Publications:

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Genetic influences vary by age and sex: Trajectories of the association of cholinergic system variants and theta band event related oscillations.

Biorxiv : The Preprint Server For Biology

Chorlian, David B DB; Meyers, Jacquelyn L JL; Manz, Niklas N; Zhang, Jian J; Kamarajan, Chella C; Pandey, Ashwini A; Wang, Jen-Chyong JC; Plawecki, Martin M; Edenberg, Howard H; Goate, Alison A; Tischfield, Jay J; Porjesz, Bernice B

Publication Date: 2023-02-28

Variant appearance in text: rs3743078

PubMed Link: 36909650

Variant Present in the following documents:

• nihpp-2023.02.27.530318v1.pdf

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Establishment and characterization of a new mantle cell lymphoma cell line with a NOTCH2 mutation, Arbo.

Ejhaem

Safa, Firas F; Rasmussen, Terri T; Lobelle-Rich, Patricia P; Collier, Stephanie S; Milligan, Nicholas N; Schmeig, John J; Schmid, Janet J; Wiewiorowski, Carol C; Totaro, Denise D; Brown, Theresa C TC; Satyavarapu, Ishwarya I; Badoo, Melody M; Ungerleider, Nathan N; Flemington, Erik K EK; Safah, Hana H; Saba, Nakhle S NS

Publication Date: 2022-11

Variant appearance in text: rs3743078

PubMed Link: 36467812

Variant Present in the following documents:

• JHA2-3-1326-s001.xlsx, sheet 1

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A Variant in the Nicotinic Acetylcholine Receptor Alpha 3 Subunit Gene Is Associated With Hypertension Risks in Hypogonadic Patients.

Frontiers In Genetics

Wu, Tao T; Wang, Yujia Y; Shi, Wei W; Zhang, Bi-Qi BQ; Raelson, John J; Yao, Yu-Mei YM; Wu, Huan-Dong HD; Xu, Zao-Xian ZX; Marois-Blanchet, Francois-Christophe FC; Ledoux, Jonathan J; Blunck, Rikard R; Sheng, Jian-Zhong JZ; Hu, Shen-Jiang SJ; Luo, Hongyu H; Wu, Jiangping J

Publication Date: 2020

Variant appearance in text: rs3743078

PubMed Link: 33329690

Variant Present in the following documents:

• Main text
• fgene-11-539862.pdf

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Functional genomics reveal gene regulatory mechanisms underlying schizophrenia risk.

Nature Communications

Huo, Yongxia Y; Li, Shiwu S; Liu, Jiewei J; Li, Xiaoyan X; Luo, Xiong-Jian XJ

Publication Date: 2019-02-08

Variant appearance in text: rs3743078

PubMed Link: 30737407

Variant Present in the following documents:

• 41467_2019_8666_MOESM1_ESM.pdf

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Is Schizophrenia a Risk Factor for Breast Cancer?-Evidence From Genetic Data.

Schizophrenia Bulletin

Byrne, Enda M EM; Ferreira, Manuel A R MAR; Xue, Angli A; Lindström, Sara S; Jiang, Xia X; Yang, Jian J; Easton, Douglas F DF; Wray, Naomi R NR; Chenevix-Trench, Georgia G

Publication Date: 2019-10-24

Variant appearance in text: rs3743078

PubMed Link: 30452727

Variant Present in the following documents:

• Main text

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Whole genome sequencing identifies high-impact variants in well-known pharmacogenomic genes.

The Pharmacogenomics Journal

Choi, Jihoon J; Tantisira, Kelan G KG; Duan, Qing Ling QL

Publication Date: 2019-04

Variant appearance in text: rs3743078

PubMed Link: 30214008

Variant Present in the following documents:

• NIHMS1503453-supplement-3.xlsx, sheet 1

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Genome-Wide Variants Shared Between Smoking Quantity and Schizophrenia on 15q25 Are Associated With CHRNA5 Expression in the Brain.

Schizophrenia Bulletin

Ohi, Kazutaka K; Kuwata, Aki A; Shimada, Takamitsu T; Kataoka, Yuzuru Y; Yasuyama, Toshiki T; Uehara, Takashi T; Kawasaki, Yasuhiro Y

Publication Date: 2019-06-18

Variant appearance in text: rs3743078

PubMed Link: 30202994

Variant Present in the following documents:

• Main text

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Genotype × Environment Interaction in Smoking Behaviors: A Systematic Review.

Nicotine & Tobacco Research : Official Journal Of The Society For Research On Nicotine And Tobacco

Do, Elizabeth K EK; Maes, Hermine H HH

Publication Date: 2017-04-01

Variant appearance in text: rs3743078

PubMed Link: 27613915

Variant Present in the following documents:

• Main text

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Converging findings from linkage and association analyses on susceptibility genes for smoking and other addictions.

Molecular Psychiatry

Yang, J J; Li, M D MD

Publication Date: 2016-08

Variant appearance in text: rs3743078

PubMed Link: 27166759

Variant Present in the following documents:

• Main text
• nihms-767542.pdf

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Narrative review of genes, environment, and cigarettes.

Annals Of Medicine

Do, Elizabeth E; Maes, Hermine H

Publication Date: 2016-08

Variant appearance in text: rs3743078

PubMed Link: 27124093

Variant Present in the following documents:

• Main text

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DiMeX: A Text Mining System for Mutation-Disease Association Extraction.

Plos One

Mahmood, A S M Ashique AS; Wu, Tsung-Jung TJ; Mazumder, Raja R; Vijay-Shanker, K K

Publication Date: 2016

Variant appearance in text: rs3743078

PubMed Link: 27073839

Variant Present in the following documents:

• pone.0152725.s001.xlsx, sheet 1

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CHRNA5/A3/B4 Variant rs3743078 and Nicotine-Related Phenotypes: Indirect Effects Through Nicotine Craving.

Journal Of Studies On Alcohol And Drugs

Shmulewitz, Dvora D; Meyers, Jacquelyn L JL; Wall, Melanie M MM; Aharonovich, Efrat E; Frisch, Amos A; Spivak, Baruch B; Weizman, Abraham A; Edenberg, Howard J HJ; Gelernter, Joel J; Hasin, Deborah S DS

Publication Date: 2016-03

Variant appearance in text: rs3743078

PubMed Link: 26997181

Variant Present in the following documents:

• Main text

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Nicotine Addiction and Psychiatric Disorders.

International Review Of Neurobiology

Kutlu, Munir Gunes MG; Parikh, Vinay V; Gould, Thomas J TJ

Publication Date: 2015

Variant appearance in text: rs3743078

PubMed Link: 26472530

Variant Present in the following documents:

• Main text

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Nicotinic receptor contributions to smoking: insights from human studies and animal models.

Current Addiction Reports

Brunzell, Darlene H DH; Stafford, Alexandra M AM; Dixon, Claire I CI

Publication Date: 2015-03

Variant appearance in text: rs3743078

PubMed Link: 26301171

Variant Present in the following documents:

• Main text

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DISTMIX: direct imputation of summary statistics for unmeasured SNPs from mixed ethnicity cohorts.

Bioinformatics (Oxford, England)

Lee, Donghyung D; Bigdeli, T Bernard TB; Williamson, Vernell S VS; Vladimirov, Vladimir I VI; Riley, Brien P BP; Fanous, Ayman H AH; Bacanu, Silviu-Alin SA

Publication Date: 2015-10-01

Variant appearance in text: rs3743078

PubMed Link: 26059716

Variant Present in the following documents:

• supp_btv348_distmix_supplementary_data.pdf

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Joint association of nicotinic acetylcholine receptor variants with abdominal obesity in American Indians: the Strong Heart Family Study.

Plos One

Zhu, Yun Y; Yang, Jingyun J; Yeh, Fawn F; Cole, Shelley A SA; Haack, Karin K; Lee, Elisa T ET; Howard, Barbara V BV; Zhao, Jinying J

Publication Date: 2014

Variant appearance in text: rs3743078

PubMed Link: 25036316

Variant Present in the following documents:

• Main text
• pone.0102220.pdf

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Nicotine dependence as a moderator of genetic influences on smoking cessation treatment outcome.

Drug And Alcohol Dependence

Leventhal, Adam M AM; Lee, Wonho W; Bergen, Andrew W AW; Swan, Gary E GE; Tyndale, Rachel F RF; Lerman, Caryn C; Conti, David V DV

Publication Date: 2014-05-01

Variant appearance in text: rs3743078

PubMed Link: 24667010

Variant Present in the following documents:

• Main text

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CHRNA5 and CHRNA3 variants and level of neuroticism in young adult Mexican American men and women.

Twin Research And Human Genetics : The Official Journal Of The International Society For Twin Studies

Criado, José R JR; Gizer, Ian R IR; Edenberg, Howard J HJ; Ehlers, Cindy L CL

Publication Date: 2014-04

Variant appearance in text: rs3743078

PubMed Link: 24588897

Variant Present in the following documents:

• Main text

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Genetic variants in nicotinic acetylcholine receptor genes jointly contribute to kidney function in American Indians: the Strong Heart Family Study.

Journal Of Hypertension

Zhu, Yun Y; Yang, Jingyun J; Li, Shengxu S; Cole, Shelley A SA; Haack, Karin K; Umans, Jason G JG; Franceschini, Nora N; Howard, Barbara V BV; Lee, Elisa T ET; Zhao, Jinying J

Publication Date: 2014-05

Variant appearance in text: rs3743078

PubMed Link: 24569419

Variant Present in the following documents:

• Main text

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Cis-regulatory variants affect CHRNA5 mRNA expression in populations of African and European ancestry.

Plos One

Wang, Jen-Chyong JC; Spiegel, Noah N; Bertelsen, Sarah S; Le, Nhung N; McKenna, Nicholas N; Budde, John P JP; Harari, Oscar O; Kapoor, Manav M; Brooks, Andrew A; Hancock, Dana D; Tischfield, Jay J; Foroud, Tatiana T; Bierut, Laura J LJ; Steinbach, Joe Henry JH; Edenberg, Howard J HJ; Traynor, Bryan J BJ; Goate, Alison M AM

Publication Date: 2013

Variant appearance in text: rs3743078

PubMed Link: 24303001

Variant Present in the following documents:

• Main text
• pone.0080204.pdf

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Joint associations of 61 genetic variants in the nicotinic acetylcholine receptor genes with subclinical atherosclerosis in American Indians: a gene-family analysis.

Circulation. Cardiovascular Genetics

Yang, Jingyun J; Zhu, Yun Y; Lee, Elisa T ET; Zhang, Ying Y; Cole, Shelley A SA; Haack, Karin K; Best, Lyle G LG; Devereux, Richard B RB; Roman, Mary J MJ; Howard, Barbara V BV; Zhao, Jinying J

Publication Date: 2013-02

Variant appearance in text: rs3743078

PubMed Link: 23264444

Variant Present in the following documents:

• Main text

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Variants located upstream of CHRNB4 on chromosome 15q25.1 are associated with age at onset of daily smoking and habitual smoking.

Plos One

Kapoor, Manav M; Wang, Jen-Chyong JC; Bertelsen, Sarah S; Bucholz, Kathy K; Budde, John P JP; Hinrichs, Anthony A; Agrawal, Arpana A; Brooks, Andrew A; Chorlian, David D; Dick, Danielle D; Hesselbrock, Victor V; Foroud, Tatiana T; Kramer, John J; Kuperman, Samuel S; Manz, Niklas N; Nurnberger, John J; Porjesz, Bernice B; Rice, John J; Tischfield, Jay J; Xuei, Xiaoling X; Schuckit, Marc M; Edenberg, Howard J HJ; Bierut, Laura J LJ; Goate, Alison M AM

Publication Date: 2012

Variant appearance in text: rs3743078

PubMed Link: 22438940

Variant Present in the following documents:

• Main text

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Analysis of detailed phenotype profiles reveals CHRNA5-CHRNA3-CHRNB4 gene cluster association with several nicotine dependence traits.

Nicotine & Tobacco Research : Official Journal Of The Society For Research On Nicotine And Tobacco

Broms, Ulla U; Wedenoja, Juho J; Largeau, Marine R MR; Korhonen, Tellervo T; Pitkäniemi, Janne J; Keskitalo-Vuokko, Kaisu K; Häppölä, Anja A; Heikkilä, Katri H KH; Heikkilä, Kauko K; Ripatti, Samuli S; Sarin, Antti-Pekka AP; Salminen, Outi O; Paunio, Tiina T; Pergadia, Michele L ML; Madden, Pamela A F PA; Kaprio, Jaakko J; Loukola, Anu A

Publication Date: 2012-06

Variant appearance in text: rs3743078

PubMed Link: 22241830

Variant Present in the following documents:

• Main text

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Gender-stratified gene and gene-treatment interactions in smoking cessation.

The Pharmacogenomics Journal

Lee, W W; Bergen, A W AW; Swan, G E GE; Li, D D; Liu, J J; Thomas, P P; Tyndale, R F RF; Benowitz, N L NL; Lerman, C C; Conti, D V DV

Publication Date: 2012-12

Variant appearance in text: rs3743078

PubMed Link: 21808284

Variant Present in the following documents:

• Main text
• nihms305090.pdf
• NIHMS305090-supplement-3.pdf

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Chromosome 15q24-25.1 variants, diet, and lung cancer susceptibility in cigarette smokers.

Cancer Causes & Control : Ccc

Sakoda, Lori C LC; Loomis, Melissa M MM; Doherty, Jennifer A JA; Neuhouser, Marian L ML; Barnett, Matt J MJ; Thornquist, Mark D MD; Weiss, Noel S NS; Goodman, Gary E GE; Chen, Chu C

Publication Date: 2011-03

Variant appearance in text: rs3743078

PubMed Link: 21229299

Variant Present in the following documents:

• Main text

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Genetic association of bipolar disorder with the β(3) nicotinic receptor subunit gene.

Psychiatric Genetics

Hartz, Sarah M SM; Lin, Peng P; Edenberg, Howard J HJ; Xuei, Xiaoling X; Rochberg, Nanette N; Saccone, Scott S; Berrettini, Wade W; Nelson, Elliot E; Nurnberger, John J; Bierut, Laura J LJ; Rice, John P JP; ,

Publication Date: 2011-04

Variant appearance in text: rs3743078

PubMed Link: 21191315

Variant Present in the following documents:

• Main text

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Interplay of Genetic Risk Factors and Parent Monitoring in Risk for Nicotine Dependence.

Addiction (Abingdon, England)

Chen, Li-Shiun LS; Johnson, Eric O EO; Breslau, Naomi N; Hatsukami, Dorothy D; Saccone, Nancy L NL; Grucza, Richard A RA; Wang, Jen C JC; Hinrichs, Anthony L AL; Fox, Louis L; Goate, Alison M AM; Rice, John P JP; Bierut, Laura J LJ

Publication Date: 2009-10

Variant appearance in text: rs3743078

PubMed Link: 20871796

Variant Present in the following documents:

• Main text

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Variation in the nicotinic acetylcholine receptor gene cluster CHRNA5-CHRNA3-CHRNB4 and its interaction with recent tobacco use influence cognitive flexibility.

Neuropsychopharmacology : Official Publication Of The American College Of Neuropsychopharmacology

Zhang, Huiping H; Kranzler, Henry R HR; Poling, James J; Gelernter, Joel J

Publication Date: 2010-10

Variant appearance in text: rs3743078

PubMed Link: 20631687

Variant Present in the following documents:

• Main text

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Variation in nicotinic acetylcholine receptor genes is associated with multiple substance dependence phenotypes.

Neuropsychopharmacology : Official Publication Of The American College Of Neuropsychopharmacology

Sherva, Richard R; Kranzler, Henry R HR; Yu, Yi Y; Logue, Mark W MW; Poling, James J; Arias, Albert J AJ; Anton, Raymond F RF; Oslin, David D; Farrer, Lindsay A LA; Gelernter, Joel J

Publication Date: 2010-08

Variant appearance in text: rs3743078

PubMed Link: 20485328

Variant Present in the following documents:

• Main text

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Association and interaction analysis of variants in CHRNA5/CHRNA3/CHRNB4 gene cluster with nicotine dependence in African and European Americans.

American Journal Of Medical Genetics. Part B, Neuropsychiatric Genetics : The Official Publication Of The International Society Of Psychiatric Genetics

Li, Ming D MD; Xu, Qing Q; Lou, Xiang-Yang XY; Payne, Thomas J TJ; Niu, Tianhua T; Ma, Jennie Z JZ

Publication Date: 2010-04-05

Variant appearance in text: rs3743078

PubMed Link: 19859904

Variant Present in the following documents:

• Main text

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The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans.

Cancer Research

Saccone, Nancy L NL; Wang, Jen C JC; Breslau, Naomi N; Johnson, Eric O EO; Hatsukami, Dorothy D; Saccone, Scott F SF; Grucza, Richard A RA; Sun, Lingwei L; Duan, Weimin W; Budde, John J; Culverhouse, Robert C RC; Fox, Louis L; Hinrichs, Anthony L AL; Steinbach, Joseph Henry JH; Wu, Meng M; Rice, John P JP; Goate, Alison M AM; Bierut, Laura J LJ

Publication Date: 2009-09-01

Variant appearance in text: rs3743078

PubMed Link: 19706762

Variant Present in the following documents:

• Main text

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Risk for nicotine dependence and lung cancer is conferred by mRNA expression levels and amino acid change in CHRNA5.

Human Molecular Genetics

Wang, Jen C JC; Cruchaga, Carlos C; Saccone, Nancy L NL; Bertelsen, Sarah S; Liu, Pengyuan P; Budde, John P JP; Duan, Weimin W; Fox, Louis L; Grucza, Richard A RA; Kern, Jason J; Mayo, Kevin K; Reyes, Oliver O; Rice, John J; Saccone, Scott F SF; Spiegel, Noah N; Steinbach, Joseph H JH; Stitzel, Jerry A JA; Anderson, Marshall W MW; You, Ming M; Stevens, Victoria L VL; Bierut, Laura J LJ; Goate, Alison M AM; ,

Publication Date: 2009-08-15

Variant appearance in text: rs3743078

PubMed Link: 19443489

Variant Present in the following documents:

• Main text

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Nicotinic receptor gene variants influence susceptibility to heavy smoking.

Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology

Stevens, Victoria L VL; Bierut, Laura J LJ; Talbot, Jeffrey T JT; Wang, Jen C JC; Sun, Juzhong J; Hinrichs, Anthony L AL; Thun, Michael J MJ; Goate, Alison A; Calle, Eugenia E EE

Publication Date: 2008-12

Variant appearance in text: rs3743078

PubMed Link: 19029397

Variant Present in the following documents:

• Main text

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Genetic variability in nicotinic acetylcholine receptors and nicotine addiction: converging evidence from human and animal research.

Behavioural Brain Research

Portugal, George S GS; Gould, Thomas J TJ

Publication Date: 2008-11-03

Variant appearance in text: rs3743078

PubMed Link: 18571741

Variant Present in the following documents:

• Main text

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Variants in nicotinic receptors and risk for nicotine dependence.

The American Journal Of Psychiatry

Bierut, Laura Jean LJ; Stitzel, Jerry A JA; Wang, Jen C JC; Hinrichs, Anthony L AL; Grucza, Richard A RA; Xuei, Xiaoling X; Saccone, Nancy L NL; Saccone, Scott F SF; Bertelsen, Sarah S; Fox, Louis L; Horton, William J WJ; Breslau, Naomi N; Budde, John J; Cloninger, C Robert CR; Dick, Danielle M DM; Foroud, Tatiana T; Hatsukami, Dorothy D; Hesselbrock, Victor V; Johnson, Eric O EO; Kramer, John J; Kuperman, Samuel S; Madden, Pamela A F PA; Mayo, Kevin K; Nurnberger, John J; Pomerleau, Ovide O; Porjesz, Bernice B; Reyes, Oliver O; Schuckit, Marc M; Swan, Gary G; Tischfield, Jay A JA; Edenberg, Howard J HJ; Rice, John P JP; Goate, Alison M AM

Publication Date: 2008-09

Variant appearance in text: rs3743078

PubMed Link: 18519524

Variant Present in the following documents:

• Main text

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Genetic variation in the CHRNA5 gene affects mRNA levels and is associated with risk for alcohol dependence.

Molecular Psychiatry

Wang, J C JC; Grucza, R R; Cruchaga, C C; Hinrichs, A L AL; Bertelsen, S S; Budde, J P JP; Fox, L L; Goldstein, E E; Reyes, O O; Saccone, N N; Saccone, S S; Xuei, X X; Bucholz, K K; Kuperman, S S; Nurnberger, J J; Rice, J P JP; Schuckit, M M; Tischfield, J J; Hesselbrock, V V; Porjesz, B B; Edenberg, H J HJ; Bierut, L J LJ; Goate, A M AM

Publication Date: 2009-05

Variant appearance in text: rs3743078

PubMed Link: 18414406

Variant Present in the following documents:

• Main text

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Identification of pharmacogenetic markers in smoking cessation therapy.

American Journal Of Medical Genetics. Part B, Neuropsychiatric Genetics : The Official Publication Of The International Society Of Psychiatric Genetics

Heitjan, Daniel F DF; Guo, Mengye M; Ray, Riju R; Wileyto, E Paul EP; Epstein, Leonard H LH; Lerman, Caryn C

Publication Date: 2008-09-05

Variant appearance in text: rs3743078

PubMed Link: 18165968

Variant Present in the following documents:

• Main text

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The diploid genome sequence of an individual human.

Plos Biology

Levy, Samuel S; Sutton, Granger G; Ng, Pauline C PC; Feuk, Lars L; Halpern, Aaron L AL; Walenz, Brian P BP; Axelrod, Nelson N; Huang, Jiaqi J; Kirkness, Ewen F EF; Denisov, Gennady G; Lin, Yuan Y; MacDonald, Jeffrey R JR; Pang, Andy Wing Chun AW; Shago, Mary M; Stockwell, Timothy B TB; Tsiamouri, Alexia A; Bafna, Vineet V; Bansal, Vikas V; Kravitz, Saul A SA; Busam, Dana A DA; Beeson, Karen Y KY; McIntosh, Tina C TC; Remington, Karin A KA; Abril, Josep F JF; Gill, John J; Borman, Jon J; Rogers, Yu-Hui YH; Frazier, Marvin E ME; Scherer, Stephen W SW; Strausberg, Robert L RL; Venter, J Craig JC

Publication Date: 2007-09-04

Variant appearance in text: rs3743078

PubMed Link: 17803354

Variant Present in the following documents:

• pbio.0050254.pdf

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Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs.

Human Molecular Genetics

Saccone, Scott F SF; Hinrichs, Anthony L AL; Saccone, Nancy L NL; Chase, Gary A GA; Konvicka, Karel K; Madden, Pamela A F PA; Breslau, Naomi N; Johnson, Eric O EO; Hatsukami, Dorothy D; Pomerleau, Ovide O; Swan, Gary E GE; Goate, Alison M AM; Rutter, Joni J; Bertelsen, Sarah S; Fox, Louis L; Fugman, Douglas D; Martin, Nicholas G NG; Montgomery, Grant W GW; Wang, Jen C JC; Ballinger, Dennis G DG; Rice, John P JP; Bierut, Laura Jean LJ

Publication Date: 2007-01-01

Variant appearance in text: rs3743078

PubMed Link: 17135278

Variant Present in the following documents:

• Main text

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