Linkage analysis identifies novel genetic modifiers of microbiome traits in families with inflammatory bowel disease.
Gut Microbes
Sharma, Arunabh A; Szymczak, Silke S; Rühlemann, Malte M; Freitag-Wolf, Sandra S; Knecht, Carolin C; Enderle, Janna J; Schreiber, Stefan S; Franke, Andre A; Lieb, Wolfgang W; Krawczak, Michael M; Dempfle, Astrid A
Linkage analysis identifies novel genetic modifiers of microbiome traits in families with inflammatory bowel disease.
Gut Microbes
Sharma, Arunabh A; Szymczak, Silke S; Rühlemann, Malte M; Freitag-Wolf, Sandra S; Knecht, Carolin C; Enderle, Janna J; Schreiber, Stefan S; Franke, Andre A; Lieb, Wolfgang W; Krawczak, Michael M; Dempfle, Astrid A
Activation of pH-Sensing Receptor OGR1 (GPR68) Induces ER Stress Via the IRE1α/JNK Pathway in an Intestinal Epithelial Cell Model.
Scientific Reports
Maeyashiki, Chiaki C; Melhem, Hassan H; Hering, Larissa L; Baebler, Katharina K; Cosin-Roger, Jesus J; Schefer, Fabian F; Weder, Bruce B; Hausmann, Martin M; Scharl, Michael M; Rogler, Gerhard G; de Vallière, Cheryl C; Ruiz, Pedro A PA
The impact of the rs8005161 polymorphism on G protein-coupled receptor GPR65 (TDAG8) pH-associated activation in intestinal inflammation.
Bmc Gastroenterology
Tcymbarevich, Irina V IV; Eloranta, Jyrki J JJ; Rossel, Jean-Benoît JB; Obialo, Nicole N; Spalinger, Marianne M; Cosin-Roger, Jesus J; Lang, Silvia S; Kullak-Ublick, Gerd A GA; Wagner, Carsten A CA; Scharl, Michael M; Seuwen, Klaus K; Ruiz, Pedro A PA; Rogler, Gerhard G; de Vallière, Cheryl C; Misselwitz, Benjamin B; ,
Phenome-wide association studies across large population cohorts support drug target validation.
Nature Communications
Diogo, Dorothée D; Tian, Chao C; Franklin, Christopher S CS; Alanne-Kinnunen, Mervi M; March, Michael M; Spencer, Chris C A CCA; Vangjeli, Ciara C; Weale, Michael E ME; Mattsson, Hannele H; Kilpeläinen, Elina E; Sleiman, Patrick M A PMA; Reilly, Dermot F DF; McElwee, Joshua J; Maranville, Joseph C JC; Chatterjee, Arnaub K AK; Bhandari, Aman A; Nguyen, Khanh-Dung H KH; Estrada, Karol K; Reeve, Mary-Pat MP; Hutz, Janna J; Bing, Nan N; John, Sally S; MacArthur, Daniel G DG; Salomaa, Veikko V; Ripatti, Samuli S; Hakonarson, Hakon H; Daly, Mark J MJ; Palotie, Aarno A; Hinds, David A DA; Donnelly, Peter P; Fox, Caroline S CS; Day-Williams, Aaron G AG; Plenge, Robert M RM; Runz, Heiko H
Fine-mapping inflammatory bowel disease loci to single-variant resolution.
Nature
Huang, Hailiang H; Fang, Ming M; Jostins, Luke L; Umićević Mirkov, Maša M; Boucher, Gabrielle G; Anderson, Carl A CA; Andersen, Vibeke V; Cleynen, Isabelle I; Cortes, Adrian A; Crins, François F; D'Amato, Mauro M; Deffontaine, Valérie V; Dmitrieva, Julia J; Docampo, Elisa E; Elansary, Mahmoud M; Farh, Kyle Kai-How KK; Franke, Andre A; Gori, Ann-Stephan AS; Goyette, Philippe P; Halfvarson, Jonas J; Haritunians, Talin T; Knight, Jo J; Lawrance, Ian C IC; Lees, Charlie W CW; Louis, Edouard E; Mariman, Rob R; Meuwissen, Theo T; Mni, Myriam M; Momozawa, Yukihide Y; Parkes, Miles M; Spain, Sarah L SL; Théâtre, Emilie E; Trynka, Gosia G; Satsangi, Jack J; van Sommeren, Suzanne S; Vermeire, Severine S; Xavier, Ramnik J RJ; , ; Weersma, Rinse K RK; Duerr, Richard H RH; Mathew, Christopher G CG; Rioux, John D JD; McGovern, Dermot P B DPB; Cho, Judy H JH; Georges, Michel M; Daly, Mark J MJ; Barrett, Jeffrey C JC
Association of NOD2 and IL23R with inflammatory bowel disease in Puerto Rico.
Plos One
Ballester, Veroushka V; Guo, Xiuqing X; Vendrell, Roberto R; Haritunians, Talin T; Klomhaus, Alexandra M AM; Li, Dalin D; McGovern, Dermot P B DP; Rotter, Jerome I JI; Torres, Esther A EA; Taylor, Kent D KD
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
Nature
Jostins, Luke L; Ripke, Stephan S; Weersma, Rinse K RK; Duerr, Richard H RH; McGovern, Dermot P DP; Hui, Ken Y KY; Lee, James C JC; Schumm, L Philip LP; Sharma, Yashoda Y; Anderson, Carl A CA; Essers, Jonah J; Mitrovic, Mitja M; Ning, Kaida K; Cleynen, Isabelle I; Theatre, Emilie E; Spain, Sarah L SL; Raychaudhuri, Soumya S; Goyette, Philippe P; Wei, Zhi Z; Abraham, Clara C; Achkar, Jean-Paul JP; Ahmad, Tariq T; Amininejad, Leila L; Ananthakrishnan, Ashwin N AN; Andersen, Vibeke V; Andrews, Jane M JM; Baidoo, Leonard L; Balschun, Tobias T; Bampton, Peter A PA; Bitton, Alain A; Boucher, Gabrielle G; Brand, Stephan S; Büning, Carsten C; Cohain, Ariella A; Cichon, Sven S; D'Amato, Mauro M; De Jong, Dirk D; Devaney, Kathy L KL; Dubinsky, Marla M; Edwards, Cathryn C; Ellinghaus, David D; Ferguson, Lynnette R LR; Franchimont, Denis D; Fransen, Karin K; Gearry, Richard R; Georges, Michel M; Gieger, Christian C; Glas, Jürgen J; Haritunians, Talin T; Hart, Ailsa A; Hawkey, Chris C; Hedl, Matija M; Hu, Xinli X; Karlsen, Tom H TH; Kupcinskas, Limas L; Kugathasan, Subra S; Latiano, Anna A; Laukens, Debby D; Lawrance, Ian C IC; Lees, Charlie W CW; Louis, Edouard E; Mahy, Gillian G; Mansfield, John J; Morgan, Angharad R AR; Mowat, Craig C; Newman, William W; Palmieri, Orazio O; Ponsioen, Cyriel Y CY; Potocnik, Uros U; Prescott, Natalie J NJ; Regueiro, Miguel M; Rotter, Jerome I JI; Russell, Richard K RK; Sanderson, Jeremy D JD; Sans, Miquel M; Satsangi, Jack J; Schreiber, Stefan S; Simms, Lisa A LA; Sventoraityte, Jurgita J; Targan, Stephan R SR; Taylor, Kent D KD; Tremelling, Mark M; Verspaget, Hein W HW; De Vos, Martine M; Wijmenga, Cisca C; Wilson, David C DC; Winkelmann, Juliane J; Xavier, Ramnik J RJ; Zeissig, Sebastian S; Zhang, Bin B; Zhang, Clarence K CK; Zhao, Hongyu H; , ; Silverberg, Mark S MS; Annese, Vito V; Hakonarson, Hakon H; Brant, Steven R SR; Radford-Smith, Graham G; Mathew, Christopher G CG; Rioux, John D JD; Schadt, Eric E EE; Daly, Mark J MJ; Franke, Andre A; Parkes, Miles M; Vermeire, Severine S; Barrett, Jeffrey C JC; Cho, Judy H JH
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
Nature Genetics
Franke, Andre A; McGovern, Dermot P B DP; Barrett, Jeffrey C JC; Wang, Kai K; Radford-Smith, Graham L GL; Ahmad, Tariq T; Lees, Charlie W CW; Balschun, Tobias T; Lee, James J; Roberts, Rebecca R; Anderson, Carl A CA; Bis, Joshua C JC; Bumpstead, Suzanne S; Ellinghaus, David D; Festen, Eleonora M EM; Georges, Michel M; Green, Todd T; Haritunians, Talin T; Jostins, Luke L; Latiano, Anna A; Mathew, Christopher G CG; Montgomery, Grant W GW; Prescott, Natalie J NJ; Raychaudhuri, Soumya S; Rotter, Jerome I JI; Schumm, Philip P; Sharma, Yashoda Y; Simms, Lisa A LA; Taylor, Kent D KD; Whiteman, David D; Wijmenga, Cisca C; Baldassano, Robert N RN; Barclay, Murray M; Bayless, Theodore M TM; Brand, Stephan S; Büning, Carsten C; Cohen, Albert A; Colombel, Jean-Frederick JF; Cottone, Mario M; Stronati, Laura L; Denson, Ted T; De Vos, Martine M; D'Inca, Renata R; Dubinsky, Marla M; Edwards, Cathryn C; Florin, Tim T; Franchimont, Denis D; Gearry, Richard R; Glas, Jürgen J; Van Gossum, Andre A; Guthery, Stephen L SL; Halfvarson, Jonas J; Verspaget, Hein W HW; Hugot, Jean-Pierre JP; Karban, Amir A; Laukens, Debby D; Lawrance, Ian I; Lemann, Marc M; Levine, Arie A; Libioulle, Cecile C; Louis, Edouard E; Mowat, Craig C; Newman, William W; Panés, Julián J; Phillips, Anne A; Proctor, Deborah D DD; Regueiro, Miguel M; Russell, Richard R; Rutgeerts, Paul P; Sanderson, Jeremy J; Sans, Miquel M; Seibold, Frank F; Steinhart, A Hillary AH; Stokkers, Pieter C F PC; Torkvist, Leif L; Kullak-Ublick, Gerd G; Wilson, David D; Walters, Thomas T; Targan, Stephan R SR; Brant, Steven R SR; Rioux, John D JD; D'Amato, Mauro M; Weersma, Rinse K RK; Kugathasan, Subra S; Griffiths, Anne M AM; Mansfield, John C JC; Vermeire, Severine S; Duerr, Richard H RH; Silverberg, Mark S MS; Satsangi, Jack J; Schreiber, Stefan S; Cho, Judy H JH; Annese, Vito V; Hakonarson, Hakon H; Daly, Mark J MJ; Parkes, Miles M