Publications:

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IGFBP2 promotes proliferation and cell migration through STAT3 signaling in Sonic hedgehog medulloblastoma.

Acta Neuropathologica Communications

Kunhiraman, Haritha H; McSwain, Leon L; Shahab, Shubin W SW; Gershon, Timothy R TR; MacDonald, Tobey J TJ; Kenney, Anna Marie AM

Publication Date: 2023-04-08

Variant appearance in text: IGF1R: S12a

PubMed Link: 37029430

Variant Present in the following documents:

• Main text
• 40478_2023_Article_1557.pdf

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RSK1 promotes mammalian axon regeneration by inducing the synthesis of regeneration-related proteins.

Plos Biology

Mao, Susu S; Chen, Yuanyuan Y; Feng, Wei W; Zhou, Songlin S; Jiang, Chunyi C; Zhang, Junjie J; Liu, Xiaohong X; Qian, Tianmei T; Liu, Kai K; Wang, Yaxian Y; Yao, Chun C; Gu, Xiaosong X; Yu, Bin B

Publication Date: 2022-06

Variant appearance in text: IGF1R: S12A

PubMed Link: 35648763

Variant Present in the following documents:

• Main text
• pbio.3001653.pdf

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SuperDendrix algorithm integrates genetic dependencies and genomic alterations across pathways and cancer types.

Cell Genomics

Park, Tae Yoon TY; Leiserson, Mark D M MDM; Klau, Gunnar W GW; Raphael, Benjamin J BJ

Publication Date: 2022-02-09

Variant appearance in text: IGFR: S12A

PubMed Link: 35382456

Variant Present in the following documents:

• NIHMS1779280-supplement-5.pdf

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Growth factor signaling predicts therapy resistance mechanisms and defines neuroblastoma subtypes.

Oncogene

Lebedev, Timofey T; Vagapova, Elmira E; Spirin, Pavel P; Rubtsov, Petr P; Astashkova, Olga O; Mikheeva, Alesya A; Sorokin, Maxim M; Vladimirova, Uliana U; Suntsova, Maria M; Konovalov, Dmitry D; Roumiantsev, Alexander A; Stocking, Carol C; Buzdin, Anton A; Prassolov, Vladimir V

Publication Date: 2021-11

Variant appearance in text: IGF1R: S12a

PubMed Link: 34556815

Variant Present in the following documents:

• Main text
• 41388_2021_Article_2018.pdf

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Growth factor signaling predicts therapy resistance mechanisms and defines neuroblastoma subtypes.

Oncogene

Lebedev, Timofey T; Vagapova, Elmira E; Spirin, Pavel P; Rubtsov, Petr P; Astashkova, Olga O; Mikheeva, Alesya A; Sorokin, Maxim M; Vladimirova, Uliana U; Suntsova, Maria M; Konovalov, Dmitry D; Roumiantsev, Alexander A; Stocking, Carol C; Buzdin, Anton A; Prassolov, Vladimir V

Publication Date: 2021-11

Variant appearance in text: IGF1R: S12a

PubMed Link: 34556815

Variant Present in the following documents:

• Main text
• 41388_2021_Article_2018.pdf

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Proteogenomic Workflow Reveals Molecular Phenotypes Related to Breast Cancer Mammographic Appearance.

Journal Of Proteome Research

De Marchi, Tommaso T; Pyl, Paul Theodor PT; Sjöström, Martin M; Klasson, Stina S; Sartor, Hanna H; Tran, Lena L; Pekar, Gyula G; Malmström, Johan J; Malmström, Lars L; Niméus, Emma E

Publication Date: 2021-05-07

Variant appearance in text: IGF1R: S12A

PubMed Link: 33855848

Variant Present in the following documents:

• Main text
• pr1c00243.pdf

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Conformational states dynamically populated by a kinase determine its function.

Science (New York, N.Y.)

Xie, Tao T; Saleh, Tamjeed T; Rossi, Paolo P; Kalodimos, Charalampos G CG

Publication Date: 2020-10-09

Variant appearance in text: IGF1R: S12A

PubMed Link: 33004676

Variant Present in the following documents:

• Main text

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Allele-specific DNA methylation is increased in cancers and its dense mapping in normal plus neoplastic cells increases the yield of disease-associated regulatory SNPs.

Genome Biology

Do, Catherine C; Dumont, Emmanuel L P ELP; Salas, Martha M; Castano, Angelica A; Mujahed, Huthayfa H; Maldonado, Leonel L; Singh, Arunjot A; DaSilva-Arnold, Sonia C SC; Bhagat, Govind G; Lehman, Soren S; Christiano, Angela M AM; Madhavan, Subha S; Nagy, Peter L PL; Green, Peter H R PHR; Feinman, Rena R; Trimble, Cornelia C; Illsley, Nicholas P NP; Marder, Karen K; Honig, Lawrence L; Monk, Catherine C; Goy, Andre A; Chow, Kar K; Goldlust, Samuel S; Kaptain, George G; Siegel, David D; Tycko, Benjamin B

Publication Date: 2020-06-29

Variant appearance in text: IGF1R: S12A

PubMed Link: 32594908

Variant Present in the following documents:

• Main text
• 13059_2020_Article_2059.pdf

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Anti-EGFR Therapy Induces EGF Secretion by Cancer-Associated Fibroblasts to Confer Colorectal Cancer Chemoresistance.

Cancers

Garvey, Colleen M CM; Lau, Roy R; Sanchez, Alyssa A; Sun, Ren X RX; Fong, Emma J EJ; Doche, Michael E ME; Chen, Oscar O; Jusuf, Anthony A; Lenz, Heinz-Josef HJ; Larson, Brent B; Mumenthaler, Shannon M SM

Publication Date: 2020-05-28

Variant appearance in text: IGF1R: S12A

PubMed Link: 32481658

Variant Present in the following documents:

• cancers-12-01393.pdf

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Combining ERBB family and MET inhibitors is an effective therapeutic strategy in cutaneous malignant melanoma independent of BRAF/NRAS mutation status.

Cell Death & Disease

Das, Ishani I; Wilhelm, Margareta M; Höiom, Veronica V; Franco Marquez, Rodolfo R; Costa Svedman, Fernanda F; Hansson, Johan J; Tuominen, Rainer R; Egyhàzi Brage, Suzanne S

Publication Date: 2019-09-10

Variant appearance in text: IGF1R: S12a

PubMed Link: 31506424

Variant Present in the following documents:

• Main text
• 41419_2019_Article_1875.pdf

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Encircling the regions of the pharmacogenomic landscape that determine drug response.

Genome Medicine

Fernández-Torras, Adrià A; Duran-Frigola, Miquel M; Aloy, Patrick P

Publication Date: 2019-03-26

Variant appearance in text: IGFR: S12A

PubMed Link: 30914058

Variant Present in the following documents:

• Main text
• 13073_2019_Article_626.pdf

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mTORC1 is a key mediator of RON-dependent breast cancer metastasis with therapeutic potential.

Npj Breast Cancer

Faham, Najme N; Zhao, Ling L; Welm, Alana L AL

Publication Date: 2018

Variant appearance in text: IGF1R: S12A

PubMed Link: 30456298

Variant Present in the following documents:

• Main text

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Genome organization and chromatin analysis identify transcriptional downregulation of insulin-like growth factor signaling as a hallmark of aging in developing B cells.

Genome Biology

Koohy, Hashem H; Bolland, Daniel J DJ; Matheson, Louise S LS; Schoenfelder, Stefan S; Stellato, Claudia C; Dimond, Andrew A; Várnai, Csilla C; Chovanec, Peter P; Chessa, Tamara T; Denizot, Jeremy J; Manzano Garcia, Raquel R; Wingett, Steven W SW; Freire-Pritchett, Paula P; Nagano, Takashi T; Hawkins, Phillip P; Stephens, Len L; Elderkin, Sarah S; Spivakov, Mikhail M; Fraser, Peter P; Corcoran, Anne E AE; Varga-Weisz, Patrick D PD

Publication Date: 2018-09-05

Variant appearance in text: IGF1R: S12a

PubMed Link: 30180872

Variant Present in the following documents:

• Main text
• 13059_2018_Article_1489.pdf

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Identification of TRA2B-DNAH5 fusion as a novel oncogenic driver in human lung squamous cell carcinoma.

Cell Research

Li, Fei F; Fang, Zhaoyuan Z; Zhang, Jian J; Li, Chen C; Liu, Hongyan H; Xia, Jufeng J; Zhu, Hongwen H; Guo, Chenchen C; Qin, Zhen Z; Li, Fuming F; Han, Xiangkun X; Wang, Yuetong Y; Feng, Yan Y; Wang, Ye Y; Zhang, Wenjing W; Wang, Zuoyun Z; Jin, Yujuan Y; Sun, Yihua Y; Wei, Wenyi W; Zeng, Rong R; Chen, Haiquan H; Ji, Hongbin H

Publication Date: 2016-10

Variant appearance in text: IGF1R: S12A

PubMed Link: 27670699

Variant Present in the following documents:

• Main text

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P-glycoprotein Mediates Ceritinib Resistance in Anaplastic Lymphoma Kinase-rearranged Non-small Cell Lung Cancer.

Ebiomedicine

Katayama, Ryohei R; Sakashita, Takuya T; Yanagitani, Noriko N; Ninomiya, Hironori H; Horiike, Atsushi A; Friboulet, Luc L; Gainor, Justin F JF; Motoi, Noriko N; Dobashi, Akito A; Sakata, Seiji S; Tambo, Yuichi Y; Kitazono, Satoru S; Sato, Shigeo S; Koike, Sumie S; John Iafrate, A A; Mino-Kenudson, Mari M; Ishikawa, Yuichi Y; Shaw, Alice T AT; Engelman, Jeffrey A JA; Takeuchi, Kengo K; Nishio, Makoto M; Fujita, Naoya N

Publication Date: 2016-01

Variant appearance in text: IGF1R: S12A

PubMed Link: 26870817

Variant Present in the following documents:

• Main text
• main.pdf

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Strategically Timing Inhibition of Phosphatidylinositol 3-Kinase to Maximize Therapeutic Index in Estrogen Receptor Alpha-Positive, PIK3CA-Mutant Breast Cancer.

Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research

Yang, Wei W; Hosford, Sarah R SR; Dillon, Lloye M LM; Shee, Kevin K; Liu, Stephanie C SC; Bean, Jennifer R JR; Salphati, Laurent L; Pang, Jodie J; Zhang, Xiaolin X; Nannini, Michelle A MA; Demidenko, Eugene E; Bates, Darcy D; Lewis, Lionel D LD; Marotti, Jonathan D JD; Eastman, Alan R AR; Miller, Todd W TW

Publication Date: 2016-05-01

Variant appearance in text: IGF1R: S12A

PubMed Link: 26733612

Variant Present in the following documents:

• Main text

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