Publications:

---

Condensed-phase signaling can expand kinase specificity and respond to macromolecular crowding.

Molecular Cell

Sang, Dajun D; Shu, Tong T; Pantoja, Christian F CF; Ibáñez de Opakua, Alain A; Zweckstetter, Markus M; Holt, Liam J LJ

Publication Date: 2022-10-06

Variant appearance in text: MAPK3: R84S

PubMed Link: 36108633

Variant Present in the following documents:

• Main text
• nihms-1838958.pdf

View BVdb publication page

---

Development of small molecule extracellular signal-regulated kinases (ERKs) inhibitors for cancer therapy.

Acta Pharmaceutica Sinica. B

Pan, Xiaoli X; Pei, Junping J; Wang, Aoxue A; Shuai, Wen W; Feng, Lu L; Bu, Faqian F; Zhu, Yumeng Y; Zhang, Lan L; Wang, Guan G; Ouyang, Liang L

Publication Date: 2022-05

Variant appearance in text: ERK1: R84S

PubMed Link: 35646548

Variant Present in the following documents:

• Main text
• main.pdf

View BVdb publication page

---

TRIM15 and CYLD regulate ERK activation via lysine-63-linked polyubiquitination.

Nature Cell Biology

Zhu, Guixin G; Herlyn, Meenhard M; Yang, Xiaolu X

Publication Date: 2021-09

Variant appearance in text: ERK1: R84S

PubMed Link: 34497368

Variant Present in the following documents:

• Main text
• NIHMS1722171-supplement-Statistical_Source_Data_for_Fig__7.xlsx, sheet 5
• nihms-1722171.pdf

View BVdb publication page

---

Monoubiquitination of p120-catenin is essential for TGFβ-induced epithelial-mesenchymal transition and tumor metastasis.

Science Advances

Wu, Qingang Q; Li, Gao G; Wen, Chengwen C; Zeng, Taoling T; Fan, Yuxi Y; Liu, Chunyan C; Fu, Guo-Feng GF; Xie, Changchuan C; Lin, Qi Q; Xie, Liping L; Huang, Lei L; Pu, Pengpeng P; Ouyang, Zhong Z; Chan, Hong-Lin HL; Zhao, Tong-Jin TJ; Chen, Xiao Lei XL; Fu, Guo G; Wang, Hong-Rui HR

Publication Date: 2020-01

Variant appearance in text: ERK1: R84S

PubMed Link: 32010791

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Mutations That Confer Drug-Resistance, Oncogenicity and Intrinsic Activity on the ERK MAP Kinases-Current State of the Art.

Cells

Smorodinsky-Atias, Karina K; Soudah, Nadine N; Engelberg, David D

Publication Date: 2020-01-06

Variant appearance in text: ERK1: R84S

PubMed Link: 31935908

Variant Present in the following documents:

• Main text
• cells-09-00129.pdf

View BVdb publication page

---

Variants of the yeast MAPK Mpk1 are fully functional independently of activation loop phosphorylation.

Molecular Biology Of The Cell

Goshen-Lago, Tal T; Goldberg-Carp, Anat A; Melamed, Dganit D; Darlyuk-Saadon, Ilona I; Bai, Chen C; Ahn, Natalie G NG; Admon, Arie A; Engelberg, David D

Publication Date: 2016-09-01

Variant appearance in text: ERK1: R84S

PubMed Link: 27413009

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Intrinsically active variants of Erk oncogenically transform cells and disclose unexpected autophosphorylation capability that is independent of TEY phosphorylation.

Molecular Biology Of The Cell

Smorodinsky-Atias, Karina K; Goshen-Lago, Tal T; Goldberg-Carp, Anat A; Melamed, Dganit D; Shir, Alexei A; Mooshayef, Navit N; Beenstock, Jonah J; Karamansha, Yael Y; Darlyuk-Saadon, Ilona I; Livnah, Oded O; Ahn, Natalie G NG; Admon, Arie A; Engelberg, David D

Publication Date: 2016-03-15

Variant appearance in text: ERK1: R84S

PubMed Link: 26658610

Variant Present in the following documents:

• Main text
• 1026.pdf

View BVdb publication page

---

Isolation of intrinsically active (MEK-independent) variants of the ERK family of mitogen-activated protein (MAP) kinases.

The Journal Of Biological Chemistry

Levin-Salomon, Vered V; Kogan, Konstantin K; Ahn, Natalie G NG; Livnah, Oded O; Engelberg, David D

Publication Date: 2008-12-12

Variant appearance in text: ERK1: R84S

PubMed Link: 18829462

Variant Present in the following documents:

• Main text

View BVdb publication page

---