AKAP13 c.3751G>C ;(p.A1251P)

Variant ID: 15-86125050-G-C

NM_007200.4(AKAP13):c.3751G>C;(p.A1251P)

This variant was identified in 3 publications

View GRCh38 version.




Publications:


Src homology 2 domain-containing phosphatase 2 (Shp2) is a component of the A-kinase-anchoring protein (AKAP)-Lbc complex and is inhibited by protein kinase A (PKA) under pathological hypertrophic conditions in the heart.

The Journal Of Biological Chemistry
Burmeister, Brian T BT; Taglieri, Domenico M DM; Wang, Li L; Carnegie, Graeme K GK
Publication Date: 2012-11-23

Variant appearance in text: AKAP-Lbc: A1251P
PubMed Link: 23045525
Variant Present in the following documents:
  • Main text
View BVdb publication page



The A-kinase-anchoring protein AKAP-Lbc facilitates cardioprotective PKA phosphorylation of Hsp20 on Ser(16).

The Biochemical Journal
Edwards, Helen V HV; Scott, John D JD; Baillie, George S GS
Publication Date: 2012-09-15

Variant appearance in text: AKAP-Lbc: A1251P
PubMed Link: 22731613
Variant Present in the following documents:
  • Main text
View BVdb publication page



Anchoring of both PKA and 14-3-3 inhibits the Rho-GEF activity of the AKAP-Lbc signaling complex.

The Embo Journal
Diviani, Dario D; Abuin, Liliane L; Cotecchia, Susanna S; Pansier, Laetitia L
Publication Date: 2004-07-21

Variant appearance in text: AKAP-Lbc: A1251P
PubMed Link: 15229649
Variant Present in the following documents:
  • Main text
View BVdb publication page