LIPC c.88+6834G>A

Variant ID: 15-58731153-G-A

NM_000236.2(LIPC):c.88+6834G>A

This variant was identified in 21 publications

View GRCh38 version.




Publications:


Establishment and characterization of a new mantle cell lymphoma cell line with a NOTCH2 mutation, Arbo.

Ejhaem
Safa, Firas F; Rasmussen, Terri T; Lobelle-Rich, Patricia P; Collier, Stephanie S; Milligan, Nicholas N; Schmeig, John J; Schmid, Janet J; Wiewiorowski, Carol C; Totaro, Denise D; Brown, Theresa C TC; Satyavarapu, Ishwarya I; Badoo, Melody M; Ungerleider, Nathan N; Flemington, Erik K EK; Safah, Hana H; Saba, Nakhle S NS
Publication Date: 2022-11

Variant appearance in text: rs261342
PubMed Link: 36467812
Variant Present in the following documents:
  • JHA2-3-1326-s001.xlsx, sheet 1
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High-throughput multivariable Mendelian randomization analysis prioritizes apolipoprotein B as key lipid risk factor for coronary artery disease.

International Journal Of Epidemiology
Zuber, Verena V; Gill, Dipender D; Ala-Korpela, Mika M; Langenberg, Claudia C; Butterworth, Adam A; Bottolo, Leonardo L; Burgess, Stephen S
Publication Date: 2021-07-09

Variant appearance in text: rs261342
PubMed Link: 33130851
Variant Present in the following documents:
  • dyaa216_supplementary_data.pdf
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Plasma lipid levels and risk of primary open angle glaucoma: a genetic study using Mendelian randomization.

Bmc Ophthalmology
Xu, Mengqiao M; Li, Shengguo S; Zhu, Jundong J; Luo, Dawei D; Song, Weitao W; Zhou, Minwen M
Publication Date: 2020-10-02

Variant appearance in text: rs261342
PubMed Link: 33008364
Variant Present in the following documents:
  • Main text
  • 12886_2020_Article_1661.pdf
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Selecting likely causal risk factors from high-throughput experiments using multivariable Mendelian randomization.

Nature Communications
Zuber, Verena V; Colijn, Johanna Maria JM; Klaver, Caroline C; Burgess, Stephen S
Publication Date: 2020-01-07

Variant appearance in text: rs261342
PubMed Link: 31911605
Variant Present in the following documents:
  • Main text
  • 41467_2019_13870_MOESM1_ESM.pdf
  • 41467_2019_Article_13870.pdf
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A Mendelian randomization study of the effects of blood lipids on breast cancer risk.

Nature Communications
Nowak, Christoph C; Ärnlöv, Johan J
Publication Date: 2018-09-27

Variant appearance in text: rs261342
PubMed Link: 30262900
Variant Present in the following documents:
  • 41467_2018_6467_MOESM1_ESM.pdf
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A mega-analysis of expression quantitative trait loci (eQTL) provides insight into the regulatory architecture of gene expression variation in liver.

Scientific Reports
Strunz, Tobias T; Grassmann, Felix F; Gayán, Javier J; Nahkuri, Satu S; Souza-Costa, Debora D; Maugeais, Cyrille C; Fauser, Sascha S; Nogoceke, Everson E; Weber, Bernhard H F BHF
Publication Date: 2018-04-12

Variant appearance in text: rs261342
PubMed Link: 29650998
Variant Present in the following documents:
  • Main text
  • 41598_2018_Article_24219.pdf
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Role of Blood Lipids in the Development of Ischemic Stroke and its Subtypes: A Mendelian Randomization Study.

Stroke
Hindy, George G; Engström, Gunnar G; Larsson, Susanna C SC; Traylor, Matthew M; Markus, Hugh S HS; Melander, Olle O; Orho-Melander, Marju M; ,
Publication Date: 2018-04

Variant appearance in text: rs261342
PubMed Link: 29535274
Variant Present in the following documents:
  • str-49-820-s001.pdf
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HDL-cholesterol levels and risk of age-related macular degeneration: a multiethnic genetic study using Mendelian randomization.

International Journal Of Epidemiology
Fan, Qiao Q; Maranville, Joseph C JC; Fritsche, Lars L; Sim, Xueling X; Cheung, Chui Ming Gemmy CMG; Chen, Li Jia LJ; Gorski, Mathias M; Yamashiro, Kenji K; Ahn, Jeeyun J; Laude, Augustinus A; Dorajoo, Rajkumar R; Lim, Tock Han TH; Teo, Yik-Ying YY; Blaustein, Robert O RO; Yoshimura, Nagahisa N; Park, Kyu-Hyung KH; Pang, Chi Pui CP; Tai, E Shyong ES; Khor, Chiea Chuen CC; Wong, Tien Yin TY; Runz, Heiko H; Cheng, Ching-Yu CY
Publication Date: 2017-12-01

Variant appearance in text: rs261342
PubMed Link: 29025108
Variant Present in the following documents:
  • Main text
  • dyx189.pdf
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Mendelian Randomization Implicates High-Density Lipoprotein Cholesterol-Associated Mechanisms in Etiology of Age-Related Macular Degeneration.

Ophthalmology
Burgess, Stephen S; Davey Smith, George G
Publication Date: 2017-08

Variant appearance in text: rs261342
PubMed Link: 28456421
Variant Present in the following documents:
  • Main text
  • main.pdf
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Triglyceride-Increasing Alleles Associated with Protection against Type-2 Diabetes.

Plos Genetics
Klimentidis, Yann C YC; Chougule, Akshay A; Arora, Amit A; Frazier-Wood, Alexis C AC; Hsu, Chiu-Hsieh CH
Publication Date: 2015-05

Variant appearance in text: rs261342
PubMed Link: 26020539
Variant Present in the following documents:
  • Main text
  • pgen.1005204.pdf
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A rare variant in APOC3 is associated with plasma triglyceride and VLDL levels in Europeans.

Nature Communications
Timpson, Nicholas J NJ; Walter, Klaudia K; Min, Josine L JL; Tachmazidou, Ioanna I; Malerba, Giovanni G; Shin, So-Youn SY; Chen, Lu L; Futema, Marta M; Southam, Lorraine L; Iotchkova, Valentina V; Cocca, Massimiliano M; Huang, Jie J; Memari, Yasin Y; McCarthy, Shane S; Danecek, Petr P; Muddyman, Dawn D; Mangino, Massimo M; Menni, Cristina C; Perry, John R B JR; Ring, Susan M SM; Gaye, Amadou A; Dedoussis, George G; Farmaki, Aliki-Eleni AE; Burton, Paul P; Talmud, Philippa J PJ; Gambaro, Giovanni G; Spector, Tim D TD; Smith, George Davey GD; Durbin, Richard R; Richards, J Brent JB; Humphries, Steve E SE; Zeggini, Eleftheria E; Soranzo, Nicole N; , ; ,
Publication Date: 2014-09-16

Variant appearance in text: rs261342
PubMed Link: 25225788
Variant Present in the following documents:
  • ncomms5871-s1.pdf
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LipidSeq: a next-generation clinical resequencing panel for monogenic dyslipidemias.

Journal Of Lipid Research
Johansen, Christopher T CT; Dubé, Joseph B JB; Loyzer, Melissa N MN; MacDonald, Austin A; Carter, David E DE; McIntyre, Adam D AD; Cao, Henian H; Wang, Jian J; Robinson, John F JF; Hegele, Robert A RA
Publication Date: 2014-04

Variant appearance in text: rs261342
PubMed Link: 24503134
Variant Present in the following documents:
  • supp_D045963_jlr.D045963-1.pdf
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Joint linkage and association analysis with exome sequence data implicates SLC25A40 in hypertriglyceridemia.

American Journal Of Human Genetics
Rosenthal, Elisabeth A EA; Ranchalis, Jane J; Crosslin, David R DR; Burt, Amber A; Brunzell, John D JD; Motulsky, Arno G AG; Nickerson, Deborah A DA; , ; Wijsman, Ellen M EM; Jarvik, Gail P GP
Publication Date: 2013-12-05

Variant appearance in text: rs261342
PubMed Link: 24268658
Variant Present in the following documents:
  • Main text
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Hypothesis-based analysis of gene-gene interactions and risk of myocardial infarction.

Plos One
Lucas, Gavin G; Lluís-Ganella, Carla C; Subirana, Isaac I; Musameh, Muntaser D MD; Gonzalez, Juan Ramon JR; Nelson, Christopher P CP; Sentí, Mariano M; , ; , ; Schwartz, Stephen M SM; Siscovick, David D; O'Donnell, Christopher J CJ; Melander, Olle O; Salomaa, Veikko V; Purcell, Shaun S; Altshuler, David D; Samani, Nilesh J NJ; Kathiresan, Sekar S; Elosua, Roberto R
Publication Date: 2012

Variant appearance in text: rs261342
PubMed Link: 22876292
Variant Present in the following documents:
  • pone.0041730.s001.pdf
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Genetic predisposition to dyslipidemia and type 2 diabetes risk in two prospective cohorts.

Diabetes
Qi, Qibin Q; Liang, Liming L; Doria, Alessandro A; Hu, Frank B FB; Qi, Lu L
Publication Date: 2012-03

Variant appearance in text: rs261342
PubMed Link: 22315312
Variant Present in the following documents:
  • Main text
  • 745.pdf
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Implications of discoveries from genome-wide association studies in current cardiovascular practice.

World Journal Of Cardiology
Jeemon, Panniyammakal P; Pettigrew, Kerry K; Sainsbury, Christopher C; Prabhakaran, Dorairaj D; Padmanabhan, Sandosh S
Publication Date: 2011-07-26

Variant appearance in text: rs261342
PubMed Link: 21860704
Variant Present in the following documents:
  • Main text
View BVdb publication page



An increased burden of common and rare lipid-associated risk alleles contributes to the phenotypic spectrum of hypertriglyceridemia.

Arteriosclerosis, Thrombosis, And Vascular Biology
Johansen, Christopher T CT; Wang, Jian J; Lanktree, Matthew B MB; McIntyre, Adam D AD; Ban, Matthew R MR; Martins, Rebecca A RA; Kennedy, Brooke A BA; Hassell, Reina G RG; Visser, Maartje E ME; Schwartz, Stephen M SM; Voight, Benjamin F BF; Elosua, Roberto R; Salomaa, Veikko V; O'Donnell, Christopher J CJ; Dallinga-Thie, Geesje M GM; Anand, Sonia S SS; Yusuf, Salim S; Huff, Murray W MW; Kathiresan, Sekar S; Cao, Henian H; Hegele, Robert A RA
Publication Date: 2011-08

Variant appearance in text: rs261342
PubMed Link: 21597005
Variant Present in the following documents:
  • Main text
View BVdb publication page



Genetic determinants of plasma triglycerides.

Journal Of Lipid Research
Johansen, Christopher T CT; Kathiresan, Sekar S; Hegele, Robert A RA
Publication Date: 2011-02

Variant appearance in text: rs261342
PubMed Link: 21041806
Variant Present in the following documents:
  • Main text
View BVdb publication page



Biological, clinical and population relevance of 95 loci for blood lipids.

Nature
Teslovich, Tanya M TM; Musunuru, Kiran K; Smith, Albert V AV; Edmondson, Andrew C AC; Stylianou, Ioannis M IM; Koseki, Masahiro M; Pirruccello, James P JP; Ripatti, Samuli S; Chasman, Daniel I DI; Willer, Cristen J CJ; Johansen, Christopher T CT; Fouchier, Sigrid W SW; Isaacs, Aaron A; Peloso, Gina M GM; Barbalic, Maja M; Ricketts, Sally L SL; Bis, Joshua C JC; Aulchenko, Yurii S YS; Thorleifsson, Gudmar G; Feitosa, Mary F MF; Chambers, John J; Orho-Melander, Marju M; Melander, Olle O; Johnson, Toby T; Li, Xiaohui X; Guo, Xiuqing X; Li, Mingyao M; Shin Cho, Yoon Y; Jin Go, Min M; Jin Kim, Young Y; Lee, Jong-Young JY; Park, Taesung T; Kim, Kyunga K; Sim, Xueling X; Twee-Hee Ong, Rick R; Croteau-Chonka, Damien C DC; Lange, Leslie A LA; Smith, Joshua D JD; Song, Kijoung K; Hua Zhao, Jing J; Yuan, Xin X; Luan, Jian'an J; Lamina, Claudia C; Ziegler, Andreas A; Zhang, Weihua W; Zee, Robert Y L RY; Wright, Alan F AF; Witteman, Jacqueline C M JC; Wilson, James F JF; Willemsen, Gonneke G; Wichmann, H-Erich HE; Whitfield, John B JB; Waterworth, Dawn M DM; Wareham, Nicholas J NJ; Waeber, Gérard G; Vollenweider, Peter P; Voight, Benjamin F BF; Vitart, Veronique V; Uitterlinden, Andre G AG; Uda, Manuela M; Tuomilehto, Jaakko J; Thompson, John R JR; Tanaka, Toshiko T; Surakka, Ida I; Stringham, Heather M HM; Spector, Tim D TD; Soranzo, Nicole N; Smit, Johannes H JH; Sinisalo, Juha J; Silander, Kaisa K; Sijbrands, Eric J G EJ; Scuteri, Angelo A; Scott, James J; Schlessinger, David D; Sanna, Serena S; Salomaa, Veikko V; Saharinen, Juha J; Sabatti, Chiara C; Ruokonen, Aimo A; Rudan, Igor I; Rose, Lynda M LM; Roberts, Robert R; Rieder, Mark M; Psaty, Bruce M BM; Pramstaller, Peter P PP; Pichler, Irene I; Perola, Markus M; Penninx, Brenda W J H BW; Pedersen, Nancy L NL; Pattaro, Cristian C; Parker, Alex N AN; Pare, Guillaume G; Oostra, Ben A BA; O'Donnell, Christopher J CJ; Nieminen, Markku S MS; Nickerson, Deborah A DA; Montgomery, Grant W GW; Meitinger, Thomas T; McPherson, Ruth R; McCarthy, Mark I MI; McArdle, Wendy W; Masson, David D; Martin, Nicholas G NG; Marroni, Fabio F; Mangino, Massimo M; Magnusson, Patrik K E PK; Lucas, Gavin G; Luben, Robert R; Loos, Ruth J F RJ; Lokki, Marja-Liisa ML; Lettre, Guillaume G; Langenberg, Claudia C; Launer, Lenore J LJ; Lakatta, Edward G EG; Laaksonen, Reijo R; Kyvik, Kirsten O KO; Kronenberg, Florian F; König, Inke R IR; Khaw, Kay-Tee KT; Kaprio, Jaakko J; Kaplan, Lee M LM; Johansson, Asa A; Jarvelin, Marjo-Riitta MR; Janssens, A Cecile J W AC; Ingelsson, Erik E; Igl, Wilmar W; Kees Hovingh, G G; Hottenga, Jouke-Jan JJ; Hofman, Albert A; Hicks, Andrew A AA; Hengstenberg, Christian C; Heid, Iris M IM; Hayward, Caroline C; Havulinna, Aki S AS; Hastie, Nicholas D ND; Harris, Tamara B TB; Haritunians, Talin T; Hall, Alistair S AS; Gyllensten, Ulf U; Guiducci, Candace C; Groop, Leif C LC; Gonzalez, Elena E; Gieger, Christian C; Freimer, Nelson B NB; Ferrucci, Luigi L; Erdmann, Jeanette J; Elliott, Paul P; Ejebe, Kenechi G KG; Döring, Angela A; Dominiczak, Anna F AF; Demissie, Serkalem S; Deloukas, Panagiotis P; de Geus, Eco J C EJ; de Faire, Ulf U; Crawford, Gabriel G; Collins, Francis S FS; Chen, Yii-der I YD; Caulfield, Mark J MJ; Campbell, Harry H; Burtt, Noel P NP; Bonnycastle, Lori L LL; Boomsma, Dorret I DI; Boekholdt, S Matthijs SM; Bergman, Richard N RN; Barroso, Inês I; Bandinelli, Stefania S; Ballantyne, Christie M CM; Assimes, Themistocles L TL; Quertermous, Thomas T; Altshuler, David D; Seielstad, Mark M; Wong, Tien Y TY; Tai, E-Shyong ES; Feranil, Alan B AB; Kuzawa, Christopher W CW; Adair, Linda S LS; Taylor, Herman A HA; Borecki, Ingrid B IB; Gabriel, Stacey B SB; Wilson, James G JG; Holm, Hilma H; Thorsteinsdottir, Unnur U; Gudnason, Vilmundur V; Krauss, Ronald M RM; Mohlke, Karen L KL; Ordovas, Jose M JM; Munroe, Patricia B PB; Kooner, Jaspal S JS; Tall, Alan R AR; Hegele, Robert A RA; Kastelein, John J P JJ; Schadt, Eric E EE; Rotter, Jerome I JI; Boerwinkle, Eric E; Strachan, David P DP; Mooser, Vincent V; Stefansson, Kari K; Reilly, Muredach P MP; Samani, Nilesh J NJ; Schunkert, Heribert H; Cupples, L Adrienne LA; Sandhu, Manjinder S MS; Ridker, Paul M PM; Rader, Daniel J DJ; van Duijn, Cornelia M CM; Peltonen, Leena L; Abecasis, Gonçalo R GR; Boehnke, Michael M; Kathiresan, Sekar S
Publication Date: 2010-08-05

Variant appearance in text: rs261342
PubMed Link: 20686565
Variant Present in the following documents:
  • NIHMS213289-supplement-1.pdf
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Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.

American Journal Of Human Genetics
Talmud, Philippa J PJ; Drenos, Fotios F; Shah, Sonia S; Shah, Tina T; Palmen, Jutta J; Verzilli, Claudio C; Gaunt, Tom R TR; Pallas, Jacky J; Lovering, Ruth R; Li, Kawah K; Casas, Juan Pablo JP; Sofat, Reecha R; Kumari, Meena M; Rodriguez, Santiago S; Johnson, Toby T; Newhouse, Stephen J SJ; Dominiczak, Anna A; Samani, Nilesh J NJ; Caulfield, Mark M; Sever, Peter P; Stanton, Alice A; Shields, Denis C DC; Padmanabhan, Sandosh S; Melander, Olle O; Hastie, Claire C; Delles, Christian C; Ebrahim, Shah S; Marmot, Michael G MG; Smith, George Davey GD; Lawlor, Debbie A DA; Munroe, Patricia B PB; Day, Ian N IN; Kivimaki, Mika M; Whittaker, John J; Humphries, Steve E SE; Hingorani, Aroon D AD; , ; , ; ,
Publication Date: 2009-11

Variant appearance in text: rs261342
PubMed Link: 19913121
Variant Present in the following documents:
  • Main text
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LIPC variants in the promoter and intron 1 modify HDL-C levels in a sex-specific fashion.

Atherosclerosis
Feitosa, Mary F MF; Myers, Richard H RH; Pankow, James S JS; Province, Michael A MA; Borecki, Ingrid B IB
Publication Date: 2009-05

Variant appearance in text: rs261342
PubMed Link: 19101670
Variant Present in the following documents:
  • Main text
View BVdb publication page