Genetic analysis of over half a million people characterises C-reactive protein loci.
Nature Communications
Said, Saredo S; Pazoki, Raha R; Karhunen, Ville V; Võsa, Urmo U; Ligthart, Symen S; Bodinier, Barbara B; Koskeridis, Fotios F; Welsh, Paul P; Alizadeh, Behrooz Z BZ; Chasman, Daniel I DI; Sattar, Naveed N; Chadeau-Hyam, Marc M; Evangelou, Evangelos E; Jarvelin, Marjo-Riitta MR; Elliott, Paul P; Tzoulaki, Ioanna I; Dehghan, Abbas A
Genetically determined elevated C-reactive protein associated with primary colorectal cancer risk: Mendelian randomization with lifestyle interactions.
American Journal Of Cancer Research
Jung, Su Yon SY; Yu, Herbert H; Pellegrini, Matteo M; Papp, Jeanette C JC; Sobel, Eric M EM; Zhang, Zuo-Feng ZF
Loss-of-function genomic variants highlight potential therapeutic targets for cardiovascular disease.
Nature Communications
Nielsen, Jonas B JB; Rom, Oren O; Surakka, Ida I; Graham, Sarah E SE; Zhou, Wei W; Roychowdhury, Tanmoy T; Fritsche, Lars G LG; Gagliano Taliun, Sarah A SA; Sidore, Carlo C; Liu, Yuhao Y; Gabrielsen, Maiken E ME; Skogholt, Anne Heidi AH; Wolford, Brooke B; Overton, William W; Zhao, Ying Y; Chen, Jin J; Zhang, He H; Hornsby, Whitney E WE; Acheampong, Akua A; Grooms, Austen A; Schaefer, Amanda A; Zajac, Gregory J M GJM; Villacorta, Luis L; Zhang, Jifeng J; Brumpton, Ben B; Løset, Mari M; Rai, Vivek V; Lundegaard, Pia R PR; Olesen, Morten S MS; Taylor, Kent D KD; Palmer, Nicholette D ND; Chen, Yii-Der YD; Choi, Seung H SH; Lubitz, Steven A SA; Ellinor, Patrick T PT; Barnes, Kathleen C KC; Daya, Michelle M; Rafaels, Nicholas N; Weiss, Scott T ST; Lasky-Su, Jessica J; Tracy, Russell P RP; Vasan, Ramachandran S RS; Cupples, L Adrienne LA; Mathias, Rasika A RA; Yanek, Lisa R LR; Becker, Lewis C LC; Peyser, Patricia A PA; Bielak, Lawrence F LF; Smith, Jennifer A JA; Aslibekyan, Stella S; Hidalgo, Bertha A BA; Arnett, Donna K DK; Irvin, Marguerite R MR; Wilson, James G JG; Musani, Solomon K SK; Correa, Adolfo A; Rich, Stephen S SS; Guo, Xiuqing X; Rotter, Jerome I JI; Konkle, Barbara A BA; Johnsen, Jill M JM; Ashley-Koch, Allison E AE; Telen, Marilyn J MJ; Sheehan, Vivien A VA; Blangero, John J; Curran, Joanne E JE; Peralta, Juan M JM; Montgomery, Courtney C; Sheu, Wayne H-H WH; Chung, Ren-Hua RH; Schwander, Karen K; Nouraie, Seyed M SM; Gordeuk, Victor R VR; Zhang, Yingze Y; Kooperberg, Charles C; Reiner, Alexander P AP; Jackson, Rebecca D RD; Bleecker, Eugene R ER; Meyers, Deborah A DA; Li, Xingnan X; Das, Sayantan S; Yu, Ketian K; LeFaive, Jonathon J; Smith, Albert A; Blackwell, Tom T; Taliun, Daniel D; Zollner, Sebastian S; Forer, Lukas L; Schoenherr, Sebastian S; Fuchsberger, Christian C; Pandit, Anita A; Zawistowski, Matthew M; Kheterpal, Sachin S; Brummett, Chad M CM; Natarajan, Pradeep P; Schlessinger, David D; Lee, Seunggeun S; Kang, Hyun Min HM; Cucca, Francesco F; Holmen, Oddgeir L OL; Åsvold, Bjørn O BO; Boehnke, Michael M; Kathiresan, Sekar S; Abecasis, Goncalo R GR; Chen, Y Eugene YE; Willer, Cristen J CJ; Hveem, Kristian K
Genome-Wide Association Study Identifies Loci for Liver Enzyme Concentrations in Mexican Americans: The GUARDIAN Consortium.
Obesity (Silver Spring, Md.)
Young, Kendra A KA; Palmer, Nicholette D ND; Fingerlin, Tasha E TE; Langefeld, Carl D CD; Norris, Jill M JM; Wang, Nan N; Xiang, Anny H AH; Guo, Xiuqing X; Williams, Adrienne H AH; Chen, Yii-Der I YI; Taylor, Kent D KD; Rotter, Jerome I JI; Raffel, Leslie J LJ; Goodarzi, Mark O MO; Watanabe, Richard M RM; Wagenknecht, Lynne E LE
Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders.
American Journal Of Human Genetics
Ligthart, Symen S; Vaez, Ahmad A; Võsa, Urmo U; Stathopoulou, Maria G MG; de Vries, Paul S PS; Prins, Bram P BP; Van der Most, Peter J PJ; Tanaka, Toshiko T; Naderi, Elnaz E; Rose, Lynda M LM; Wu, Ying Y; Karlsson, Robert R; Barbalic, Maja M; Lin, Honghuang H; Pool, René R; Zhu, Gu G; Macé, Aurélien A; Sidore, Carlo C; Trompet, Stella S; Mangino, Massimo M; Sabater-Lleal, Maria M; Kemp, John P JP; Abbasi, Ali A; Kacprowski, Tim T; Verweij, Niek N; Smith, Albert V AV; Huang, Tao T; Marzi, Carola C; Feitosa, Mary F MF; Lohman, Kurt K KK; Kleber, Marcus E ME; Milaneschi, Yuri Y; Mueller, Christian C; Huq, Mahmudul M; Vlachopoulou, Efthymia E; Lyytikäinen, Leo-Pekka LP; Oldmeadow, Christopher C; Deelen, Joris J; Perola, Markus M; Zhao, Jing Hua JH; Feenstra, Bjarke B; , ; Amini, Marzyeh M; , ; Lahti, Jari J; Schraut, Katharina E KE; Fornage, Myriam M; Suktitipat, Bhoom B; Chen, Wei-Min WM; Li, Xiaohui X; Nutile, Teresa T; Malerba, Giovanni G; Luan, Jian'an J; Bak, Tom T; Schork, Nicholas N; Del Greco M, Fabiola F; Thiering, Elisabeth E; Mahajan, Anubha A; Marioni, Riccardo E RE; Mihailov, Evelin E; Eriksson, Joel J; Ozel, Ayse Bilge AB; Zhang, Weihua W; Nethander, Maria M; Cheng, Yu-Ching YC; Aslibekyan, Stella S; Ang, Wei W; Gandin, Ilaria I; Yengo, Loïc L; Portas, Laura L; Kooperberg, Charles C; Hofer, Edith E; Rajan, Kumar B KB; Schurmann, Claudia C; den Hollander, Wouter W; Ahluwalia, Tarunveer S TS; Zhao, Jing J; Draisma, Harmen H M HHM; Ford, Ian I; Timpson, Nicholas N; Teumer, Alexander A; Huang, Hongyan H; Wahl, Simone S; Liu, YongMei Y; Huang, Jie J; Uh, Hae-Won HW; Geller, Frank F; Joshi, Peter K PK; Yanek, Lisa R LR; Trabetti, Elisabetta E; Lehne, Benjamin B; Vozzi, Diego D; Verbanck, Marie M; Biino, Ginevra G; Saba, Yasaman Y; Meulenbelt, Ingrid I; O'Connell, Jeff R JR; Laakso, Markku M; Giulianini, Franco F; Magnusson, Patrik K E PKE; Ballantyne, Christie M CM; Hottenga, Jouke Jan JJ; Montgomery, Grant W GW; Rivadineira, Fernando F; Rueedi, Rico R; Steri, Maristella M; Herzig, Karl-Heinz KH; Stott, David J DJ; Menni, Cristina C; Frånberg, Mattias M; St Pourcain, Beate B; Felix, Stephan B SB; Pers, Tune H TH; Bakker, Stephan J L SJL; Kraft, Peter P; Peters, Annette A; Vaidya, Dhananjay D; Delgado, Graciela G; Smit, Johannes H JH; Großmann, Vera V; Sinisalo, Juha J; Seppälä, Ilkka I; Williams, Stephen R SR; Holliday, Elizabeth G EG; Moed, Matthijs M; Langenberg, Claudia C; Räikkönen, Katri K; Ding, Jingzhong J; Campbell, Harry H; Sale, Michele M MM; Chen, Yii-Der I YI; James, Alan L AL; Ruggiero, Daniela D; Soranzo, Nicole N; Hartman, Catharina A CA; Smith, Erin N EN; Berenson, Gerald S GS; Fuchsberger, Christian C; Hernandez, Dena D; Tiesler, Carla M T CMT; Giedraitis, Vilmantas V; Liewald, David D; Fischer, Krista K; Mellström, Dan D; Larsson, Anders A; Wang, Yunmei Y; Scott, William R WR; Lorentzon, Matthias M; Beilby, John J; Ryan, Kathleen A KA; Pennell, Craig E CE; Vuckovic, Dragana D; Balkau, Beverly B; Concas, Maria Pina MP; Schmidt, Reinhold R; Mendes de Leon, Carlos F CF; Bottinger, Erwin P EP; Kloppenburg, Margreet M; Paternoster, Lavinia L; Boehnke, Michael M; Musk, A W AW; Willemsen, Gonneke G; Evans, David M DM; Madden, Pamela A F PAF; Kähönen, Mika M; Kutalik, Zoltán Z; Zoledziewska, Magdalena M; Karhunen, Ville V; Kritchevsky, Stephen B SB; Sattar, Naveed N; Lachance, Genevieve G; Clarke, Robert R; Harris, Tamara B TB; Raitakari, Olli T OT; Attia, John R JR; van Heemst, Diana D; Kajantie, Eero E; Sorice, Rossella R; Gambaro, Giovanni G; Scott, Robert A RA; Hicks, Andrew A AA; Ferrucci, Luigi L; Standl, Marie M; Lindgren, Cecilia M CM; Starr, John M JM; Karlsson, Magnus M; Lind, Lars L; Li, Jun Z JZ; Chambers, John C JC; Mori, Trevor A TA; de Geus, Eco J C N EJCN; Heath, Andrew C AC; Martin, Nicholas G NG; Auvinen, Juha J; Buckley, Brendan M BM; de Craen, Anton J M AJM; Waldenberger, Melanie M; Strauch, Konstantin K; Meitinger, Thomas T; Scott, Rodney J RJ; McEvoy, Mark M; Beekman, Marian M; Bombieri, Cristina C; Ridker, Paul M PM; Mohlke, Karen L KL; Pedersen, Nancy L NL; Morrison, Alanna C AC; Boomsma, Dorret I DI; Whitfield, John B JB; Strachan, David P DP; Hofman, Albert A; Vollenweider, Peter P; Cucca, Francesco F; Jarvelin, Marjo-Riitta MR; Jukema, J Wouter JW; Spector, Tim D TD; Hamsten, Anders A; Zeller, Tanja T; Uitterlinden, André G AG; Nauck, Matthias M; Gudnason, Vilmundur V; Qi, Lu L; Grallert, Harald H; Borecki, Ingrid B IB; Rotter, Jerome I JI; März, Winfried W; Wild, Philipp S PS; Lokki, Marja-Liisa ML; Boyle, Michael M; Salomaa, Veikko V; Melbye, Mads M; Eriksson, Johan G JG; Wilson, James F JF; Penninx, Brenda W J H BWJH; Becker, Diane M DM; Worrall, Bradford B BB; Gibson, Greg G; Krauss, Ronald M RM; Ciullo, Marina M; Zaza, Gianluigi G; Wareham, Nicholas J NJ; Oldehinkel, Albertine J AJ; Palmer, Lyle J LJ; Murray, Sarah S SS; Pramstaller, Peter P PP; Bandinelli, Stefania S; Heinrich, Joachim J; Ingelsson, Erik E; Deary, Ian J IJ; Mägi, Reedik R; Vandenput, Liesbeth L; van der Harst, Pim P; Desch, Karl C KC; Kooner, Jaspal S JS; Ohlsson, Claes C; Hayward, Caroline C; Lehtimäki, Terho T; Shuldiner, Alan R AR; Arnett, Donna K DK; Beilin, Lawrence J LJ; Robino, Antonietta A; Froguel, Philippe P; Pirastu, Mario M; Jess, Tine T; Koenig, Wolfgang W; Loos, Ruth J F RJF; Evans, Denis A DA; Schmidt, Helena H; Smith, George Davey GD; Slagboom, P Eline PE; Eiriksdottir, Gudny G; Morris, Andrew P AP; Psaty, Bruce M BM; Tracy, Russell P RP; Nolte, Ilja M IM; Boerwinkle, Eric E; Visvikis-Siest, Sophie S; Reiner, Alex P AP; Gross, Myron M; Bis, Joshua C JC; Franke, Lude L; Franco, Oscar H OH; Benjamin, Emelia J EJ; Chasman, Daniel I DI; Dupuis, Josée J; Snieder, Harold H; Dehghan, Abbas A; Alizadeh, Behrooz Z BZ
Bivariate genome-wide association study identifies novel pleiotropic loci for lipids and inflammation.
Bmc Genomics
Ligthart, Symen S; Vaez, Ahmad A; Hsu, Yi-Hsiang YH; , ; , ; , ; Stolk, Ronald R; Uitterlinden, André G AG; Hofman, Albert A; Alizadeh, Behrooz Z BZ; Franco, Oscar H OH; Dehghan, Abbas A
Loci affecting gamma-glutamyl transferase in adults and adolescents show age × SNP interaction and cardiometabolic disease associations.
Human Molecular Genetics
Middelberg, Rita P RP; Benyamin, Beben B; de Moor, Marleen H M MH; Warrington, Nicole M NM; Gordon, Scott S; Henders, Anjali K AK; Medland, Sarah E SE; Nyholt, Dale R DR; de Geus, Eco J C EJ; Hottenga, Jouke J JJ; Willemsen, Gonneke G; Beilin, Lawrence J LJ; Mori, Trevor A TA; Wright, Margaret J MJ; Heath, Andrew C AC; Madden, Pamela A F PA; Boomsma, Dorret I DI; Pennell, Craig E CE; Montgomery, Grant W GW; Martin, Nicholas G NG; Whitfield, John B JB