bMSAF is a prognostic predictor for advanced hepatocellular carcinoma patients treated with immune checkpoint inhibitor camrelizumab and anti-angiogenic agent apatinib combination therapy.
Architecture of the Tuberous Sclerosis Protein Complex.
Journal Of Molecular Biology
Ramlaul, Kailash K; Fu, Wencheng W; Li, Hua H; de Martin Garrido, Natàlia N; He, Lin L; Trivedi, Manjari M; Cui, Wei W; Aylett, Christopher H S CHS; Wu, Geng G
Phenotypic Screen with TSC-Deficient Neurons Reveals Heat-Shock Machinery as a Druggable Pathway for mTORC1 and Reduced Cilia.
Cell Reports
Di Nardo, Alessia A; Lenoël, Isadora I; Winden, Kellen D KD; Rühmkorf, Alina A; Modi, Meera E ME; Barrett, Lee L; Ercan-Herbst, Ebru E; Venugopal, Pooja P; Behne, Robert R; Lopes, Carla A M CAM; Kleiman, Robin J RJ; Bettencourt-Dias, Mónica M; Sahin, Mustafa M
Publication Date: 2020-06-23
Variant appearance in text: TSC2: 4952A>G; Asn1651Ser
REVEL and BayesDel outperform other in silico meta-predictors for clinical variant classification.
Scientific Reports
Tian, Yuan Y; Pesaran, Tina T; Chamberlin, Adam A; Fenwick, R Bryn RB; Li, Shuwei S; Gau, Chia-Ling CL; Chao, Elizabeth C EC; Lu, Hsiao-Mei HM; Black, Mary Helen MH; Qian, Dajun D
TSC1/2 mutations define a molecular subset of HCC with aggressive behaviour and treatment implication.
Gut
Ho, Daniel W H DWH; Chan, Lo K LK; Chiu, Yung T YT; Xu, Iris M J IMJ; Poon, Ronnie T P RTP; Cheung, Tan T TT; Tang, Chung N CN; Tang, Victor W L VWL; Lo, Irene L O ILO; Lam, Polly W Y PWY; Yau, Derek T W DTW; Li, Miao X MX; Wong, Chun M CM; Ng, Irene O L IOL
Lack of association of rare functional variants in TSC1/TSC2 genes with autism spectrum disorder.
Molecular Autism
Bahl, Samira S; Chiang, Colby C; Beauchamp, Roberta L RL; Neale, Benjamin M BM; Daly, Mark J MJ; Gusella, James F JF; Talkowski, Michael E ME; Ramesh, Vijaya V
DAXX/ATRX, MEN1, and mTOR pathway genes are frequently altered in pancreatic neuroendocrine tumors.
Science (New York, N.Y.)
Jiao, Yuchen Y; Shi, Chanjuan C; Edil, Barish H BH; de Wilde, Roeland F RF; Klimstra, David S DS; Maitra, Anirban A; Schulick, Richard D RD; Tang, Laura H LH; Wolfgang, Christopher L CL; Choti, Michael A MA; Velculescu, Victor E VE; Diaz, Luis A LA; Vogelstein, Bert B; Kinzler, Kenneth W KW; Hruban, Ralph H RH; Papadopoulos, Nickolas N