Publications:

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Missense VKOR mutants exhibit severe warfarin resistance but lack VKCFD via shifting to an aberrantly reduced state.

Blood Advances

Li, Shuang S; Sun, Jie J; Liu, Shixuan S; Zhou, Fengbo F; Gross, Michael M; Li, Weikai W

Publication Date: 2022-12-12

Variant appearance in text: VKORC1: W59C

PubMed Link: 36508285

Variant Present in the following documents:

• Main text
• main.pdf

View BVdb publication page

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Multiplexed measurement of variant abundance and activity reveals VKOR topology, active site and human variant impact.

Elife

Chiasson, Melissa A MA; Rollins, Nathan J NJ; Stephany, Jason J JJ; Sitko, Katherine A KA; Matreyek, Kenneth A KA; Verby, Marta M; Sun, Song S; Roth, Frederick P FP; DeSloover, Daniel D; Marks, Debora S DS; Rettie, Allan E AE; Fowler, Douglas M DM

Publication Date: 2020-09-01

Variant appearance in text: VKORC1: W59C

PubMed Link: 32870157

Variant Present in the following documents:

• elife-58026.pdf

View BVdb publication page

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Assessment of coding region variants in Kuwaiti population: implications for medical genetics and population genomics.

Scientific Reports

John, Sumi Elsa SE; Antony, Dinu D; Eaaswarkhanth, Muthukrishnan M; Hebbar, Prashantha P; Channanath, Arshad Mohamed AM; Thomas, Daisy D; Devarajan, Sriraman S; Tuomilehto, Jaakko J; Al-Mulla, Fahd F; Alsmadi, Osama O; Thanaraj, Thangavel Alphonse TA

Publication Date: 2018-11-08

Variant appearance in text: VKORC1: 177G>C

PubMed Link: 30409984

Variant Present in the following documents:

• Main text
• 41598_2018_Article_34815.pdf

View BVdb publication page

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Structural Modeling Insights into Human VKORC1 Phenotypes.

Nutrients

Czogalla, Katrin J KJ; Watzka, Matthias M; Oldenburg, Johannes J

Publication Date: 2015-08-14

Variant appearance in text: VKORC1: Trp59Cys

PubMed Link: 26287237

Variant Present in the following documents:

• Main text

View BVdb publication page

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VKORC1 and VKORC1L1: Why do Vertebrates Have Two Vitamin K 2,3-Epoxide Reductases?

Nutrients

Oldenburg, Johannes J; Watzka, Matthias M; Bevans, Carville G CG

Publication Date: 2015-07-30

Variant appearance in text: VKORC1: W59C

PubMed Link: 26264021

Variant Present in the following documents:

• Main text
• nutrients-07-05280.pdf

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GESPA: classifying nsSNPs to predict disease association.

Bmc Bioinformatics

Khurana, Jay K JK; Reeder, Jay E JE; Shrimpton, Antony E AE; Thakar, Juilee J

Publication Date: 2015-07-25

Variant appearance in text: VKORC1: W59C

PubMed Link: 26206375

Variant Present in the following documents:

• 12859_2015_673_MOESM1_ESM.xls, sheet 5

View BVdb publication page

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Confirmation of warfarin resistance of naturally occurring VKORC1 variants by coexpression with coagulation factor IX and in silico protein modelling.

Bmc Genetics

Müller, Elisabeth E; Keller, Alexander A; Fregin, Andreas A; Müller, Clemens R CR; Rost, Simone S

Publication Date: 2014-02-04

Variant appearance in text: VKORC1: Trp59Cys

PubMed Link: 24491178

Variant Present in the following documents:

• Main text
• 1471-2156-15-17.pdf

View BVdb publication page

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