Comparative Analysis of Dopaminergic and Cholinergic Mechanisms of Sensory and Sensorimotor Gating in Healthy Individuals and in Patients With Schizophrenia.
Genome-Wide Association Study of Peripheral Artery Disease.
Circulation. Genomic And Precision Medicine
van Zuydam, Natalie R NR; Stiby, Alexander A; Abdalla, Moustafa M; Austin, Erin E; Dahlström, Emma H EH; McLachlan, Stela S; Vlachopoulou, Efthymia E; Ahlqvist, Emma E; Di Liao, Chen C; Sandholm, Niina N; Forsblom, Carol C; Mahajan, Anubha A; Robertson, Neil R NR; Rayner, N William NW; Lindholm, Eero E; Sinisalo, Juha J; Perola, Markus M; Kallio, Milla M; Weiss, Emily E; Price, Jackie J; Paterson, Andrew A; Klein, Barbara B; Salomaa, Veikko V; Palmer, Colin N A CNA; Groop, Per-Henrik PH; Groop, Leif L; McCarthy, Mark I MI; de Andrade, Mariza M; Morris, Andrew P AP; Hopewell, Jemma C JC; Colhoun, Helen M HM; Kullo, Iftikhar J IJ; ,
Genetic Variants in Smoking-Related Genes in Two Smoking Cessation Programs: A Cross-Sectional Study.
International Journal Of Environmental Research And Public Health
Pérez-Rubio, Gloria G; López-Flores, Luis Alberto LA; Cupertino, Ana Paula AP; Cartujano-Barrera, Francisco F; Reynales-Shigematsu, Luz Myriam LM; Ramírez, Mariana M; Ellerbeck, Edward F EF; Rodríguez-Bolaños, Rosibel R; Falfan-Valencia, Ramcés R
Proper conditional analysis in the presence of missing data: Application to large scale meta-analysis of tobacco use phenotypes.
Plos Genetics
Jiang, Yu Y; Chen, Sai S; McGuire, Daniel D; Chen, Fang F; Liu, Mengzhen M; Iacono, William G WG; Hewitt, John K JK; Hokanson, John E JE; Krauter, Kenneth K; Laakso, Markku M; Li, Kevin W KW; Lutz, Sharon M SM; McGue, Matthew M; Pandit, Anita A; Zajac, Gregory J M GJM; Boehnke, Michael M; Abecasis, Goncalo R GR; Vrieze, Scott I SI; Zhan, Xiaowei X; Jiang, Bibo B; Liu, Dajiang J DJ
Human longevity: 25 genetic loci associated in 389,166 UK biobank participants.
Aging
Pilling, Luke C LC; Kuo, Chia-Ling CL; Sicinski, Kamil K; Tamosauskaite, Jone J; Kuchel, George A GA; Harries, Lorna W LW; Herd, Pamela P; Wallace, Robert R; Ferrucci, Luigi L; Melzer, David D
Modeling the Causal Role of DNA Methylation in the Association Between Cigarette Smoking and Inflammation in African Americans: A 2-Step Epigenetic Mendelian Randomization Study.
American Journal Of Epidemiology
Jhun, Min A MA; Smith, Jennifer A JA; Ware, Erin B EB; Kardia, Sharon L R SLR; Mosley, Thomas H TH; Turner, Stephen T ST; Peyser, Patricia A PA; Park, Sung Kyun SK
Positive Selection on Loci Associated with Drug and Alcohol Dependence.
Plos One
Sadler, Brooke B; Haller, Gabe G; Edenberg, Howard H; Tischfield, Jay J; Brooks, Andy A; Kramer, John J; Schuckit, Marc M; Nurnberger, John J; Goate, Alison A
Genetic variants in nicotinic acetylcholine receptor genes jointly contribute to kidney function in American Indians: the Strong Heart Family Study.
Journal Of Hypertension
Zhu, Yun Y; Yang, Jingyun J; Li, Shengxu S; Cole, Shelley A SA; Haack, Karin K; Umans, Jason G JG; Franceschini, Nora N; Howard, Barbara V BV; Lee, Elisa T ET; Zhao, Jinying J
Distinct loci in the CHRNA5/CHRNA3/CHRNB4 gene cluster are associated with onset of regular smoking.
Genetic Epidemiology
Stephens, Sarah H SH; Hartz, Sarah M SM; Hoft, Nicole R NR; Saccone, Nancy L NL; Corley, Robin C RC; Hewitt, John K JK; Hopfer, Christian J CJ; Breslau, Naomi N; Coon, Hilary H; Chen, Xiangning X; Ducci, Francesca F; Dueker, Nicole N; Franceschini, Nora N; Frank, Josef J; Han, Younghun Y; Hansel, Nadia N NN; Jiang, Chenhui C; Korhonen, Tellervo T; Lind, Penelope A PA; Liu, Jason J; Lyytikäinen, Leo-Pekka LP; Michel, Martha M; Shaffer, John R JR; Short, Susan E SE; Sun, Juzhong J; Teumer, Alexander A; Thompson, John R JR; Vogelzangs, Nicole N; Vink, Jacqueline M JM; Wenzlaff, Angela A; Wheeler, William W; Yang, Bao-Zhu BZ; Aggen, Steven H SH; Balmforth, Anthony J AJ; Baumeister, Sebastian E SE; Beaty, Terri H TH; Benjamin, Daniel J DJ; Bergen, Andrew W AW; Broms, Ulla U; Cesarini, David D; Chatterjee, Nilanjan N; Chen, Jingchun J; Cheng, Yu-Ching YC; Cichon, Sven S; Couper, David D; Cucca, Francesco F; Dick, Danielle D; Foroud, Tatiana T; Furberg, Helena H; Giegling, Ina I; Gillespie, Nathan A NA; Gu, Fangyi F; Hall, Alistair S AS; Hällfors, Jenni J; Han, Shizhong S; Hartmann, Annette M AM; Heikkilä, Kauko K; Hickie, Ian B IB; Hottenga, Jouke Jan JJ; Jousilahti, Pekka P; Kaakinen, Marika M; Kähönen, Mika M; Koellinger, Philipp D PD; Kittner, Stephen S; Konte, Bettina B; Landi, Maria-Teresa MT; Laatikainen, Tiina T; Leppert, Mark M; Levy, Steven M SM; Mathias, Rasika A RA; McNeil, Daniel W DW; Medland, Sarah E SE; Montgomery, Grant W GW; Murray, Tanda T; Nauck, Matthias M; North, Kari E KE; Paré, Peter D PD; Pergadia, Michele M; Ruczinski, Ingo I; Salomaa, Veikko V; Viikari, Jorma J; Willemsen, Gonneke G; Barnes, Kathleen C KC; Boerwinkle, Eric E; Boomsma, Dorret I DI; Caporaso, Neil N; Edenberg, Howard J HJ; Francks, Clyde C; Gelernter, Joel J; Grabe, Hans Jörgen HJ; Hops, Hyman H; Jarvelin, Marjo-Riitta MR; Johannesson, Magnus M; Kendler, Kenneth S KS; Lehtimäki, Terho T; Magnusson, Patrik K E PK; Marazita, Mary L ML; Marchini, Jonathan J; Mitchell, Braxton D BD; Nöthen, Markus M MM; Penninx, Brenda W BW; Raitakari, Olli O; Rietschel, Marcella M; Rujescu, Dan D; Samani, Nilesh J NJ; Schwartz, Ann G AG; Shete, Sanjay S; Spitz, Margaret M; Swan, Gary E GE; Völzke, Henry H; Veijola, Juha J; Wei, Qingyi Q; Amos, Chris C; Cannon, Dale S DS; Grucza, Richard R; Hatsukami, Dorothy D; Heath, Andrew A; Johnson, Eric O EO; Kaprio, Jaakko J; Madden, Pamela P; Martin, Nicholas G NG; Stevens, Victoria L VL; Weiss, Robert B RB; Kraft, Peter P; Bierut, Laura J LJ; Ehringer, Marissa A MA
The impact of polymorphic variations in the 5p15, 6p12, 6p21 and 15q25 Loci on the risk and prognosis of portuguese patients with non-small cell lung cancer.
Plos One
de Mello, Ramon Andrade RA; Ferreira, Mónica M; Soares-Pires, Filipa F; Costa, Sandra S; Cunha, João J; Oliveira, Pedro P; Hespanhol, Venceslau V; Reis, Rui Manuel RM
Joint associations of 61 genetic variants in the nicotinic acetylcholine receptor genes with subclinical atherosclerosis in American Indians: a gene-family analysis.
Circulation. Cardiovascular Genetics
Yang, Jingyun J; Zhu, Yun Y; Lee, Elisa T ET; Zhang, Ying Y; Cole, Shelley A SA; Haack, Karin K; Best, Lyle G LG; Devereux, Richard B RB; Roman, Mary J MJ; Howard, Barbara V BV; Zhao, Jinying J
Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction.
American Journal Of Respiratory And Critical Care Medicine
Wilk, Jemma B JB; Shrine, Nick R G NR; Loehr, Laura R LR; Zhao, Jing Hua JH; Manichaikul, Ani A; Lopez, Lorna M LM; Smith, Albert Vernon AV; Heckbert, Susan R SR; Smolonska, Joanna J; Tang, Wenbo W; Loth, Daan W DW; Curjuric, Ivan I; Hui, Jennie J; Cho, Michael H MH; Latourelle, Jeanne C JC; Henry, Amanda P AP; Aldrich, Melinda M; Bakke, Per P; Beaty, Terri H TH; Bentley, Amy R AR; Borecki, Ingrid B IB; Brusselle, Guy G GG; Burkart, Kristin M KM; Chen, Ting-hsu TH; Couper, David D; Crapo, James D JD; Davies, Gail G; Dupuis, Josée J; Franceschini, Nora N; Gulsvik, Amund A; Hancock, Dana B DB; Harris, Tamara B TB; Hofman, Albert A; Imboden, Medea M; James, Alan L AL; Khaw, Kay-Tee KT; Lahousse, Lies L; Launer, Lenore J LJ; Litonjua, Augusto A; Liu, Yongmei Y; Lohman, Kurt K KK; Lomas, David A DA; Lumley, Thomas T; Marciante, Kristin D KD; McArdle, Wendy L WL; Meibohm, Bernd B; Morrison, Alanna C AC; Musk, Arthur W AW; Myers, Richard H RH; North, Kari E KE; Postma, Dirkje S DS; Psaty, Bruce M BM; Rich, Stephen S SS; Rivadeneira, Fernando F; Rochat, Thierry T; Rotter, Jerome I JI; Soler Artigas, María M; Starr, John M JM; Uitterlinden, André G AG; Wareham, Nicholas J NJ; Wijmenga, Cisca C; Zanen, Pieter P; Province, Michael A MA; Silverman, Edwin K EK; Deary, Ian J IJ; Palmer, Lyle J LJ; Cassano, Patricia A PA; Gudnason, Vilmundur V; Barr, R Graham RG; Loos, Ruth J F RJ; Strachan, David P DP; London, Stephanie J SJ; Boezen, H Marike HM; Probst-Hensch, Nicole N; Gharib, Sina A SA; Hall, Ian P IP; O'Connor, George T GT; Tobin, Martin D MD; Stricker, Bruno H BH
Low dose morphine adjuvant therapy for enhanced efficacy of antipsychotic drug action: potential involvement of endogenous morphine in the pathophysiology of schizophrenia.
Medical Science Monitor : International Medical Journal Of Experimental And Clinical Research
Stefano, George B GB; Králíčková, Milena M; Ptacek, Radek R; Kuzelova, Hana H; Esch, Tobias T; Kream, Richard M RM
DRD1 associations with smoking abstinence across slow and normal nicotine metabolizers.
Pharmacogenetics And Genomics
Lee, Wonho W; Ray, Riju R; Bergen, Andrew W AW; Swan, Gary E GE; Thomas, Paul P; Tyndale, Rachel F RF; Benowitz, Neal L NL; Lerman, Caryn C; Conti, David V DV
Chromosome 15q24-25.1 variants, diet, and lung cancer susceptibility in cigarette smokers.
Cancer Causes & Control : Ccc
Sakoda, Lori C LC; Loomis, Melissa M MM; Doherty, Jennifer A JA; Neuhouser, Marian L ML; Barnett, Matt J MJ; Thornquist, Mark D MD; Weiss, Noel S NS; Goodman, Gary E GE; Chen, Chu C
Nicotinic acetylcholine receptor region on chromosome 15q25 and lung cancer risk among African Americans: a case-control study.
Journal Of The National Cancer Institute
Amos, Christopher I CI; Gorlov, Ivan P IP; Dong, Qiong Q; Wu, Xifeng X; Zhang, Huifeng H; Lu, Emily Y EY; Scheet, Paul P; Greisinger, Anthony J AJ; Mills, Gordon B GB; Spitz, Margaret R MR
Replication of lung cancer susceptibility loci at chromosomes 15q25, 5p15, and 6p21: a pooled analysis from the International Lung Cancer Consortium.
Journal Of The National Cancer Institute
Truong, Therese T; Hung, Rayjean J RJ; Amos, Christopher I CI; Wu, Xifeng X; Bickeböller, Heike H; Rosenberger, Albert A; Sauter, Wiebke W; Illig, Thomas T; Wichmann, H-Erich HE; Risch, Angela A; Dienemann, Hendrik H; Kaaks, Rudolph R; Yang, Ping P; Jiang, Ruoxiang R; Wiencke, John K JK; Wrensch, Margaret M; Hansen, Helen H; Kelsey, Karl T KT; Matsuo, Keitaro K; Tajima, Kazuo K; Schwartz, Ann G AG; Wenzlaff, Angie A; Seow, Adeline A; Ying, Chen C; Staratschek-Jox, Andrea A; Nürnberg, Peter P; Stoelben, Erich E; Wolf, Jürgen J; Lazarus, Philip P; Muscat, Joshua E JE; Gallagher, Carla J CJ; Zienolddiny, Shanbeh S; Haugen, Aage A; van der Heijden, Henricus F M HF; Kiemeney, Lambertus A LA; Isla, Dolores D; Mayordomo, Jose Ignacio JI; Rafnar, Thorunn T; Stefansson, Kari K; Zhang, Zuo-Feng ZF; Chang, Shen-Chih SC; Kim, Jin Hee JH; Hong, Yun-Chul YC; Duell, Eric J EJ; Andrew, Angeline S AS; Lejbkowicz, Flavio F; Rennert, Gad G; Müller, Heiko H; Brenner, Hermann H; Le Marchand, Loïc L; Benhamou, Simone S; Bouchardy, Christine C; Teare, M Dawn MD; Xue, Xiaoyan X; McLaughlin, John J; Liu, Geoffrey G; McKay, James D JD; Brennan, Paul P; Spitz, Margaret R MR
Sensorimotor gating is associated with CHRNA3 polymorphisms in schizophrenia and healthy volunteers.
Neuropsychopharmacology : Official Publication Of The American College Of Neuropsychopharmacology
Petrovsky, Nadine N; Quednow, Boris B BB; Ettinger, Ulrich U; Schmechtig, Anne A; Mössner, Rainald R; Collier, David A DA; Kühn, Kai-Uwe KU; Maier, Wolfgang W; Wagner, Michael M; Kumari, Veena V
Association and interaction analysis of variants in CHRNA5/CHRNA3/CHRNB4 gene cluster with nicotine dependence in African and European Americans.
American Journal Of Medical Genetics. Part B, Neuropsychiatric Genetics : The Official Publication Of The International Society Of Psychiatric Genetics
Li, Ming D MD; Xu, Qing Q; Lou, Xiang-Yang XY; Payne, Thomas J TJ; Niu, Tianhua T; Ma, Jennie Z JZ
The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans.
Cancer Research
Saccone, Nancy L NL; Wang, Jen C JC; Breslau, Naomi N; Johnson, Eric O EO; Hatsukami, Dorothy D; Saccone, Scott F SF; Grucza, Richard A RA; Sun, Lingwei L; Duan, Weimin W; Budde, John J; Culverhouse, Robert C RC; Fox, Louis L; Hinrichs, Anthony L AL; Steinbach, Joseph Henry JH; Wu, Meng M; Rice, John P JP; Goate, Alison M AM; Bierut, Laura J LJ
Risk for nicotine dependence and lung cancer is conferred by mRNA expression levels and amino acid change in CHRNA5.
Human Molecular Genetics
Wang, Jen C JC; Cruchaga, Carlos C; Saccone, Nancy L NL; Bertelsen, Sarah S; Liu, Pengyuan P; Budde, John P JP; Duan, Weimin W; Fox, Louis L; Grucza, Richard A RA; Kern, Jason J; Mayo, Kevin K; Reyes, Oliver O; Rice, John J; Saccone, Scott F SF; Spiegel, Noah N; Steinbach, Joseph H JH; Stitzel, Jerry A JA; Anderson, Marshall W MW; You, Ming M; Stevens, Victoria L VL; Bierut, Laura J LJ; Goate, Alison M AM; ,
Gene by smoking interaction in hypertension: identification of a major quantitative trait locus on chromosome 15q for systolic blood pressure in Mexican-Americans.
Journal Of Hypertension
Montasser, May E ME; Shimmin, Lawrence C LC; Hanis, Craig L CL; Boerwinkle, Eric E; Hixson, James E JE
Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes.
American Journal Of Medical Genetics. Part B, Neuropsychiatric Genetics : The Official Publication Of The International Society Of Psychiatric Genetics
Saccone, Nancy L NL; Saccone, Scott F SF; Hinrichs, Anthony L AL; Stitzel, Jerry A JA; Duan, Weimin W; Pergadia, Michele L ML; Agrawal, Arpana A; Breslau, Naomi N; Grucza, Richard A RA; Hatsukami, Dorothy D; Johnson, Eric O EO; Madden, Pamela A F PA; Swan, Gary E GE; Wang, Jen C JC; Goate, Alison M AM; Rice, John P JP; Bierut, Laura J LJ
A variant associated with nicotine dependence, lung cancer and peripheral arterial disease.
Nature
Thorgeirsson, Thorgeir E TE; Geller, Frank F; Sulem, Patrick P; Rafnar, Thorunn T; Wiste, Anna A; Magnusson, Kristinn P KP; Manolescu, Andrei A; Thorleifsson, Gudmar G; Stefansson, Hreinn H; Ingason, Andres A; Stacey, Simon N SN; Bergthorsson, Jon T JT; Thorlacius, Steinunn S; Gudmundsson, Julius J; Jonsson, Thorlakur T; Jakobsdottir, Margret M; Saemundsdottir, Jona J; Olafsdottir, Olof O; Gudmundsson, Larus J LJ; Bjornsdottir, Gyda G; Kristjansson, Kristleifur K; Skuladottir, Halla H; Isaksson, Helgi J HJ; Gudbjartsson, Tomas T; Jones, Gregory T GT; Mueller, Thomas T; Gottsäter, Anders A; Flex, Andrea A; Aben, Katja K H KKH; de Vegt, Femmie F; Mulders, Peter F A PFA; Isla, Dolores D; Vidal, Maria J MJ; Asin, Laura L; Saez, Berta B; Murillo, Laura L; Blondal, Thorsteinn T; Kolbeinsson, Halldor H; Stefansson, Jon G JG; Hansdottir, Ingunn I; Runarsdottir, Valgerdur V; Pola, Roberto R; Lindblad, Bengt B; van Rij, Andre M AM; Dieplinger, Benjamin B; Haltmayer, Meinhard M; Mayordomo, Jose I JI; Kiemeney, Lambertus A LA; Matthiasson, Stefan E SE; Oskarsson, Hogni H; Tyrfingsson, Thorarinn T; Gudbjartsson, Daniel F DF; Gulcher, Jeffrey R JR; Jonsson, Steinn S; Thorsteinsdottir, Unnur U; Kong, Augustine A; Stefansson, Kari K