Fine-mapping, trans-ancestral and genomic analyses identify causal variants, cells, genes and drug targets for type 1 diabetes.
Nature Genetics
Robertson, Catherine C CC; Inshaw, Jamie R J JRJ; Onengut-Gumuscu, Suna S; Chen, Wei-Min WM; Santa Cruz, David Flores DF; Yang, Hanzhi H; Cutler, Antony J AJ; Crouch, Daniel J M DJM; Farber, Emily E; Bridges, S Louis SL; Edberg, Jeffrey C JC; Kimberly, Robert P RP; Buckner, Jane H JH; Deloukas, Panos P; Divers, Jasmin J; Dabelea, Dana D; Lawrence, Jean M JM; Marcovina, Santica S; Shah, Amy S AS; Greenbaum, Carla J CJ; Atkinson, Mark A MA; Gregersen, Peter K PK; Oksenberg, Jorge R JR; Pociot, Flemming F; Rewers, Marian J MJ; Steck, Andrea K AK; Dunger, David B DB; , ; Wicker, Linda S LS; Concannon, Patrick P; Todd, John A JA; Rich, Stephen S SS
Fine-mapping, trans-ancestral and genomic analyses identify causal variants, cells, genes and drug targets for type 1 diabetes.
Nature Genetics
Robertson, Catherine C CC; Inshaw, Jamie R J JRJ; Onengut-Gumuscu, Suna S; Chen, Wei-Min WM; Santa Cruz, David Flores DF; Yang, Hanzhi H; Cutler, Antony J AJ; Crouch, Daniel J M DJM; Farber, Emily E; Bridges, S Louis SL; Edberg, Jeffrey C JC; Kimberly, Robert P RP; Buckner, Jane H JH; Deloukas, Panos P; Divers, Jasmin J; Dabelea, Dana D; Lawrence, Jean M JM; Marcovina, Santica S; Shah, Amy S AS; Greenbaum, Carla J CJ; Atkinson, Mark A MA; Gregersen, Peter K PK; Oksenberg, Jorge R JR; Pociot, Flemming F; Rewers, Marian J MJ; Steck, Andrea K AK; Dunger, David B DB; , ; Wicker, Linda S LS; Concannon, Patrick P; Todd, John A JA; Rich, Stephen S SS
Associations of Mitochondrial and Nuclear Mitochondrial Variants and Genes with Seven Metabolic Traits.
American Journal Of Human Genetics
Kraja, Aldi T AT; Liu, Chunyu C; Fetterman, Jessica L JL; Graff, Mariaelisa M; Have, Christian Theil CT; Gu, Charles C; Yanek, Lisa R LR; Feitosa, Mary F MF; Arking, Dan E DE; Chasman, Daniel I DI; Young, Kristin K; Ligthart, Symen S; Hill, W David WD; Weiss, Stefan S; Luan, Jian'an J; Giulianini, Franco F; Li-Gao, Ruifang R; Hartwig, Fernando P FP; Lin, Shiow J SJ; Wang, Lihua L; Richardson, Tom G TG; Yao, Jie J; Fernandez, Eliana P EP; Ghanbari, Mohsen M; Wojczynski, Mary K MK; Lee, Wen-Jane WJ; Argos, Maria M; Armasu, Sebastian M SM; Barve, Ruteja A RA; Ryan, Kathleen A KA; An, Ping P; Baranski, Thomas J TJ; Bielinski, Suzette J SJ; Bowden, Donald W DW; Broeckel, Ulrich U; Christensen, Kaare K; Chu, Audrey Y AY; Corley, Janie J; Cox, Simon R SR; Uitterlinden, Andre G AG; Rivadeneira, Fernando F; Cropp, Cheryl D CD; Daw, E Warwick EW; van Heemst, Diana D; de Las Fuentes, Lisa L; Gao, He H; Tzoulaki, Ioanna I; Ahluwalia, Tarunveer S TS; de Mutsert, Renée R; Emery, Leslie S LS; Erzurumluoglu, A Mesut AM; Perry, James A JA; Fu, Mao M; Forouhi, Nita G NG; Gu, Zhenglong Z; Hai, Yang Y; Harris, Sarah E SE; Hemani, Gibran G; Hunt, Steven C SC; Irvin, Marguerite R MR; Jonsson, Anna E AE; Justice, Anne E AE; Kerrison, Nicola D ND; Larson, Nicholas B NB; Lin, Keng-Hung KH; Love-Gregory, Latisha D LD; Mathias, Rasika A RA; Lee, Joseph H JH; Nauck, Matthias M; Noordam, Raymond R; Ong, Ken K KK; Pankow, James J; Patki, Amit A; Pattie, Alison A; Petersmann, Astrid A; Qi, Qibin Q; Ribel-Madsen, Rasmus R; Rohde, Rebecca R; Sandow, Kevin K; Schnurr, Theresia M TM; Sofer, Tamar T; Starr, John M JM; Taylor, Adele M AM; Teumer, Alexander A; Timpson, Nicholas J NJ; de Haan, Hugoline G HG; Wang, Yujie Y; Weeke, Peter E PE; Williams, Christine C; Wu, Hongsheng H; Yang, Wei W; Zeng, Donglin D; Witte, Daniel R DR; Weir, Bruce S BS; Wareham, Nicholas J NJ; Vestergaard, Henrik H; Turner, Stephen T ST; Torp-Pedersen, Christian C; Stergiakouli, Evie E; Sheu, Wayne Huey-Herng WH; Rosendaal, Frits R FR; Ikram, M Arfan MA; Franco, Oscar H OH; Ridker, Paul M PM; Perls, Thomas T TT; Pedersen, Oluf O; Nohr, Ellen A EA; Newman, Anne B AB; Linneberg, Allan A; Langenberg, Claudia C; Kilpeläinen, Tuomas O TO; Kardia, Sharon L R SLR; Jørgensen, Marit E ME; Jørgensen, Torben T; Sørensen, Thorkild I A TIA; Homuth, Georg G; Hansen, Torben T; Goodarzi, Mark O MO; Deary, Ian J IJ; Christensen, Cramer C; Chen, Yii-Der Ida YI; Chakravarti, Aravinda A; Brandslund, Ivan I; Bonnelykke, Klaus K; Taylor, Kent D KD; Wilson, James G JG; Rodriguez, Santiago S; Davies, Gail G; Horta, Bernardo L BL; Thyagarajan, Bharat B; Rao, D C DC; Grarup, Niels N; Davila-Roman, Victor G VG; Hudson, Gavin G; Guo, Xiuqing X; Arnett, Donna K DK; Hayward, Caroline C; Vaidya, Dhananjay D; Mook-Kanamori, Dennis O DO; Tiwari, Hemant K HK; Levy, Daniel D; Loos, Ruth J F RJF; Dehghan, Abbas A; Elliott, Paul P; Malik, Afshan N AN; Scott, Robert A RA; Becker, Diane M DM; de Andrade, Mariza M; Province, Michael A MA; Meigs, James B JB; Rotter, Jerome I JI; North, Kari E KE
Fine-mapping inflammatory bowel disease loci to single-variant resolution.
Nature
Huang, Hailiang H; Fang, Ming M; Jostins, Luke L; Umićević Mirkov, Maša M; Boucher, Gabrielle G; Anderson, Carl A CA; Andersen, Vibeke V; Cleynen, Isabelle I; Cortes, Adrian A; Crins, François F; D'Amato, Mauro M; Deffontaine, Valérie V; Dmitrieva, Julia J; Docampo, Elisa E; Elansary, Mahmoud M; Farh, Kyle Kai-How KK; Franke, Andre A; Gori, Ann-Stephan AS; Goyette, Philippe P; Halfvarson, Jonas J; Haritunians, Talin T; Knight, Jo J; Lawrance, Ian C IC; Lees, Charlie W CW; Louis, Edouard E; Mariman, Rob R; Meuwissen, Theo T; Mni, Myriam M; Momozawa, Yukihide Y; Parkes, Miles M; Spain, Sarah L SL; Théâtre, Emilie E; Trynka, Gosia G; Satsangi, Jack J; van Sommeren, Suzanne S; Vermeire, Severine S; Xavier, Ramnik J RJ; , ; Weersma, Rinse K RK; Duerr, Richard H RH; Mathew, Christopher G CG; Rioux, John D JD; McGovern, Dermot P B DPB; Cho, Judy H JH; Georges, Michel M; Daly, Mark J MJ; Barrett, Jeffrey C JC
New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk.
Nature Communications
Lu, Yingchang Y; Day, Felix R FR; Gustafsson, Stefan S; Buchkovich, Martin L ML; Na, Jianbo J; Bataille, Veronique V; Cousminer, Diana L DL; Dastani, Zari Z; Drong, Alexander W AW; Esko, Tõnu T; Evans, David M DM; Falchi, Mario M; Feitosa, Mary F MF; Ferreira, Teresa T; Hedman, Åsa K ÅK; Haring, Robin R; Hysi, Pirro G PG; Iles, Mark M MM; Justice, Anne E AE; Kanoni, Stavroula S; Lagou, Vasiliki V; Li, Rui R; Li, Xin X; Locke, Adam A; Lu, Chen C; Mägi, Reedik R; Perry, John R B JR; Pers, Tune H TH; Qi, Qibin Q; Sanna, Marianna M; Schmidt, Ellen M EM; Scott, William R WR; Shungin, Dmitry D; Teumer, Alexander A; Vinkhuyzen, Anna A E AA; Walker, Ryan W RW; Westra, Harm-Jan HJ; Zhang, Mingfeng M; Zhang, Weihua W; Zhao, Jing Hua JH; Zhu, Zhihong Z; Afzal, Uzma U; Ahluwalia, Tarunveer Singh TS; Bakker, Stephan J L SJ; Bellis, Claire C; Bonnefond, Amélie A; Borodulin, Katja K; Buchman, Aron S AS; Cederholm, Tommy T; Choh, Audrey C AC; Choi, Hyung Jin HJ; Curran, Joanne E JE; de Groot, Lisette C P G M LC; De Jager, Philip L PL; Dhonukshe-Rutten, Rosalie A M RA; Enneman, Anke W AW; Eury, Elodie E; Evans, Daniel S DS; Forsen, Tom T; Friedrich, Nele N; Fumeron, Frédéric F; Garcia, Melissa E ME; Gärtner, Simone S; Han, Bok-Ghee BG; Havulinna, Aki S AS; Hayward, Caroline C; Hernandez, Dena D; Hillege, Hans H; Ittermann, Till T; Kent, Jack W JW; Kolcic, Ivana I; Laatikainen, Tiina T; Lahti, Jari J; Mateo Leach, Irene I; Lee, Christine G CG; Lee, Jong-Young JY; Liu, Tian T; Liu, Youfang Y; Lobbens, Stéphane S; Loh, Marie M; Lyytikäinen, Leo-Pekka LP; Medina-Gomez, Carolina C; Michaëlsson, Karl K; Nalls, Mike A MA; Nielson, Carrie M CM; Oozageer, Laticia L; Pascoe, Laura L; Paternoster, Lavinia L; Polašek, Ozren O; Ripatti, Samuli S; Sarzynski, Mark A MA; Shin, Chan Soo CS; Narančić, Nina Smolej NS; Spira, Dominik D; Srikanth, Priya P; Steinhagen-Thiessen, Elisabeth E; Sung, Yun Ju YJ; Swart, Karin M A KM; Taittonen, Leena L; Tanaka, Toshiko T; Tikkanen, Emmi E; van der Velde, Nathalie N; van Schoor, Natasja M NM; Verweij, Niek N; Wright, Alan F AF; Yu, Lei L; Zmuda, Joseph M JM; Eklund, Niina N; Forrester, Terrence T; Grarup, Niels N; Jackson, Anne U AU; Kristiansson, Kati K; Kuulasmaa, Teemu T; Kuusisto, Johanna J; Lichtner, Peter P; Luan, Jian'an J; Mahajan, Anubha A; Männistö, Satu S; Palmer, Cameron D CD; Ried, Janina S JS; Scott, Robert A RA; Stancáková, Alena A; Wagner, Peter J PJ; Demirkan, Ayse A; Döring, Angela A; Gudnason, Vilmundur V; Kiel, Douglas P DP; Kühnel, Brigitte B; Mangino, Massimo M; Mcknight, Barbara B; Menni, Cristina C; O'Connell, Jeffrey R JR; Oostra, Ben A BA; Shuldiner, Alan R AR; Song, Kijoung K; Vandenput, Liesbeth L; van Duijn, Cornelia M CM; Vollenweider, Peter P; White, Charles C CC; Boehnke, Michael M; Boettcher, Yvonne Y; Cooper, Richard S RS; Forouhi, Nita G NG; Gieger, Christian C; Grallert, Harald H; Hingorani, Aroon A; Jørgensen, Torben T; Jousilahti, Pekka P; Kivimaki, Mika M; Kumari, Meena M; Laakso, Markku M; Langenberg, Claudia C; Linneberg, Allan A; Luke, Amy A; Mckenzie, Colin A CA; Palotie, Aarno A; Pedersen, Oluf O; Peters, Annette A; Strauch, Konstantin K; Tayo, Bamidele O BO; Wareham, Nicholas J NJ; Bennett, David A DA; Bertram, Lars L; Blangero, John J; Blüher, Matthias M; Bouchard, Claude C; Campbell, Harry H; Cho, Nam H NH; Cummings, Steven R SR; Czerwinski, Stefan A SA; Demuth, Ilja I; Eckardt, Rahel R; Eriksson, Johan G JG; Ferrucci, Luigi L; Franco, Oscar H OH; Froguel, Philippe P; Gansevoort, Ron T RT; Hansen, Torben T; Harris, Tamara B TB; Hastie, Nicholas N; Heliövaara, Markku M; Hofman, Albert A; Jordan, Joanne M JM; Jula, Antti A; Kähönen, Mika M; Kajantie, Eero E; Knekt, Paul B PB; Koskinen, Seppo S; Kovacs, Peter P; Lehtimäki, Terho T; Lind, Lars L; Liu, Yongmei Y; Orwoll, Eric S ES; Osmond, Clive C; Perola, Markus M; Pérusse, Louis L; Raitakari, Olli T OT; Rankinen, Tuomo T; Rao, D C DC; Rice, Treva K TK; Rivadeneira, Fernando F; Rudan, Igor I; Salomaa, Veikko V; Sørensen, Thorkild I A TI; Stumvoll, Michael M; Tönjes, Anke A; Towne, Bradford B; Tranah, Gregory J GJ; Tremblay, Angelo A; Uitterlinden, André G AG; van der Harst, Pim P; Vartiainen, Erkki E; Viikari, Jorma S JS; Vitart, Veronique V; Vohl, Marie-Claude MC; Völzke, Henry H; Walker, Mark M; Wallaschofski, Henri H; Wild, Sarah S; Wilson, James F JF; Yengo, Loïc L; Bishop, D Timothy DT; Borecki, Ingrid B IB; Chambers, John C JC; Cupples, L Adrienne LA; Dehghan, Abbas A; Deloukas, Panos P; Fatemifar, Ghazaleh G; Fox, Caroline C; Furey, Terrence S TS; Franke, Lude L; Han, Jiali J; Hunter, David J DJ; Karjalainen, Juha J; Karpe, Fredrik F; Kaplan, Robert C RC; Kooner, Jaspal S JS; McCarthy, Mark I MI; Murabito, Joanne M JM; Morris, Andrew P AP; Bishop, Julia A N JA; North, Kari E KE; Ohlsson, Claes C; Ong, Ken K KK; Prokopenko, Inga I; Richards, J Brent JB; Schadt, Eric E EE; Spector, Tim D TD; Widén, Elisabeth E; Willer, Cristen J CJ; Yang, Jian J; Ingelsson, Erik E; Mohlke, Karen L KL; Hirschhorn, Joel N JN; Pospisilik, John Andrew JA; Zillikens, M Carola MC; Lindgren, Cecilia C; Kilpeläinen, Tuomas Oskari TO; Loos, Ruth J F RJ
Modification of genetic influences on adiposity between 36 and 63 years of age by physical activity and smoking in the 1946 British Birth Cohort Study.
Nutrition & Diabetes
Johnson, W W; Ong, K K KK; Elks, C E CE; Wareham, N J NJ; Wong, A A; Muniz-Terrera, G G; Hardy, R R; ,
Genome-wide analysis of BMI in adolescents and young adults reveals additional insight into the effects of genetic loci over the life course.
Human Molecular Genetics
Graff, Mariaelisa M; Ngwa, Julius S JS; Workalemahu, Tsegaselassie T; Homuth, Georg G; Schipf, Sabine S; Teumer, Alexander A; Völzke, Henry H; Wallaschofski, Henri H; Abecasis, Goncalo R GR; Edward, Lakatta L; Francesco, Cucca C; Sanna, Serena S; Scheet, Paul P; Schlessinger, David D; Sidore, Carlo C; Xiao, Xiangjun X; Wang, Zhaoming Z; Chanock, Stephen J SJ; Jacobs, Kevin B KB; Hayes, Richard B RB; Hu, Frank F; Van Dam, Rob M RM; , ; Crout, Richard J RJ; Marazita, Mary L ML; Shaffer, John R JR; Atwood, Larry D LD; Fox, Caroline S CS; Heard-Costa, Nancy L NL; White, Charles C; Choh, Audrey C AC; Czerwinski, Stefan A SA; Demerath, Ellen W EW; Dyer, Thomas D TD; Towne, Bradford B; Amin, Najaf N; Oostra, Ben A BA; Van Duijn, Cornelia M CM; Zillikens, M Carola MC; Esko, Tõnu T; Nelis, Mari M; Nikopensius, Tit T; Metspalu, Andres A; Strachan, David P DP; Monda, Keri K; Qi, Lu L; North, Kari E KE; Cupples, L Adrienne LA; Gordon-Larsen, Penny P; Berndt, Sonja I SI
Modelling BMI trajectories in children for genetic association studies.
Plos One
Warrington, Nicole M NM; Wu, Yan Yan YY; Pennell, Craig E CE; Marsh, Julie A JA; Beilin, Lawrence J LJ; Palmer, Lyle J LJ; Lye, Stephen J SJ; Briollais, Laurent L
Adult obesity susceptibility variants are associated with greater childhood weight gain and a faster tempo of growth: the 1946 British Birth Cohort Study.
The American Journal Of Clinical Nutrition
Elks, Cathy E CE; Loos, Ruth J F RJ; Hardy, Rebecca R; Wills, Andrew K AK; Wong, Andrew A; Wareham, Nicholas J NJ; Kuh, Diana D; Ong, Ken K KK
Genetic susceptibility to obesity and related traits in childhood and adolescence: influence of loci identified by genome-wide association studies.
Diabetes
den Hoed, Marcel M; Ekelund, Ulf U; Brage, Søren S; Grontved, Anders A; Zhao, Jing Hua JH; Sharp, Stephen J SJ; Ong, Ken K KK; Wareham, Nicholas J NJ; Loos, Ruth J F RJ