Publications:

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Caspase-1 and Cathepsin B Inhibitors from Marine Invertebrates, Aiming at a Reduction in Neuroinflammation.

Marine Drugs

Moreno, Rafaela Indalecio RI; Zambelli, Vanessa O VO; Picolo, Gisele G; Cury, Yara Y; Morandini, André C AC; Marques, Antonio Carlos AC; Sciani, Juliana Mozer JM

Publication Date: 2022-09-29

Variant appearance in text: PS1: E64d

PubMed Link: 36286438

Variant Present in the following documents:

• marinedrugs-20-00614.pdf

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Role of NLRP3 Inflammasome and Its Inhibitors as Emerging Therapeutic Drug Candidate for Alzheimer's Disease: a Review of Mechanism of Activation, Regulation, and Inhibition.

Inflammation

Sharma, Barkha B; Satija, Garvit G; Madan, Anish A; Garg, Mansi M; Alam, M Mumtaz MM; Shaquiquzzaman, M M; Khanna, Suruchi S; Tiwari, Prachi P; Parvez, Suhel S; Iqubal, Ashif A; Haque, Syed Ehtaishamul SE; Khan, Mohammad Ahmed MA

Publication Date: 2022-08-25

Variant appearance in text: PS1: E64d

PubMed Link: 36006570

Variant Present in the following documents:

• 10753_2022_Article_1730.pdf

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Ovocystatin Induced Changes in Expression of Alzheimer's Disease Relevant Proteins in APP/PS1 Transgenic Mice.

Journal Of Clinical Medicine

Stanczykiewicz, Bartlomiej B; Gburek, Jakub J; Rutkowska, Maria M; Lemieszewska, Marta M; Gołąb, Krzysztof K; Juszczyńska, Katarzyna K; Piotrowska, Aleksandra A; Trziszka, Tadeusz T; Dzięgiel, Piotr P; Podhorska-Okołów, Marzenna M; Zabłocka, Agnieszka A; Rymaszewska, Joanna J

Publication Date: 2022-04-23

Variant appearance in text: PSEN1: E64d

PubMed Link: 35566501

Variant Present in the following documents:

• Main text
• jcm-11-02372.pdf

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Identification of Novel Cathepsin B Inhibitors with Implications in Alzheimer's Disease: Computational Refining and Biochemical Evaluation.

Cells

Chitranshi, Nitin N; Kumar, Ashutosh A; Sheriff, Samran S; Gupta, Veer V; Godinez, Angela A; Saks, Danit D; Sarkar, Soumalya S; Shen, Ting T; Mirzaei, Mehdi M; Basavarajappa, Devaraj D; Abyadeh, Morteza M; Singh, Sachin K SK; Dua, Kamal K; Zhang, Kam Y J KYJ; Graham, Stuart L SL; Gupta, Vivek V

Publication Date: 2021-07-31

Variant appearance in text: PSEN1: E64d

PubMed Link: 34440715

Variant Present in the following documents:

• Main text

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Effects of GrandFusion Diet on Cognitive Impairment in Transgenic Mouse Model of Alzheimer's Disease.

Nutrients

Yu, Jin J; Zhu, Hong H; Taheri, Saeid S; Mondy, William W; Perry, Stephen S; Kirstein, Cheryl C; Kindy, Mark S MS

Publication Date: 2020-12-30

Variant appearance in text: PS1: E64d

PubMed Link: 33396967

Variant Present in the following documents:

• nutrients-13-00117.pdf

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Pharmacological targeting of MCL-1 promotes mitophagy and improves disease pathologies in an Alzheimer's disease mouse model.

Nature Communications

Cen, Xufeng X; Chen, Yanying Y; Xu, Xiaoyan X; Wu, Ronghai R; He, Fusheng F; Zhao, Qingwei Q; Sun, Qiming Q; Yi, Cong C; Wu, Jie J; Najafov, Ayaz A; Xia, Hongguang H

Publication Date: 2020-11-12

Variant appearance in text: PS1: E64D

PubMed Link: 33184293

Variant Present in the following documents:

• 41467_2020_Article_19547.pdf

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Neuroprotective effects of p62(SQSTM1)-engineered lactic acid bacteria in Alzheimer's disease: a pre-clinical study.

Aging

Cecarini, Valentina V; Bonfili, Laura L; Gogoi, Olee O; Lawrence, Solomon S; Venanzi, Franco M FM; Azevedo, Vasco V; Mancha-Agresti, Pamela P; Drumond, Mariana Martins MM; Rossi, Giacomo G; Berardi, Sara S; Galosi, Livio L; Cuccioloni, Massimiliano M; Angeletti, Mauro M; Suchodolski, Jan S JS; Pilla, Rachel R; Lidbury, Jonathan A JA; Eleuteri, Anna Maria AM

Publication Date: 2020-08-28

Variant appearance in text: PSEN1: E64d

PubMed Link: 32855357

Variant Present in the following documents:

• aging-12-103900.pdf

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The Role of Lysosomes in a Broad Disease-Modifying Approach Evaluated across Transgenic Mouse Models of Alzheimer's Disease and Parkinson's Disease and Models of Mild Cognitive Impairment.

International Journal Of Molecular Sciences

Hwang, Jeannie J; Estick, Candice M CM; Ikonne, Uzoma S US; Butler, David D; Pait, Morgan C MC; Elliott, Lyndsie H LH; Ruiz, Sarah S; Smith, Kaitlan K; Rentschler, Katherine M KM; Mundell, Cary C; Almeida, Michael F MF; Stumbling Bear, Nicole N; Locklear, James P JP; Abumohsen, Yara Y; Ivey, Cecily M CM; Farizatto, Karen L G KLG; Bahr, Ben A BA

Publication Date: 2019-09-09

Variant appearance in text: PS1: E64d

PubMed Link: 31505809

Variant Present in the following documents:

• Main text
• ijms-20-04432.pdf

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Putative roles of cathepsin B in Alzheimer's disease pathology: The good, the bad, and the ugly in one?

Neural Regeneration Research

Bernstein, Hans-Gert HG; Keilhoff, Gerburg G

Publication Date: 2018-12

Variant appearance in text: PSEN1: E64d

PubMed Link: 30323135

Variant Present in the following documents:

• Main text
• NRR-13-2100.pdf

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The Metalloprotease Meprin β Is an Alternative β-Secretase of APP.

Frontiers In Molecular Neuroscience

Becker-Pauly, Christoph C; Pietrzik, Claus U CU

Publication Date: 2016

Variant appearance in text: PSEN1: E64d

PubMed Link: 28105004

Variant Present in the following documents:

• fnmol-09-00159.pdf

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Soluble adenylyl cyclase is essential for proper lysosomal acidification.

The Journal Of General Physiology

Rahman, Nawreen N; Ramos-Espiritu, Lavoisier L; Milner, Teresa A TA; Buck, Jochen J; Levin, Lonny R LR

Publication Date: 2016-10

Variant appearance in text: PS1: E64D

PubMed Link: 27670898

Variant Present in the following documents:

• JGP_201611606.pdf

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Cysteine proteases as therapeutic targets: does selectivity matter? A systematic review of calpain and cathepsin inhibitors.

Acta Pharmaceutica Sinica. B

Siklos, Marton M; BenAissa, Manel M; Thatcher, Gregory R J GR

Publication Date: 2015-11

Variant appearance in text: PS1: E64d

PubMed Link: 26713267

Variant Present in the following documents:

• main.pdf

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c-Abl and Arg induce cathepsin-mediated lysosomal degradation of the NM23-H1 metastasis suppressor in invasive cancer.

Oncogene

Fiore, Leann S LS; Ganguly, Sourik S SS; Sledziona, James J; Cibull, Michael L ML; Wang, Chi C; Richards, Dana L DL; Neltner, Janna M JM; Beach, Carol C; McCorkle, Joseph R JR; Kaetzel, David M DM; Plattner, Rina R

Publication Date: 2014-09-04

Variant appearance in text: PS1: E64d

PubMed Link: 24096484

Variant Present in the following documents:

• Main text
• nihms-550235.pdf

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Cross-talk between two cysteine protease families. Activation of caspase-12 by calpain in apoptosis.

The Journal Of Cell Biology

Nakagawa, T T; Yuan, J J

Publication Date: 2000-08-21

Variant appearance in text: S182: E64d

PubMed Link: 10953012

Variant Present in the following documents:

• 0004105.pdf

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