Publications:

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The Tuberin and Cyclin B1 complex functions as a novel G2/M sensor of serum conditions and Akt signaling.

Plos One

Fidalgo da Silva, Elizabeth E; Botsford, Sabrina S; Dare-Shih, Jessica J; Hanna, Miranda A MA; Porter, Lisa A LA

Publication Date: 2019

Variant appearance in text: TSC2: S939A

PubMed Link: 30629673

Variant Present in the following documents:

• Main text
• pone.0210612.pdf

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Epstein-Barr Virus-Encoded Latent Membrane Protein 1 Upregulates Glucose Transporter 1 Transcription via the mTORC1/NF-κB Signaling Pathways.

Journal Of Virology

Zhang, Jun J; Jia, Lin L; Lin, Weitao W; Yip, Yim Ling YL; Lo, Kwok Wai KW; Lau, Victoria Ming Yi VMY; Zhu, Dandan D; Tsang, Chi Man CM; Zhou, Yuan Y; Deng, Wen W; Lung, Hong Lok HL; Lung, Maria Li ML; Cheung, Lai Man LM; Tsao, Sai Wah SW

Publication Date: 2017-03-15

Variant appearance in text: TSC2: S939A

PubMed Link: 28053105

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• Main text

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PDK1-SGK1 Signaling Sustains AKT-Independent mTORC1 Activation and Confers Resistance to PI3Kα Inhibition.

Cancer Cell

Castel, Pau P; Ellis, Haley H; Bago, Ruzica R; Toska, Eneda E; Razavi, Pedram P; Carmona, F Javier FJ; Kannan, Srinivasaraghavan S; Verma, Chandra S CS; Dickler, Maura M; Chandarlapaty, Sarat S; Brogi, Edi E; Alessi, Dario R DR; Baselga, José J; Scaltriti, Maurizio M

Publication Date: 2016-08-08

Variant appearance in text: TSC2: S939A

PubMed Link: 27451907

Variant Present in the following documents:

• mmc2.pdf

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Differential IKK/NF-κB Activity Is Mediated by TSC2 through mTORC1 in PTEN-Null Prostate Cancer and Tuberous Sclerosis Complex Tumor Cells.

Molecular Cancer Research : Mcr

Gao, Yu Y; Gartenhaus, Ronald B RB; Lapidus, Rena G RG; Hussain, Arif A; Zhang, Yanting Y; Wang, Xinghuan X; Dan, Han C HC

Publication Date: 2015-12

Variant appearance in text: TSC2: S939A

PubMed Link: 26374334

Variant Present in the following documents:

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A novel Hap1-Tsc1 interaction regulates neuronal mTORC1 signaling and morphogenesis in the brain.

The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience

Mejia, Luis A LA; Litterman, Nadia N; Ikeuchi, Yoshiho Y; de la Torre-Ubieta, Luis L; Bennett, Eric J EJ; Zhang, Chi C; Harper, J Wade JW; Bonni, Azad A

Publication Date: 2013-11-13

Variant appearance in text: TSC2: Ser939Ala

PubMed Link: 24227713

Variant Present in the following documents:

• Main text

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Insulin like growth factor-1-induced phosphorylation and altered distribution of tuberous sclerosis complex (TSC)1/TSC2 in C2C12 myotubes.

The Febs Journal

Miyazaki, Mitsunori M; McCarthy, John J JJ; Esser, Karyn A KA

Publication Date: 2010-05

Variant appearance in text: TSC2: S939A

PubMed Link: 20412061

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The tuberous sclerosis complex.

Annals Of The New York Academy Of Sciences

Orlova, Ksenia A KA; Crino, Peter B PB

Publication Date: 2010-01

Variant appearance in text: TSC2: S939A

PubMed Link: 20146692

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Insulin stimulates adipogenesis through the Akt-TSC2-mTORC1 pathway.

Plos One

Zhang, Hui H HH; Huang, Jingxiang J; Düvel, Katrin K; Boback, Bernard B; Wu, Shulin S; Squillace, Rachel M RM; Wu, Chin-Lee CL; Manning, Brendan D BD

Publication Date: 2009-07-10

Variant appearance in text: TSC2: S939A

PubMed Link: 19593385

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The TSC1-TSC2 complex: a molecular switchboard controlling cell growth.

The Biochemical Journal

Huang, Jingxiang J; Manning, Brendan D BD

Publication Date: 2008-06-01

Variant appearance in text: TSC2: S939A

PubMed Link: 18466115

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Pam (Protein associated with Myc) functions as an E3 ubiquitin ligase and regulates TSC/mTOR signaling.

Cellular Signalling

Han, Sangyeul S; Witt, Rochelle M RM; Santos, Túlio M TM; Polizzano, Carolyn C; Sabatini, Bernardo L BL; Ramesh, Vijaya V

Publication Date: 2008-06

Variant appearance in text: TSC2: S939A

PubMed Link: 18308511

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Activity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioning.

The Journal Of Cell Biology

Cai, Sheng-Li SL; Tee, Andrew R AR; Short, John D JD; Bergeron, Judith M JM; Kim, Jinhee J; Shen, Jianjun J; Guo, Ruifeng R; Johnson, Charles L CL; Kiguchi, Kaoru K; Walker, Cheryl Lyn CL

Publication Date: 2006-04-24

Variant appearance in text: TSC2: S939A

PubMed Link: 16636147

Variant Present in the following documents:

• Main text
• jcb1730279.pdf

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The NF1 tumor suppressor critically regulates TSC2 and mTOR.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Johannessen, Cory M CM; Reczek, Elizabeth E EE; James, Marianne F MF; Brems, Hilde H; Legius, Eric E; Cichowski, Karen K

Publication Date: 2005-06-14

Variant appearance in text: tuberin: S939A

PubMed Link: 15937108

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Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Roux, Philippe P PP; Ballif, Bryan A BA; Anjum, Rana R; Gygi, Steven P SP; Blenis, John J

Publication Date: 2004-09-14

Variant appearance in text: tuberin: S939A

PubMed Link: 15342917

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