Retinal pathological features and proteome signatures of Alzheimer's disease.
Acta Neuropathologica
Koronyo, Yosef Y; Rentsendorj, Altan A; Mirzaei, Nazanin N; Regis, Giovanna C GC; Sheyn, Julia J; Shi, Haoshen H; Barron, Ernesto E; Cook-Wiens, Galen G; Rodriguez, Anthony R AR; Medeiros, Rodrigo R; Paulo, Joao A JA; Gupta, Veer B VB; Kramerov, Andrei A AA; Ljubimov, Alexander V AV; Van Eyk, Jennifer E JE; Graham, Stuart L SL; Gupta, Vivek K VK; Ringman, John M JM; Hinton, David R DR; Miller, Carol A CA; Black, Keith L KL; Cattaneo, Antonino A; Meli, Giovanni G; Mirzaei, Mehdi M; Fuchs, Dieu-Trang DT; Koronyo-Hamaoui, Maya M
Aβ and tau prions feature in the neuropathogenesis of Down syndrome.
Proceedings Of The National Academy Of Sciences Of The United States Of America
Condello, Carlo C; Maxwell, Alison M AM; Castillo, Erika E; Aoyagi, Atsushi A; Graff, Caroline C; Ingelsson, Martin M; Lannfelt, Lars L; Bird, Thomas D TD; Keene, C Dirk CD; Seeley, William W WW; Perl, Daniel P DP; Head, Elizabeth E; Prusiner, Stanley B SB
A Targeted Gene Panel That Covers Coding, Non-coding and Short Tandem Repeat Regions Improves the Diagnosis of Patients With Neurodegenerative Diseases.
Frontiers In Neuroscience
Yu, Allen Chi-Shing AC; Yim, Aldrin Kay-Yuen AK; Chan, Anne Yin-Yan AY; Yuen, Liz Y P LYP; Au, Wing Chi WC; Cheng, Timothy H T THT; Lin, Xiao X; Li, Jing-Woei JW; Chan, Larry W L LWL; Mok, Vincent C T VCT; Chan, Ting-Fung TF; Chan, Ho Yin Edwin HYE
Brain somatic mutations observed in Alzheimer's disease associated with aging and dysregulation of tau phosphorylation.
Nature Communications
Park, Jun Sung JS; Lee, Junehawk J; Jung, Eun Sun ES; Kim, Myeong-Heui MH; Kim, Il Bin IB; Son, Hyeonju H; Kim, Sangwoo S; Kim, Sanghyeon S; Park, Young Mok YM; Mook-Jung, Inhee I; Yu, Seok Jong SJ; Lee, Jeong Ho JH
Impairment of memory generalization in preclinical autosomal dominant Alzheimer's disease mutation carriers.
Neurobiology Of Aging
Petok, Jessica R JR; Myers, Catherine E CE; Pa, Judy J; Hobel, Zachary Z; Wharton, David M DM; Medina, Luis D LD; Casado, Maria M; Coppola, Giovanni G; Gluck, Mark A MA; Ringman, John M JM
Disease-related mutations among Caribbean Hispanics with familial dementia.
Molecular Genetics & Genomic Medicine
Lee, Joseph H JH; Kahn, Amanda A; Cheng, Rong R; Reitz, Christiane C; Vardarajan, Badri B; Lantigua, Rafael R; Medrano, Martin M; Jiménez-Velázquez, Ivonne Z IZ; Williamson, Jennifer J; Nagy, Peter P; Mayeux, Richard R
Genetic heterogeneity in Alzheimer disease and implications for treatment strategies.
Current Neurology And Neuroscience Reports
Ringman, John M JM; Goate, Alison A; Masters, Colin L CL; Cairns, Nigel J NJ; Danek, Adrian A; Graff-Radford, Neill N; Ghetti, Bernardino B; Morris, John C JC; ,
U1 small nuclear ribonucleoproteins (snRNPs) aggregate in Alzheimer's disease due to autosomal dominant genetic mutations and trisomy 21.
Molecular Neurodegeneration
Hales, Chadwick M CM; Seyfried, Nicholas T NT; Dammer, Eric B EB; Duong, Duc D; Yi, Hong H; Gearing, Marla M; Troncoso, Juan C JC; Mufson, Elliott J EJ; Thambisetty, Madhav M; Levey, Allan I AI; Lah, James J JJ
A paired RNAi and RabGAP overexpression screen identifies Rab11 as a regulator of β-amyloid production.
Cell Reports
Udayar, Vinod V; Buggia-Prévot, Virginie V; Guerreiro, Rita L RL; Siegel, Gabriele G; Rambabu, Naresh N; Soohoo, Amanda L AL; Ponnusamy, Moorthi M; Siegenthaler, Barbara B; Bali, Jitin J; , ; Simons, Mikael M; Ries, Jonas J; Puthenveedu, Manojkumar A MA; Hardy, John J; Thinakaran, Gopal G; Rajendran, Lawrence L
Subjects harboring presenilin familial Alzheimer's disease mutations exhibit diverse white matter biochemistry alterations.
American Journal Of Neurodegenerative Disease
Roher, Alex E AE; Maarouf, Chera L CL; Malek-Ahmadi, Michael M; Wilson, Jeffrey J; Kokjohn, Tyler A TA; Daugs, Ian D ID; Whiteside, Charisse M CM; Kalback, Walter M WM; Macias, Mimi P MP; Jacobson, Sandra A SA; Sabbagh, Marwan N MN; Ghetti, Bernardino B; Beach, Thomas G TG
Novel antibody capture assay for paraffin-embedded tissue detects wide-ranging amyloid beta and paired helical filament-tau accumulation in cognitively normal older adults.
Brain Pathology (Zurich, Switzerland)
Postupna, Nadia N; Rose, Shannon E SE; Bird, Thomas D TD; Gonzalez-Cuyar, Luis F LF; Sonnen, Joshua A JA; Larson, Eric B EB; Keene, C Dirk CD; Montine, Thomas J TJ
Presenilin1/gamma-secretase promotes the EphB2-induced phosphorylation of ephrinB2 by regulating phosphoprotein associated with glycosphingolipid-enriched microdomains/Csk binding protein.
Faseb Journal : Official Publication Of The Federation Of American Societies For Experimental Biology
Georgakopoulos, Anastasios A; Xu, Jindong J; Xu, Chijie C; Mauger, Gweltas G; Barthet, Gael G; Robakis, Nikolaos K NK
Histopathological and molecular heterogeneity among individuals with dementia associated with Presenilin mutations.
Molecular Neurodegeneration
Maarouf, Chera L CL; Daugs, Ian D ID; Spina, Salvatore S; Vidal, Ruben R; Kokjohn, Tyler A TA; Patton, R Lyle RL; Kalback, Walter M WM; Luehrs, Dean C DC; Walker, Douglas G DG; Castaño, Eduardo M EM; Beach, Thomas G TG; Ghetti, Bernardino B; Roher, Alex E AE
Genetic screening of Alzheimer's disease genes in Iberian and African samples yields novel mutations in presenilins and APP.
Neurobiology Of Aging
Guerreiro, Rita Joao RJ; Baquero, Miquel M; Blesa, Rafael R; Boada, Mercè M; Brás, Jose Miguel JM; Bullido, Maria J MJ; Calado, Ana A; Crook, Richard R; Ferreira, Carla C; Frank, Ana A; Gómez-Isla, Teresa T; Hernández, Isabel I; Lleó, Alberto A; Machado, Alvaro A; Martínez-Lage, Pablo P; Masdeu, José J; Molina-Porcel, Laura L; Molinuevo, José L JL; Pastor, Pau P; Pérez-Tur, Jordi J; Relvas, Rute R; Oliveira, Catarina Resende CR; Ribeiro, Maria Helena MH; Rogaeva, Ekaterina E; Sa, Alfredo A; Samaranch, Lluís L; Sánchez-Valle, Raquel R; Santana, Isabel I; Tàrraga, Lluís L; Valdivieso, Fernando F; Singleton, Andrew A; Hardy, John J; Clarimón, Jordi J
Ligand binding and calcium influx induce distinct ectodomain/gamma-secretase-processing pathways of EphB2 receptor.
The Journal Of Biological Chemistry
Litterst, Claudia C; Georgakopoulos, Anastasios A; Shioi, Junichi J; Ghersi, Enrico E; Wisniewski, Thomas T; Wang, Rong R; Ludwig, Andreas A; Robakis, Nikolaos K NK