Distinct genetic variation and heterogeneity of the Iranian population.
Plos Genetics
Z Mehrjoo, Z Fattahi, M Beheshtian, M Mohseni, H Poustchi, F Ardalani, K Jalalvand, S Arzhangi, Z Mohammadi, S Khoshbakht, F Najafi, P Nikuei, M Haddadi, E Zohrehvand, M Oladnabi, A Mohammadzadeh, MH Jafari, T Akhtarkhavari, ES Gooshki, A Haghdoost, R Najafipour, LM Niestroj, B Helwing, Y Gossmann, MR Toliat, R Malekzadeh, P Nürnberg, K Kahrizi, H Najmabadi, M Nothnagel
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Plos One
I Gómez-Acebo, T Dierssen-Sotos, C Palazuelos, P Fernández-Navarro, G Castaño-Vinyals, J Alonso-Molero, C Urtiaga, T Fernández-Villa, E Ardanaz, M Rivas-Del-Fresno, A Molina-Barceló, JJ Jiménez-Moleón, L García-Martinez, P Amiano, P Rodriguez-Cundin, V Moreno, B Pérez-Gómez, N Aragonés, M Kogevinas, M Pollán, J Llorca
Loci associated with skin pigmentation identified in African populations.
Science (New York, N.Y.)
NG Crawford, DE Kelly, MEB Hansen, MH Beltrame, S Fan, SL Bowman, E Jewett, A Ranciaro, S Thompson, Y Lo, SP Pfeifer, JD Jensen, MC Campbell, W Beggs, F Hormozdiari, SW Mpoloka, GG Mokone, T Nyambo, DW Meskel, G Belay, J Haut, , H Rothschild, L Zon, Y Zhou, MA Kovacs, M Xu, T Zhang, K Bishop, J Sinclair, C Rivas, E Elliot, J Choi, SA Li, B Hicks, S Burgess, C Abnet, DE Watkins-Chow, E Oceana, YS Song, E Eskin, KM Brown, MS Marks, SK Loftus, WJ Pavan, M Yeager, S Chanock, SA Tishkoff
A GWAS in uveal melanoma identifies risk polymorphisms in the CLPTM1L locus.
Npj Genomic Medicine
L Mobuchon, A Battistella, C Bardel, G Scelo, A Renoud, A Houy, N Cassoux, M Milder, G Cancel-Tassin, O Cussenot, O Delattre, C Besse, A Boland, JF Deleuze, DG Cox, MH Stern
Variants at the OCA2/HERC2 locus affect time to first cutaneous squamous cell carcinoma in solid organ transplant recipients collected using two different study designs.
The British Journal Of Dermatology
L Wei, DC Allain, MN Bernhardt, JL Gillespie, SB Peters, OH Iwenofu, HH Nelson, ST Arron, AE Toland
Genetic markers of pigmentation are novel risk loci for uveal melanoma.
Scientific Reports
R Ferguson, M Vogelsang, E Ucisik-Akkaya, K Rai, R Pilarski, CN Martinez, J Rendleman, E Kazlow, K Nagdimov, I Osman, RJ Klein, FH Davidorf, CM Cebulla, MH Abdel-Rahman, T Kirchhoff
Early farmers from across Europe directly descended from Neolithic Aegeans.
Proceedings Of The National Academy Of Sciences Of The United States Of America
Z Hofmanová, S Kreutzer, G Hellenthal, C Sell, Y Diekmann, D Díez-Del-Molino, L van Dorp, S López, A Kousathanas, V Link, K Kirsanow, LM Cassidy, R Martiniano, M Strobel, A Scheu, K Kotsakis, P Halstead, S Triantaphyllou, N Kyparissi-Apostolika, D Urem-Kotsou, C Ziota, F Adaktylou, S Gopalan, DM Bobo, L Winkelbach, J Blöcher, M Unterländer, C Leuenberger, Ç Çilingiroğlu, B Horejs, F Gerritsen, SJ Shennan, DG Bradley, M Currat, KR Veeramah, D Wegmann, MG Thomas, C Papageorgopoulou, J Burger
Crowdsourced direct-to-consumer genomic analysis of a family quartet.
Bmc Genomics
M Corpas, W Valdivia-Granda, N Torres, B Greshake, A Coletta, A Knaus, AP Harrison, M Cariaso, F Moran, F Nielsen, D Swan, DY Weiss Solís, P Krawitz, F Schacherer, P Schols, H Yang, P Borry, G Glusman, PN Robinson
Genome-wide analysis of the genetic regulation of gene expression in human neutrophils.
Nature Communications
AK Andiappan, R Melchiotti, TY Poh, M Nah, KJ Puan, E Vigano, D Haase, N Yusof, B San Luis, J Lum, D Kumar, S Foo, L Zhuang, A Vasudev, A Irwanto, B Lee, A Nardin, H Liu, F Zhang, J Connolly, J Liu, A Mortellaro, Y Wang, M Poidinger, A Larbi, F Zolezzi, O Rotzschke
Derived immune and ancestral pigmentation alleles in a 7,000-year-old Mesolithic European.
Nature
I Olalde, ME Allentoft, F Sánchez-Quinto, G Santpere, CW Chiang, M DeGiorgio, J Prado-Martinez, JA Rodríguez, S Rasmussen, J Quilez, O Ramírez, UM Marigorta, M Fernández-Callejo, ME Prada, JM Encinas, R Nielsen, MG Netea, J Novembre, RA Sturm, P Sabeti, T Marquès-Bonet, A Navarro, E Willerslev, C Lalueza-Fox
Melanoma risk loci as determinants of melanoma recurrence and survival.
Journal Of Translational Medicine
J Rendleman, S Shang, C Dominianni, JF Shields, P Scanlon, C Adaniel, A Desrichard, M Ma, R Shapiro, R Berman, A Pavlick, D Polsky, Y Shao, I Osman, T Kirchhoff
Genotype/phenotype analyses for 53 Crohn's disease associated genetic polymorphisms.
Plos One
C Jung, JF Colombel, M Lemann, L Beaugerie, M Allez, J Cosnes, G Vernier-Massouille, JM Gornet, JP Gendre, JP Cezard, FM Ruemmele, D Turck, F Merlin, H Zouali, C Libersa, P Dieudé, N Soufir, G Thomas, JP Hugot
Integration of GWAS SNPs and tissue specific expression profiling reveal discrete eQTLs for human traits in blood and brain.
Neurobiology Of Disease
DG Hernandez, MA Nalls, M Moore, S Chong, A Dillman, D Trabzuni, JR Gibbs, M Ryten, S Arepalli, ME Weale, AB Zonderman, J Troncoso, R O'Brien, R Walker, C Smith, S Bandinelli, BJ Traynor, J Hardy, AB Singleton, MR Cookson
A global view of the OCA2-HERC2 region and pigmentation.
Human Genetics
MP Donnelly, P Paschou, E Grigorenko, D Gurwitz, C Barta, RB Lu, OV Zhukova, JJ Kim, M Siniscalco, M New, H Li, SL Kajuna, VG Manolopoulos, WC Speed, AJ Pakstis, JR Kidd, KK Kidd
Trans-eQTLs reveal that independent genetic variants associated with a complex phenotype converge on intermediate genes, with a major role for the HLA.
Plos Genetics
RS Fehrmann, RC Jansen, JH Veldink, HJ Westra, D Arends, MJ Bonder, J Fu, P Deelen, HJ Groen, A Smolonska, RK Weersma, RM Hofstra, WA Buurman, S Rensen, MG Wolfs, M Platteel, A Zhernakova, CC Elbers, EM Festen, G Trynka, MH Hofker, CG Saris, RA Ophoff, LH van den Berg, DA van Heel, C Wijmenga, GJ Te Meerman, L Franke
Three ulcerative colitis susceptibility loci are associated with primary sclerosing cholangitis and indicate a role for IL2, REL, and CARD9.
Hepatology (Baltimore, Md.)
M Janse, LE Lamberts, L Franke, S Raychaudhuri, E Ellinghaus, K Muri Boberg, E Melum, T Folseraas, E Schrumpf, A Bergquist, E Björnsson, J Fu, H Jan Westra, HJ Groen, RS Fehrmann, J Smolonska, LH van den Berg, RA Ophoff, RJ Porte, TJ Weismüller, J Wedemeyer, C Schramm, M Sterneck, R Günther, F Braun, S Vermeire, L Henckaerts, C Wijmenga, CY Ponsioen, S Schreiber, TH Karlsen, A Franke, RK Weersma
Digital quantification of human eye color highlights genetic association of three new loci.
Plos Genetics
F Liu, A Wollstein, PG Hysi, GA Ankra-Badu, TD Spector, D Park, G Zhu, M Larsson, DL Duffy, GW Montgomery, DA Mackey, S Walsh, O Lao, A Hofman, F Rivadeneira, JR Vingerling, AG Uitterlinden, NG Martin, CJ Hammond, M Kayser
Comparative genetic analysis of inflammatory bowel disease and type 1 diabetes implicates multiple loci with opposite effects.
Human Molecular Genetics
K Wang, R Baldassano, H Zhang, HQ Qu, M Imielinski, S Kugathasan, V Annese, M Dubinsky, JI Rotter, RK Russell, JP Bradfield, PM Sleiman, JT Glessner, T Walters, C Hou, C Kim, EC Frackelton, M Garris, J Doran, C Romano, C Catassi, J Van Limbergen, SL Guthery, L Denson, D Piccoli, MS Silverberg, CA Stanley, D Monos, DC Wilson, A Griffiths, SF Grant, J Satsangi, C Polychronakos, H Hakonarson
Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study.
Nature Genetics
MS Silverberg, JH Cho, JD Rioux, DP McGovern, J Wu, V Annese, JP Achkar, P Goyette, R Scott, W Xu, MM Barmada, L Klei, MJ Daly, C Abraham, TM Bayless, F Bossa, AM Griffiths, AF Ippoliti, RG Lahaie, A Latiano, P Paré, DD Proctor, MD Regueiro, AH Steinhart, SR Targan, LP Schumm, EO Kistner, AT Lee, PK Gregersen, JI Rotter, SR Brant, KD Taylor, K Roeder, RH Duerr
Investigation of Crohn's disease risk loci in ulcerative colitis further defines their molecular relationship.
Gastroenterology
CA Anderson, DC Massey, JC Barrett, NJ Prescott, M Tremelling, SA Fisher, R Gwilliam, J Jacob, ER Nimmo, H Drummond, CW Lees, CM Onnie, C Hanson, K Blaszczyk, R Ravindrarajah, S Hunt, D Varma, N Hammond, G Lewis, H Attlesey, N Watkins, W Ouwehand, D Strachan, W McArdle, CM Lewis, , A Lobo, J Sanderson, DP Jewell, P Deloukas, JC Mansfield, CG Mathew, J Satsangi, M Parkes
A genome-wide association study identifies novel alleles associated with hair color and skin pigmentation.
Plos Genetics
J Han, P Kraft, H Nan, Q Guo, C Chen, A Qureshi, SE Hankinson, FB Hu, DL Duffy, ZZ Zhao, NG Martin, GW Montgomery, NK Hayward, G Thomas, RN Hoover, S Chanock, DJ Hunter
Three genome-wide association studies and a linkage analysis identify HERC2 as a human iris color gene.
American Journal Of Human Genetics
M Kayser, F Liu, AC Janssens, F Rivadeneira, O Lao, K van Duijn, M Vermeulen, P Arp, MM Jhamai, WF van Ijcken, JT den Dunnen, S Heath, D Zelenika, DD Despriet, CC Klaver, JR Vingerling, PT de Jong, A Hofman, YS Aulchenko, AG Uitterlinden, BA Oostra, CM van Duijn
Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility.
Nature Genetics
M Parkes, JC Barrett, NJ Prescott, M Tremelling, CA Anderson, SA Fisher, RG Roberts, ER Nimmo, FR Cummings, D Soars, H Drummond, CW Lees, SA Khawaja, R Bagnall, DA Burke, CE Todhunter, T Ahmad, CM Onnie, W McArdle, D Strachan, G Bethel, C Bryan, CM Lewis, P Deloukas, A Forbes, J Sanderson, DP Jewell, J Satsangi, JC Mansfield, , L Cardon, CG Mathew