MAP4K3 inhibits Sirtuin-1 to repress the LKB1-AMPK pathway to promote amino acid-dependent activation of the mTORC1 complex.
Life Science Alliance
Branch, Mary Rose MR; Hsu, Cynthia L CL; Ohnishi, Kohta K; Shen, Wen-Chuan WC; Lee, Elian E; Meisenhelder, Jill J; Winborn, Brett B; Sopher, Bryce L BL; Taylor, J Paul JP; Hunter, Tony T; La Spada, Albert R AR
ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS.
Proceedings Of The National Academy Of Sciences Of The United States Of America
Alexander, Angela A; Cai, Sheng-Li SL; Kim, Jinhee J; Nanez, Adrian A; Sahin, Mustafa M; MacLean, Kirsteen H KH; Inoki, Ken K; Guan, Kun-Liang KL; Shen, Jianjun J; Person, Maria D MD; Kusewitt, Donna D; Mills, Gordon B GB; Kastan, Michael B MB; Walker, Cheryl Lyn CL