKT1: E17K
PMID: 32457826
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Inhibitors in AKTion: ATP-competitive vs allosteric.

Biochemical Society Transactions
G Lazaro, E Kostaras, I Vivanco
Publication Date: 2020-05-26

Variant appearance in text: AKT: E17K
PMID: 32453400
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A systematic molecular and pharmacologic evaluation of AKT inhibitors reveals new insight into their biological activity.

British Journal Of Cancer
E Kostaras, T Kaserer, G Lazaro, SF Heuss, A Hussain, P Casado, A Hayes, C Yandim, N Palaskas, Y Yu, B Schwartz, F Raynaud, YL Chung, PR Cutillas, I Vivanco
Publication Date: 2020-05-22

Variant appearance in text: AKT: E17K
PMID: 32439931
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Integrative Analysis of the Genes Induced by the Intestine Microbiota of Infant Born to Term and Breastfed.

Bioinformatics And Biology Insights
B Nouadi, Y Sbaoui, M El Messal, F Bennis, F Chegdani
Publication Date: 2020

Variant appearance in text: AKT1: E17K
PMID: 32425510
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Pharmacogenomic Testing to Guide Personalized Cancer Medicine Decisions in Private Oncology Practice: A Case Study.

Frontiers In Oncology
G Astras, CI Papagiannopoulos, KA Kyritsis, C Markitani, IS Vizirianakis
Publication Date: 2020

Variant appearance in text: AKT1: 49G>A
PMID: 32411592
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Exomes of Ductal Luminal Breast Cancer Patients from Southwest Colombia: Gene Mutational Profile and Related Expression Alterations.

Biomolecules
C Cortes-Urrea, F Bueno-Gutiérrez, M Solarte, M Guevara-Burbano, F Tobar-Tosse, PE Vélez-Varela, JC Bonilla, G Barreto, J Velasco-Medina, PA Moreno, JL Rivas
Publication Date: 2020-04-30

Variant appearance in text: rs121434592
PMID: 32365829
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Role of PI3K/AKT pathway in cancer: the framework of malignant behavior.

Molecular Biology Reports
N Jiang, Q Dai, X Su, J Fu, X Feng, J Peng
Publication Date: 2020-04-24

Variant appearance in text: AKT1: E17K
PMID: 32333246
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Allelic heterogeneity of Proteus syndrome.

Cold Spring Harbor Molecular Case Studies
A Buser, MJ Lindhurst, HC Kondolf, MR Yourick, KM Keppler-Noreuil, JC Sapp, LG Biesecker
Publication Date: 2020-04-23

Variant appearance in text: AKT1: 49G>A
PMID: 32327430
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Targeted next generation sequencing identifies somatic mutations in a cohort of Egyptian breast cancer patients.

Journal Of Advanced Research
A Nassar, M Abouelhoda, O Mansour, SA Loutfy, MM Hafez, M Gomaa, A Bahnassy, AS El-Din Youssef, MM Lotfy, H Ismail, OS Ahmed, AA Abou-Bakr, AN Zekri
Publication Date: 2020-07

Variant appearance in text: AKT1: 49G>A
PMID: 32322420
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Use of an Integrated Pan-Cancer Oncology Enrichment Next-Generation Sequencing Assay to Measure Tumour Mutational Burden and Detect Clinically Actionable Variants.

Molecular Diagnosis & Therapy
V Pestinger, M Smith, T Sillo, JM Findlay, JF Laes, G Martin, G Middleton, P Taniere, AD Beggs
Publication Date: 2020-04-18

Variant appearance in text: AKT: E17K
PMID: 32306292
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The role of ubiquitination in tumorigenesis and targeted drug discovery.

Signal Transduction And Targeted Therapy
L Deng, T Meng, L Chen, W Wei, P Wang
Publication Date: 2020-02-29

Variant appearance in text: AKT: E17K
PMID: 32296023
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Ovarian mucinous tumors with mural nodules: immunohistochemical and molecular analysis of 3 cases.

Diagnostic Pathology
Y Shao, Q Liu, H Shi, B Lu
Publication Date: 2020-04-14

Variant appearance in text: AKT1: E17K
PMID: 32290854
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Comparison of commercially available whole-genome sequencing kits for variant detection in circulating cell-free DNA.

Scientific Reports
F Mauger, C Horgues, M Pierre-Jean, N Oussada, L Mesrob, JF Deleuze
Publication Date: 2020-04-10

Variant appearance in text: AKT1: E17K
PMID: 32277101
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Multiplexed molecular profiling of lung cancer with malignant pleural effusion using next generation sequencing in Chinese patients.

Oncology Letters
X Ruan, Y Sun, W Wang, J Ye, D Zhang, Z Gong, M Yang
Publication Date: 2020-05

Variant appearance in text: AKT1: E17K
PMID: 32269623
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KLF4K409Q-mutated meningiomas show enhanced hypoxia signaling and respond to mTORC1 inhibitor treatment.

Acta Neuropathologica Communications
N von Spreckelsen, N Waldt, R Poetschke, C Kesseler, H Dohmen, HK Jiao, A Nemeth, S Schob, C Scherlach, IE Sandalcioglu, M Deckert, F Angenstein, B Krischek, P Stavrinou, M Timmer, M Remke, E Kirches, R Goldbrunner, EA Chiocca, S Huettelmaier, T Acker, C Mawrin
Publication Date: 2020-04-03

Variant appearance in text: AKT1: E17K
PMID: 32245394
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Recent Improvements in Genomic and Transcriptomic Understanding of Anaplastic and Poorly Differentiated Thyroid Cancers.

Endocrinology And Metabolism (Seoul, Korea)
SK Yoo, YS Song, YJ Park, JS Seo
Publication Date: 2020-03

Variant appearance in text: AKT1: E17K
PMID: 32207263
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A phase I dose-escalation study of enzalutamide in combination with the AKT inhibitor AZD5363 (capivasertib) in patients with metastatic castration-resistant prostate cancer.

Annals Of Oncology : Official Journal Of The European Society For Medical Oncology
MP Kolinsky, P Rescigno, D Bianchini, Z Zafeiriou, N Mehra, J Mateo, V Michalarea, R Riisnaes, M Crespo, I Figueiredo, S Miranda, D Nava Rodrigues, P Flohr, N Tunariu, U Banerji, R Ruddle, A Sharp, J Welti, M Lambros, S Carreira, FI Raynaud, KE Swales, S Plymate, J Luo, H Tovey, N Porta, R Slade, L Leonard, E Hall, JS de Bono
Publication Date: 2020-02-21

Variant appearance in text: AKT: E17K
PMID: 32205016
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The role of ubiquitination in tumorigenesis and targeted drug discovery.

Signal Transduction And Targeted Therapy
L Deng, T Meng, L Chen, W Wei, P Wang
Publication Date: 2020

Variant appearance in text: AKT: E17K
PMID: 32140262
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Control of Akt activity and substrate phosphorylation in cells.

Iubmb Life
I Yudushkin
Publication Date: 2020-03-03

Variant appearance in text: AKT: E17K
PMID: 32125765
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Novel pathogenic alterations in pediatric and adult desmoid-type fibromatosis - A systematic analysis of 204 cases.

Scientific Reports
M Trautmann, J Rehkämper, H Gevensleben, J Becker, E Wardelmann, W Hartmann, I Grünewald, S Huss
Publication Date: 2020-02-25

Variant appearance in text: AKT1: E17K
PMID: 32099073
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A Rapid Robust Method for Subgrouping Non-NF2 Meningiomas According to Genotype and Detection of Lower Levels of M2 Macrophages in AKT1 E17K Mutated Tumours.

International Journal Of Molecular Sciences
CL Adams, E Ercolano, S Ferluga, A Sofela, F Dave, C Negroni, KM Kurian, DA Hilton, CO Hanemann
Publication Date: 2020-02-13

Variant appearance in text: AKT1: 49G>A; E17K
PMID: 32070062
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The paradox of cancer genes in non-malignant conditions: implications for precision medicine.

Genome Medicine
JJ Adashek, S Kato, SM Lippman, R Kurzrock
Publication Date: 2020-02-17

Variant appearance in text: AKT: E17K
PMID: 32066498
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NOTCH target gene HES5 mediates oncogenic and tumor suppressive functions in hepatocarcinogenesis.

Oncogene
S Luiken, A Fraas, M Bieg, R Sugiyanto, B Goeppert, S Singer, C Ploeger, G Warsow, JU Marquardt, C Sticht, C De La Torre, S Pusch, A Mehrabi, N Gretz, M Schlesner, R Eils, P Schirmacher, T Longerich, S Roessler
Publication Date: 2020-02-13

Variant appearance in text: AKT: E17K
PMID: 32055024
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Targeting non-small cell lung cancer: driver mutation beyond epidermal growth factor mutation and anaplastic lymphoma kinase fusion.

Therapeutic Advances In Medical Oncology
QS Chu
Publication Date: 2020

Variant appearance in text: AKT: E17K
PMID: 32047535
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Response to mTOR and PI3K inhibitors in enzalutamide-resistant luminal androgen receptor triple-negative breast cancer patient-derived xenografts.

Theranostics
F Coussy, M Lavigne, L de Koning, RE Botty, F Nemati, A Naguez, G Bataillon, B Ouine, A Dahmani, E Montaudon, P Painsec, S Chateau-Joubert, F Laetitia, T Larcher, S Vacher, W Chemlali, A Briaux, S Melaabi, AV Salomon, JM Guinebretiere, I Bieche, E Marangoni
Publication Date: 2020

Variant appearance in text: AKT1: E17K
PMID: 32042320
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Cell fitness screens reveal a conflict between LINE-1 retrotransposition and DNA replication.

Nature Structural & Molecular Biology
D Ardeljan, JP Steranka, C Liu, Z Li, MS Taylor, LM Payer, M Gorbounov, JS Sarnecki, V Deshpande, RH Hruban, JD Boeke, D Fenyö, PH Wu, A Smogorzewska, AJ Holland, KH Burns
Publication Date: 2020-02

Variant appearance in text: AKT1: E17K
PMID: 32042151
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Is There a Role for Dual PI3K/mTOR Inhibitors for Patients Affected with Lymphoma?

International Journal Of Molecular Sciences
C Tarantelli, A Lupia, A Stathis, F Bertoni
Publication Date: 2020-02-05

Variant appearance in text: AKT: E17K
PMID: 32033478
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Gene Prioritization through Consensus Strategy, Enrichment Methodologies Analysis, and Networking for Osteosarcoma Pathogenesis.

International Journal Of Molecular Sciences
A Cabrera-Andrade, A López-Cortés, G Jaramillo-Koupermann, C Paz-Y-Miño, Y Pérez-Castillo, CR Munteanu, H González-Díaz, A Pazos, E Tejera
Publication Date: 2020-02-05

Variant appearance in text: AKT: E17K
PMID: 32033398
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Clinical report: one year of treatment of Proteus syndrome with miransertib (ARQ 092).

Cold Spring Harbor Molecular Case Studies
LG Biesecker, M Edwards, S O'Donnell, P Doherty, T MacDougall, K Tith, J Kazakin, B Schwartz
Publication Date: 2020-02

Variant appearance in text: AKT1: 49G>A; rs121434592
PMID: 32014856
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Circulating tumor DNA analysis in the era of precision oncology.

Oncotarget
R Said, N Guibert, GR Oxnard, AM Tsimberidou
Publication Date: 2020-01-14

Variant appearance in text: AKT1: E17K
PMID: 32010431
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PIK3CA gene mutations in the helical domain correlate with high tumor mutation burden and poor prognosis in metastatic breast carcinomas with late-line therapies.

Aging
Y Tang, J Li, N Xie, X Yang, L Liu, H Wu, C Tian, Y He, X Wang, Q He, ZY Hu, Q Ouyang
Publication Date: 2020-01-24

Variant appearance in text: AKT1: E17K
PMID: 31980592
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Recent Advances in Meningioma Immunogenetics.

Frontiers In Oncology
M Al-Rashed, K Foshay, M Abedalthagafi
Publication Date: 2019

Variant appearance in text: AKT1: E17K
PMID: 31970090
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A case report of Proteus syndrome (PS).

Bmc Medical Genetics
X Zeng, X Wen, X Liang, L Wang, L Xu
Publication Date: 2020-01-21

Variant appearance in text: AKT1: Glu17Lys
PMID: 31964351
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Mutation Status and Epithelial Differentiation Stratify Recurrence Risk in Chordoid Meningioma-A Multicenter Study with High Prognostic Relevance.

Cancers
MM Georgescu, A Nanda, Y Li, BC Mobley, PL Faust, JM Raisanen, A Olar
Publication Date: 2020-01-17

Variant appearance in text: AKT1: E17K
PMID: 31963394
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Genome-wide DNA copy number profiling and bioinformatics analysis of ovarian cancer reveals key genes and pathways associated with distinct invasive/migratory capabilities.

Aging
G Liu, G Ruan, M Huang, L Chen, P Sun
Publication Date: 2020-01-02

Variant appearance in text: AKT1: E17K
PMID: 31895688
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Overview of the relevance of PI3K pathway in HR-positive breast cancer.

Annals Of Oncology : Official Journal Of The European Society For Medical Oncology
N Vasan, E Toska, M Scaltriti
Publication Date: 2019-12-01

Variant appearance in text: AKT: E17K
PMID: 31859348
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Phase 1 Dose Escalation Study of the Allosteric AKT Inhibitor BAY 1125976 in Advanced Solid Cancer-Lack of Association between Activating AKT Mutation and AKT Inhibition-Derived Efficacy.

Cancers
A Schneeweiss, D Hess, M Joerger, A Varga, S Moulder, AM Tsimberidou, C Ma, SA Hurvitz, C Rentzsch, M Rudolph, S Thiele, O Boix, G Wilkinson, E Lagkadinou, M Ocker
Publication Date: 2019-12-10

Variant appearance in text: AKT: E17K
PMID: 31835495
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Combing the Cancer Genome for Novel Kinase Drivers and New Therapeutic Targets.

Cancers
P Torres-Ayuso, J Brognard
Publication Date: 2019-12-07

Variant appearance in text: AKT: E17K
PMID: 31817861
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Hyperprogressive Disease In Cervical Small Cell Carcinoma Treated By Immune Checkpoint Inhibitor.

Oncotargets And Therapy
Z Xu, L Chen, L Zheng, Q Yang, M Chen, J Wang, G Zhu, Z Chen, J Sun
Publication Date: 2019

Variant appearance in text: AKT1: E17K
PMID: 31802899
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MiRNA therapeutics based on logic circuits of biological pathways.

Bmc Bioinformatics
V Boscaino, A Fiannaca, L La Paglia, M La Rosa, R Rizzo, A Urso
Publication Date: 2019-11-22

Variant appearance in text: AKT1: 49G>A
PMID: 31757209
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Distinct functions of AKT isoforms in breast cancer: a comprehensive review.

Cell Communication And Signaling : Ccs
N Hinz, M Jücker
Publication Date: 2019-11-21

Variant appearance in text: AKT: E17K
PMID: 31752925
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The Role of Merlin/NF2 Loss in Meningioma Biology.

Cancers
S Lee, PJ Karas, CC Hadley, JC Bayley V, AB Khan, A Jalali, AD Sweeney, TJ Klisch, AJ Patel
Publication Date: 2019-10-24

Variant appearance in text: AKT: E17K
PMID: 31652973
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Response to Mammalian Target of Rapamycin-Based Therapy and Incidental Finding of Lynch Syndrome in a Patient With Solid Pseudopapillary Neoplasm of the Pancreas With AKT1_E17K Mutation.

Jco Precision Oncology
B Cuglievan, V Subbiah, H Wang, A Morani, F Meric-Bernstam, V Holla, CE Herzog
Publication Date: 2018

Variant appearance in text: AKT1: E17K
PMID: 31650099
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Epigenetic modifiers DNMT3A and BCOR are recurrently mutated in CYLD cutaneous syndrome.

Nature Communications
HR Davies, K Hodgson, E Schwalbe, J Coxhead, N Sinclair, X Zou, S Cockell, A Husain, S Nik-Zainal, N Rajan
Publication Date: 2019-10-17

Variant appearance in text: AKT1: E17K
PMID: 31624251
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Towards precision oncology in advanced prostate cancer.

Nature Reviews. Urology
SY Ku, ME Gleave, H Beltran
Publication Date: 2019-11

Variant appearance in text: AKT1: E17K
PMID: 31591549
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Prognostic and Predictive Implications of PTEN in Breast Cancer: Unfulfilled Promises but Intriguing Perspectives.

Cancers
L Carbognin, F Miglietta, I Paris, MV Dieci
Publication Date: 2019-09-19

Variant appearance in text: AKT: E17K
PMID: 31546901
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Molecular Alterations in Thyroid Cancer: From Bench to Clinical Practice.

Genes
E Tirrò, F Martorana, C Romano, SR Vitale, G Motta, S Di Gregorio, M Massimino, MS Pennisi, S Stella, A Puma, F Gianì, M Russo, L Manzella, P Vigneri
Publication Date: 2019-09-13

Variant appearance in text: AKT: E17K
PMID: 31540307
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Allosteric AKT Inhibitors Target Synthetic Lethal Vulnerabilities in E-Cadherin-Deficient Cells.

Cancers
N Bougen-Zhukov, Y Nouri, T Godwin, M Taylor, C Hakkaart, A Single, T Brew, E Permina, A Chen, MA Black, P Guilford
Publication Date: 2019-09-13

Variant appearance in text: AKT: E17K
PMID: 31540244
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Intraventricular meningiomas frequently harbor NF2 mutations but lack common genetic alterations in TRAF7, AKT1, SMO, KLF4, PIK3CA, and TERT.

Acta Neuropathologica Communications
G Jungwirth, R Warta, C Beynon, F Sahm, A von Deimling, A Unterberg, C Herold-Mende, C Jungk
Publication Date: 2019-08-30

Variant appearance in text: AKT: E17K
PMID: 31470906
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Targeted therapies for non-HPV-related head and neck cancer: challenges and opportunities in the context of predictive, preventive, and personalized medicine.

The Epma Journal
LA Shahoumi, WA Yeudall
Publication Date: 2019-09

Variant appearance in text: AKT: E17K
PMID: 31462945
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Next-generation sequencing for the general cancer patient.

Clinical Advances In Hematology & Oncology : H&O
M Avila, F Meric-Bernstam
Publication Date: 2019-08

Variant appearance in text: AKT1: E17K
PMID: 31449513
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Molecular heterogeneity of the cerebriform connective tissue nevus in mosaic overgrowth syndromes.

Cold Spring Harbor Molecular Case Studies
KM Keppler-Noreuil, J Burton-Akright, MJ Lindhurst, J Shwetar, JC Sapp, T Darling, LG Biesecker
Publication Date: 2019-08

Variant appearance in text: AKT1: 49G>A; Glu17Lys
PMID: 31371346
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Blood-based monitoring identifies acquired and targetable driver HER2 mutations in endocrine-resistant metastatic breast cancer.

Npj Precision Oncology
AJ Medford, TD Dubash, D Juric, L Spring, A Niemierko, N Vidula, J Peppercorn, S Isakoff, BA Reeves, JA LiCausi, B Wesley, G Malvarosa, M Yuen, BS Wittner, MS Lawrence, AJ Iafrate, L Ellisen, B Moy, M Toner, S Maheswaran, DA Haber, A Bardia
Publication Date: 2019

Variant appearance in text: AKT1: E17K
PMID: 31341951
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Molecular profiling and molecular classification of endometrioid ovarian carcinomas.

Gynecologic Oncology
P Cybulska, ADC Paula, J Tseng, MM Leitao, A Bashashati, DG Huntsman, TM Nazeran, C Aghajanian, NR Abu-Rustum, DF DeLair, SP Shah, B Weigelt
Publication Date: 2019-09

Variant appearance in text: AKT1: E17K
PMID: 31340883
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Safety and tolerability of CFI-400945, a first-in-class, selective PLK4 inhibitor in advanced solid tumours: a phase 1 dose-escalation trial.

British Journal Of Cancer
ZW Veitch, DW Cescon, T Denny, LM Yonemoto, G Fletcher, R Brokx, P Sampson, SW Li, TJ Pugh, J Bruce, MR Bray, DJ Slamon, TW Mak, ZA Wainberg, PL Bedard
Publication Date: 2019-08

Variant appearance in text: AKT1: E17K
PMID: 31303643
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Oncogene Amplification in Growth Factor Signaling Pathways Renders Cancers Dependent on Membrane Lipid Remodeling.

Cell Metabolism
J Bi, TA Ichu, C Zanca, H Yang, W Zhang, Y Gu, S Chowdhry, A Reed, S Ikegami, KM Turner, W Zhang, GR Villa, S Wu, O Quehenberger, WH Yong, HI Kornblum, JN Rich, TF Cloughesy, WK Cavenee, FB Furnari, BF Cravatt, PS Mischel
Publication Date: 2019-09-03

Variant appearance in text: AKT: E17K
PMID: 31303424
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A functional genetic screen defines the AKT-induced senescence signaling network.

Cell Death And Differentiation
KT Chan, S Blake, H Zhu, J Kang, AS Trigos, PB Madhamshettiwar, J Diesch, L Paavolainen, P Horvath, RD Hannan, AJ George, E Sanij, KM Hannan, KJ Simpson, RB Pearson
Publication Date: 2019-07-08

Variant appearance in text: AKT: E17K
PMID: 31285545
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PI3K-AKT-mTOR and NFκB Pathways in Ovarian Cancer: Implications for Targeted Therapeutics.

Cancers
A Ghoneum, N Said
Publication Date: 2019-07-05

Variant appearance in text: AKT1: E17K
PMID: 31284467
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Phase II trial of AKT inhibitor MK-2206 in patients with advanced breast cancer who have tumors with PIK3CA or AKT mutations, and/or PTEN loss/PTEN mutation.

Breast Cancer Research : Bcr
Y Xing, NU Lin, MA Maurer, H Chen, A Mahvash, A Sahin, A Akcakanat, Y Li, V Abramson, J Litton, M Chavez-MacGregor, V Valero, SA Piha-Paul, D Hong, KA Do, E Tarco, D Riall, AK Eterovic, GM Wulf, LC Cantley, GB Mills, LA Doyle, E Winer, GN Hortobagyi, AM Gonzalez-Angulo, F Meric-Bernstam
Publication Date: 2019-07-05

Variant appearance in text: AKT: E17K
PMID: 31277699
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STK11 p.G270W: A Novel Mutation Detected in a Case of MSI High Mixed Medullary-Mucinous Carcinoma of the Transverse Colon.

Cancer Genomics & Proteomics
M Shahid, D Wang, J Saller, E Ryzhova, D Qin, A Magliocco, D Coppola
Publication Date: 2019

Variant appearance in text: AKT1: E17K
PMID: 31243107
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Prospective Comprehensive Genomic Profiling of Primary and Metastatic Prostate Tumors.

Jco Precision Oncology
JH Chung, N Dewal, E Sokol, P Mathew, R Whitehead, SZ Millis, GM Frampton, G Bratslavsky, SK Pal, RJ Lee, A Necchi, JP Gregg, P Lara, ES Antonarakis, VA Miller, JS Ross, SM Ali, N Agarwal
Publication Date: 2019

Variant appearance in text: AKT: E17K
PMID: 31218271
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Analysis of the Clinical Relevance of Histological Classification of Benign Epithelial Salivary Gland Tumours.

Advances In Therapy
H Hellquist, A Paiva-Correia, V Vander Poorten, M Quer, JC Hernandez-Prera, S Andreasen, P Zbären, A Skalova, A Rinaldo, A Ferlito
Publication Date: 2019-08

Variant appearance in text: AKT1: Glu17Lys
PMID: 31209701
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Comprehensive validation of liquid-based cytology specimens for next-generation sequencing in cancer genome analysis.

Plos One
T Akahane, T Yamaguchi, Y Kato, S Yokoyama, T Hamada, Y Nishida, M Higashi, H Nishihara, S Suzuki, S Ueno, A Tanimoto
Publication Date: 2019

Variant appearance in text: AKT1: Glu17Lys
PMID: 31199826
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A mouse model of Proteus syndrome.

Human Molecular Genetics
MJ Lindhurst, LR Brinster, HC Kondolf, JJ Shwetar, MR Yourick, H Shiferaw, KM Keppler-Noreuil, G Elliot, C Rivas, L Garrett, J Gomez-Rodriguez, NJ Sebire, SM Hewitt, PL Schwartzberg, LG Biesecker
Publication Date: 2019-09-01

Variant appearance in text: AKT: E17K
PMID: 31194862
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The deubiquitinase Otub1 controls the activation of CD8+ T cells and NK cells by regulating IL-15-mediated priming.

Nature Immunology
X Zhou, J Yu, X Cheng, B Zhao, GC Manyam, L Zhang, K Schluns, P Li, J Wang, SC Sun
Publication Date: 2019-07

Variant appearance in text: AKT: E17K
PMID: 31182807
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Characterization of frequently mutated cancer genes in Chinese breast tumors: a comparison of Chinese and TCGA cohorts.

Annals Of Translational Medicine
G Zhang, Y Wang, B Chen, L Guo, L Cao, C Ren, L Wen, K Li, M Jia, C Li, H Mok, X Chen, G Wei, J Lin, Z Zhang, T Hou, H Han-Zhang, C Liu, H Liu, J Liu, CM Balch, F Meric-Bernstam, N Liao
Publication Date: 2019-04

Variant appearance in text: AKT1: E17K
PMID: 31168460
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Activated Signaling Pathways and Targeted Therapies in Desmoid-Type Fibromatosis: A Literature Review.

Frontiers In Oncology
MJM Timbergen, R Smits, DJ Grünhagen, C Verhoef, S Sleijfer, EAC Wiemer
Publication Date: 2019

Variant appearance in text: AKT: E17K
PMID: 31165043
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Tamoxifen withdrawal in women with progressive metastatic breast cancer: a case series of six patients.

International Cancer Conference Journal
K Hagio, M Baba, N Ishida, T Oshino, R Kasahara, M Nara, H Yamashita
Publication Date: 2018-10

Variant appearance in text: AKT1: E17K
PMID: 31149534
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AKT1E17K Activates Focal Adhesion Kinase and Promotes Melanoma Brain Metastasis.

Molecular Cancer Research : Mcr
DA Kircher, KA Trombetti, MR Silvis, GL Parkman, GM Fischer, SN Angel, CM Stehn, SC Strain, AH Grossmann, KL Duffy, KM Boucher, M McMahon, MA Davies, MC Mendoza, MW VanBrocklin, SL Holmen
Publication Date: 2019-09

Variant appearance in text: AKT: E17K
PMID: 31138602
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ALPK1 hotspot mutation as a driver of human spiradenoma and spiradenocarcinoma.

Nature Communications
M Rashid, M van der Horst, T Mentzel, F Butera, I Ferreira, A Pance, A Rütten, B Luzar, Z Marusic, N de Saint Aubain, JS Ko, SD Billings, S Chen, M Abi Daoud, J Hewinson, S Louzada, PW Harms, G Cerretelli, CD Robles-Espinoza, RM Patel, L van der Weyden, C Bakal, JL Hornick, MJ Arends, T Brenn, DJ Adams
Publication Date: 2019-05-17

Variant appearance in text: AKT1: E17K
PMID: 31101826
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A Comparison of DNA Mutation and Copy Number Profiles of Primary Breast Cancers and Paired Brain Metastases for Identifying Clinically Relevant Genetic Alterations in Brain Metastases.

Cancers
M Tyran, N Carbuccia, S Garnier, A Guille, J Adelaïde, P Finetti, J Toulzian, P Viens, A Tallet, A Goncalves, P Metellus, D Birnbaum, M Chaffanet, F Bertucci
Publication Date: 2019-05-13

Variant appearance in text: AKT1: E17K
PMID: 31086113
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The Pathogenesis of Port Wine Stain and Sturge Weber Syndrome: Complex Interactions between Genetic Alterations and Aberrant MAPK and PI3K Activation.

International Journal Of Molecular Sciences
V Nguyen, M Hochman, MC Mihm, JS Nelson, W Tan
Publication Date: 2019-05-07

Variant appearance in text: AKT: E17K
PMID: 31067686
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BRIP-1 germline mutation and its role in colon cancer: presentation of two case reports and review of literature.

Bmc Medical Genetics
M Ali, CD Delozier, U Chaudhary
Publication Date: 2019-05-07

Variant appearance in text: AKT1: E17K
PMID: 31064327
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Intratumoral Adaptive Immunosuppression and Type 17 Immunity in Mismatch Repair Proficient Colorectal Tumors.

Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research
NJ Llosa, B Luber, AJ Tam, KN Smith, N Siegel, AH Awan, H Fan, T Oke, J Zhang, J Domingue, EL Engle, CA Roberts, BR Bartlett, LK Aulakh, ED Thompson, JM Taube, JN Durham, CL Sears, DT Le, LA Diaz, DM Pardoll, H Wang, RA Anders, F Housseau
Publication Date: 2019-09-01

Variant appearance in text: AKT1: E17K
PMID: 31061070
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Multilaboratory Assessment of a New Reference Material for Quality Assurance of Cell-Free Tumor DNA Measurements.

The Journal Of Molecular Diagnostics : Jmd
HJ He, EV Stein, Y Konigshofer, T Forbes, FL Tomson, R Garlick, E Yamada, T Godfrey, T Abe, K Tamura, M Borges, M Goggins, S Elmore, ML Gulley, JL Larson, L Ringel, BC Haynes, C Karlovich, PM Williams, A Garnett, A Ståhlberg, S Filges, L Sorbara, MR Young, S Srivastava, KD Cole
Publication Date: 2019-07

Variant appearance in text: AKT1: 49G>A; E17K
PMID: 31055023
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Therapeutic Potency of PI3K Pharmacological Inhibitors of Gastrointestinal Cancer.

Middle East Journal Of Digestive Diseases
K Hashemzadeh, MH Jokar, S Sedighi, M Moradzadeh
Publication Date: 2019-01

Variant appearance in text: AKT: E17K
PMID: 31049177
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Clinical validation of the tempus xT next-generation targeted oncology sequencing assay.

Oncotarget
N Beaubier, R Tell, D Lau, JR Parsons, S Bush, J Perera, S Sorrells, T Baker, A Chang, J Michuda, C Iguartua, S MacNeil, K Shah, P Ellis, K Yeatts, B Mahon, T Taxter, M Bontrager, A Khan, R Huether, E Lefkofsky, KP White
Publication Date: 2019-03-22

Variant appearance in text: AKT1: E17K
PMID: 31040929
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Basket Trials for Intractable Cancer.

Frontiers In Oncology
BD Qin, XD Jiao, K Liu, Y Wu, X He, J Liu, WX Qin, Z Wang, YS Zang
Publication Date: 2019

Variant appearance in text: AKT: E17K
PMID: 31032221
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The PTEN⁻PI3K Axis in Cancer.

Biomolecules
A Papa, PP Pandolfi
Publication Date: 2019-04-17

Variant appearance in text: AKT: E17K
PMID: 30999672
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Alternative transcript annotations:

Transcript cDNA Protein Consequence Exon Intron
ENST00000349310.3 c.49G>A p.Glu17Lys missense_variant,splice_region_variant 4/15 -
ENST00000402615.2 c.49G>A p.Glu17Lys missense_variant,splice_region_variant 3/14 -
ENST00000407796.2 c.49G>A p.Glu17Lys missense_variant,splice_region_variant 3/14 -
ENST00000554581.1 c.49G>A p.Glu17Lys missense_variant,splice_region_variant 2/13 -
ENST00000554848.1 c.49G>A p.Glu17Lys missense_variant,splice_region_variant 3/14 -
ENST00000555380.1 c.-138G>A - splice_region_variant,5_prime_UTR_variant 2/5 -
ENST00000555528.1 c.49G>A p.Glu17Lys missense_variant,splice_region_variant 3/14 -
ENST00000555926.1 c.49G>A p.Glu17Lys missense_variant,splice_region_variant 4/5 -
NM_001014431.2 c.49G>A p.Glu17Lys missense_variant,splice_region_variant 3/14 -
NM_001014432.1 c.49G>A p.Glu17Lys missense_variant,splice_region_variant 4/15 -
NM_005163.2 c.49G>A p.Glu17Lys missense_variant,splice_region_variant 3/14 -