CHRNA3 c.377+1710A>G

Variant ID: 15-78907656-T-C

NM_000743.4(CHRNA3):c.377+1710A>G

This variant was identified in 62 publications

View GRCh38 version.




Publications:


Associations of cognitive impairment in patients with schizophrenia with genetic features and with schizophrenia-related structural and functional brain changes.

Frontiers In Genetics
Zhuo, Chuanjun C; Tian, Hongjun H; Chen, Jiayue J; Li, Qianchen Q; Yang, Lei L; Zhang, Qiuyu Q; Chen, Guangdong G; Cheng, Langlang L; Zhou, Chunhua C; Song, Xueqin X
Publication Date: 2022

Variant appearance in text: rs6495308
PubMed Link: 36061201
Variant Present in the following documents:
  • Main text
  • fgene-13-880027.pdf
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Neural circuits and nicotinic acetylcholine receptors mediate the cholinergic regulation of midbrain dopaminergic neurons and nicotine dependence.

Acta Pharmacologica Sinica
Xiao, Cheng C; Zhou, Chun-Yi CY; Jiang, Jin-Hong JH; Yin, Cui C
Publication Date: 2020-01

Variant appearance in text: rs6495308
PubMed Link: 31554960
Variant Present in the following documents:
  • Main text
  • 41401_2019_Article_299.pdf
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Combining lifestyle risks to disentangle brain structure and functional connectivity differences in older adults.

Nature Communications
Bittner, Nora N; Jockwitz, Christiane C; Mühleisen, Thomas W TW; Hoffstaedter, Felix F; Eickhoff, Simon B SB; Moebus, Susanne S; Bayen, Ute J UJ; Cichon, Sven S; Zilles, Karl K; Amunts, Katrin K; Caspers, Svenja S
Publication Date: 2019-02-06

Variant appearance in text: rs6495308
PubMed Link: 30728360
Variant Present in the following documents:
  • Main text
  • 41467_2019_Article_8500.pdf
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Combined genetic influence of the nicotinic receptor gene cluster CHRNA5/A3/B4 on nicotine dependence.

Bmc Genomics
Lee, Sung-Ha SH; Ahn, Woo-Young WY; Seweryn, Michał M; Sadee, Wolfgang W
Publication Date: 2018-11-20

Variant appearance in text: rs6495308
PubMed Link: 30453884
Variant Present in the following documents:
  • Main text
  • 12864_2018_Article_5219.pdf
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Whole genome sequencing identifies high-impact variants in well-known pharmacogenomic genes.

The Pharmacogenomics Journal
Choi, Jihoon J; Tantisira, Kelan G KG; Duan, Qing Ling QL
Publication Date: 2019-04

Variant appearance in text: rs6495308
PubMed Link: 30214008
Variant Present in the following documents:
  • NIHMS1503453-supplement-3.xlsx, sheet 1
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Genome-Wide Variants Shared Between Smoking Quantity and Schizophrenia on 15q25 Are Associated With CHRNA5 Expression in the Brain.

Schizophrenia Bulletin
Ohi, Kazutaka K; Kuwata, Aki A; Shimada, Takamitsu T; Kataoka, Yuzuru Y; Yasuyama, Toshiki T; Uehara, Takashi T; Kawasaki, Yasuhiro Y
Publication Date: 2019-06-18

Variant appearance in text: rs6495308
PubMed Link: 30202994
Variant Present in the following documents:
  • Main text
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SNP rs16969968 as a Strong Predictor of Nicotine Dependence and Lung Cancer Risk in a North Indian Population

Asian Pacific Journal Of Cancer Prevention : Apjcp
Pandey, Namita N; Pal, Soumyadip S; Sharma, Lokesh Kumar LK; Guleria, Randeep R; Mohan, Anant A; Srivastava, Tapasya T
Publication Date: 2017-11-26

Variant appearance in text: rs6495308
PubMed Link: 29172281
Variant Present in the following documents:
  • Main text
  • APJCP-18-3073.pdf
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Genome-wide genetic heterogeneity discovery with categorical covariates.

Bioinformatics (Oxford, England)
Llinares-López, Felipe F; Papaxanthos, Laetitia L; Bodenham, Dean D; Roqueiro, Damian D; , ; Borgwardt, Karsten K
Publication Date: 2017-06-15

Variant appearance in text: rs6495308
PubMed Link: 28200033
Variant Present in the following documents:
  • btx071_supp.pdf
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Replicated Risk Nicotinic Cholinergic Receptor Genes for Nicotine Dependence.

Genes
Zuo, Lingjun L; Garcia-Milian, Rolando R; Guo, Xiaoyun X; Zhong, Chunlong C; Tan, Yunlong Y; Wang, Zhiren Z; Wang, Jijun J; Wang, Xiaoping X; Kang, Longli L; Lu, Lu L; Chen, Xiangning X; Li, Chiang-Shan R CR; Luo, Xingguang X
Publication Date: 2016-11-07

Variant appearance in text: rs6495308
PubMed Link: 27827986
Variant Present in the following documents:
  • Main text
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Classification Tree Analysis as a Method for Uncovering Relations Between CHRNA5A3B4 and CHRNB3A6 in Predicting Smoking Progression in Adolescent Smokers.

Nicotine & Tobacco Research : Official Journal Of The Society For Research On Nicotine And Tobacco
Pugach, Oksana O; Cannon, Dale S DS; Weiss, Robert B RB; Hedeker, Donald D; Mermelstein, Robin J RJ
Publication Date: 2017-04-01

Variant appearance in text: rs6495308
PubMed Link: 27613882
Variant Present in the following documents:
  • Main text
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Association of variations in HLA class II and other loci with susceptibility to EGFR-mutated lung adenocarcinoma.

Nature Communications
Shiraishi, Kouya K; Okada, Yukinori Y; Takahashi, Atsushi A; Kamatani, Yoichiro Y; Momozawa, Yukihide Y; Ashikawa, Kyota K; Kunitoh, Hideo H; Matsumoto, Shingo S; Takano, Atsushi A; Shimizu, Kimihiro K; Goto, Akiteru A; Tsuta, Koji K; Watanabe, Shun-Ichi SI; Ohe, Yuichiro Y; Watanabe, Yukio Y; Goto, Yasushi Y; Nokihara, Hiroshi H; Furuta, Koh K; Yoshida, Akihiko A; Goto, Koichi K; Hishida, Tomoyuki T; Tsuboi, Masahiro M; Tsuchihara, Katsuya K; Miyagi, Yohei Y; Nakayama, Haruhiko H; Yokose, Tomoyuki T; Tanaka, Kazumi K; Nagashima, Toshiteru T; Ohtaki, Yoichi Y; Maeda, Daichi D; Imai, Kazuhiro K; Minamiya, Yoshihiro Y; Sakamoto, Hiromi H; Saito, Akira A; Shimada, Yoko Y; Sunami, Kuniko K; Saito, Motonobu M; Inazawa, Johji J; Nakamura, Yusuke Y; Yoshida, Teruhiko T; Yokota, Jun J; Matsuda, Fumihiko F; Matsuo, Keitaro K; Daigo, Yataro Y; Kubo, Michiaki M; Kohno, Takashi T
Publication Date: 2016-08-09

Variant appearance in text: rs6495308
PubMed Link: 27501781
Variant Present in the following documents:
  • ncomms12451-s1.pdf
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Associations between smoking behavior-related alleles and the risk of melanoma.

Oncotarget
Wu, Wenting W; Liu, Hongliang H; Song, Fengju F; Chen, Li-Shiun LS; Kraft, Peter P; Wei, Qingyi Q; Han, Jiali J
Publication Date: 2016-07-26

Variant appearance in text: rs6495308
PubMed Link: 27344179
Variant Present in the following documents:
  • Main text
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A prospective and retrospective analysis of smoking behavior changes in ever smokers with high risk for lung cancer from New Mexico and Pennsylvania.

International Journal Of Molecular Epidemiology And Genetics
Leng, Shuguang S; Weissfeld, Joel L JL; Picchi, Maria A MA; Styn, Mindi A MA; Claus, Eric D ED; Clark, Vincent P VP; Wu, Guodong G; Thomas, Cynthia L CL; Gilliland, Frank D FD; Yuan, Jianmin J; Siegfried, Jill M JM; Belinsky, Steven A SA
Publication Date: 2016

Variant appearance in text: rs6495308
PubMed Link: 27335628
Variant Present in the following documents:
  • Main text
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Converging findings from linkage and association analyses on susceptibility genes for smoking and other addictions.

Molecular Psychiatry
Yang, J J; Li, M D MD
Publication Date: 2016-08

Variant appearance in text: rs6495308
PubMed Link: 27166759
Variant Present in the following documents:
  • Main text
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Association Between CHRNA3 and CHRNA5 Nicotine Receptor Subunit Gene Variants and Nicotine Dependence in an Isolated Populationof Kashubians in Poland.

Medical Science Monitor : International Medical Journal Of Experimental And Clinical Research
Kita-Milczarska, Karolina K; Sieminska, Alicja A; Jassem, Ewa E
Publication Date: 2016-04-29

Variant appearance in text: rs6495308
PubMed Link: 27127891
Variant Present in the following documents:
  • Main text
  • medscimonit-22-1442.pdf
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Genetic scores of smoking behaviour in a Chinese population.

Scientific Reports
Yang, Shanshan S; He, Yao Y; Wang, Jianhua J; Wang, Yiyan Y; Wu, Lei L; Zeng, Jing J; Liu, Miao M; Zhang, Di D; Jiang, Bin B; Li, Xiaoying X
Publication Date: 2016-03-07

Variant appearance in text: rs6495308
PubMed Link: 26948517
Variant Present in the following documents:
  • Main text
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Chromosome 15q25 (CHRNA3-CHRNB4) Variation Indirectly Impacts Lung Cancer Risk in Chinese Males.

Plos One
Zhang, Yalei Y; Jiang, Mei M; Li, Qin Q; Liang, Wenhua W; He, Qihua Q; Chen, Weiqing W; He, Jianxing J
Publication Date: 2016

Variant appearance in text: rs6495308
PubMed Link: 26942719
Variant Present in the following documents:
  • Main text
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Mendelian Randomization - the Key to Understanding Aspects of Parkinson's Disease Causation?

Movement Disorders : Official Journal Of The Movement Disorder Society
Noyce, Alastair J AJ; Nalls, Mike A MA
Publication Date: 2016-04

Variant appearance in text: rs6495308
PubMed Link: 26695521
Variant Present in the following documents:
  • Main text
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Nicotinic receptor contributions to smoking: insights from human studies and animal models.

Current Addiction Reports
Brunzell, Darlene H DH; Stafford, Alexandra M AM; Dixon, Claire I CI
Publication Date: 2015-03

Variant appearance in text: rs6495308
PubMed Link: 26301171
Variant Present in the following documents:
  • Main text
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CHRNA3 rs6495308 genotype as an effect modifier of the association between daily cigarette consumption and hypertension in Chinese male smokers.

International Journal Of Environmental Research And Public Health
Wu, Xiao-Ying XY; Zhou, Shan-Yu SY; Niu, Zhong-Zheng ZZ; Liu, Tao T; Xie, Chuan-Bo CB; Chen, Wei-Qing WQ
Publication Date: 2015-04-14

Variant appearance in text: rs6495308
PubMed Link: 25874685
Variant Present in the following documents:
  • Main text
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The DYX2 locus and neurochemical signaling genes contribute to speech sound disorder and related neurocognitive domains.

Genes, Brain, And Behavior
Eicher, J D JD; Stein, C M CM; Deng, F F; Ciesla, A A AA; Powers, N R NR; Boada, R R; Smith, S D SD; Pennington, B F BF; Iyengar, S K SK; Lewis, B A BA; Gruen, J R JR
Publication Date: 2015-04

Variant appearance in text: rs6495308
PubMed Link: 25778907
Variant Present in the following documents:
  • Main text
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Association between genetic variants on chromosome 15q25 locus and several nicotine dependence traits in Polish population: a case-control study.

Biomed Research International
Buczkowski, Krzysztof K; Sieminska, Alicja A; Linkowska, Katarzyna K; Czachowski, Slawomir S; Przybylski, Grzegorz G; Jassem, Ewa E; Grzybowski, Tomasz T
Publication Date: 2015

Variant appearance in text: rs6495308
PubMed Link: 25632390
Variant Present in the following documents:
  • Main text
  • BMRI2015-350348.pdf
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The contribution of rare and common variants in 30 genes to risk nicotine dependence.

Molecular Psychiatry
Yang, J J; Wang, S S; Yang, Z Z; Hodgkinson, C A CA; Iarikova, P P; Ma, J Z JZ; Payne, T J TJ; Goldman, D D; Li, M D MD
Publication Date: 2015-11

Variant appearance in text: rs6495308
PubMed Link: 25450229
Variant Present in the following documents:
  • Main text
  • nihms634433.pdf
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Determining the causes and consequences of nicotine dependence: emerging genetic research methods.

Current Psychiatry Reports
Ware, Jennifer J JJ; Munafò, Marcus R MR
Publication Date: 2014-10

Variant appearance in text: rs6495308
PubMed Link: 25135777
Variant Present in the following documents:
  • Main text
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Joint association of nicotinic acetylcholine receptor variants with abdominal obesity in American Indians: the Strong Heart Family Study.

Plos One
Zhu, Yun Y; Yang, Jingyun J; Yeh, Fawn F; Cole, Shelley A SA; Haack, Karin K; Lee, Elisa T ET; Howard, Barbara V BV; Zhao, Jinying J
Publication Date: 2014

Variant appearance in text: rs6495308
PubMed Link: 25036316
Variant Present in the following documents:
  • Main text
  • pone.0102220.pdf
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Genetic variants in nicotinic acetylcholine receptor genes jointly contribute to kidney function in American Indians: the Strong Heart Family Study.

Journal Of Hypertension
Zhu, Yun Y; Yang, Jingyun J; Li, Shengxu S; Cole, Shelley A SA; Haack, Karin K; Umans, Jason G JG; Franceschini, Nora N; Howard, Barbara V BV; Lee, Elisa T ET; Zhao, Jinying J
Publication Date: 2014-05

Variant appearance in text: rs6495308
PubMed Link: 24569419
Variant Present in the following documents:
  • Main text
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Neurophysiologic effect of GWAS derived schizophrenia and bipolar risk variants.

American Journal Of Medical Genetics. Part B, Neuropsychiatric Genetics : The Official Publication Of The International Society Of Psychiatric Genetics
Hall, Mei-Hua MH; Levy, Deborah L DL; Salisbury, Dean F DF; Haddad, Steve S; Gallagher, Patience P; Lohan, Mary M; Cohen, Bruce B; Ongür, Dost D; Smoller, Jordan W JW
Publication Date: 2014-01

Variant appearance in text: rs6495308
PubMed Link: 24339136
Variant Present in the following documents:
  • Main text
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Cis-regulatory variants affect CHRNA5 mRNA expression in populations of African and European ancestry.

Plos One
Wang, Jen-Chyong JC; Spiegel, Noah N; Bertelsen, Sarah S; Le, Nhung N; McKenna, Nicholas N; Budde, John P JP; Harari, Oscar O; Kapoor, Manav M; Brooks, Andrew A; Hancock, Dana D; Tischfield, Jay J; Foroud, Tatiana T; Bierut, Laura J LJ; Steinbach, Joe Henry JH; Edenberg, Howard J HJ; Traynor, Bryan J BJ; Goate, Alison M AM
Publication Date: 2013

Variant appearance in text: rs6495308
PubMed Link: 24303001
Variant Present in the following documents:
  • Main text
  • pone.0080204.pdf
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Distinct loci in the CHRNA5/CHRNA3/CHRNB4 gene cluster are associated with onset of regular smoking.

Genetic Epidemiology
Stephens, Sarah H SH; Hartz, Sarah M SM; Hoft, Nicole R NR; Saccone, Nancy L NL; Corley, Robin C RC; Hewitt, John K JK; Hopfer, Christian J CJ; Breslau, Naomi N; Coon, Hilary H; Chen, Xiangning X; Ducci, Francesca F; Dueker, Nicole N; Franceschini, Nora N; Frank, Josef J; Han, Younghun Y; Hansel, Nadia N NN; Jiang, Chenhui C; Korhonen, Tellervo T; Lind, Penelope A PA; Liu, Jason J; Lyytikäinen, Leo-Pekka LP; Michel, Martha M; Shaffer, John R JR; Short, Susan E SE; Sun, Juzhong J; Teumer, Alexander A; Thompson, John R JR; Vogelzangs, Nicole N; Vink, Jacqueline M JM; Wenzlaff, Angela A; Wheeler, William W; Yang, Bao-Zhu BZ; Aggen, Steven H SH; Balmforth, Anthony J AJ; Baumeister, Sebastian E SE; Beaty, Terri H TH; Benjamin, Daniel J DJ; Bergen, Andrew W AW; Broms, Ulla U; Cesarini, David D; Chatterjee, Nilanjan N; Chen, Jingchun J; Cheng, Yu-Ching YC; Cichon, Sven S; Couper, David D; Cucca, Francesco F; Dick, Danielle D; Foroud, Tatiana T; Furberg, Helena H; Giegling, Ina I; Gillespie, Nathan A NA; Gu, Fangyi F; Hall, Alistair S AS; Hällfors, Jenni J; Han, Shizhong S; Hartmann, Annette M AM; Heikkilä, Kauko K; Hickie, Ian B IB; Hottenga, Jouke Jan JJ; Jousilahti, Pekka P; Kaakinen, Marika M; Kähönen, Mika M; Koellinger, Philipp D PD; Kittner, Stephen S; Konte, Bettina B; Landi, Maria-Teresa MT; Laatikainen, Tiina T; Leppert, Mark M; Levy, Steven M SM; Mathias, Rasika A RA; McNeil, Daniel W DW; Medland, Sarah E SE; Montgomery, Grant W GW; Murray, Tanda T; Nauck, Matthias M; North, Kari E KE; Paré, Peter D PD; Pergadia, Michele M; Ruczinski, Ingo I; Salomaa, Veikko V; Viikari, Jorma J; Willemsen, Gonneke G; Barnes, Kathleen C KC; Boerwinkle, Eric E; Boomsma, Dorret I DI; Caporaso, Neil N; Edenberg, Howard J HJ; Francks, Clyde C; Gelernter, Joel J; Grabe, Hans Jörgen HJ; Hops, Hyman H; Jarvelin, Marjo-Riitta MR; Johannesson, Magnus M; Kendler, Kenneth S KS; Lehtimäki, Terho T; Magnusson, Patrik K E PK; Marazita, Mary L ML; Marchini, Jonathan J; Mitchell, Braxton D BD; Nöthen, Markus M MM; Penninx, Brenda W BW; Raitakari, Olli O; Rietschel, Marcella M; Rujescu, Dan D; Samani, Nilesh J NJ; Schwartz, Ann G AG; Shete, Sanjay S; Spitz, Margaret M; Swan, Gary E GE; Völzke, Henry H; Veijola, Juha J; Wei, Qingyi Q; Amos, Chris C; Cannon, Dale S DS; Grucza, Richard R; Hatsukami, Dorothy D; Heath, Andrew A; Johnson, Eric O EO; Kaprio, Jaakko J; Madden, Pamela P; Martin, Nicholas G NG; Stevens, Victoria L VL; Weiss, Robert B RB; Kraft, Peter P; Bierut, Laura J LJ; Ehringer, Marissa A MA
Publication Date: 2013-12

Variant appearance in text: rs6495308
PubMed Link: 24186853
Variant Present in the following documents:
  • Main text
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Introduction to deep sequencing and its application to drug addiction research with a focus on rare variants.

Molecular Neurobiology
Wang, Shaolin S; Yang, Zhongli Z; Ma, Jennie Z JZ; Payne, Thomas J TJ; Li, Ming D MD
Publication Date: 2014-02

Variant appearance in text: rs6495308
PubMed Link: 23990377
Variant Present in the following documents:
  • Main text
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Effect of neuronal nicotinic acetylcholine receptor genes (CHRN) on longitudinal cigarettes per day in adolescents and young adults.

Nicotine & Tobacco Research : Official Journal Of The Society For Research On Nicotine And Tobacco
Cannon, Dale S DS; Mermelstein, Robin J RJ; Hedeker, Donald D; Coon, Hilary H; Cook, Edwin H EH; McMahon, William M WM; Hamil, Cindy C; Dunn, Diane D; Weiss, Robert B RB
Publication Date: 2014-02

Variant appearance in text: rs6495308
PubMed Link: 23943838
Variant Present in the following documents:
  • Main text
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CHRNA5-A3-B4 genetic variants alter nicotine intake and interact with tobacco use to influence body weight in Alaska Native tobacco users.

Addiction (Abingdon, England)
Zhu, Andy Z X AZ; Renner, Caroline C CC; Hatsukami, Dorothy K DK; Benowitz, Neal L NL; Tyndale, Rachel F RF
Publication Date: 2013-10

Variant appearance in text: rs6495308
PubMed Link: 23692359
Variant Present in the following documents:
  • Main text
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Associations of prenatal nicotine exposure and the dopamine related genes ANKK1 and DRD2 to verbal language.

Plos One
Eicher, John D JD; Powers, Natalie R NR; Cho, Kelly K; Miller, Laura L LL; Mueller, Kathryn L KL; Ring, Susan M SM; Tomblin, J Bruce JB; Gruen, Jeffrey R JR
Publication Date: 2013

Variant appearance in text: rs6495308
PubMed Link: 23691092
Variant Present in the following documents:
  • Main text
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Polygenic risk and the developmental progression to heavy, persistent smoking and nicotine dependence: evidence from a 4-decade longitudinal study.

Jama Psychiatry
Belsky, Daniel W DW; Moffitt, Terrie E TE; Baker, Timothy B TB; Biddle, Andrea K AK; Evans, James P JP; Harrington, HonaLee H; Houts, Renate R; Meier, Madeline M; Sugden, Karen K; Williams, Benjamin B; Poulton, Richie R; Caspi, Avshalom A
Publication Date: 2013-05

Variant appearance in text: rs6495308
PubMed Link: 23536134
Variant Present in the following documents:
  • Main text
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Joint associations of 61 genetic variants in the nicotinic acetylcholine receptor genes with subclinical atherosclerosis in American Indians: a gene-family analysis.

Circulation. Cardiovascular Genetics
Yang, Jingyun J; Zhu, Yun Y; Lee, Elisa T ET; Zhang, Ying Y; Cole, Shelley A SA; Haack, Karin K; Best, Lyle G LG; Devereux, Richard B RB; Roman, Mary J MJ; Howard, Barbara V BV; Zhao, Jinying J
Publication Date: 2013-02

Variant appearance in text: rs6495308
PubMed Link: 23264444
Variant Present in the following documents:
  • Main text
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Molecular mechanisms underlying behaviors related to nicotine addiction.

Cold Spring Harbor Perspectives In Medicine
Picciotto, Marina R MR; Kenny, Paul J PJ
Publication Date: 2013-01-01

Variant appearance in text: rs6495308
PubMed Link: 23143843
Variant Present in the following documents:
  • Main text
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Development of novel pharmacotherapeutics for tobacco dependence: progress and future directions.

Nicotine & Tobacco Research : Official Journal Of The Society For Research On Nicotine And Tobacco
Harmey, Dympna D; Griffin, Patrick R PR; Kenny, Paul J PJ
Publication Date: 2012-11

Variant appearance in text: rs6495308
PubMed Link: 23024249
Variant Present in the following documents:
  • Main text
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Influence of common genetic variation on lung cancer risk: meta-analysis of 14 900 cases and 29 485 controls.

Human Molecular Genetics
Timofeeva, Maria N MN; Hung, Rayjean J RJ; Rafnar, Thorunn T; Christiani, David C DC; Field, John K JK; Bickeböller, Heike H; Risch, Angela A; McKay, James D JD; Wang, Yufei Y; Dai, Juncheng J; Gaborieau, Valerie V; McLaughlin, John J; Brenner, Darren D; Narod, Steven A SA; Caporaso, Neil E NE; Albanes, Demetrius D; Thun, Michael M; Eisen, Timothy T; Wichmann, H-Erich HE; Rosenberger, Albert A; Han, Younghun Y; Chen, Wei W; Zhu, Dakai D; Spitz, Margaret M; Wu, Xifeng X; Pande, Mala M; Zhao, Yang Y; Zaridze, David D; Szeszenia-Dabrowska, Neonilia N; Lissowska, Jolanta J; Rudnai, Peter P; Fabianova, Eleonora E; Mates, Dana D; Bencko, Vladimir V; Foretova, Lenka L; Janout, Vladimir V; Krokan, Hans E HE; Gabrielsen, Maiken Elvestad ME; Skorpen, Frank F; Vatten, Lars L; Njølstad, Inger I; Chen, Chu C; Goodman, Gary G; Lathrop, Mark M; Benhamou, Simone S; Vooder, Tõnu T; Välk, Kristjan K; Nelis, Mari M; Metspalu, Andres A; Raji, Olaide O; Chen, Ying Y; Gosney, John J; Liloglou, Triantafillos T; Muley, Thomas T; Dienemann, Hendrik H; Thorleifsson, Gudmar G; Shen, Hongbing H; Stefansson, Kari K; Brennan, Paul P; Amos, Christopher I CI; Houlston, Richard R; Landi, Maria Teresa MT; ,
Publication Date: 2012-11-15

Variant appearance in text: rs6495308
PubMed Link: 22899653
Variant Present in the following documents:
  • Main text
  • dds334.pdf
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From men to mice: CHRNA5/CHRNA3, smoking behavior and disease.

Nicotine & Tobacco Research : Official Journal Of The Society For Research On Nicotine And Tobacco
Ware, Jennifer J JJ; van den Bree, Marianne M; Munafò, Marcus R MR
Publication Date: 2012-11

Variant appearance in text: rs6495308
PubMed Link: 22544838
Variant Present in the following documents:
  • Main text
  • nts106.pdf
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Smoking and genetic risk variation across populations of European, Asian, and African American ancestry--a meta-analysis of chromosome 15q25.

Genetic Epidemiology
Chen, Li-Shiun LS; Saccone, Nancy L NL; Culverhouse, Robert C RC; Bracci, Paige M PM; Chen, Chien-Hsiun CH; Dueker, Nicole N; Han, Younghun Y; Huang, Hongyan H; Jin, Guangfu G; Kohno, Takashi T; Ma, Jennie Z JZ; Przybeck, Thomas R TR; Sanders, Alan R AR; Smith, Jennifer A JA; Sung, Yun Ju YJ; Wenzlaff, Angie S AS; Wu, Chen C; Yoon, Dankyu D; Chen, Ying-Ting YT; Cheng, Yu-Ching YC; Cho, Yoon Shin YS; David, Sean P SP; Duan, Jubao J; Eaton, Charles B CB; Furberg, Helena H; Goate, Alison M AM; Gu, Dongfeng D; Hansen, Helen M HM; Hartz, Sarah S; Hu, Zhibin Z; Kim, Young Jin YJ; Kittner, Steven J SJ; Levinson, Douglas F DF; Mosley, Thomas H TH; Payne, Thomas J TJ; Rao, D C DC; Rice, John P JP; Rice, Treva K TK; Schwantes-An, Tae-Hwi TH; Shete, Sanjay S SS; Shi, Jianxin J; Spitz, Margaret R MR; Sun, Yan V YV; Tsai, Fuu-Jen FJ; Wang, Jen C JC; Wrensch, Margaret R MR; Xian, Hong H; Gejman, Pablo V PV; He, Jiang J; Hunt, Steven C SC; Kardia, Sharon L SL; Li, Ming D MD; Lin, Dongxin D; Mitchell, Braxton D BD; Park, Taesung T; Schwartz, Ann G AG; Shen, Hongbing H; Wiencke, John K JK; Wu, Jer-Yuarn JY; Yokota, Jun J; Amos, Christopher I CI; Bierut, Laura J LJ
Publication Date: 2012-05

Variant appearance in text: rs6495308
PubMed Link: 22539395
Variant Present in the following documents:
  • Main text
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Alpha-5 and -3 nicotinic receptor gene variants predict nicotine dependence but not cessation: findings from the COMMIT cohort.

American Journal Of Medical Genetics. Part B, Neuropsychiatric Genetics : The Official Publication Of The International Society Of Psychiatric Genetics
Bousman, Chad A CA; Rivard, Cheryl C; Haese, Jason Den JD; Ambrosone, Christine C; Hyland, Andrew A
Publication Date: 2012-03

Variant appearance in text: rs6495308
PubMed Link: 22223462
Variant Present in the following documents:
  • Main text
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GENES AS INSTRUMENTS FOR STUDYING RISK BEHAVIOR EFFECTS: AN APPLICATION TO MATERNAL SMOKING AND OROFACIAL CLEFTS.

Health Services & Outcomes Research Methodology
Wehby, George G; Jugessur, Astanand A; Murray, Jeffrey C JC; Moreno, Lina L; Wilcox, Allen A; Lie, Rolv T RT
Publication Date: 2011-07-01

Variant appearance in text: rs6495308
PubMed Link: 22102793
Variant Present in the following documents:
  • Main text
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A twin association study of nicotine dependence with markers in the CHRNA3 and CHRNA5 genes.

Behavior Genetics
Maes, Hermine H HH; Neale, Michael C MC; Chen, Xiangning X; Chen, Jingchun J; Prescott, Carol A CA; Kendler, Kenneth S KS
Publication Date: 2011-09

Variant appearance in text: rs6495308
PubMed Link: 21748402
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An exploratory study on the CHRNA3-CHRNA5-CHRNB4 cluster, smoking, and Parkinson's disease.

Neuro-Degenerative Diseases
Gao, Jianjun J; Xu, Hong H; Weinberg, Clarice C; Huang, Xuemei X; Park, Yikyung Y; Hollenbeck, Albert A; Blair, Aaron A; Schatzkin, Arthur A; Burch, Lauranell L; Chen, Honglei H
Publication Date: 2011

Variant appearance in text: rs6495308
PubMed Link: 21228559
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Associations of variants in CHRNA5/A3/B4 gene cluster with smoking behaviors in a Korean population.

Plos One
Li, Ming D MD; Yoon, Dankyu D; Lee, Jong-Young JY; Han, Bok-Ghee BG; Niu, Tianhua T; Payne, Thomas J TJ; Ma, Jennie Z JZ; Park, Taesung T
Publication Date: 2010-08-16

Variant appearance in text: rs6495308
PubMed Link: 20808433
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Resequencing of nicotinic acetylcholine receptor genes and association of common and rare variants with the Fagerström test for nicotine dependence.

Neuropsychopharmacology : Official Publication Of The American College Of Neuropsychopharmacology
Wessel, Jennifer J; McDonald, Sarah M SM; Hinds, David A DA; Stokowski, Renee P RP; Javitz, Harold S HS; Kennemer, Michael M; Krasnow, Ruth R; Dirks, William W; Hardin, Jill J; Pitts, Steven J SJ; Michel, Martha M; Jack, Lisa L; Ballinger, Dennis G DG; McClure, Jennifer B JB; Swan, Gary E GE; Bergen, Andrew W AW
Publication Date: 2010-11

Variant appearance in text: rs6495308
PubMed Link: 20736995
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Multiple independent loci at chromosome 15q25.1 affect smoking quantity: a meta-analysis and comparison with lung cancer and COPD.

Plos Genetics
Saccone, Nancy L NL; Culverhouse, Robert C RC; Schwantes-An, Tae-Hwi TH; Cannon, Dale S DS; Chen, Xiangning X; Cichon, Sven S; Giegling, Ina I; Han, Shizhong S; Han, Younghun Y; Keskitalo-Vuokko, Kaisu K; Kong, Xiangyang X; Landi, Maria Teresa MT; Ma, Jennie Z JZ; Short, Susan E SE; Stephens, Sarah H SH; Stevens, Victoria L VL; Sun, Lingwei L; Wang, Yufei Y; Wenzlaff, Angela S AS; Aggen, Steven H SH; Breslau, Naomi N; Broderick, Peter P; Chatterjee, Nilanjan N; Chen, Jingchun J; Heath, Andrew C AC; Heliövaara, Markku M; Hoft, Nicole R NR; Hunter, David J DJ; Jensen, Majken K MK; Martin, Nicholas G NG; Montgomery, Grant W GW; Niu, Tianhua T; Payne, Thomas J TJ; Peltonen, Leena L; Pergadia, Michele L ML; Rice, John P JP; Sherva, Richard R; Spitz, Margaret R MR; Sun, Juzhong J; Wang, Jen C JC; Weiss, Robert B RB; Wheeler, William W; Witt, Stephanie H SH; Yang, Bao-Zhu BZ; Caporaso, Neil E NE; Ehringer, Marissa A MA; Eisen, Tim T; Gapstur, Susan M SM; Gelernter, Joel J; Houlston, Richard R; Kaprio, Jaakko J; Kendler, Kenneth S KS; Kraft, Peter P; Leppert, Mark F MF; Li, Ming D MD; Madden, Pamela A F PA; Nöthen, Markus M MM; Pillai, Sreekumar S; Rietschel, Marcella M; Rujescu, Dan D; Schwartz, Ann A; Amos, Christopher I CI; Bierut, Laura J LJ
Publication Date: 2010-08-05

Variant appearance in text: rs6495308
PubMed Link: 20700436
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  • pgen.1001053.pdf
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Chipping away at the genetics of smoking behavior.

Nature Genetics
Amos, Christopher I CI; Spitz, Margaret R MR; Cinciripini, Paul P
Publication Date: 2010-05

Variant appearance in text: rs6495308
PubMed Link: 20428092
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Meta-analysis and imputation refines the association of 15q25 with smoking quantity.

Nature Genetics
Liu, Jason Z JZ; Tozzi, Federica F; Waterworth, Dawn M DM; Pillai, Sreekumar G SG; Muglia, Pierandrea P; Middleton, Lefkos L; Berrettini, Wade W; Knouff, Christopher W CW; Yuan, Xin X; Waeber, Gérard G; Vollenweider, Peter P; Preisig, Martin M; Wareham, Nicholas J NJ; Zhao, Jing Hua JH; Loos, Ruth J F RJ; Barroso, Inês I; Khaw, Kay-Tee KT; Grundy, Scott S; Barter, Philip P; Mahley, Robert R; Kesaniemi, Antero A; McPherson, Ruth R; Vincent, John B JB; Strauss, John J; Kennedy, James L JL; Farmer, Anne A; McGuffin, Peter P; Day, Richard R; Matthews, Keith K; Bakke, Per P; Gulsvik, Amund A; Lucae, Susanne S; Ising, Marcus M; Brueckl, Tanja T; Horstmann, Sonja S; Wichmann, H-Erich HE; Rawal, Rajesh R; Dahmen, Norbert N; Lamina, Claudia C; Polasek, Ozren O; Zgaga, Lina L; Huffman, Jennifer J; Campbell, Susan S; Kooner, Jaspal J; Chambers, John C JC; Burnett, Mary Susan MS; Devaney, Joseph M JM; Pichard, Augusto D AD; Kent, Kenneth M KM; Satler, Lowell L; Lindsay, Joseph M JM; Waksman, Ron R; Epstein, Stephen S; Wilson, James F JF; Wild, Sarah H SH; Campbell, Harry H; Vitart, Veronique V; Reilly, Muredach P MP; Li, Mingyao M; Qu, Liming L; Wilensky, Robert R; Matthai, William W; Hakonarson, Hakon H HH; Rader, Daniel J DJ; Franke, Andre A; Wittig, Michael M; Schäfer, Arne A; Uda, Manuela M; Terracciano, Antonio A; Xiao, Xiangjun X; Busonero, Fabio F; Scheet, Paul P; Schlessinger, David D; St Clair, David D; Rujescu, Dan D; Abecasis, Gonçalo R GR; Grabe, Hans Jörgen HJ; Teumer, Alexander A; Völzke, Henry H; Petersmann, Astrid A; John, Ulrich U; Rudan, Igor I; Hayward, Caroline C; Wright, Alan F AF; Kolcic, Ivana I; Wright, Benjamin J BJ; Thompson, John R JR; Balmforth, Anthony J AJ; Hall, Alistair S AS; Samani, Nilesh J NJ; Anderson, Carl A CA; Ahmad, Tariq T; Mathew, Christopher G CG; Parkes, Miles M; Satsangi, Jack J; Caulfield, Mark M; Munroe, Patricia B PB; Farrall, Martin M; Dominiczak, Anna A; Worthington, Jane J; Thomson, Wendy W; Eyre, Steve S; Barton, Anne A; , ; Mooser, Vincent V; Francks, Clyde C; Marchini, Jonathan J
Publication Date: 2010-05

Variant appearance in text: rs6495308
PubMed Link: 20418889
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Sensorimotor gating is associated with CHRNA3 polymorphisms in schizophrenia and healthy volunteers.

Neuropsychopharmacology : Official Publication Of The American College Of Neuropsychopharmacology
Petrovsky, Nadine N; Quednow, Boris B BB; Ettinger, Ulrich U; Schmechtig, Anne A; Mössner, Rainald R; Collier, David A DA; Kühn, Kai-Uwe KU; Maier, Wolfgang W; Wagner, Michael M; Kumari, Veena V
Publication Date: 2010-06

Variant appearance in text: rs6495308
PubMed Link: 20393456
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Association and interaction analysis of variants in CHRNA5/CHRNA3/CHRNB4 gene cluster with nicotine dependence in African and European Americans.

American Journal Of Medical Genetics. Part B, Neuropsychiatric Genetics : The Official Publication Of The International Society Of Psychiatric Genetics
Li, Ming D MD; Xu, Qing Q; Lou, Xiang-Yang XY; Payne, Thomas J TJ; Niu, Tianhua T; Ma, Jennie Z JZ
Publication Date: 2010-04-05

Variant appearance in text: rs6495308
PubMed Link: 19859904
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Genetics and genomics of chronic obstructive pulmonary disease.

Proceedings Of The American Thoracic Society
Silverman, Edwin K EK; Spira, Avrum A; Paré, Peter D PD
Publication Date: 2009-09-15

Variant appearance in text: rs6495308
PubMed Link: 19741265
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The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans.

Cancer Research
Saccone, Nancy L NL; Wang, Jen C JC; Breslau, Naomi N; Johnson, Eric O EO; Hatsukami, Dorothy D; Saccone, Scott F SF; Grucza, Richard A RA; Sun, Lingwei L; Duan, Weimin W; Budde, John J; Culverhouse, Robert C RC; Fox, Louis L; Hinrichs, Anthony L AL; Steinbach, Joseph Henry JH; Wu, Meng M; Rice, John P JP; Goate, Alison M AM; Bierut, Laura J LJ
Publication Date: 2009-09-01

Variant appearance in text: rs6495308
PubMed Link: 19706762
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Risk for nicotine dependence and lung cancer is conferred by mRNA expression levels and amino acid change in CHRNA5.

Human Molecular Genetics
Wang, Jen C JC; Cruchaga, Carlos C; Saccone, Nancy L NL; Bertelsen, Sarah S; Liu, Pengyuan P; Budde, John P JP; Duan, Weimin W; Fox, Louis L; Grucza, Richard A RA; Kern, Jason J; Mayo, Kevin K; Reyes, Oliver O; Rice, John J; Saccone, Scott F SF; Spiegel, Noah N; Steinbach, Joseph H JH; Stitzel, Jerry A JA; Anderson, Marshall W MW; You, Ming M; Stevens, Victoria L VL; Bierut, Laura J LJ; Goate, Alison M AM; ,
Publication Date: 2009-08-15

Variant appearance in text: rs6495308
PubMed Link: 19443489
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Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes.

American Journal Of Medical Genetics. Part B, Neuropsychiatric Genetics : The Official Publication Of The International Society Of Psychiatric Genetics
Saccone, Nancy L NL; Saccone, Scott F SF; Hinrichs, Anthony L AL; Stitzel, Jerry A JA; Duan, Weimin W; Pergadia, Michele L ML; Agrawal, Arpana A; Breslau, Naomi N; Grucza, Richard A RA; Hatsukami, Dorothy D; Johnson, Eric O EO; Madden, Pamela A F PA; Swan, Gary E GE; Wang, Jen C JC; Goate, Alison M AM; Rice, John P JP; Bierut, Laura J LJ
Publication Date: 2009-06-05

Variant appearance in text: rs6495308
PubMed Link: 19259974
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Variants in nicotinic acetylcholine receptors alpha5 and alpha3 increase risks to nicotine dependence.

American Journal Of Medical Genetics. Part B, Neuropsychiatric Genetics : The Official Publication Of The International Society Of Psychiatric Genetics
Chen, Xiangning X; Chen, Jingchun J; Williamson, Vernell S VS; An, Seon-Sook SS; Hettema, John M JM; Aggen, Steven H SH; Neale, Michael C MC; Kendler, Kenneth S KS
Publication Date: 2009-10-05

Variant appearance in text: rs6495308
PubMed Link: 19132693
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Genetics of smoking behavior and its consequences: the role of nicotinic acetylcholine receptors.

Biological Psychiatry
Thorgeirsson, Thorgeir E TE; Stefansson, Kari K
Publication Date: 2008-12-01

Variant appearance in text: rs6495308
PubMed Link: 19000575
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Genetic variability in nicotinic acetylcholine receptors and nicotine addiction: converging evidence from human and animal research.

Behavioural Brain Research
Portugal, George S GS; Gould, Thomas J TJ
Publication Date: 2008-11-03

Variant appearance in text: rs6495308
PubMed Link: 18571741
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Variants in nicotinic receptors and risk for nicotine dependence.

The American Journal Of Psychiatry
Bierut, Laura Jean LJ; Stitzel, Jerry A JA; Wang, Jen C JC; Hinrichs, Anthony L AL; Grucza, Richard A RA; Xuei, Xiaoling X; Saccone, Nancy L NL; Saccone, Scott F SF; Bertelsen, Sarah S; Fox, Louis L; Horton, William J WJ; Breslau, Naomi N; Budde, John J; Cloninger, C Robert CR; Dick, Danielle M DM; Foroud, Tatiana T; Hatsukami, Dorothy D; Hesselbrock, Victor V; Johnson, Eric O EO; Kramer, John J; Kuperman, Samuel S; Madden, Pamela A F PA; Mayo, Kevin K; Nurnberger, John J; Pomerleau, Ovide O; Porjesz, Bernice B; Reyes, Oliver O; Schuckit, Marc M; Swan, Gary G; Tischfield, Jay A JA; Edenberg, Howard J HJ; Rice, John P JP; Goate, Alison M AM
Publication Date: 2008-09

Variant appearance in text: rs6495308
PubMed Link: 18519524
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Genetic variation in the CHRNA5 gene affects mRNA levels and is associated with risk for alcohol dependence.

Molecular Psychiatry
Wang, J C JC; Grucza, R R; Cruchaga, C C; Hinrichs, A L AL; Bertelsen, S S; Budde, J P JP; Fox, L L; Goldstein, E E; Reyes, O O; Saccone, N N; Saccone, S S; Xuei, X X; Bucholz, K K; Kuperman, S S; Nurnberger, J J; Rice, J P JP; Schuckit, M M; Tischfield, J J; Hesselbrock, V V; Porjesz, B B; Edenberg, H J HJ; Bierut, L J LJ; Goate, A M AM
Publication Date: 2009-05

Variant appearance in text: rs6495308
PubMed Link: 18414406
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A variant associated with nicotine dependence, lung cancer and peripheral arterial disease.

Nature
Thorgeirsson, Thorgeir E TE; Geller, Frank F; Sulem, Patrick P; Rafnar, Thorunn T; Wiste, Anna A; Magnusson, Kristinn P KP; Manolescu, Andrei A; Thorleifsson, Gudmar G; Stefansson, Hreinn H; Ingason, Andres A; Stacey, Simon N SN; Bergthorsson, Jon T JT; Thorlacius, Steinunn S; Gudmundsson, Julius J; Jonsson, Thorlakur T; Jakobsdottir, Margret M; Saemundsdottir, Jona J; Olafsdottir, Olof O; Gudmundsson, Larus J LJ; Bjornsdottir, Gyda G; Kristjansson, Kristleifur K; Skuladottir, Halla H; Isaksson, Helgi J HJ; Gudbjartsson, Tomas T; Jones, Gregory T GT; Mueller, Thomas T; Gottsäter, Anders A; Flex, Andrea A; Aben, Katja K H KKH; de Vegt, Femmie F; Mulders, Peter F A PFA; Isla, Dolores D; Vidal, Maria J MJ; Asin, Laura L; Saez, Berta B; Murillo, Laura L; Blondal, Thorsteinn T; Kolbeinsson, Halldor H; Stefansson, Jon G JG; Hansdottir, Ingunn I; Runarsdottir, Valgerdur V; Pola, Roberto R; Lindblad, Bengt B; van Rij, Andre M AM; Dieplinger, Benjamin B; Haltmayer, Meinhard M; Mayordomo, Jose I JI; Kiemeney, Lambertus A LA; Matthiasson, Stefan E SE; Oskarsson, Hogni H; Tyrfingsson, Thorarinn T; Gudbjartsson, Daniel F DF; Gulcher, Jeffrey R JR; Jonsson, Steinn S; Thorsteinsdottir, Unnur U; Kong, Augustine A; Stefansson, Kari K
Publication Date: 2008-04-03

Variant appearance in text: rs6495308
PubMed Link: 18385739
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Identification of pharmacogenetic markers in smoking cessation therapy.

American Journal Of Medical Genetics. Part B, Neuropsychiatric Genetics : The Official Publication Of The International Society Of Psychiatric Genetics
Heitjan, Daniel F DF; Guo, Mengye M; Ray, Riju R; Wileyto, E Paul EP; Epstein, Leonard H LH; Lerman, Caryn C
Publication Date: 2008-09-05

Variant appearance in text: rs6495308
PubMed Link: 18165968
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