TSC2 c.5392T>G ;(p.S1798A)

Variant ID: 16-2138579-T-G

NM_000548.3(TSC2):c.5392T>G;(p.S1798A)

This variant was identified in 5 publications

View GRCh38 version.




Publications:


PDK1-SGK1 Signaling Sustains AKT-Independent mTORC1 Activation and Confers Resistance to PI3Kα Inhibition.

Cancer Cell
Castel, Pau P; Ellis, Haley H; Bago, Ruzica R; Toska, Eneda E; Razavi, Pedram P; Carmona, F Javier FJ; Kannan, Srinivasaraghavan S; Verma, Chandra S CS; Dickler, Maura M; Chandarlapaty, Sarat S; Brogi, Edi E; Alessi, Dario R DR; Baselga, José J; Scaltriti, Maurizio M
Publication Date: 2016-08-08

Variant appearance in text: TSC2: S1798A
PubMed Link: 27451907
Variant Present in the following documents:
  • mmc2.pdf
View BVdb publication page



Pim2 is required for maintaining multiple myeloma cell growth through modulating TSC2 phosphorylation.

Blood
Lu, Jing J; Zavorotinskaya, Tatiana T; Dai, Yumin Y; Niu, Xiao-Hong XH; Castillo, Joseph J; Sim, Janet J; Yu, Jianjun J; Wang, Yingyun Y; Langowski, John L JL; Holash, Jocelyn J; Shannon, Kevin K; Garcia, Pablo D PD
Publication Date: 2013-08-29

Variant appearance in text: TSC2: S1798A
PubMed Link: 23818547
Variant Present in the following documents:
  • Main text
View BVdb publication page



Pharmacological and genetic evaluation of proposed roles of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK), extracellular signal-regulated kinase (ERK), and p90(RSK) in the control of mTORC1 protein signaling by phorbol esters.

The Journal Of Biological Chemistry
Fonseca, Bruno D BD; Alain, Tommy T; Finestone, Leona K LK; Huang, Brandon P H BP; Rolfe, Mark M; Jiang, Tian T; Yao, Zhong Z; Hernandez, Greco G; Bennett, Christopher F CF; Proud, Christopher G CG
Publication Date: 2011-08-05

Variant appearance in text: TSC2: S1798A
PubMed Link: 21659537
Variant Present in the following documents:
  • Main text
View BVdb publication page



Pam (Protein associated with Myc) functions as an E3 ubiquitin ligase and regulates TSC/mTOR signaling.

Cellular Signalling
Han, Sangyeul S; Witt, Rochelle M RM; Santos, Túlio M TM; Polizzano, Carolyn C; Sabatini, Bernardo L BL; Ramesh, Vijaya V
Publication Date: 2008-06

Variant appearance in text: TSC2: S1798A
PubMed Link: 18308511
Variant Present in the following documents:
  • Main text
View BVdb publication page



Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase.

Proceedings Of The National Academy Of Sciences Of The United States Of America
Roux, Philippe P PP; Ballif, Bryan A BA; Anjum, Rana R; Gygi, Steven P SP; Blenis, John J
Publication Date: 2004-09-14

Variant appearance in text: tuberin: S1798A
PubMed Link: 15342917
Variant Present in the following documents:
  • Main text
View BVdb publication page