Profiling of warfarin pharmacokinetics-associated genetic variants: Black Africans portray unique genetic markers important for an African specific warfarin pharmacogenetics-dosing algorithm.
Journal Of Thrombosis And Haemostasis : Jth
Ndadza, Arinao A; Muyambo, Sarudzai S; Mntla, Pindile P; Wonkam, Ambroise A; Chimusa, Emile E; Kengne, Andre P AP; Ntsekhe, Mpiko M; Dandara, Collet C
Development and Analytical Validation of a 29 Gene Clinical Pharmacogenetic Genotyping Panel: Multi-Ethnic Allele and Copy Number Variant Detection.
Clinical And Translational Science
Scott, Stuart A SA; Scott, Erick R ER; Seki, Yoshinori Y; Chen, Annette J AJ; Wallsten, Richard R; Owusu Obeng, Aniwaa A; Botton, Mariana R MR; Cody, Neal N; Shi, Huanzhi H; Zhao, Geping G; Brake, Paul P; Nicoletti, Paola P; Yang, Yao Y; Delio, Maria M; Shi, Lisong L; Kornreich, Ruth R; Schadt, Eric E EE; Edelmann, Lisa L
Publication Date: 2021-01
Variant appearance in text: VKORC1: 196G>A; rs72547529
Multiplexed measurement of variant abundance and activity reveals VKOR topology, active site and human variant impact.
Elife
Chiasson, Melissa A MA; Rollins, Nathan J NJ; Stephany, Jason J JJ; Sitko, Katherine A KA; Matreyek, Kenneth A KA; Verby, Marta M; Sun, Song S; Roth, Frederick P FP; DeSloover, Daniel D; Marks, Debora S DS; Rettie, Allan E AE; Fowler, Douglas M DM
Population Pharmacokinetic and Pharmacogenetic Analysis of Mitotane in Patients with Adrenocortical Carcinoma: Towards Individualized Dosing.
Clinical Pharmacokinetics
Yin, Anyue A; Ettaieb, Madeleine H T MHT; Swen, Jesse J JJ; van Deun, Liselotte L; Kerkhofs, Thomas M A TMA; van der Straaten, Robert J H M RJHM; Corssmit, Eleonora P M EPM; Gelderblom, Hans H; Kerstens, Michiel N MN; Feelders, Richard A RA; Eekhoff, Marelise M; Timmers, Henri J L M HJLM; D'Avolio, Antonio A; Cusato, Jessica J; Guchelaar, Henk-Jan HJ; Haak, Harm R HR; Moes, Dirk Jan A R DJAR
Publication Date: 2021-01
Variant appearance in text: VKORC1: 196G>A; V66M; rs72547529
Recommendations for Clinical Warfarin Genotyping Allele Selection: A Report of the Association for Molecular Pathology and the College of American Pathologists.
The Journal Of Molecular Diagnostics : Jmd
Pratt, Victoria M VM; Cavallari, Larisa H LH; Del Tredici, Andria L AL; Hachad, Houda H; Ji, Yuan Y; Kalman, Lisa V LV; Ly, Reynold C RC; Moyer, Ann M AM; Scott, Stuart A SA; Whirl-Carrillo, Michelle M; Weck, Karen E KE
Publication Date: 2020-07
Variant appearance in text: VKORC1: 196G>A; Val66Met; rs72547529
A Novel Admixture-Based Pharmacogenetic Approach to Refine Warfarin Dosing in Caribbean Hispanics.
Plos One
Duconge, Jorge J; Ramos, Alga S AS; Claudio-Campos, Karla K; Rivera-Miranda, Giselle G; Bermúdez-Bosch, Luis L; Renta, Jessicca Y JY; Cadilla, Carmen L CL; Cruz, Iadelisse I; Feliu, Juan F JF; Vergara, Cunegundo C; Ruaño, Gualberto G
Characterization of 137 Genomic DNA Reference Materials for 28 Pharmacogenetic Genes: A GeT-RM Collaborative Project.
The Journal Of Molecular Diagnostics : Jmd
Pratt, Victoria M VM; Everts, Robin E RE; Aggarwal, Praful P; Beyer, Brittany N BN; Broeckel, Ulrich U; Epstein-Baak, Ruth R; Hujsak, Paul P; Kornreich, Ruth R; Liao, Jun J; Lorier, Rachel R; Scott, Stuart A SA; Smith, Chingying Huang CH; Toji, Lorraine H LH; Turner, Amy A; Kalman, Lisa V LV
Pharmacogenetic allele nomenclature: International workgroup recommendations for test result reporting.
Clinical Pharmacology And Therapeutics
Kalman, L V LV; Agúndez, Jag J; Appell, M Lindqvist ML; Black, J L JL; Bell, G C GC; Boukouvala, S S; Bruckner, C C; Bruford, E E; Caudle, K K; Coulthard, S A SA; Daly, A K AK; Del Tredici, Al A; den Dunnen, J T JT; Drozda, K K; Everts, R E RE; Flockhart, D D; Freimuth, R R RR; Gaedigk, A A; Hachad, H H; Hartshorne, T T; Ingelman-Sundberg, M M; Klein, T E TE; Lauschke, V M VM; Maglott, D R DR; McLeod, H L HL; McMillin, G A GA; Meyer, U A UA; Müller, D J DJ; Nickerson, D A DA; Oetting, W S WS; Pacanowski, M M; Pratt, V M VM; Relling, M V MV; Roberts, A A; Rubinstein, W S WS; Sangkuhl, K K; Schwab, M M; Scott, S A SA; Sim, S C SC; Thirumaran, R K RK; Toji, L H LH; Tyndale, R F RF; van Schaik, Rhn R; Whirl-Carrillo, M M; Yeo, Ktj K; Zanger, U M UM
The Affymetrix DMET Plus platform reveals unique distribution of ADME-related variants in ethnic Arabs.
Disease Markers
Wakil, Salma M SM; Nguyen, Cao C; Muiya, Nzioka P NP; Andres, Editha E; Lykowska-Tarnowska, Agnieszka A; Baz, Batoul B; Tahir, Asma I AI; Meyer, Brian F BF; Morahan, Grant G; Dzimiri, Nduna N
Genetic studies of body mass index yield new insights for obesity biology.
Nature
Locke, Adam E AE; Kahali, Bratati B; Berndt, Sonja I SI; Justice, Anne E AE; Pers, Tune H TH; Day, Felix R FR; Powell, Corey C; Vedantam, Sailaja S; Buchkovich, Martin L ML; Yang, Jian J; Croteau-Chonka, Damien C DC; Esko, Tonu T; Fall, Tove T; Ferreira, Teresa T; Gustafsson, Stefan S; Kutalik, Zoltán Z; Luan, Jian'an J; Mägi, Reedik R; Randall, Joshua C JC; Winkler, Thomas W TW; Wood, Andrew R AR; Workalemahu, Tsegaselassie T; Faul, Jessica D JD; Smith, Jennifer A JA; Zhao, Jing Hua JH; Zhao, Wei W; Chen, Jin J; Fehrmann, Rudolf R; Hedman, Åsa K ÅK; Karjalainen, Juha J; Schmidt, Ellen M EM; Absher, Devin D; Amin, Najaf N; Anderson, Denise D; Beekman, Marian M; Bolton, Jennifer L JL; Bragg-Gresham, Jennifer L JL; Buyske, Steven S; Demirkan, Ayse A; Deng, Guohong G; Ehret, Georg B GB; Feenstra, Bjarke B; Feitosa, Mary F MF; Fischer, Krista K; Goel, Anuj A; Gong, Jian J; Jackson, Anne U AU; Kanoni, Stavroula S; Kleber, Marcus E ME; Kristiansson, Kati K; Lim, Unhee U; Lotay, Vaneet V; Mangino, Massimo M; 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Determinants of the over-anticoagulation response during warfarin initiation therapy in Asian patients based on population pharmacokinetic-pharmacodynamic analyses.
Plos One
Ohara, Minami M; Takahashi, Harumi H; Lee, Ming Ta Michael MT; Wen, Ming-Shien MS; Lee, Tsong-Hai TH; Chuang, Hui-Ping HP; Luo, Chen-Hui CH; Arima, Aki A; Onozuka, Akiko A; Nagai, Rui R; Shiomi, Mari M; Mihara, Kiyoshi K; Morita, Takashi T; Chen, Yuan-Tsong YT
Development of a pharmacogenetic-guided warfarin dosing algorithm for Puerto Rican patients.
Pharmacogenomics
Ramos, Alga S AS; Seip, Richard L RL; Rivera-Miranda, Giselle G; Felici-Giovanini, Marcos E ME; Garcia-Berdecia, Rafael R; Alejandro-Cowan, Yirelia Y; Kocherla, Mohan M; Cruz, Iadelisse I; Feliu, Juan F JF; Cadilla, Carmen L CL; Renta, Jessica Y JY; Gorowski, Krystyna K; Vergara, Cunegundo C; Ruaño, Gualberto G; Duconge, Jorge J
Effect of the VKORC1 D36Y variant on warfarin dose requirement and pharmacogenetic dose prediction.
Thrombosis And Haemostasis
Kurnik, Daniel D; Qasim, Husam H; Sominsky, Sophie S; Lubetsky, Aharon A; Markovits, Noa N; Li, Chun C; Stein, C Michael CM; Halkin, Hillel H; Gak, Eva E; Loebstein, Ronen R
Predicting warfarin dosage in European-Americans and African-Americans using DNA samples linked to an electronic health record.
Pharmacogenomics
Ramirez, Andrea H AH; Shi, Yaping Y; Schildcrout, Jonathan S JS; Delaney, Jessica T JT; Xu, Hua H; Oetjens, Matthew T MT; Zuvich, Rebecca L RL; Basford, Melissa A MA; Bowton, Erica E; Jiang, Min M; Speltz, Peter P; Zink, Raquel R; Cowan, James J; Pulley, Jill M JM; Ritchie, Marylyn D MD; Masys, Daniel R DR; Roden, Dan M DM; Crawford, Dana C DC; Denny, Joshua C JC
Oral anticoagulant therapy: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines.
Chest
Ageno, Walter W; Gallus, Alexander S AS; Wittkowsky, Ann A; Crowther, Mark M; Hylek, Elaine M EM; Palareti, Gualtiero G
Prediction of warfarin dose reductions in Puerto Rican patients, based on combinatorial CYP2C9 and VKORC1 genotypes.
The Annals Of Pharmacotherapy
Valentin, Isa Ivette II; Vazquez, Joan J; Rivera-Miranda, Giselle G; Seip, Richard L RL; Velez, Meredith M; Kocherla, Mohan M; Bogaard, Kali K; Cruz-Gonzalez, Iadelisse I; Cadilla, Carmen L CL; Renta, Jessica Y JY; Feliu, Juan F JF; Ramos, Alga S AS; Alejandro-Cowan, Yirelia Y; Gorowski, Krystyna K; Ruaño, Gualberto G; Duconge, Jorge J
CYP2C9 and VKORC1 genotypes in Puerto Ricans: A case for admixture-matching in clinical pharmacogenetic studies.
Clinica Chimica Acta; International Journal Of Clinical Chemistry
Villagra, David D; Duconge, Jorge J; Windemuth, Andreas A; Cadilla, Carmen L CL; Kocherla, Mohan M; Gorowski, Krystyna K; Bogaard, Kali K; Renta, Jessica Y JY; Cruz, Irelys A IA; Mirabal, Sara S; Seip, Richard L RL; Ruaño, Gualberto G
Comparative performance of gene-based warfarin dosing algorithms in a multiethnic population.
Journal Of Thrombosis And Haemostasis : Jth
Lubitz, S A SA; Scott, S A SA; Rothlauf, E B EB; Agarwal, A A; Peter, I I; Doheny, D D; Van Der Zee, S S; Jaremko, M M; Yoo, C C; Desnick, R J RJ; Halperin, J L JL
Prevalence of combinatorial CYP2C9 and VKORC1 genotypes in Puerto Ricans: implications for warfarin management in Hispanics.
Ethnicity & Disease
Duconge, Jorge J; Cadilla, Carmen L CL; Windemuth, Andreas A; Kocherla, Mohan M; Gorowski, Krystyna K; Seip, Richard L RL; Bogaard, Kali K; Renta, Jessica Y JY; Piovanetti, Paola P; D'Agostino, Darrin D; Santiago-Borrero, Pedro J PJ; Ruaño, Gualberto G
Novel mutations in the VKORC1 gene of wild rats and mice--a response to 50 years of selection pressure by warfarin?
Bmc Genetics
Rost, Simone S; Pelz, Hans-Joachim HJ; Menzel, Sandra S; MacNicoll, Alan D AD; León, Vanina V; Song, Ki-Joon KJ; Jäkel, Thomas T; Oldenburg, Johannes J; Müller, Clemens R CR
Warfarin pharmacogenetics: CYP2C9 and VKORC1 genotypes predict different sensitivity and resistance frequencies in the Ashkenazi and Sephardi Jewish populations.
American Journal Of Human Genetics
Scott, Stuart A SA; Edelmann, Lisa L; Kornreich, Ruth R; Desnick, Robert J RJ